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Review Article
EUROPEAN JOURNAL OF PHARMACEUTICAL
Tariq. AND MEDICAL RESEARCH
European ISSN 2394-3211
Journal of Pharmaceutical and Medical Research
www.ejpmr.com EJPMR
Sikander Ali1, Rabia Akram2, Shahbaz Tariq*3, Faiza Riaz4 and Syeda Fatima Nadeem5
ABSTRACT
Fermenter control and media formulation has been a dynamic area of research and it captivated the attention of
world. All this is because of the new advances in other interrelated areas which may be utilized to overcome the
inherent complications in control of fermenter. Organization with conventional dictatorial control of variables
such as pH, temperature and dissolved oxygen concentration, research in control of fermenter has undergone
important changes including the current neural network based methods. At industrial scale fermentation, media
are required for growth of specific microbes in a fermenter. Thus fermenter control, nutrients availability and
fermentation efficiency, all are important factors in medium formulation process. The microorganisms used for
process of fermentation grow in specially designed medium having appropriate supply of nutrients such as sources
of nitrogen and carbon, energy sources, certain mineral elements, and water and perhaps vitamins plus oxygen in
case of aerobic nature of microbes. Trace nutrients and growth factors are also important for microbes which are
incapable of fulfilling their nutrient requirements. Trace elements including copper, zinc, cobalt, molybdenum, iron
and manganese are added to medium when purified nitrogen and carbon sources are used. Phosphates and
carbonates are used as mineral buffering salts to stabilize pH and antifoaming agents are used to prevent foam
formation during fermentation process. Chelating agents are also used at higher concentrations of metal ions.
There should be perfection in organism selection and correctness in medium formulation for large scale
production of particular product. Although complete analysis is necessary to develop a suitable medium for
fermentation process.
KEY WORDS: fermenter, fermentation, media, nutrients, microbes, aerobic, variables, trace elements, growth
factors, chelating agents, antifoaming agents.
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Tariq. European Journal of Pharmaceutical and Medical Research
3.1 Sensors
Sensors are available to measure and control the different For on line biosensors sensitivity and specificity
variables in fermenter. require which indicate substantial potential (Cleland
et al., 1983).
For process control it is also possible in relation to its Offline sensor: For process control measured value
application characterize a sensor cannot be used straightforwardly. Sensor is actually
Online sensor: The measured values cannot be use not a part of equipment of fermentation. For actual
promptly for control, sensor play role as integral part measurement an operator is needed and for process
of fermentation equipment. In process control if the control enrolling the measured values in control
data is to be use operator should enter the measured system with high stability and sterilization.
values in process control. In line sensor: This type of sensor is most complex
part of the fermenter and values measured by them
are precise.
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