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CICLO DE LA ÚREA
Principal producto
terminal del metabolismo
proteico.
Se sintetiza
exclusivamente en el
hígado.
Se elimina por vía renal.
Enzima reguladora: CPS I.
(cuya deficiencia provoca
hiperamonemia, ataxia,
letargo, convulsiones,
coma y muerte).
Fallas en el ciclo de la
úrea: hiperamonemia,
encefalopatía, alcalosis
respiratoria.

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GLUTAMATO – GABA –
GLUTAMINA EN CEREBRO

SYNAPSIS
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CREATINA - CREATININA
Gly AGAT GAA GAA GAMT Creatina
+ + + +
Arg Ornitina SAMet SAHCys

Creatinina Síntesis en hígado,


riñón y páncreas.
Almacenamiento en
músculo, Cerebro, S.N.
P-Creatina CK Creatina Creatinina es formada
+ + en músculo y eliminada
ADP ATP de manera constante
por vía renal.
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Porfiria
eritropoyética Porfiria
Porfiria congénita cutánea
ALAD tardía

Porfiria aguda
intermitente

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PORFIRIAS

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