Professional Documents
Culture Documents
CHEMICAL ENGINEERING
MODULE DESCRIPTIONS
2017-18
1
Chemical Engineering Module Descriptions 2017-181
Module Registration
Students can view the modules they are registered for on Portico (http://www.ucl.ac.uk/portico) and choose
the optional modules they wish to take during their programme.
Full details of all modules offered by the Department can be found in this document. Details on modules
offered by other Departments is included where this is available.
When choosing options, please ensure you check for timetable clashes using the Online Timetable
(https://timetable.ucl.ac.uk/tt/).
Queries relating to module choices should be directed to the appropriate tutor, Deputy Head (Education) or
the Teaching & Learning Team:
Safety
Many of the activities in the Department have potential dangers unless sensible precautions are taken at all
times. The Department's safety regulations are contained in the departmental booklet "Arrangements for
Safety and Security" which is available on the Student Intranet as well as in the Programme Handbooks.
UCL has a duty of care to safeguard, so far as is reasonably practicable, the health, safety and welfare of
their employees, students and general public who may be affected by its activities. Similarly, students have a
duty to take reasonable care to avoid injury to themselves or to others who may be affected by their work
activities.
All undergraduate laboratory work must be supervised by an appropriate member of staff - this is part of our
duty of care. Similarly, for safety and personal security reasons, unsupervised undergraduates are not
allowed inside the Department outside the Department's normal hours of work.
Safety Contacts:
Dr Simon Barrass - Departmental Safety Officer
Mr Mike Gorecki - Chair of the Departmental Safety Committee
Ms Becki Belgrave
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Version 1: 8 September 2017
2
BEng and MEng Programmes modules
Year 1
ENGS101P Engineering Challenges
ENGS102P Design & Professional Skills I
ENGS103P Mathematical Modelling & Analysis
CENG101P Introduction to Chemical Engineering
CENG102P Transport Phenomena
CENG103P Thermodynamics
CENG104P Physical Chemistry
CENG105P Computational Modelling & Analysis
Year 2
ENGS203P Mathematical Modelling and Analysis II
CENG201P Design and Professional Skills II
CENG202P Engineering Experimentation
CENG203P Process Heat Transfer
CENG204P Separation Processes I
CENG205P Particulate Systems and Separation Processes II
CENG206P Chemical Reaction Engineering I (0.25cu)
CENG207P Process Design Principles (0.25cu)
Minor I (see IEP Minor website)
o CENG251P Inorganic Chemistry for Engineers
Year 3
CENG301P Process Plant Design Project (1.0cu)
CENG302P Process Dynamics & Control
CENG303P Chemical Reaction Engineering
CENG304P Transport Phenomena II
CENG305P Advanced Safety & Loss Prevention
Minor II and Minor III (see IEP Minor website)
o CENG351P Organic Chemistry for Engineers (from 2018/19)
o CENG352P From Molecules to Molecular Engineering (from 2018/19)
3
MEng Chemical Engineering - Year 4
Compulsory modules
CENGM001 Research Project (1.0cu)
CENGM01P Process Systems Modelling and Design
4
MEng Chemical Engineering with Biochemical Engineering - Year 4
Compulsory modules
Department of Biochemical Engineering:
BENGM001 Integrated Downstream Processing
BENGM002 Design and Control of Biochemical Reactors
BENGM004 Cell Therapy Biology, Bioprocessing and Clinical Translation
BENGM008 Applied Molecular Biology
BENGM010 Bioprocess Validation and Quality Control
BENGM011 Integrated Biochemical Engineering Design
BENGM022 Sustainable Industrial Bioprocesses and Biorefineries
BENGM029 Fundamental Biosciences
Please contact the Year Abroad Tutor, Dr Ryan Wang, for information.
5
MSc Chemical Process Engineering
Compulsory modules
CENGG099 Chemical Process Engineering Research Project (90 credits)
OR
CENGG098 Advanced Design Project (90 credits)
6
MSc Global Management of Natural Resources
Compulsory modules
CENGGA99 Dissertation
CENGGA01 Natural Gas Processing
CENGGA02 Minerals Usage, Extraction and Processing
CENGGA03 Prevention and Remediation of Environmental Contamination
GEOLG043 Geology for Global Managers and Engineers
GEOLG044 Earth Resources and Sustainability
BENVGED8 Business and Sustainability
MSING014B Decision and Risk Analysis
SERAG018 Social Licensing
7
Module Code: ENGS101P Module Title: Engineering Challenges
Coursework: 100%
Examination: 0%
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Module Code: ENGS102P Module Title: Design and Professional Skills
Teaching Staff: Dr F Akinmolayan, Dr G Manos, Prof D Bogle, and other Faculty staff
Coursework: 100%
Examination: 0%
9
Module Code: ENGS103P Module Title: Mathematical Modelling and Analysis
Aims: To provide the core mathematics, modelling and analysis skills that underpin
studies in engineering through a blended learning and teaching programme of
mathematics that:
Emphasises the modelling of engineering systems and the analysis of data;
Integrates mathematics theory and engineering practice.
Learning Outcomes: On successfully completing the ENGSP103 Modelling and Analysis module,
students will be able to:
Recognise the connections between mathematics and engineering, and how
mathematical ideas are embedded in engineering contexts;
Represent real-world systems from engineering in a mathematical framework;
Identify and draw upon a range of mathematical concepts, including Calculus,
Linear Algebra and Differential Equations to analyse specific problems and
identify the appropriate mathematics to realise a solution;
Employ appropriate computer programming and modelling techniques and
statistical analysis to efficiently solve and evaluate the performance of
engineering systems;
Use estimation, approximation and dimensional analysis to reduce complexity;
Relate the behaviour of the output of mathematical models to the underlying
physical or conceptual models of interest;
Carry our engineering problem solving both collaboratively in a team and
independently;
Present and interpret mathematical results in effective and appropriate ways to
varied audiences, including non-mathematical engineering audiences.
