A

Report on
INDUSTRIAL TRAINING
By
PIYUSH RAJ SINGH CHAUHAN
(Roll. No: -1500450028)

Faculty of Pharmacy
RAJA BALWANT SINGH ENGINEERING TECHNICAL CAMPUS,
BICHPURI, AGRA

to the
DR. A.P.J ABDUL KALAM TECHNICAL UNIVERSITY, LUCKNOW
May 2018

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 ACKNOWLEDGMENT
I wish to express my heart full gratitude to my institution faculty of pharmacy Raja Balwant
Singh Engineering Technical Campus, Bichpuri,Agra.
I praise god, the almighty, merciful and passionate, for providing me this opportunity and
granting me the capability to proceed successfully.
The appear in its current form due to the assistance and Guidance of several people. I would
like to offer my sincere thanks to all.
First and for most I would like to thanks to Dr. Akhand Pratap Singh, Director, R.B.S. Engg.
They gave me an excellence opportunity to learn the subjects. I express my sincere gratitude to
All those who have directly or indirectly helped me in the completion of project.
I am highly Indebted to.Dr. Shyamveer Singh Mr Krishna Kumar Agrawal,
Mr. Tripanshu Gupta, Mr. Amit Yadav, Ms. Jyoti, Ms. Pooja Bharti and other
respected faculty members.Above all I am Thankful to my parents who are the
foundation stone of the Platform on which I am standing on.
My work is the result of their blessings and hardship.

PIYUSH RAJ SINGH CHAUHAN

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 TABLE OF CONTENTS:

• Introduction.
• Industry Overview.
• Moto of Envoy Pharmaceutical.
• Aim &Objective.
• Departments of Industry.
• Toll Manufacturing.
• Observation.
• Discussion.
• Conclusion & Recommendation.

3
 INTRODUCTION

PHARMACEUTICAL INDUSTRY:

INDUSTRY OVERVIEW
Founded in september 1982 Schon Pharmaceuticals has since achieved many
milestones. It is situated at 27-Km, janudi road, indore MP.
Because of their strong dedication to high quality products and services they have
developed a great portfolio of International Clients, Toll Partners, Institutional
Buyers and Marketing.

Schon pharmaceuticals is an ISO 9001:2008 certified company and therefore

assures that cGMP ( current good manufacturing practice ) and GLP (good lab
practice ) are strictly followed at all levels of manufacturing process. The
manufacturing facility has been planned keeping in view the up-to-date cGMP
rules

Schon Pharmaceutical achieved another milestone by establishing a high-tech

Inject able Plant which is completely dedicated for manufacturing of cephalosporin
injections.
This industry has all the essential Sections of Medicine. They have a layout
according to the international standard. Itis centrally air conditioned and have latest
machinery.
Schon is armed with the modern equipment for production, quality control and
quality assurance. Envoy manufacture all forms of drug delivery systems like, solid
orals (tablets, capsules, dry suspensions), liquid orals (syrups, suspensions), and
injectable.

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 MOTO OF SCHON PHARMACEUTICAL

Schon Pharmaceuticals is a name of trust, excellence and quality in the

pharmaceutical industry of Pakistan. We strive to serve the humanity in the
best possible way by providing them a wide range of innovative and quality
medicines. This is because Envoy:

AIMS & OBJECTIVES:

Following are the aims & objectives of Schon pharmaceuticals:

• To establish the marketing relationships with the leading

international pharmaceutical companies in future by launching their
innovative and research product
• To discover new ways, technologies and products to manage health
• To promote the growth and success of its associates and
international competitiveness and export performance of industry.
• To offer effective solutions for various healthcare challenges, with
products and services that are well-focused, within customers reach
and contribute to improved healthcare of the people of Pakistan.
• To develop and promote Pakistan image as an attractive
manufacturing giant in innovative healthcare products.

