a b c

8.5e−21 1.00
40
25 3.6e−19

Frequency
0.75
FBG (mmol/L)

FBG (mmol/L)
20 30
3.2e−39 Top
●
●
●
Rank (median): 0.50 Median
15
●

Tail
●

Median (5.37)
●

●
●
●

20 Tail (5.2)
●
● ●
●
● ●

10
●
●

Top (5.9)
●
●
● ● ●
●
●
●
●
● ●
●
●
●

0.25
●
● ● ●
●
●
●
● ●
●
● ●
●
● ●
●
● ● ●
●
● ● ●
●
●
● ●
●
● ●
●
●
●
● ●
●
●

5
●
●
● ●
●
●
● ● ●
●
● ● ●
●
●
● ● ●
●
● ●
●
●
●
● ● ●
●
● ●
●
●
●
● ●
●
● ● ●
●
●
● ● ●
●
●
●
● ●
● ●
● ●

10
●
● ●
●
●
●
● ●
●
●
●
●
●
●
●
●
● ●
●
●
● ●
●
●
●
● ●
●

0.00
●
●
● ●
●
●
● ●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●

80
●
●
●
●

0.005

Mi i
Lin tral Han
an
uth an
No Han
So Eas Han
an
ng n
Ma an
Tib hu
n
Zh ui
ng

ao
Y
60
●
●
●
●

Mo st Ha

eta
● ●

H
n H

So an H

uth t H

oli
nc

ua
Age 0.000
40 Median Tail Top
Score

Ce est

rth

ea
-0.005

gn
w
20

rth
No
d e 3.2e−33
f 1.00
60
40
2h-PBG (mmol/L)

9.7e−23

Frequency
0.75
2h-PBG (mmol/L)

30
1.9e−54
40 ● Rank (median): 0.50 Top
Median (6.7) Median
●
●

20
●

Tail
●

●
●
●
●
●
●
●
●
●
●
●
●
Tail (6.1)
Top (8.60)
● ●
●
● ●
●
●
●
● ●
●
●
●
● ●
● ● ●
●

0.25
●
● ●
●
● ● ●
●
●
● ●

10
●
●
●
● ● ●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
● ●
●
●
● ●
● ●

20
●
● ●
●
● ●
●
● ●
●
●
●
●
● ●
●
● ●
●
●
● ●
●
● ●
●
●
●
● ●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●

0.00
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●
●

80 0.005

Mi i
Lin tral Han
an
uth an
No Han
So Eas Han
an
ng n

ao
Ma an
Tib hu
n
Zh ui
ng
Y
60

Mo st Ha

eta
H
0.000

n H

So an H

uth t H

oli
nc

ua
0

Ce est

rth
Age 40 Score Median Tail Top

ea
-0.005

gn
w
20

rth
No
Fig. S6 Polygenic risk scores for blood glucose from European base dataset. a, d

The three-dimensional position of age, PRS and values of FBG and 2h-PBG for each

individual, which is colored by top, median and tail PRS groups. b, e Boxplot

comparison of the average FBG and 2h-PBG levels from the top, median and tail PRS

groups. c, f Histogram of the PRS percentage (top, median and tail) in different

Chinese populations.