Coursework: 50%
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Module Code: CENG101P Module Title: Introduction to Chemical Engineering
Coursework: 20%
11
Module Code: CENG102P Module Title: Transport Phenomena I
Synopsis: Nature of transport processes and fluids, laminar and turbulent flow
Fluid statics, pressure measurement, buoyancy
Dimensional analysis and similarity, Buckingham's Pi theorem
Conservation of mass, momentum and energy equations, Bernoulli's
equation
Heat, momentum and mass transport in laminar flow and in solids
Transport in turbulent flow: characteristics of turbulent flow
Momentum, heat and mass transfer coefficients
Frictional losses due to roughness and fittings
Whitman two-film theory for mass transfer
Simple momentum, heat and mass transfer analogies
Coursework: 20%
12
Examination: 80% (3 hour written exam)
13
Module Code: CENG103P Module Title: Thermodynamics
Synopsis:
Fundamentals and basic definitions
First Law of Thermodynamics
Internal energy, enthalpy and heat capacity
Equations of state
Second Law of Thermodynamics
Criteria for spontaneous change and equilibrium
Definition of reversible and irreversible work
Thermodynamic properties of fluids
Thermodynamics of compressors and refrigeration systems
Gas liquefaction and power cycles
Introduction to phase equilibrium
Fugacity and activity
Introduction to solution thermodynamics
Textbooks: Smith, J.M. and H.C. Van Ness, Introduction to Chemical Engineering
Thermodynamics, McGraw-Hill, 2005.
Sandler, S.I., Chemical, Biochemical, and Engineering Thermodynamics, Wiley,
2006.
Contact Time: 40 hours
Coursework: 20%
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Module Code: CENG104P Module Title: Physical Chemistry
Textbooks: Archer, M.D. and A.J. Nozik, Nanostructured and photoelectrochemical systems
for solar photon conversion, IC Press, 2008.
Atkins, P. and J. de Paula, Atkins’ Physical Chemistry, Oxford University Press,
9th ed., 2009.
Froment. G.F. and K.B. Bischoff, Chemical Reactor Analysis & Design, Wiley, 3rd
ed., 2010.
Fogler, H.S., Elements of Chemical Reaction Engineering, Pearson, 2013.
Hill, C.G. and T. W. Root, An Introduction to Chemical Engineering Kinetics and
Reactor Design, Wiley, 2nd ed., 2014.
Levenspiel, O., Chemical Reaction Engineering, John Wiley & Son, 3rd ed., 1998.
Coursework: 20%
15
Module Code: CENG105P Module Title: Computational Modelling and Analysis
Textbooks: Gerald, C.F. and P.O. Wheatley, Applied Numerical Analysis, Pearson Addison
th
Wesley, 7 ed., 2003.
Seider, W.D., J.D. Seader, D. Lewin, S. Widagdo, Process Design Principles -
rd
Synthesis, Analysis and Evaluation, Wiley, 3 ed., 2009.
Westerberg, A., H. P. Hutchison, R.L. Motard and P. Winter, Process Flowsheeting,
Cambridge University Press, 2011.
Coursework: 40%
16
Module Code: ENGS203P Module Title Mathematical Modelling and Analysis II
Coursework: 40%
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Module Code: CENG201P Module Title Design and Professional Skills II
Aims: The module aims to offer the student a variety of authentic engineering problems
and experiences in order to promote professional values and behaviour, and to
locate Chemical Engineering theory in a realistic context.
The topics selected for the scenarios will be related to material taught in other Year
2 modules.
Textbooks: TBC
Coursework: 100%
Examination: 0%
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Module Code: CENG202P Module Title Experimentation
Coursework: 100%
Examination: 0%
Learning Outcomes:
On completion of this module students should:
be able to understand the physical phenomena present in heat transfer
processes;
be able to calculate or estimate heat transfer coefficients;
be familiar with the procedures for the design of heat transfer equipment ;
Understand pressure drop and fouling factors in a heat exchanger;
Select an appropriate heat exchanger to meet the required heat transfer rate or
heat transfer area
Textbooks: Cengel, Y.A., Heat Transfer a Practical Approach, Higher Education, 2006.
Incropera, F.P. and D.P. Dewitt, Principles of Heat and Mass Transfer, Wiley,
2012.
Levenspiel, O., Engineering Flow and Heat Exchange, Springer, 2014.
Coursework: 30%
20
Module Code: CENG204P Module Separation Processes I
Alternative Code: CENGM26P Title:
CENGG26P
Coursework: 30%
21
Module Code: CENG205P Module Title: Particulate Systems and Separation
Processes II
Learning
On completion of this module students should:
Outcomes:
be able to understand the mass and heat transfer phenomena involved in
particulate processes and related processes;
be familiar with the procedures for the design of separation equipment in the
context of sustainability and sustainable development;
be able to select an appropriate separation process to meet a required separation
performance
Textbooks:
Cussler, E.L., Diffusion: Mass Transfer in Fluid Systems, Cambridge University
rd
Press, 3 ed., 2009.
Jones, A.G., Crystallization Process Systems, Oxford: Butterworth-Heinemann, 2002.
McCabe, W.L., J.C. Smith and P. Harriott, Unit Operations of Chemical Engineering,
th
McGraw-Hill International Editions, 7 ed., 2005.
Mulder, M., Basic Principles of Membrane Technology, Kluwer Academic Publishers,
1996.
Richardson, J.F. and J.H. Harker, Coulson & Richardson’s Chemical Engineering,
th
Vol 2, 5 ed., Butterworth Heinemann, 2002.
rd
Seader, J.D., E.J. Henley and D.K. Roper, Separation Process Principles, 3 ed.,
John Wiley & Sons, 2013.
Coursework: 30%
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Module Code: CENG206P Module Title Chemical Reaction Engineering I
Aims: To provide a basic understanding of the principles of reactor design and of the
reasons underlying the selection of reactor type to meet particular sets of process
conditions for single phase systems.