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 Products
These are following few products of Schon Pharmaceutical:

 Akurate (Cefixime) Cap/Sus 400 & 100 mg

 Enspor (Cefaclor) Cap/sus/syp 250mg ‘125 mg

 Kombat (Cephradine) Tab/sus250’500 mg

 Mylid (Azithromycin) Cap 250 mg

 Ancip (Ciprofloxacin) Tab250;500mg

 Aligant (Levofloxacin) Tab 250.500 mg

 Aknidox (Doxycycline) Cap100 mg

 Brilgen (Ceftriaxone) Inj1 gm

 Ometor (Omeprazole) Cap 20 mg

 Emage (Esomeprazole) Cap 20,40 mg

 Desgen (Deloratadine) Tab 5 mg

 Deconazole (Fluconazole) Cap. 150mg

 Ensp (Cefaclor) Drops

8

6
DEPARTMENTS OF INDUSTRY:

 The Company is involved in the manufacturing of almost all segments

of products having its independent manufacturing sections which are
controlled with centrally air-handling system. There are following main
departments of ENVOY Pharmaceutical.
 Ware house
Raw Material Store
Qurantine Area
Finish Good Store
 Production department
 Quality control department
 Procurement department
 Business development department
 I.T department
 Marketing department

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 WARE HOUSE
It receives raw material. Until this material is cleared it is remains there.
Temperature and humidity is kept under control.

 Manager store & distribution

 Distribution in charge
 System operator
 Raw material operator
 Finish Good operator

PREMISES:
• It is was well situated, well laid out, tidy, clean and well secured enabling
good preservation of raw material, packaging material and finished products.
• Temperature was maintained between 15-30 °C.
• Humidity was set between 35-60%.
• Job description of the warehouse included:
Responsibility to control inventory of stocks (Finished, Packaging and
Raw material Stores).
• Checking physical stocks regularly.
• Preparing Daily & Weekly Stocks Reports.
• In Schon ware house was separated into:
• Raw material store.
• Packing material store.
• Finish good store.
RAW MATERIAL STORE:
Raw material store was further divided into following:

1. Quarantine area
 Packing material quarantine
 Raw material quarantine
2. Excipient area
3. Active pharmaceutical ingredients

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  Toll
 Envoy
4. Dispensing area
 For antibiotics
 For cephalosporin
 For general materials
5. Chiller area

 QUARANTINE:

All raw materials, components, packaging, and labeling materials are

held in our "quarantine" area until they are sampled, tested and/or examined,
and released for use by our "quality control laboratory". The sampling is
performed according to specific procedures by trained personnel.

This area is divided into two sections

 Packing material quarantine

In this section packing material for different dosage forms is kept
under recommended and controlled atmosphere
 Raw material quarantine
In this section raw material is kept under normal conditions active
pharmaceutical ingredients is kept in 15-25 C®, excipients are kept at 25
C® in subsection of this area

 Chiller area
In this area normally temperature sensitive products are kept in separate
area to prevent them from damage or detoriation.

 Dispensing area
Dispensing area is also present in raw material section where
dispensing is performed under manufacturing order of a product at
time of dispensing 4
9
personnel’s should be present there to check the process of dispensing
according to SOP.

 Production pharmacist
 Q.A pharmacist
 Raw material store pharmacist
 Raw material dispenser

PURCHASE ORDER FOR RAW MATERIAL:

A stock delivery report is prepared. Checking of documentation is done.COA is

issued. The Assistant Store Manager receives the raw materials and transfers it to
the quarantine with the label “Quarantined” before getting it transfer to the bulk
after clearance from QCD. The QCD collects the sample and reports for its release,
it is according to the specifications or rejection if not. After rejection from Quality
Control Department, red “Rejected” slip is pasted on each of the Quarantined
material and the “Quarantined” slip is removed. After released by the Quality
Control Department, green “Released” Slip is pasted on each of the Quarantined
material and the “Quarantined” slip is removed. The material released
information’s is entered in the material log sheet. The Store Keeper manages to
transfer the RM to the bulk with necessary information pasted on it. Two copies of
GRN after release of R/M from QC are proposed. One copy of GRN is retained by
store keeper and one copy is send to accounts department for costing. The Store
Keeper (Raw Material) transfers whole the consignment of the material with the
help of section workers by means of trolley, lifter to the bulk store.

