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  • Cancer Patho

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    Trisha Dicang
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    In 3 sentences: Mutations from environmental factors or inherited genes can cause DNA damage in normal cells. If the DNA repair is unsuccessful, mutations accumulate in the genome and can activate oncogenes or inactivate tumor suppressor genes. This can lead to uncontrolled cell growth and division resulting in the formation of malignant tumors through clonal expansion and acquisition of further mutations.

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    Original Title

    CANCER PATHO

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    In 3 sentences: Mutations from environmental factors or inherited genes can cause DNA damage in normal cells. If the DNA repair is unsuccessful, mutations accumulate in the genome and can activate oncogenes or inactivate tumor suppressor genes. This can lead to uncontrolled cell growth and division resulting in the formation of malignant tumors through clonal expansion and acquisition of further mutations.

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    © All Rights Reserved
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    5 views1 page

    Cancer Patho

    Uploaded by

    Trisha Dicang
    In 3 sentences: Mutations from environmental factors or inherited genes can cause DNA damage in normal cells. If the DNA repair is unsuccessful, mutations accumulate in the genome and can activate oncogenes or inactivate tumor suppressor genes. This can lead to uncontrolled cell growth and division resulting in the formation of malignant tumors through clonal expansion and acquisition of further mutations.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    of 1

    Acquired (environmental DNA Normal Cell

    damaging agents: Inherited Mutations


    in:
     Chemicals Successful DNA repair
     Radiation  Genes
     Viruses affecting DNA
    DNA damage
    repair
    Failure of DNA repair  Genes
    affecting cell
    growth
    Mutations in the Genome of
    apoptosis
    Somatic Cells

    Activavtion of growth
    Alterations of genes Inactivation of Cancer
    promoting Oncogenes
    that regulate Apoptosis Suppressor Genes

    Expression of altered Gene products


    And loss of regulatory Gene products

    Colonal expansion

    Additional mutations (progression)

    Heterogenity

    Malignant Neoplasm

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