Synopsis: Introduction: Brief survey of the scope of the subject together with a review of
some of its foundations.
Mole Balances: Definition of reaction rate. The general mole balance. The
batch, plug flow and continuous stirred reactors. Industrial reactors.
Conversion and Reactor Sizing: Definition of conversion. Design equations for
batch and flow systems. Reactors in series. Space velocity and space time.
Rate Laws and Stoichiometry: Concepts of reaction rate, reaction order,
elementary reaction and molecularity. Stoichiometric table.
Isothermal Reactor Design: Design structure for isothermal batch, plug flow
and continuous stirred reactors. Design of multiple reactor systems. Reversible
reactions.
Multiple Reactions: Conditions for maximising yield and selectivity in parallel
and series reactions
Non-isothermal Reactor Design: The energy balance. Algorithms for non-
isothermal plug flow and continuous stirred reactor design. Equilibrium
conversion. Steady state multiplicity.
th
Textbooks: Fogler, H.S., Elements of Chemical Reaction Engineering, 4 Ed.,Pearson, 2013.
rd
Levenspiel, O., Chemical Reaction Engineering, John Wiley & Son, 3 ed., 1998.
Coursework: 20%
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Module Code: CENG207P Module Title Process Design Principles
Examination: 0%
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Module Code: CENG251P Module Title Inorganic Chemistry for Engineers
Textbooks:
Atkins, P., Overton, T., Rourke, J., Weller, M., Armstrong, F., Shriver and Atkins’
th
Inorganic Chemistry, Oxford: Oxford University Press 5 Ed. 2010.
th
Housecroft, C. E., Sharpe, A. G., Inorganic Chemistry, Harlow: Pearson 4 ed.,
2012.
Coursework: 20%
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Module Code: CENG301P Module Title: Process Plant Design Project
Aims: The module aims to further develop and test the students' ability to apply the
knowledge gained in earlier modules and to apply this to the design of a chemical
processing plant in a sustainable context.
Lectures, tutorials and group meetings will provide training in the techniques and
tools required to carry out the design project, applying appropriate design
concepts and computational tools.
The module also develops the following transferable skills: teamwork,
presentation, written communication and project management.
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Towler, G. and R. Sinnott, Chemical Engineering Design: Principles, Practice and
nd
Economics of Plant and Process Design, 2 rev. ed., Butterworth-Heinemann,
2012.
Felder, R.M. and R W Rousseau, Elementary Principles of Chemical Processes,
Wiley, 2004.
McCabe, W.L., J.C. Smith and P. Harriott, Unit Operations of Chemical
th
Engineering, McGraw-Hill International Editions, 7 ed., 2005.
Mannan, A., Lees, F. Lee’s loss prevention in the process industries: hazard
identification, assessment, and control, Elsevier 2012.
Klemeš, J. Assessing and Measuring Environmental Impact and Sustainability,
Elsevier, 2015.
Examination: 0%
27
Module Code: CENG302P Module Process Dynamics and Control
Alternative Code: CENGM22P Title:
CENGG22P
Aims: The aim of the module is to consider the concepts of process dynamics and control
showing why, and how, control ensures safe, smooth and stable operation of process
plants, in the context of sustainability and sustainable development.
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Examination: 80% (3 hour written exam)
Updated August 2017
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Module Code: CENG303P Module Chemical Reaction Engineering II
Alternative Code: CENGG23P Title:
Aims: To provide an understanding of advanced reactor design and the principles and phenomena
that are present in multiphase and catalytic reactions.
30
Module Code: CENG304P Module Transport Phenomena II
Alternative Code: CENGM24P Title:
CENGG24P
Aims: To convey advanced concepts and their application to problem solving in the areas
of fluid dynamics, transport phenomena (with focus on mass and linear momentum
transport), non-Newtonian flow and mass transfer with chemical reaction.
Synopsis: - Mass and linear momentum balance equations (Eulerian and Lagrangian forms)
- Stress within a fluid and problem of closure
- Scaling of transport equations and order of magnitude analysis
- Penetration theory (diffusion of mass, linear momentum and energy)
- Boundary layer theory
- Turbulent flow (characteristics of turbulent flows, averaged transport equations,
Reynolds stress, problem of closure, mixing length theory, Kolmogorov theory)
- Non-Newtonian fluids (shear thinning, shear thickening, Bingham fluids)
- Mass transfer with chemical reaction (film and penetration theories)
The Masters level (level 7) version of the module (CENGM24P and CENGG24P) has
a stronger focus on unseen, and more open ended, problem solving.
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Module Code: CENG305P Module Advanced Safety and Loss
Alternative Code: CENGM25P Title: Prevention
CENGG25P
Aims: To provide students with advanced training in hazard identification, quantification and
mitigation as well as risk management.
On completion students should:
Learning
Outcomes: be able to fully appreciate the importance of Safety and Loss Prevention in the
process industries;
be able to identify, quantify and manage hazards in terms of their potential to cause
damage to the environment, the work force and the general population outside the
perimeter fence;
be able to apply their knowledge during conceptual design, operation and
decommissioning of process plant.
Synopsis: The application of safety as an inherent part of process plant design will be dealt with
and procedures for its implementation are discussed. Incidents which have been
significant in achieving changes in culture will be highlighted. Formal present-day
requirements of engineering for safety, including the methodology for establishing
necessary criteria, implementation and monitoring, verification and validation of safety
systems, and responsibility for auditing.
Basic procedures for Hazard Identification and Development (HAZID), Hazard and
Operability Studies (HAZOP) and Quantitative Risk Assessment (QRA). Safety Studies,
Safety Cases and their development, Safety Management Systems and the role of the
Health and Safety Executive.
Key consequences arising from gas accumulation and dispersion, explosion, escalation
and smoke, area classification and transportation.
