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  • Virology - Biology 3310/4310 Spring 2019 Prof V. Racaniello Study Questions For Lecture 6 - RNA-directed RNA Synthesis

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    Elvis J. Davis
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    This document provides study questions for a lecture on RNA-directed RNA synthesis. The questions cover topics like why negative-strand viral RNA must be coated with protein, whether all RNA viruses encode their own replication system, the flow of information for positive-strand, negative-strand, and double-stranded RNA genomes, primers used for replication of picornaviruses and influenza viruses, and how poly(A) tails are added to mRNA of RNA viruses.

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    This document provides study questions for a lecture on RNA-directed RNA synthesis. The questions cover topics like why negative-strand viral RNA must be coated with protein, whether all RNA viruses encode their own replication system, the flow of information for positive-strand, negative-strand, and double-stranded RNA genomes, primers used for replication of picornaviruses and influenza viruses, and how poly(A) tails are added to mRNA of RNA viruses.

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    15 views1 page

    Virology - Biology 3310/4310 Spring 2019 Prof V. Racaniello Study Questions For Lecture 6 - RNA-directed RNA Synthesis

    Uploaded by

    Elvis J. Davis
    This document provides study questions for a lecture on RNA-directed RNA synthesis. The questions cover topics like why negative-strand viral RNA must be coated with protein, whether all RNA viruses encode their own replication system, the flow of information for positive-strand, negative-strand, and double-stranded RNA genomes, primers used for replication of picornaviruses and influenza viruses, and how poly(A) tails are added to mRNA of RNA viruses.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    Virology – Biology 3310/4310 Spring 2019

    Prof V. Racaniello
    Study questions for Lecture 6 – RNA-directed RNA synthesis

    1. Why must (-) strand viral RNA be coated with protein in the virion? Why not (+)
    strand viral genomes? Are there exceptions for the latter?

    2. All RNA viruses encode their own replication system. True or False? Why?

    3. Know the flow of information for (+), (-), and ds RNA genomes. Which genomes are
    accompanied by an RdRp in the virus particle? How are proteins encoded in viral RNA
    genomes?

    4. For viruses with (–) sense RNA genomes, the (+) strands and mRNA are the same.
    True or False? Why or why not?

    5. What is the primer for picornavirus replication? The primer for synthesis of influenza
    mRNAs? Is all viral RNA synthesis primer-dependent?

    6. When the genome of a (-)ssRNA virus is purified and introduced into cells that are
    permissive for the original virus, does replication occur? Why? If you did this same
    experiment with a (+) sense ssRNA virus, would viral replication ensue?

    7. How is poly(A) added to mRNAs of RNA viruses?

    Study questions 3310/4310 2019

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