ISSUANCE OF RAW MATERIAL:

The weighing of raw materials is carried out in the presence of pharmacist.
Production Pharmacist checks all the Raw Material by weight/volume on the
weighing balance according to manufacturing order. After weighing, the raw
material is transferred in the relevant section of production department. The copy
of the manufacturing order is kept by the Assistant Store Manager for record and
another copy is given to production pharmacist.

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DOCUMENTATION:
Following documentations were done in ware house at different stages:

• Temperature/humidity chart.
• Dispensing log book.
• Raw material requisition.
• Raw material analysis report.
• Request for retest.
• Certificate of analysis.
• Issuance of slips (Pink slip: material identification, Yellow slip: sampled at
QC, Green slip: passed from QC).

PRODUCTION AREA
Production team is committed to produce highest quality products, which can
satisfy the needs of both doctors and patients. The production team endeavors to
manufacture products that are cost-effective through best utilization of their
resources. This department is well equipped with latest equipment.

Warning in industry:

You are entering to Production Area please wear,

• Cap.
• Overall.
• Shoes cover or change your shoes.

In Schon pharmaceutical Production Area is divided into following section:

 General Tablet Section

 General Capsule Section
 Oral Liquids Section
 Dry Powder Injectible Section
 Cephalosporins (Oral) Section

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  The Cephalosporin (Oral) Section has been further divided into two areas
i.e.
 • Cephalosporin Dry Powder Section.
 • Cephalosporin Capsules Section.
 And have the latest machinery including:
 • Cone Mixer.
 • De-humidifier.
 • Semi-Automatic Capsule Filling Machine.
 • Bottle Blowing Machine.
 • Semi-Automatic Powder Filling Machine.

 Role of production department

 Whole pharmaceutical stand on this department
 Manufacturing of different pharmaceutical products are controlled by
this department
 This department produce tablets capsules oral liquid preparation in
industry and other pharmaceutical dosages
 Role of production department in industry is to make quality medicine

 Procedure of manufacturing in production area

In production area following sequences is followed for proper manufacturing of
medicine

 Generation of M.O (manufacturing order) under instruction of

business development department that pass buyers order of medicine
to production department
 M.O is checked by Q.C department API quantity is checked and signed by
Q.C if quantity is within reign otherwise it will be rejected
 M.O is sent to raw material store and dispensed according to cGMP
 Dispensed material is shifted into production area for further
processing and manufacturing of medicines
 Oral liquid preparation procedure is different tablet and capsules
re quit different from liquid preparation all these will be discussed
later
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  For sterile preparation sterile material is dispensed in sterile area
under laminar air flow hood

 Personnel in Production department

These are following personnel in production department

 Production manager
 Assistant production manager
 Tablet section in-charge
 Capsule section in-charge
 Oral liquid section in-charge
 Dry powder injectable section in-charge
 Packing pharmacist
 workers

TABLET SECTION:
“Tablets are unit solid dosage form of medicament or medicaments with
or without suitable diluents.
Types of tablets manufactured in Schon:

 (Ancip)
 (Aligant)
 (Delide)
 (Myodine)

STEPS INVOLVED IN TABLET MANUFACTURING:

• DISPENSING OF RAW MATERIAL:
Tabletting process starts with dispensing of active ingredients. Weigh and dispense
system begins with a pharmacist getting a bill of materials for ingredients that
make up a recipe for a batch to be manufactured. Each material must be gathered

13
from a warehouse. Then it is verified as the proper material, carefully weighed,
checked again, and finally readed for mixing in the recipe.

• DRY MIXING:
Ribbon mixer is used for mixing.

RIBBON MIXER

• WET MIXING:
After dry mixing, wet mixing is done in the ribbon mixer.

• WET GRANULATION:
Wet granulation is used for wet granulation and mesh size 4 & 6 are used.

• DRYING:
• FBD (Fluidized Bed Dryer).
Or
• Tray dryer is used for the purpose of drying.