The Masters level (level 7) version of the module (CENGM25P and CENGG25P) has a
stronger focus on unseen, and more open ended, problem solving.
Textbooks: Mannan, S., Lees’ Loss Prevention in the Process Industries: Hazard, Identification,
th
Assessment and Control, 4 Ed., Butterworth-Heinemann, 2012.
CCPS Publication, Introduction to Process Safety for Undergraduates and Engineers,
Willey, 2016.
Daniel A. Crowl and Joseph F. Louvar, Chemical Process Safety Fundamentals with
rd
Applications, 3 Ed., Prentice Hall, 2011.
32
Module Code: CENG351P Module Title Organic Chemistry for Engineers
Coursework: 20%
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Module Code: CENG352P Module Title From Molecules to Molecular
Engineering
Aims: To provide a sound overview over fundamental principles and practical examples
of molecular engineering, including molecular design, molecular assembly and
system functionality.
Textbooks: Steed, J.W., Atwood, J.L., Supramolecular Chemistry, 2nd ed, Wiley, 2009.
Hamley, I.W., Introduction to Soft Matter, 2nd ed, Wiley, 2007.
Hirst, L.S., Fundamentals of Soft Matter Science, 1st ed, CRC press, 2012.
Jones, R.A.L., Soft Machines: Nanotechnology and Life, Jones, 1st ed, Oxford
University Press, 2009.
Coursework: 20%
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Module Code: CENGM001 Module Title: Research Project
Alternative Code: -
Examination: 25% Oral Examination (must be passed (at 50%) in order to pass module)
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Module Code: CENGM002 Module Advanced Process
Alternative Code: CENGG013 Title: Engineering
Aims: Advanced use of computers in process design, operation and management. Particular
emphasis is placed on Process Synthesis.
Learning
On completion the students will be expected:
Outcomes:
to be aware of the role of optimisation techniques in plant design, operation and
management;
to be aware of numerical techniques for solving continuous and discrete
optimisation problems;
to be able to formulate and solve complex optimisation problems both analytically
and using computational tools;
to be aware of techniques for process synthesis and be familiar with a
contemporary tool.
Synopsis:
Approaches to process synthesis and process optimisation.
Linear programming by the simplex and graphical methods.
Introduction non-linear process optimisation, optimality criteria, conditions for an
optimum, unconstrained optimisation, constrained optimisation. Application to
flowsheet optimisation.
Discrete modelling of process systems. Solution methods for discrete optimisation
problems: integer programming, mixed integer linear programming, mixed integer
non-linear programming. Process synthesis using implicit enumeration. Algorithmic
approaches to synthesis of sustainable systems: heat exchanger networks.
Process synthesis under uncertainty. Flexibility analysis.
Textbooks:
Beigler, L.T., I.E. Grossmann and A.W. Westerberg, Systematic Methods of Chemical
Process Design, Prentice Hall, 1997.
Edgar, T.F. and D.A. Himmelblau, Optimisation of Chemical Processes, McGraw Hill
1988.
Floudas, C.A., Nonlinear and mixed-integer Optimization, Oxford University Press
1995.
Seider, W.D., J.D Seader, D.R Lewin and S. Widagdo, Product and Process Design
rd
Principles: Synthesis, Analysis and Design, 3 ed., Wiley, 2009.
Williams, H.P., Model Building in Mathematical Programming, Wiley 2013.
Coursework: 50%
Updated TBC
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Module Code: CENGM006 Module Title: Fluid Particle Systems
Alternative Code: CENGG018
Aims: This course is designed to convey the fundamentals of fluidization and crystallization
and their applications to industrial scale units and sustainable development.
Learning
On completion, students are expected:
Outcomes:
to be able to formulate realistic differential equation descriptions of multiphase
systems;
to have an understanding of the two-phase nature of gas-solid fluidized beds and of
how to apply their basic quantitative features to the design of reactors;
to be able to apply methods to analyse the characteristics and performance of
particulate crystal formation systems and to design crystallization equipment.
Synopsis:
Fundamentals of gas-solid and liquid-solid systems. Fluid-particle interaction. Fluid-bed
stability theory. Bubble dynamics. Particle mixing and segregation. Heat and mass
transfer. Fluidized bed chemical reactors.
Theories of nucleation and crystal growth. Measurement of nucleation and growth
kinetics.
Crystallization processes and crystallizers. The population balance equation and
crystallizer design.
Textbooks:
Gibilaro, L.G., Fluidization-Dynamics, Butterworth-Heinemann, 2001.
nd
Kunii, D. and O. Levenspiel, Fluidization Engineering, 2 ed., Butterworth-Heinemann,
1991.
rd
Mullin, J.W., Crystallization, 3 ed., Crystallization, Butterworth-Heinemann, 1993,
Jones, A.G., Crystallization Process Systems, Oxford: Butterworth-Heinemann, 2002.
Coursework: 20%
37
Module Code: CENGM010 Module Energy Systems and
Alternative Code: CENGG020 Title: Sustainability
Coursework: 40%
Updated TBC
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Module Code: CENGM01P Module Process Systems Modelling
Alternative Code: CENGG01P Title: and Design
Lectures, tutorials and e-learning resources will provide training in the techniques
and tools required to carry out design projects applying advanced design concepts
and computational tools.
Coursework: 100%
Examination: 0%
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Module Code CENGM02P Module Molecular Thermodynamics
Alternative Code: CENGG02P Title:
Examples will include, but will not be limited to, self-assembling structures, materials
and processes for separations, and strategies for energy storage.
40
Module Code CENGM03P Module Title: Electrochemical
Alternative Code: CENGG03P Engineering and Power
Sources
41
West, A.C., Electrochemistry and Electrochemical Engineering. An Introduction, 2012.
42
Module Code CENGM04P Module Nature Inspired
Alternative Code: CENGG04P Title: Chemical Engineering
Textbooks: Bejan, A., Shape and Structure, From Engineering to Nature, Cambridge
University Press, 2000.
