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  • Pharmacocynetics: Fitri Alfiani, S.Farm., M.KM., Apt

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    Pharmacokinetics describes how the body affects a drug after administration through processes of absorption, distribution, metabolism and excretion. It relates to the mobility and movement of drugs through the body from the site of administration to the site of action. Key factors that determine absorption include drug solubility, molecular size, dosage form, area of absorptive surface and gastrointestinal motility. Distribution involves the drug reaching its site of action through the bloodstream while considering barriers like the blood-brain barrier. Metabolism chemically transforms drugs through enzyme systems to protect the body or reduce toxicity, with over 90% of drugs metabolized in the liver. Excretion is the final pathway of drug elimination from the body.

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    Pharmacokinetics describes how the body affects a drug after administration through processes of absorption, distribution, metabolism and excretion. It relates to the mobility and movement of drugs through the body from the site of administration to the site of action. Key factors that determine absorption include drug solubility, molecular size, dosage form, area of absorptive surface and gastrointestinal motility. Distribution involves the drug reaching its site of action through the bloodstream while considering barriers like the blood-brain barrier. Metabolism chemically transforms drugs through enzyme systems to protect the body or reduce toxicity, with over 90% of drugs metabolized in the liver. Excretion is the final pathway of drug elimination from the body.

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    10 views18 pages

    Pharmacocynetics: Fitri Alfiani, S.Farm., M.KM., Apt

    Uploaded by

    Mel
    Pharmacokinetics describes how the body affects a drug after administration through processes of absorption, distribution, metabolism and excretion. It relates to the mobility and movement of drugs through the body from the site of administration to the site of action. Key factors that determine absorption include drug solubility, molecular size, dosage form, area of absorptive surface and gastrointestinal motility. Distribution involves the drug reaching its site of action through the bloodstream while considering barriers like the blood-brain barrier. Metabolism chemically transforms drugs through enzyme systems to protect the body or reduce toxicity, with over 90% of drugs metabolized in the liver. Excretion is the final pathway of drug elimination from the body.

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    © All Rights Reserved
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    of 18

    Pharmacocynetics

    Fitri Alfiani, S.Farm., M.KM., Apt


    The Effect of
    Pharmacology Drugs

    Pharmacodynamic Pharmacocynetic

    Drug Action Drug Mobility


    Pharmacocynetics
    Absorption

    Related to drugs
    Related to body
    Drug Solubility

    Molecular size

    Particle size
    Physical & chemical forms

    Formulation

    Dosage Form
    Area of Absortive surface

    pH

    GI Motility

    Presence of other substance

    Disease
    Distribution

    A drug has to reach its site of action

    Bloodstream
    Distribution
    • Blood-Brain Barrier
    • Placenta Transfer

    Be carefull !!
    Index
    A, B, C, D, X
    Metabolism
    The chemical chemical-
    modification of transforming
    drugs in the body enzyme systems

    Protect from
    Toxic
    substance
    the hepatic–portal system
    (Gluthathione)
    Metabolism

    > 90%
    Excretion
    The final common pathway for the
    elimination of drugs

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