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FLUIDIZED BED DRYERTRAY DRYER

• DRY GRANULATION:
Oscillating granulator is used for dry granulation & mesh size used is 16.

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OSCILLATING GRANULATOR

• LUBRICATION & FINAL MIXING:

Final mixing is done in DC (Double Cone) mixer.

DOUBLE CONE MIXER

• COMPRESSION:

Rotary tablet machine is used for compression. Zp-

17and ZP-33 are being used.

• COATING:

Spray Gun (High Efficiency Coating Machine)

&

Thiocota is used for coating of tablets.

SPRAY GUN MACHINE

• LABELING & PACKING:

Two types of packing is done:

• Alu-PVC.
• Alu-Alu.
Tablets are packaged into strip and blister packaging
and then finally in shippers.

 Alu-PVC Packing:
For Alu-PVC packing Alu-PVC blistering
machine is used.

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 Specification:
• Having heater in start.
• Batch no. & Expiry date.

ALU-PVC PACKING MACHINE

 Alu-AluPacking:
For Alu-Alu packing Alu-Alu blistering machine is used.
Specification:
• 3 pinch.
• Temperature 140-150°C.
• Batch no. & Expiry date is printed.
• Sealing foil.

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ALU-ALU PACKING MACHINE;

CAPSULE SECTION:

“Capsules are solid unit dosage form of medicament.”

Followings are some examples of capsules manufactured by ENVOY;

 Ometor (Omeprazole)
 Emage (Esomeprazole)
 Mylid (Azithromycin)
 Akurate (Cefixime)

STEPS INVOLVED IN CAPSULE MANUFACTURING:

• DISPENSING OF RAW MATERIAL:

Capsulation process starts with dispensing of active ingredients. Weigh

and dispense system begins with a pharmacist getting a bill of materials for
ingredients that make up a recipe for a batch to be manufactured. Each material
must be gathered from a warehouse. Then it is verified as the proper material,
carefully weighed, checked again, and finally readed for mixing in the recipe.

• FILLING OF CAPSULE:
The mixture is filled in empty capsule. Schon pharmaceutical, presents an
exclusive array of capsule filling machinery. This capsule section machinery
is semi automatic. Capsule section machinery is simple to operate.

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CAPSULE FILLING MACHINE

• CAPSULE POLISHING:
After capsule filling capsules were
polishes in full automatic capsule
polishing machine.

CAPSULE POLISHING MACHINE

• LABELING & PACKING:

Two types of packing is done:

• Alu-PVC.
• Alu-Alu.
Capsules are packaged into strip and blister

packaging and then finally in shippers

INJECTABLE SECTION:
For injectables there is a need of sterile area.
In practical the term sterile area is generally
replaced by clean room. Clean rooms in

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pharmaceutical industry are classified by the cleanliness of their air. According to
Federal standard 209D class limits are decided according to the number of particles
equal to and greater than 0.5 mm in one cubic foot of air.STERILE ROOM
 Akurate (Cefixime) Sus 100 mg

 Enspor (Cefaclor) Sus 125 mg

SYRUP SECTION:
“A viscous concentrated solution of a sugar, such as sucrose, in water or
other aqueous liquid; combined with other ingredients, such a solution
is used as a flavored vehicle for medications.”
Syrups are manufactured by Schon is

 Anspor (Cefaclor)

STEPS INVOLVED IN SYRUP MANUFACTURING:

• Dispensing of ingredients.
• Prepared simple syrup.
• Add ingredients one by one.
• Filling of syrup.
• Labeling & Packing.

APPARATUS:
• Silver son mixer (300 & 2000 liters).
• R.O water storage tank.
• Double stream jacket.
• Syrup transfer pump.
• Automatic bottle filling (4 nozzels).