Mandelbrot, B.B., The Fractal Geometry of Nature, Updated and augmented
ed. Freeman, San Francisco, 1983.
nd
Vicsek, T., Fractal Growth Phenomena, World Scientific, 2 ed., Singapore
1992.
Links from http://cnie.org.uk (Centre for Nature Inspired Engineering)
43
Module Code: CENGM05P Module Advanced Materials Processes
Alternative Code: CENGG05P Title: and Nanotechnology
Coursework: 20%
44
Module Code: CENGM09P Module Advanced Separation
Alternative Code: CENGG09P Title: Processes
Coursework: 40%
45
Module Code: CENGG098 Module Title: Advanced Design Project
Alternative Code: -
Aims: The advanced design project is available to MSc students without a chemical
engineering first degree wishing to fulfil one of the main requirements for becoming
chartered chemical engineers. The course develops and tests the students' ability to
co-ordinate the knowledge gained in earlier courses and to apply it to the complete
design of a process plant with particular emphasis on advanced safety, control and
optimisation techniques. The course also develops the following transferable skills:
research, teamwork, presentation skills, written communication and project
management.
Learning On completion of this course, the students will be expected to be able to:
Outcomes: - Evaluate the risks associated with the loss of containment from process plant
- Develop /utilise mathematical models and where necessary translation them
into computer codes for simulating the failure consequences associated with
plant failure
- Develop mitigating strategies for reducing the consequences of plant failure
to safe and acceptable levels
- Develop model-based process and control design strategies;
- Use a contemporary tool for modelling process dynamics;
- Develop computational models for complex process plant;
- Use contemporary tools for advanced model-based process design
Synopsis: The course comprises two parts. In Part I, MSc students work in a team to perform
the detailed design of a chemical process plant to the project requirements.. In Part II,
conducted more in the form of a research project, the MSc students extend the
chemical engineering process plant designed in Part Ito consider its advanced safety,
optimization and control aspects. The safety aspects will in the main investigate the
consequences associated with the accidental release of hazardous materials from the
process plant. These will typically include jet fire impingement analysis, atmospheric
dispersion, pipeline rupture, pool fire and explosion modelling. The results will in turn
be used to develop mitigation procedures, determine minimum safe distances and
determine plant layout.
The model-based design, control and optimisation aspects take Part 1 further by
incorporating different objectives into the design which will allow a decision maker to
take informed decisions. This is achieved by formulating and solving the problem as a
multi-objective optimization problem to obtain the Pareto or non-inferior curves.
Trade-offs between Cost and Environmental Impact, Energy Consumption and
Controllability or Operability are studied in a quantitative framework.
Textbooks:
As recommended for the particular project.
General:
Towler, G., Sinnott, R.K., Chemical Engineering Design, Principles, Practice and
Economics of Plant and Process Design, 2nd ed., Elsevier, 2013.
Sinnott, R.K., Coulson & Richardson’s Chemical Engineering, Vol 6, 4th ed.,
Butterworth Heinemann, 2005.
McCabe, W.L., Smith, J.C., Harriott, P., Unit Operations of Chemical Engineering”,
7th ed., McGraw-Hill, 2005.
Kirk-Othmer Encyclopedia of Chemical Technology, 5th ed., Wiley & Sons, 2007.
Ullmann's Encyclopedia of Industrial Chemistry, 2nd ed., Wiley & Sons, 2002
Yaws, C.L., Yaws' Handbook of Thermodynamic Properties for Hydrocarbons and
Chemicals, 2nd ed., Gulf Professional Publishing, 2015.
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Hazop and Safety Integrity Analysis
Center for Chemical Process Safety, Pilot Plant Operation Phase: An Illustration of
the HAZOP Study Method, in: Guidelines for Hazard Evaluation Procedures, 3rd ed.,
John Wiley & Sons, 2008.
Kletz, T., Hazard identification and assessment, in: HAZOP AND HAZAN: Identifying
and assessing process industry hazards, 4th ed., Institution of Chemical Engineers,
1999.
Kletz, T., Hazard and operability studies (Hazop), in: HAZOP AND HAZAN:
Identifying and assessing process industry hazards, 4th ed., Institution of Chemical
Engineers, 1999.
Lees, F., Lees’ loss prevention in the process industries: hazard identification,
assessment, and control, 4th ed., Elsevier, 2012.
Marzal, E.M., Scharpf, E.W., Safety Integrity Level Selection - Systematic Methods
Including Layer of Protection Analysis, ISA, 2011.
P&ID development:
Hall, S., Rules of thumb for chemical engineers, Elsevier, 5th ed., 2012, pp 291-295,
337-346.
Mayer, F. A., A P&ID standard: What, why, how?, ISA transactions, 41 Issue 4, 2002,
pp 389-394.
Process Control:
Ponton J.W., Degrees of freedom analysis in process control, Chemical Engineering
Science, Vol. 49, No. 13, 1994, pp 2089 – 2095.
Pham, Q.T. Degrees of freedom of equipment and processes, Chemical Engineering
Science, Vol. 49, No. 15, 1994, pp 2507 – 2512.
Gorak, A., Schienmakers, H., Distillation Control, in: Distillation: Operation and
Applications, Academic Press, 2014.
Luyben, W.L., Chemical Reactor Design and Control, AlChe, Wiley, 2007.
Examination: 25% Oral Examination (must be passed at 50% in order to pass module)
47
Module Code: CENGG099 Module Title: Chemical Process Engineering
Research Project
Alternative Code: -
Synopsis: An individual research project working under the supervision of a member of the
academic staff of the department. Topics are usually selected from aspects of a
continuing research speciality of the department. Each student normally undertakes
a literature survey, experimental work, modelling, discussion and analysis of data
followed by conclusions and recommendations for future work presented in the form
of a thesis and oral presentation.
