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Insult Latent Secondary Tertiary

Cell death
Secondary
Multiple programmed
Reperfusion mitochondrial failure Late cell death
cell death pathways

Response Seizures Remodeling

Excitotoxicity Astrogliosis
Glucose 02 Ordinary
Inflammation
Oxidative stress Repair
ATP production

30 min 6 - 12 h ≥ 3 day Months

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