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SYRUP FILLING MACHINE

 Suspension

A Pharmaceutical suspension is a coarse dispersion in which internal

phase is dispersed uniformly throughout the external phase. The internal
phase consisting of insoluble solid
particles having a specific range of size which is maintained uniformly
throughout the suspending vehicle with aid of single or combination of
suspending agent. The external phase (suspending medium) is generally
aqueous in some instance, may be an organic or oily liquid for non oral use.
In ENVOY following suspensions are prepared

 Akurate (Cefixime)
 Kombat (Cephradine)

DRY POWDER SUSPENSION SECTION:

Commercial manufacturers provide them in dry powder or granules form for
reconstitution with prescribed amount of purified water.

STEPS INVOLVED IN DRY POWDER SUSPENSION

MANUFACTURING:
• Dispensing of ingredients.
• Reduction of sizes of ingredients.
• Mixing of all ingredients.
• Filling.
• Labeling & packing.

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22
APPRATUS
• Fitz mill.
• Cone mixer.
• Dehumidifier.
• Filling machine.

DRY POWDER SUSPENSION FILLING MACHINE

PACKING ROOM:
In Schon pharmaceutical industry there are 2 packing hall.

INSTRUCTIONS FOR PACKING:

 Packing area must be cleaned with detergent.
 Packing belt must contain the identification slip.
 Material which is to packed should be released for packing by Quality
assurance department.
 Before staring the packing, get line clearance from Quality Assurance
department.
 All the packaging material of the product to be packed should be checked
and approved by In-charge pharmacist and Q.A inspector respectively.
 No irrelevant material should b present in packing area.
 Batch Manufacturing Record should be present in packing area during
packing.
 Shipper packed must contain the proper identification ship.
 Transfer the shippers to Finished Goods Store at the completion of
packaging process after getting approval.

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  Shipper in Finished Goods Store must contain the identification slip released
by Quality Control department.
 Please the rejected material separately in a container labeled as “Rejected”.
 At the completion of packing process, count the rejected material .

QUALITY CONTROL DEPARTMENT:

“Quality is our priority.”

“Quality is never an accident, always the result of intelligent effort.”

The quality control department is responsible to ensure that all materials
meet the established criteria throughout all phases of the process. Raw materials,
components, and packaging and labeling are examined and tested according to a
rigorous written program designed to assure uniformity from batch to batch. Every
raw material received is tested for identity and conformance to specifications.
Every bottle, cap, and label is examined to assure that they match the written
specifications. During the manufacture of all batches of all products, in-process
samples are tested and the results documented. If any results fall outside of the
written specifications, the product is rejected and the information is submitted to
the research and development group for evaluation and further disposition.
Samples of finished, packaged product are tested for stability to allow for
determination of expiration dating. Accelerated stability testing as well as real time
stability testing isdone concurrently to validate the results of the tests.

QUALITY POLICY:
• To gain customer’s satisfaction through manufacturing and providing high
quality pharmaceutical products. While believing in continual improvement
of our system.
• To achieve sustained growth in market share by developing satisfied
customers.
• Healthy environment to develop dedicated professional teams in order to
serve in the best interest of external and internal customers. Suppliers and
share holders.

24
 • To benefit the community by adopting environment friendly policies and
establishing standards of ethics.
• To improve the standard of life through the value of developing innovative
products by research and development. And to pursue Total Quality
Management.

The ISO definition states that quality control is the operational techniques and
activities that are used to fulfill requirements for quality. Quality control is a
process for maintaining standards and not for creating them. The quality control
department has the responsibility and authority to approve or reject all
components, drug product containers, closures, in-process materials, packaging
material, labeling, and drug products.

Activities of Quality control department in Schon were:

• Testing and release or rejection of all incoming raw materials, packing
materials, in-process / intermediates and finished products as per specified
specifications.
• Maintaining testing records as per standard procedures for raw materials,
packing materials, in-process / intermediates and finished products.
• Calibration of laboratory instrument / equipment.
• Performing stability study.
• Analytical method validation.
• Preparation of standard volumetric solutions and maintain standardization
record.
• Maintain Labeling procedure at all the stages and records.
• Maintain working / reference standard record of products.
• Analysis of complaint samples as and when required.
• Follow safety norms at all the stage during handling of chemicals and using
instruments.
• Follow good laboratory practices.