Examination: 25% Oral Examination (must be passed (at 50%) in order to pass module)
48
Module Code: CENGGA01 Module Natural Gas Processing
Title:
Alternative Code: CENGMA01
Aims: The aim of this module is to equip the students with a broad understanding of the unit
operations (reactors, separations, pumping, cooling/heating, etc.) that are part of a
chemical plant. The students will also understand the costing of a chemical plant, as
well as the impact of managing both the construction of a plant and its operation. The
students will learn how to design a chemical process, which will become essential
should they decide to attain accreditation from professional bodies such as IChemE.
Some elements of financing will be included, as they will prepare the students for
subsequent courses in this MSc.
The module will consider:
- Natural Gas Fundamentals
- Basic Concepts of Natural Gas Processing
- Gas Plant Project Management
- Natural Gas Treating (Dehydration and Denitrification)
- Natural Gas Compression and Plant Automation
- Design of a Natural Gas Processing Plant
- Maximizing Profitability of Gas Plant Assets
- Gas Processing Operations
Learning Upon successful completion of this module the students will be able to:
Outcomes: 1. Formulate the typical composition of natural gas,
2. Appraise the unit operations needed to render the raw material into a
commodity,
3. Quantify the finances regarding the plant,
4. Evaluate and explain possible complications in the design of the process,
5. Defend the limitations and trade-offs when a plant is commissioned,
6. Appraise the uncertainties and the risks connected with a vast capital
investment;
7. Design a chemical process plant using commercial software.
Synopsis: This module has the goal of providing an overview on the chemical processes typically
implemented to transform the natural gas extracted from the ground into a valuable
commodity. The module includes elements of project management, economics
analysis, optimization, process control, and the description of a few unit operations that
are essential for the implementation of natural gas processing plants. The course also
includes a tutorial on process design using chemical process design software packages
such as Aspen Plus.
rd
Textbooks: Handbook of Natural Gas Transmission & Processing, 3 Edition, by Saeid Mokhatab,
William A. Poe, John Y. Mak, Elsevier, 2015.
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Module Code: CENGGA02 Module Title: Minerals Usage, Extraction and
Processing
Alternative Code: -
Aims: The module will include several parts, each with well-defined aims:
This portion of the dissertation has the goal of preparing the students towards being
able to complete their research. The goals of this section include: (a) explaining what is
the rationale for the research projects; (b) what are the project items offered; (c) what
are the expectations and the resources available to the students. The students will be
presented with an expected timeline, will choose the research projects of their
preference, and will be paired with the research advisors.
B- Research Project
During the third term the students will conduct their independent research. The students
are expected to gather the information developed during most of the taught classes.
The students will be divided in groups, and each group will face one ‘scenario’.
Each group of students will function as a consultancy team, with the goal of providing
recommendations, in the form of a dissertation. However, within these scenarios, each
student is expected to analyze in depth one individual aspect of the scenario, which will
set the basis for the individual assessment, and which will be complementary to the
ones explored by the other students. Within a scenario each student will be expected to
be aware of the development of all the projects. The projects are intended to be open-
ended and to allow the students to develop their own critical thinking.
These individual parts of the dissertation will be completed during Term 3 and summer.
The projects on fundamental research will be conducted by the students embedded in
research programs with adequate experience on the subject matter. Some students will,
for example, investigate new methods for mineral flotation, new processes for
environmental remediation, etc. The students will be closely supervised, with particular
attention to safeguard their health and safety.
These individual projects will be combined within the scenarios discussed above, and
they will need to be integrated with the rest of the projects conducted by a team. Hence
the students involved in these projects will need to be aware of the projects conducted
by their peers on the other aspects listed above.
C - Presentation skills
One learning objective is for the students to be able to present critically their results
both via oral presentation and in a written form. The Oral Examination is designed to
test this ability as well as to test the fundamental understanding they have achieved,
both within the boundaries of their specific research projects, and in a wider boundary
within the subject matter of the MSc in Global Management of Natural Resources. The
students are expected to be able to work in groups and to relate each individual results
to the results of the other students within each group. This is the reason beyond the
requirements of their group presentation and group dissertation, which will be within
well-defined page limits.
The students will also be required to experience, first hand, a mining site (e.g., a copper
/ gold / uranium mine). The scope is to see the physical aspects of such an operation,
as well as to appreciate the scales of mining.
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Learning Upon successful completion of this module the students will be able to
Outcomes:
6. Formulate a complex problem in simpler tasks;
7. Design and conduct research;
8. Appraise individual research tasks;
9. Judge individual research results to literature;
10. Conduct literature review;
11. Assess the scale of mining operations;
12. Present research results in various forms;
13. Defend codes of conducts and operate within them;
14. Manage time and commitments;
15. Work in groups.
Synopsis: The goal of the dissertation is to bring to fruition the material learned by the students
during the programme. The students will also learn how to plan and execute research
projects, as well as to report the results, discuss them openly, compare them to the
literature, and defend their conclusions. The students will learn to work in groups and to
manage their time towards a satisfactory completion of the dissertation.
Textbooks: Dissertations and Project Reports: A Step By Step Guide, Stella Cottrell, Palgrave
MacMillan, 2014
Examination: 0%
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Module Code: BENGM001 Module Integrated Downstream Processing
Alternative Code: BENGG005 Title:
Aims: To provide training for MSc biochemical engineers, via lectures, case studies
and pilot plant study, in the engineering principles underlying the operations and
processes for the recovery and purification of biological materials. The course
focuses on how operations need to be integrated to create a whole sequence
where issues of ease of operation, safety and environmental impact are
considered at the selection stage. Taught alongside industrial delegates this
course provides a blend of theory and application supported by insights to
cutting-edge developments in the field.
Learning Following completion of the course, students will have an understanding of:
Outcomes:
- the reasons for selection of particular operations considered from a whole
bioprocess perspective.
