TOPIC : MULTI COMPARTMENT

MODELS
(METHOD OF RESIDUALS, THREE COMPARTMENT OPEN
MODEL)

PREPARED BY
MD. ASADUZZAMAN
ASSISTANT PROFESSOR
DEPARTMENT OF PHARMACY
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Two Compartment Open Model
Method of Residual
Again, Cr = Cp - C exp =
Method of Residual
The rate constants for the transfer of drug between
compartments are referred to as micro-constants or transfer
constants.
Two Compartment Open Model
Extrapolated Volume of Distribution
The extrapolated volume of distribution (VD)exp is calculated by
the following equation:
 Two Compartment Open Model
Distribution of tissues to the Compartments
Classification of a particular tissue, for example brain, into central or
peripheral compartment depends upon the physicochemical properties of
the drug.
A highly lipophilic drug can cross the BBB, and brain would be included into
the central compartment.
In contrast, a polar drug can’t penetrate the BBB and brain in this case will
be a part of peripheral compartment despite the fact that it is a highly
perfused organ.
Ref: Brahmankar; pg-260
Three Compartment Open Model
► The three-compartment model is an extension of the two-compartment model,
with an additional deep tissue compartment.
► A drug that demonstrates the necessity of a three-compartment open model is
distributed most rapidly to a highly perfused central compartment, less rapidly to
the second or tissue compartment, and very slowly to the third or deep tissue
compartment, containing such poorly perfused tissue as bone and fat.
► The deep tissue compartment may also represent tightly bound drug in the tissues.

Ref: Shargel; pg- 114-115

Three Compartment Open Model
Refereces

✔ Applied Biopharmaceutics and Pharmacokinetics – Leon Shargel

and Andrew Yu; 7th edition.
Chapter-5, Pg: 103-104,109,114-115
✔ Biopharmaceutics and pharmacokinetics- D.M.Brahmankar and
Sunil B. Jaiswal
Chapter-10, Pg: 260
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