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FLOW CHART OF Q.C

Raw Material Inspection

Raw Material

Receipt

Verification

Sampling

Under Test

Q.C Testing

Approved Rejected

For manufacturing Return to supplier/Destruction

26
FINISHED PRODUCT INSECPTION
Completion of Batch of

Finished products

Sampling by Q.A

Under Test

testing

Preparation of Report & checking

Approved Rejected

For Dispatch Reprocess/ Destruction

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Quality Control test for material by Q.C
department
For different materials and dosage form different tests are performed, following
of them are

 Test for Raw Material

For testing of raw material following test are performed according to
SOP or referenced set by supplier

 Description or Physical appearance ( crystalline, powder, smell, color,)

 Solubility (solubility is check by dissolving in alcohol, chloroform or in

water if substance organic in nature and non polar t will dissolve in
alcohol and chloroform and if substance is inorganic n polar in nature
will easily dissolve in water)

 Identification (identified by using FTIR, TLC, UV spectrometer)

 pH (checked by pH meter pH should be within range as

recommended by official books)

 Viscosity (viscosity is checked by viscometer and it should be within

range as recommended by official book)

 Assay (percentage purity of sample is checked by analyzing the sample

by using U.V spectrometer or HPLC, FTIR but mostly used apparatus
is U.V spectrophotometer)

 LOD/ Loss on Drying

Wt. of empty Petri-dish =

A Wt. of Petri-dish +

Sample = B

Wt. of sample = B-A = C

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 After drying at 105C® for 30 minutes wt. of Petri-dish + sample = D

Difference between wt. before drying and after drying = B-D =

E
Diffrence
% 𝐿𝑂𝐷 = x 100
Wt. of
Sample
=E
x 100 = E
c
 Test for
Tablets

For finished product following test are performed

 Description or Physical appearance ( crystalline, powder, smell, color,

size, shape)

 Identification (identified by using FTIR, TLC, UV spectrometer)

 Assay (percentage purity of sample is checked by analyzing the sample

by using U.V spectrometer or HPLC, FTIR but mostly used apparatus
is U.V spectrophotometer)

 Shining test

 Dissolution time

 Packaging test

 Direct loss test

For bulk only assay is performed to check its percentage purity

 Test for capsules

For capsules following tests are performed

 Description or Physical appearance ( crystalline, powder, smell, color,

size, shape)
29
 Identification (identified by using FTIR, TLC, UV spectrometer)

30
 Assay (percentage purity of sample is checked by analyzing the sample
by using U.V spectrometer or HPLC, FTIR but mostly used apparatus
is U.V spectrophotometer)

 Shining test

 Dissolution time

 Packaging test

 Direct loss test

 Test for liquids

For liquids preparation following tests are performed
 Description
 Weight variation
 Identification test
 Viscosity
 pH
 Assay
 Cap sealing

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INSTRUMENTS IN Q.C DEPARTMENT:
Different instruments are use for testing in Q.C department:

• Fourier Transform Infrared Spectrophotometer.

• UV/visible Spectrophotometer.
• High Performance Liquid Chromatography.
• Moisture Analyzer.
• Automatic Polarimeter.
• Dissolution Apparatus.
• Disintegration Test Apparatus.
• Thin Layer Chromatography.
• Hot Plate Magnetic Stirrer.
• Viscometer.
• Sonication Bath.
• Melting Point Apparatus.
• Refractometer.
• Friability Apparatus.
• Vacuum Pump Filtration Assembly.
• Cooled Incubator.
• Water Bath Digital.
• Forced Convection Oven.
• pH meter.
• Conductivity meter.

• Centrifuge Machine.
• Dead Weights.

32
• Analytical Balance.
• Desiccators
• Atomic Absorption Spectrophotometer.