- the mechanisms of operation and the key design equations needed for
equipment sizing and performance estimation.
- the full implications of operation selection on the robustness of operation and
the ease/safety/cost of operation.
- the whole bioprocess operation through practical application of these
principles via extended individual and team-based pilot-scale activity.
Synopsis: The recovery and purification of biological products from complex sources such
as fermentation or cell culture represents the major challenge for the provision of
safe and effective materials, for therapeutic use and for industrial applications.
The course is designed to progress through the logic of a bioprocess sequence
from basic cell removal through to high resolution purification and formulation.
Particle recovery and purification processes are examined as the early stages in
the separation of biological materials. Operations include centrifugation,
filtration, membrane separation, precipitation and crystallisation. Complementary
extraction operations include liquid/liquid reaction and cell disruption
High resolution purification and finishing operations take the material to final form
for use - operations studied include chromatography.
The course is concluded with a summary of how complete recovery and
purification sequences may be best put together.
Case studies in the design of selected operations will form the basis of team
exercises to help with the understanding and application of the lecture notes.
Textbooks: Mcabe W.L., Smith J.C. and Elliot P. 2000. Unit operations of Chemical
Engineering (7th edition). McGraw-Hill, London.
Bioseparation and Bioprocessing Handbook (2nd edition). 2007. Edited by
Ganapathy Subramanian, Wiley-VCH Verlag, Weinheim.
Najafpour G.D. 2007. Biochemical Engineering and Biotechnology, Elsevier,
London.
Cutlip, M.B and Shacham, M. 2008. Problem solving in Chemical and
Biochemical Engineering with Polymath, Excel and MATLAB. Prentice-Hall,
London.
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Doran, P.M. 1995. Bioprocess Engineering Principles. Academic press, London.
Perry’s Chemical Engineers’ Handbook (8th edition). 2008. Edited by Perry, R.H
and Green, D.W. McGraw Hill, London.
Belter, P.A., Cussler, E.L. and Hu, W.S. 1988. Bioseparations: downstream
processing for biotechnology. John Wiley & Sons, New York.
Bailey, J.E and Ollis, D.F. 1986. Biochemical Engineering Fundamentals.
McGraw Hill International Editions. London.
Coursework: 25%
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Module Code: BENGM002 Module Design and Control of Biochemical
Alternative Code: BENGG004 Title: Reactors
Aims: This course provides students with a detailed understanding of bioreactor design,
scale-up and operation. It considers both whole cell (i.e. fermentation) and
enzymatic (i.e. biotransformation) conversion processes for the synthesis of
complex materials such as therapeutic proteins, antibiotics, gene therapy vectors
and chiral pharmaceuticals.
Particular themes of the course include the interaction of biological catalysts and
pharmaceuticals with the engineering environment within a bioreactor, the
theoretical basis of process scale-up and scale-down, and the impact of rDNA
techniques on bioreactor design and operation. Particular attention is paid to the
instrumentation and control of bioreactors and issues underlying biosafety with
respect to contained operation.
Learning Following completion of the course, students will have an understanding of:
Outcomes:
- how to design and specify bioreactor design and control systems
- how bioreactor operation impacts on cell growth and productivity
- how the kinetics of free and immobilised biocatalysts impact on biocatalytic
reactor design and selection
- how to relate fundamental knowledge of bioreactor engineering to industrial
application
- how rDNA technologies can be applied to improve biocatalyst stability and
bioprocess productivity
Textbooks: P.A. Doran, Bioprocess Engineering Principles, Academic Press, London (1995)
J. Villadsen & J. Nielsen, Bioreaction Engineering Principles, Plenum, NY (1994)
M-N Pons, Bioprocess Monitoring and Control, Hanser Press (1992)
Ed. J.M.S Cabral et al, Applied Biocatalysis, Harwood Academic (1994)
Coursework: 30%
Examination: 70%
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Module Code: BENGM004 Module Cell Therapy Biology, Bioprocessing and
Alternative Code: - Title: Clinical Translation
Aims: The course provides the biochemical engineering student with the necessary
knowledge to understand the translational challenges of moving from promising
scientific discoveries through to advanced therapeutic products for use in routine
clinical practice. A coordinated series of lectures examines these challenges, from
rigorously assessing robustness of the science that underpins a therapy, to
understanding the critical pathways to clinic and considerations for
commercialization of advanced therapies.
Learning Following completion of this course, students will have an understanding of:
Outcomes:
- Fundamental science underpinning several cell-based therapies
- Pathways required to take a ground-breaking scientific discovery from the
laboratory bench through the clinical, scalable manufacturing and
commercialization route into routine clinical practice
- Regulation, clinical trials, intellectual property rights, ethics and reimbursement
with respect to advanced therapies
- How to evaluate the potential of advanced medical technology with respect to
clinical, bioprocessing and commercial opportunities
- Current technologies and critical decision making with respect to new
disruptive healthcare technologies.
Synopsis: The course expands on the core cell biology knowledge acquired from the third
year course BENG3012 (Applied Molecular Biology) to gain understanding of the
scientific, clinical and commercial interactions required to translate basic science
into a routinely deployed advanced therapy. In particular, the course examines the
requirements for cutting edge platform technologies that offer a paradigm shift in
medical care and intervention of diseases that are becoming more problematic as
the global population ages. The underlying requirement is to produce quality
therapies that are safe, clinically effective and cost effective. Throughout the
course, all the material is based on real world examples and data.
Major themes: Stem cells, tissue engineering, gene therapy.
Subthemes: Basic science research underpinning candidate cell therapy
interventions, research and development process, clinical trials, regulation,
bioprocessing, reimbursement, translation cycle, law and ethics.
Research, development and full commercialisation (including post market
surveillance). Impact of stage of development (including animal studies, clinical
trials), timelines, resources and outcomes. Development cycle and product life.
Patents and other IPR approaches.
