IMMUNOFREE

SUPPORTING RESEARCH
 Immunofree blends a wide variety of phytochemicals,such as
alkaloids,polyphenols, flavonoids, saponins, terpenoids, lignans,
  Xantones, etc.
These herbs have specifically been chosen based on research
done in 2020. We use highly concentrated full spectrum extracts
of these herbs in Immunofree.
Many ground breaking researches
like, Traditional Chinese medicine
2020, have shown the benefits of
Immunofree ingredients for
Immunity in 2020.

The ingredients and their

researches have been discussed
hereafter.
Studies done on 01 In Vivo study (in the body)
individual ingredients
have been conducted in 02 In Vitro study (on cells in labs)
the following set-ups:
03 In Silica research
(Computer modelling of plant DNA
against Viral RNA)

Disclaimer: This peer reviewed and published research has most probably not been studied or approved by the FDA in your
country as a treatment or cure. Hence no disease claims can be made and you are welcome to take the natural ingredients
for (immunity, lung health, cardiovascular health, etc)
 Andrographis/ Kalmegh

is the king of bitters. Various studies suggest it

dissolves viral envelopes and may help the body get
rid of RNA viruses.
It is known as chuān xīn lián in chinese medicine and
has been mandated in China since Feb 18 2020.
Kalmegh -
Andrographis Paniculata

Studies suggest that Paniculata has potent

antiviral effect. Among the four
phytochemicals, AGP3 has shown promising
binding affinity.
The residue-wise contributions of binding
free energies has shown that in the case of
3CLpro and RdRp there is still scope for the
improvement through the chemical
modification of the ligand.
Review articles on Phytochemicals new
line of treatment

A paniculata ethanol  extract  inhibited the virus  titer 

similar  to  the positive  control and  it  was not  toxic  to the 
A459  cell line. Furthermore,  low  concentration 
(1  μg/mL)  of a paniculata  extract  could stimulated
lymphocyte   cell proliferation about 38% compared to the
control lymphocyte cell without any treatment.
 Supporting research articles for Paniculata

01 02
Andrographolide as a potential Experimental and Clinical
inhibitor : an in silico approach Pharmacology of Andrographis
paniculata and Its Major Bioactive
Phytoconstituent Andrographolide

03
Computational investigation on Andrographis paniculata
phytochemicals to evaluate their potency
 Bhumyamalaki-  Phyllanthus niruri

is popularly known for its Hepato-protective

properties. You will find this herb in numerous
traditionally used medicines in order to support the
liver and immunity. The herb may have the ability to
inhibit and also destroy viral envelopes.
Bhumyamalaki -
Phyllanthus Niruri

Phyllantus is one of the top ranked phytochemicals

screened against 3CLpro receptor binding site with their
respective structures, docking score, binding affinity and
interacting residues.

Phyllanthus have been widely used in Ayurveda

(traditional Indian medicine) and their biological properties
have been intensely studied for its antiviral activity.
 Supporting research articles for
Bhumyamalaki-  Phyllanthus niruri

01 02
Structural basis of  discovery from Relevance of Fast Track Integrative
medicinal plants Approaches

03
Ayurvedic Preventive and
Immunity Protocol
 Yastimadhu- Glycirhizza Glabra

is traditionally known as Elixir for the lung, believed to have properties

to liquefy phlegm and enable easy expectoration and clear airway.
Liquorice root, or 'radix glycyrrhizae', is one of the 50 fundamental
herbs used in traditional Chinese medicine, where it has the name
gancao.

Yastimadhu tops the list of Jivaniya Mahakashaya which means

nutrient as well as rejuvenating remedy. it is natural tonic for general
debility, chronic fatigue, and physical exhaustion
Yastimadhu -
Glycirhizza Glabra

Glycyrrhiza glabra plant potentially showed

antiviral activities
Research studies conducted to test Glycyrrhiza glabra plant:
Review of antiviral effects
of Glycyrrhiza glabra L.
and its active component,
glycyrrhizin
presented a review of the
antiviral activity of
Glycyrrhiza glabra.
Scope of Glycyrrhiza
glabra (Yashtimadhu) as
an Antiviral agent: A
Review
reviewed the antiviral activity
of Glycyrrhiza glabra plant.
Suppression of porcine
reproductive and
respiratory syndrome virus
proliferation by
glycyrrhizin
presented a review of the
antiviral and antimicrobial
activities of Glycyrrhiza
glabra. The authors
described the presence of
more than 300 flavonoids
and 20 triterpenoids in this
plant.
Supporting research articles for Glycyrrhiza glabra plant:

01 02
Immunomodulatory Herbs of Epidemiology, Treatment and
Ayurveda Microbiological Surveillance
A review article

03
In Silico Molecular Docking Studies of Medicinal Arabic Plant-Based
Bioactive Compounds
 Tulsi - Ocimum sanctum (Queen of herbs)

Tulsi is a sacred plant in Hindu mythology also known as Vishnu Priya,

The plant also known as apet- rakshasi and bhutagni may be related to
its properties to ward-off all evil.
Tulsi - Ocimum sanctum

Tulsi has  been  well  documented  for 

its  therapeutic potentials and   
described    as    Dashemani
Shwasaharni (antiasthmatic) and anti-
kaphic  drugs  (Kaphaghna).

