Pemeriksaan Immunoserologi

Covid 19 - DBD
Oleh: Heri Setiyo Bekti

Disampaikan dalam
Webinar Poltekkes Kemenkes Denpasar
Jurusan Teknologi Laboratorium Medis
8 Agustus 2020
Yi Ye, et al., 2020.Int. J. Biol. Sci, pp: 1753-66
Satuan Tugas Penanganan Covid-19; 6 Agustus 2020
 Astuti., et al. 2020.Diabetes & metabolic syndrome: clinical research & reviews
14, pp: 407-12

S. Felsenstein, et al. t al. 2020. Clinical Immunology, pp: 1084-48

Virus corona (Coronaviruses; named crown-like spike (latin: corona-crown), virus RNA)

S (spike); glikoprotein= Berperan dalam memfasilitasi interaksi dengan sel host

(ACE2/Angiotensin-converting enzyme 2)
E (envelope) glikoprotein
M (membrane) glikoprotein
N (nukleokapsid) protein
Lin., et al, 2020. emerging Microbes & Infections 9, pp: 727-32
a Viral infection caused by the DENV virus

fever: The body temperature is usually between 39C and 40C, and
fever may be biphasic, lasting 5-7 days in 5-7 days in the majority
of cases

rash: Diffuse flushing or fleeting eruptions may be observed on the

face, neck, and chest during the first two to three days, and
conspicuous rash that nay be maculopapular or rubelliform appers
on approximately the third or fourth day

Manifestation ranging from mild dengue fever (DF) to severe and

life-threatening dengue hemorrhagic fever (DHF) and dengue shock
syndrome (DSS)
 The dengue virus has a roughly spherical shape
 inside the virus is the nucleocapsid, which made of the viral
genome and C proteins
 The nucleocapsid is surrounded by a membrane called the viral
envelope, a lipid bilayer that is taken from the host
 Embedded in the viral envelope are E and M proteins that span
through the lipid bilayer
 These proteins form a proctective aouter layer that controls the
entry of the virus into human cells
 Immunology is the study of the body's immune system and its
functions and disorder
 Serology is the study of blood serum (the clear fluid that
separates when blood closts)
...is a paper-based platform for the detection and
quantification of analytes in complex mixtures, where
the sample is placed on a test device and the results
are displayed within 5-30min
1. Spesimen rapid tes antigen: swab
nasofaring/orofaring
2. Spesimen rapid antibody: whole
blood/plasma/serum

https://www.centerforhealthsecurity.org/resources/COVID-
19/serology/Serology-based-tests-for-COVID-19.html
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