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KINETICS OF DRUGS Recommended

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First-order process takes place at a constant proportion of the drug concentration

available at that time so the process is depending on the initial concentration.
concentration.

Example: Kinetics of 12-Hydrox… Drugs. Types of Drugs…

A patient was given 100 mg of drug B orally and it was assumed to be following first-order
kinetics, a proportion of 10% per minute of the existing concentration at that time.
time. x
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For this example, the dose given to the patient
patient is again 100 mg but the proportion beingbeing
absorbed is 10% per mi
minute.
nute. This
This means that in the first minute,
minute, 10% of the initial drug will
be absorbed (10 mg in the example). For the second minute, again 10% of of the drug that
remained for absorption will be absorbed (10% of 90 mg = 9 mg, meaning, aft after
er the

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Discussion of the importance of understanding the kinetics of drugs.

1. Chemical kinetics - … Cytotoxic drugs Antin…

TRANSCRIPT

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Dandamun, Benbellah Ali Y. BSCHE-5 Engr. Elaine G. Mission KINETICS OF DRUGS 1 KINETICS OF
DRUGS Contents Introduction
...................................................................................................................................... 2 Drug kinetics
..................................................................................................................................... 2 Rate, Order, and
Molecularity .................................................................................................. 2 Zero-Order, First-Order, and
Second-Order Reactions and Their Rate Equations, Half-Life and Shelf-Life
......................................................................................................................... 3 Zero-Order Reaction
................................................................................................................ 4 First-Order Reaction
................................................................................................................. 7 Second-Order Reactions
...................................................................................................... 10 Special Cases
......................................................................................................................... 13 Sample Problems
....................................................................................................................... 13 Solutions to Problems
................................................................................................................ 15 References
...................................................................................................................................... 17 2 KINETICS OF

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