Product Information Novel Kinase Inhibitors

for cell signaling & oncology research

Toll Free:
S1561 BMS 777607 (877)796-6397
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» MEK
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Technical Data:
Orders
M.Wt: 512.89
+1-713-922-4115
Formula: C25H19ClF2N4O4 O
enquiry@selleckchem.com
H
Solubility: DMSO F N N

Purity: 99% O
O O
F Tech Support
Cl
tech@selleckchem.com
Storage: at -20℃ 2 years
H2N N (chemistry support)
CAS No.: 1196681-44-3 techbio@selleckchem.com
(bio support)

Web
Biological Activity
www.selleckchem.com
BMS 777607 is a Small-Molecule Met Kinase Inhibitor with an IC50 of < 0.1 μM. Its treatment
had little effect on tumor cell growth but inhibited cell scattering activated by exogenous HGF,
with almost complete inhibition at 0.5 μmol/L in PC-3 and DU145 cells. This agent also suppressed
HGF-stimulated cell migration and invasion in a dose-dependent fashion (IC50 < 0.1 μmol/L) in
both cell lines. Mechanistically, nanomolar doses of BMS 777607 potently blocked HGF-stimulated
c-Met autophosphorylation and downstream activation of Akt and extracellular signal-regulated
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kinase. In addition, both wortmannin and U0126, but not dasatinib, attenuated cell scattering and
migration induced by HGF, suggesting the involvement of the phosphoinositide 3-kinase and
mitogen-activated protein kinase pathways, but not of Src or focal adhesion kinase, in HGF-mediated
motogenic effects. [1][2]
Return Policy
References Please inspect packages immediately upon

receipt and notify customer service within

[1] Dai Y et al. Mol Cancer Ther. 2010 Jun;9(6):1554-61. 3 days of delivery of any damage or

discrepancies.Our team will take quick and

[2] Schroeder GM et al .J Med Chem. 2009 Mar 12;52(5):1251-4. appropriate action to correct any problem.

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