Impact on bioprocessing unit operations on production of cells for therapy from the
perspective of the economics, speed to market, regulation, current Good
Manufacturing Practice (cGMP) including current Good Clinical Practice (cGCP).
Students will work in small groups (<5), to create reports and presentations
focused on clinical trials of advanced therapies for final assessment.
Textbooks: Bruce Alberts et al., Molecular Biology of the Cell. 5th Edition. 2008.
Jackie Fenn and Mark Raskino, Mastering the Hype Cycle: How to Choose the
Right Innovation at the Right Time. Harvard Business Press 2008.
Yali Friedman, Building Biotechnology: Business, Regulations, Patents, Law,
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Politics, Science. Logos Press 2008.
Shreefal S. Mehta, Commercializing Successful Biomedical Technologies: Basic
Principles for the Development of Drugs, Diagnostics and Devices. Cambridge
2008.
Coursework: 30%
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Module Code: BENGM008 Module Applied Molecular Biology
Alternative Code: BENGGB03 Title:
Synopsis: Stem cell biology, DNA structure, replication, central dogma, genetic code,
transcription, RNA structure, translation, tRNA and ribosome structure, nascent
polypeptides, proteins, plasmids, chromosomes, genomes, cultivation of
mammalian, yeast and bacterial cells, human cells as therapeutics, gene syntax in
mammalian, yeast and bacterial cells, transfection of human cells, transformation
of yeast and bacterial cells, DNA analytics
Textbooks: TBC
Coursework: 30%
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Module Code: BENGM010 Module Bioprocess Validation and Quality Control
Alternative Code: - Title:
Aims: The course addresses the challenge of the safe delivery to patients of
biopharmaceuticals and in particular injectables. The aim of the course is to
familiarise students with current validation methodology using leading edge
developments with expert speakers in a workshop format. Particular focus is given
to development of concepts of Critical Process Parameters (CPPs) and Quality by
Design (QbD).
Synopsis: Regulations (FDA and EMEA) to meet product safety for biologics; analytical
methods to support process validation; fermentor and control system validation;
validation of recovery and purification operations; cleaning, sterilisation and
turnaround systems; operation and control of multiproduct plants; change control in
the event of process failures /planned enhancements.
Case study reports assessed as pre-prepared oral presentations on topics from:
- appraisal of multiproduct facilities and change control
- validation of process change – scale up and scale out
- disposable versus conventional equipment – validation appraisal
Project report assessed as a validation master plan on theanalysis of process
change and revalidation strategy
Textbooks: TBC
Examination: -
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Module Code: BENGM011 Module Integrated Biochemical Engineering
Alternative Code: BENGG006 Title: Design
Aims: This course is designed to provide a structured approach to understanding the ways
in which a discovery in bioprocessing and biological sciences is taken through to a
real outcome and the value of process design and operation to the overall business
success. The students will learn about ways of evaluating potential commercial
opportunities, selecting an optimal route for their exploitation. They will then be able to
gain hands on experience of pilot scale operations where the conceptual.
Learning Following completion of the course, students will have an understanding of:
Outcomes: - how to undertake the technical and commercial assessment of research projects.
- what it takes to patent research
- the requirements for clinical trials
- how to assess the manufacturing facilities requirements or outsourcing alternatives
- know how to structure a business plan
- how to create financial spreadsheets.
Textbooks: Students are provided with tailored lecture notes by industrial speakers and tailor-
made pilot-plant booklet
Examination: 70%
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Module Code: BENGM022 Module Sustainable Industrial Bioprocesses and
Alternative Code: - Title: Biorefineries
Aims: This module provides students with an understanding of the principles, technologies
and design of sustainable bioprocesses and biorefineries. A biorefinery is an overall
concept of a processing plant where biomass feedstocks are converted and extracted
into a spectrum of valuable products (in analogy to petro-chemical refinery).
Particular themes include the use of renewable resources, process integration
including energy supply and waste treatment, design, operation and control of
complex plants and life cycle assessment. These will be addressed using a
combination of lectures, simulation case studies and a design project.
Coursework: 50%
Examination: 50%
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Module Code: BENGM029 Module Title: Fundamental Biosciences
Alternative Code: -BENGG029
Aims: The course provides students who have zero or basic life science background with a
rigorous introduction to those elements of the biosciences likely to have most
relevance to interdisciplinary work in fields such as engineering or applied chemistry.
The course also aims to introduce students to the requirements of bioscience
research and to encourage them to develop skills they will need to succeed when
collaborating with life scientists or carrying out biological research themselves in
future.
Learning By the end of this Module students will have developed knowledge and
Outcomes: understanding of the following aspects of the biosciences:
- DNA and 'omic' data
- Protein structure and function as it relates to enzymes, antibodies and
misfolding
- The prokaryotae and archaea
- Metabolism and associated analytical techniques
- Mammalian cell biology
- Stem cell biology
- Virus biology
- Vaccines and Immunity
- Yeast biology
Synopsis: The Module is divided into seven major themes; recombinant DNA technology,
proteins, bacteria, metabolism, mammalian cells, stem cells, yeast and vaccines.
Each topic will be introduced in a way that assumes no previous knowledge of the
area. However, the content will advance rapidly to the level of rigour appropriate for
Masters level. The topics have been selected to develop a broad palette of
bioscience knowledge that has maximal utility at the interface of disciplines in both
research and professional settings. As such the most widely-used materials of
bioscience; viruses, bacteria, yeast and mammalian cells, are explained in fine
biological detail, as are the most important tools; DNA and protein.
Textbooks: Bruce Alberts et al. Molecular Biology of the Cell, 5th Edition. 2008.
Rob Phillips et al. Physical Biology of the Cell, 1st Edition. 2008.
Ivan Roitt et al. Immunology, 7th Edition. 2006
Richard A. Harvey et al. Microbiology, 2nd Edition. 2007.
Coursework: 30%
Examination: 70%
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