8/20/2021 What Happened in the Animal Trials for mRNA vaccines? | Regenerative Medicine Center - Dr.

er - Dr. Valerie Donaldson MD Pittsburgh, P…

(https://regenerativemc.com/)

What Happened in the Animal Trials for

mRNA vaccines?
April 8, 2021

Animal studies related to mRNA vaccines were definitely difficult to read and analyze.  My intent today is to begin to
comprehensively present salient features of these studies one at a time addressing concerns of the vaccine being
brought up on the internet.

An interesting fact to note is no animal study went beyond 56 days presumably because the immediate goal was to
prove mRNA vaccines could mount a good immune response with little acute adverse effects.  Hence, we have no
data even in animal studies as to long term adverse effects of mRNA vaccines.   mRNA vaccines are still considered
experimental and people receiving these vaccines are part of the experiment.  Long term data is currently being
collected until 2022. Bottom line is we don’t know the long term adverse effects.  What can we learn from the animal
studies?

The first study I reviewed entitled,  Immunization with SARS coronavirus vaccines leads to pulmonary
immunopathology on challenge with the SARS Virus, published in 2012, began by stating, “The research  for
vaccine development of coronavirus was initiated in 2002 in response to the 2002 spread of SARS which emerged in
China and the “concern for reemergence of a deliberate release of the SARS coronavirus”. *

This study is sited by some researchers who imply, ‘All animals died from autoimmune lung disease after receiving
the vaccine upon being challenged with the virus’   Is this true?

The paper states,” evaluations of an inactivated whole virus vaccine (similar to customary vaccines) in ferrets,
nonhuman primates; and a virus-like-particle in mice induced protection against infection but challenged animals
(those administered vaccines) exhibited an immunopathologic-type lung disease.”*

“The virus-like-particle was an rDNA produced S protein injected in mice on day 0 and 28, some were sacrificed for
serum antibody measurements and the rest challenged with the virus on day 56.  On day 56 those mice were
sacrificed and lungs obtained for virus and pathology”*

The papers’ conclusion was “These SARS-CoV vaccines all induced antibody and protection against infection with
SARS-CoV. However, challenge of mice given any of the vaccines led to occurrence of Th2-type immunopathology
suggesting hypersensitivity to SARS-CoV components was induced. Caution in proceeding to application of a SARS-
CoV vaccine in humans is indicated.”*

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8/20/2021 What Happened in the Animal Trials for mRNA vaccines? | Regenerative Medicine Center - Dr. Valerie Donaldson MD Pittsburgh, P…

All the vaccines used in this research experiment in 2012 triggered hypersensitivity of Th2 immunity. Th2 cells are a
subset of CD4+ T helper cells hence the name Th2.   The results from this study showed as Th2 immunity triggered by
the vaccines increased, the body’s defense system was pushed out of balance and this reaction started to cause
tissue breakdown in the lung.  This, of course, is concerning.

However, the vaccines given in this paper were not the same as the current mRNA vaccines.  The challenging virus
was, of course, not SARS-CoV-2.  The animals did not die of the disease, they were sacrificed.  All other statements
concerning this paper are opinions.  Does this paper have anything to do with the current vaccines?

Next week we will look at Pfizer and Moderna animal studies.  What response do these vaccines mount?  Are they
dangerous? Is the immunity induced by these vaccines effective?

Have an awesome day! Dr. D

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035421
(https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035421) full article

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