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Kryukov 1983 Genetics-V19-N1 PDF
Kryukov 1983 Genetics-V19-N1 PDF
58-63
575.11:599.323.4
t-
II.
, .
-
(t- ), Mus musculus L. -
. , ,
>50%. ,
t- . musculus
(t0, t9, t12 tw5), -
. , t-
.
– t- t- –
: (tv – viable),
sl
(semilethal – t ) (lethal – t1) [1, 2]. tv
1
t -
. -
; tv , [3,
4].
tsl 2 51% ,
, .
t v- tsl : (twPa-2
wPa-3
t ), , ,
tv- [4], tsl (tw2) 51%- [5].
[6]
tsl -
. tsl «
t- » -
. , ,
tsl 10% -
100%- . ,
»,
tv
twPa-2 twPa-3),
tsl 10-100%. -
, tsl , , ,
.
– tl . -
, , , -
. tl
[2, 4, 7, 8]. , -
, ,
. tl -
. – tl1/tl2
1
, [9, 10]. t -
. musculus. , , -
, , ,
-2 [11, 12].
t- , -
(0,5);
t- >0,5.
t-
. musculus,
[8]. t- -
-
: « » « » [13, 14].
11 t- . , ,
tl , , ,
(t0, t9, t12 tw5).
,
+/tw , [13] (
tw – , ; . wild
[2]). ,
,
(T/t) .
T/t, . N=2T/t. ,
: ( )
0,5 ( . [2]), -
: T/T + tl1/tl2 = T/tl1/ + T/tl2. , , -
(T/t1), -
. , N=2T/t.
tl1/tl2 ) St : n=N:2×St.
K=n : n ×100%.
3
( ) (tw
.1 , tw ,
tw
(T/tw /tw) -
(Stw) . -
: -
(T/tw) . -
,
tv tsl. -
(2,6-3,8 ) ,
(3,0-3,8 ). -
(St 0,80) (St 0,80)
.
(1:1) . -
t- , [2, 15].
.2 -
(t6, twl8, t12, tw5), t0-, t9-,
t12- tw5 .
, . ., ,
[2, 8, 9].
),
tw -
( . . 2), ,
tw . K tw -
( . 3). -
, t- [9].
. .2 3) ,
, , .
, tw , . mus-
culus ( ), -
, [2, 4,
15]. , – tw5,
. -
, tw5 , ,
[4, 16, 17]. ,
. musculus [18], ,
-
, .
-
– tw73 twPa-l, [4, 16].
,
tw
: twl ( ), tw73 twPa~l
. musculus).
.1 , tw -
1 sl
t -, t . , -
tsl ,
sl sl sl
/t t /t ,
[5]. tsl/tsl
(T/tw /tw) . , tw
, ,
, tw tsl 10%-
.
tsl [2].
2
, twM16, twM17-6, twM41, twM28,
twM45, twM08, twM010 twM024 ,
t1 . twM07, twM017 twM018 -
, t1-, ts1 .
,
(T/t× /t), -
t1-, ts1 .
. musculus tw
w
(t ) , -
(1:1). ,
, -
, [6, 15].
tw ,
Kcp tw ( .
. 3). , , , tw -
,
. ,
, .
,
,
tw ,
( . . 3). , Kcp
. « » « »
, tl
.
1. Bennett D., Dunn L. . Transmission ratio distorting genes on chromosome IX and their interaction.
–In: Immunogenetics of the H-2 System. Karger, Basel, 1971, p. 90.
2. Bennett D. The T-locus of the mouse. -Cell, 1975, v. 6, p. 441.
3. Braden A. W. H. T-locus in mice: segregation distortion and sterility in the male. – In: The genetics
of the spermatozoon.– Proc. Int. Sympos. Edinburgh, 1972, p. 289.
4. Guenet J.L., Condamine H., Gaillard J., Jacob F. twPa-1, twPa-2, twPa-3: three new t-haplotypes in
the mouse. - Genet. Res., 1980, v. 36. 2, p. 211.
5. Bennett D., Dunn L. C. Genetical and embriological comparisons of semilethal t alleles from wild
mouse populations. – Genetics, 1969, v. 61, 2, p. 411.
6. Lewontin R. C. The effect of differential viability on the population dinamics of t-alleles in the
mouse.- Evolution, 1968, v. 22, 2, p. 262.
7. Artzl K., Rabiarz ., Bennett D. A t-haplotype (tw35) overlapping two complementation groups. -
Genet. Res., 1979, v. 33, 3, p. 279.
8. . ., . . (Mus musculus L.).– .:
. . 9. .: , 1980, . 97.
9. Silagi S. A genetical and embriological study of partial complementation between lethal alleles at the
T locus of the house mouse. –Develop. Biol., 1962, v. 5, 1, p. 35.
10. . . (Mus musculus L.).
– . ., 1980, . 14, 2, . 73.
11. Hammerberg G., Klein J., Artzt K., Bennett D. Histocompatibility-2-system in wild mice. II. H-2
haplotypes of t-bearing mice. – Transplantation. 1976, v. 21, 3, p. 199.
12. Snell G. D. The H-2 locus of the mouse: observations and speculations concerning its comparative
genetics and its polymorphism. –Folia Biol. (Praha), 1968, v. 14, 5, p. 335.
13. , ., . t-
. I. t- Mus mus-
culus L. .- . 1980, . 16, 7, . 1270.
14. . , . ., . . -
(Mus musculus L.).– . ., 1981, . 16, 12, . 182.
15. . : -
Mus musculus.– .: . .:
, 1977, . 39.
16. Dunn L. , Bennett D., Cookingham J. Polymorphisms for lethal alleles in European populations of
Mus musculus. – J. Mammal., 1973. v. 54, 4, p. 822.
17. Klein J., Hammerberg The control of differentiation by the T complex. – Immunol. Revs, 1977, v.
33, p. 70.
18. Chaline J. Rodents, evolution and prehistory. – Endeavour, 1977, v. 1, 2, p. 44.
29.V.1981
. . ,
25.IX.1984
:
, , , . t- .
II. // . –1983. – . XIX,
1. – . 58-63