33
QUALITY ASSURANCE DEPARTMENT:
Quality Assurance (Q.A) is the sum total of organized arrangements made with the
object of ensuring that product will be of the quality required by their intended use.
Quality assurance is the systematic monitoring and evaluation of the various
aspects of a project, service or facility to maximize the probability that minimum
standards of quality are being attained by the production process . QA cannot
absolutely guarantee the production of quality products.
In Schon, there was a pharmacist to maintain the reliability at every stage of
manufacturing process starting from Research, Clinical studies, Quality Control,
Production, Distribution and provides information on appropriate use, and analyzes
safety and information of the products. This department assists in the strategic
direction and development of Quality Systems, standard operating procedures and
document control programs, to ensure with the company policies and regulatory
requirement.

Role of Quality Assurance in industry

 Temperature check
 Humidity checking
 Line clearance (at different stages, in line clearance our focus is on
cleanliness proper identification of product batch No. packing
procedure, product labeling)
 Stability testing
 Maintain record
 Dispatch testing
 Handling of market complains
 Dispensing checking
 In-process testing
 SOP designing
 Workers training
 Validation
 Self inspection / internal audit

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 Art work
 Market return

In-process test for Tablets

perform following test for in-process testing of tablets

 Appearance (color, size, shape)

 Wt. variation
80 mg o <± 10 %
80 – 250 mg ±7.5%
> 250mg ± 5%
 Average wt.
 Disintegration
 Hardness
 Thickness
 Diameter
 Dissolution time
 Friability test

Wt. before =A
Wt. after= B

A−
𝑥= B X 100
𝐴

In-process test for Capsule

 Physical appearance
 Disintegration test
 Average wt.

 Wt. variation
350 mg or <± 10 %
350 mg or <± 7.5 %

35
 35

In-process test for Liquid Preparation

 pH
 Viscosity
 Weight per ml

Wt. of empty pychno-meter = A

Wt. of pychno-meter + liquid/ suspension =
B Wt of liquid/ suspension = B – A =C
C
Wt./ml =
25
 Deliverable
volume

RESEARCH & DEVELOPMENT DEPARTMENT:

Schon Pharmaceuticals has dedicated research teams at both national and
international level. Their R&D team has all the necessary skills and equipment
to formulate and produce even unique and new combinations of medicine.
There is a R&D department in Schon which worked in discovering new
knowledge about products, processes, and services and then applying that
knowledge to create new and improved products, processes and services that fill
market needs.

They used following apparatus:

• 3 In 1 apparatus(DT+DIS+FR).
• Aluminum foil sealing machine.
• Manual ointment filling machine.
• Sugar coating machine.
• Cone mixer.

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 FINISH GOOD STORE:
Finished products are stored in this area. Temperature and humidity is controlled
here to assure stability and effectiveness of products. Products that require cold
storage are stored in refrigerator. Finished good received report is also signed.
After passing Q.C tests, quality products after manufacturing and packing are kept
here.And then products are supplied to different institutes etc.
Today Schon Pharmaceuticals (Pvt) Ltd. products are being promoted & sold in
various countries around the globe .

DISCUSSION:

Schon Pharmaceutical enhanced understanding of my academic knowledge and

skills. It indeed polished my knowledge and experience. Classroom studies are
confined only to books and theoretical learning majorly. Application of these
theories and lectures delivered in classrooms differ a little from the specifically set
format.
Through this internship, I not only got the opportunity to experience but I also
learnt the applications of these theories in actual the application. I got to observe
the whole working environment of pharmaceutical industry & the important
aspects regarding the production of high quality pharmaceuticals & carrying out
important quality control tests to ensure that all the procedures carried out
during production are according to GMP.

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I was able to understand the working conditions of pharmaceutical industry in

Indian circumstances much better than before. It also improved my general
knowledge about equipments commonly used in our industries.
Not only pharmacists in production areas but even workers helped me to
understand important procedures regarding the production. The entire journey of
internship allowed me to identify my strengths and weaknesses, and use both of
them to the best advantage of my career.

CONCLUSION & RECOMMENDATIONS

CONCLUSION:
Though serving on humanity is not only a person’s responsibility but also of
community. And this community comprises of all the members starting from the
very first of disposal of quality products. No work is penniless rather the
knowledge it keeps in, internship at any working area is a great learning experience
in itself

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