Primeasia University

a mission with a vision

Department of Microbiology
Mid Semester Examination, Summer-2020
Course Code: MPG-503 Full Marks: 20
Course Title: Immunopathology and Vaccine Development Time: 1 Hour

1. Write ‘T’, if the statement is true and ‘F’, if the statement is false- 1×5=5
a) In 1796, Jenner inoculated a boy with vaccinia virus to confer immunity to cowpox.
b) When you get a vaccine, it is strong enough to make you sick and trigger your immune system to
generate antibodies against it.
c) Vaccines against Tetanus is made with tetanospasmin toxoid.
d) The inactivated polio vaccine offers its effectiveness after multiple doses.
e) Live attenuated vaccines are out of danger for individuals who are cancer patients.

2. Fill in the blanks- 1×5=5

a) ___________ vaccines can cause serious problems for individuals with weakened immune systems.
b) Vaccines train your immune system to create __________, just as it does when it’s exposed to a
disease.
c) Killed vaccines are less effective in inducing ____________ immunity.
d) __________ vaccines are live replicating viruses that are engineered to carry extra genes derived from
a pathogen and these extra genes produce proteins against which we want to generate immunity.
e) The ____ subunit of cholera toxin activates adenylate cyclase to cause a net increase in ________.

3. Explain the following mechanism of action of Cholera Toxin 3

4. A recent vaccination strategy is DNA vaccine- Interpret its advantages. 2

5. Make a comparison between Attenuated live and Killed vaccines. 5