Tulsi is traditionally used in fever,

bronchitis, and lung health
preparations.
 Supporting research articles for Tulsi:

01 02
Ayurveda’s Holistic Lifestyle Ayurveda Practitioners Consensus
Approach for immunity: Possible to Develop Strategies for Immunity
Role of Tulsi

03 04
Evaluation of traditional ayurvedic Exploring alternative medicine
preparations using molecular options for immunity A systematic
docking approach scoping review
Guduchi - Tinospora cordifolia- Giloy, Amritha

It is called Amrita in Sanskrit, meaning which never dies.  

The term signifies longevity and immortality.
Guduchi

Guduchi is widely used plant in folk and Ayurvedic

systems of medicine is well known for its
immunomodulatory activity.

Following is a study that suggests the benefits of

Guduchi plant:
Immunostimulatory properties of the major protein from
the stem of the Ayurvedic medicinal herb, guduchi
 Supporting research articles for Guduchi:

01 02
Indian traditional Ayurvedic Deploying Biomolecules for
treatment regime for Immunity Immunity

03 04
Exploring alternative medicine Immunity prospective chemical
options for Immunity in 2020- A drug therapeutics
systematic scoping review
 Pushkarmool-Inula racemose

Pushkarmool is one of the reputed medicinal plants used in traditional

system of medicine (Ayurveda) for its potential benefits in cardio-
respiratory and cardiovascular diseases.
Supporting research for
Pushkarmool-Inula racemose

Following is the study that attempts to validate the

benefits of Pushkarmool:

An Experimental Evaluation of Anti-Asthmatic

Potentialitis of Inula racemosa (Puskar Mul)

Nature to Nurture- Identifying Phytochemicals from

Indian Medicinal Plants as Prophylactic Medicine by
Rational Screening to be Potent
Rasna-Alpinia Sugandhimool (aromatic roots)  -
Sugandhimool

Studies suggest Natural Compounds in Alpinia officinarum are Potent

Protease Inhibitors.

Some of these studies are:

Revealing the Potency of Citrus and Galangal Constituents
Natural Product Compounds in Alpinia officinarum and Ginger
 Draksha – Vitis Vinefera

Research suggests  Drakha to be beneficial in coagulatory disorder and

also help in improving circulation.
The anticoagulant effect of polyphenols-rich extracts from black
choke berry and grape seeds.
Draksha

The Ministry of AYUSH recommended the use of a

decoction of the mixture of Ocimumtenuiorum,
Cinnamomum verum, Piper nigrum, Zingiber ocinale,
and Vitis vinifera as a preventive measure to boost
immunity
Following researches support the same:
Network pharmacology of AYUSH recommended
immune-boosting medicinal plants
Anticoagulant effect of polyphenols-rich extracts from
black chokeberry and grape seeds

Rasayana as Orac Connotation - An Intercessional

Health Promotion in 2020
 Haridra – Curcuma longa

Studies suggest curcumin extracts derived from Turmeric is found to be a strong Immunomodulator
Curcumin is also considered as a potential immune booster.

Following studies support the claim:

Virtual screening and Curcumin as a potential

Potential effects of curcumin
repurposing of FDA approved Mechanism of Pathogenesis,
in Immunity
drugs 

Ayurveda Practitioners
Immunity Options and Immunity to Save Humanity: A
Consensus to Develop
Developments Study
Strategies for Immunity
 Haritaki- Terminalia chebula- Abhaya,
Patya, Harda

The extract of fruits of T. chebula potentially showed inhibitory effects on

viruses
 Supporting research articles for Haritaki:

01 02
Ayurvedic Immunity: A Proposal Immunomodulatory herbs of
Ayurveda : A review article

03 04
Biological and Pharmacological Ayurvedic practitioners consensus
Propoerties of Terminalia Chebula to develop strategies for Immunity
Retz. (Haritaki) - An Overview
 Kumari- Aloe vera-  Gritkumari, Kanyasara, Surasa

Kumari is traditionally used as a  liver support and inflammation.

Following studies attempt to show its benefits :

Aloe vera (L.) Burm. F. as a Potential Identification of potential inhibitors of

Immuno booster: A Mini-review of Its protease from Aloe vera compounds: A
Antiviral Activity molecular docking study

A two-pronged strategy to suppress

Suppression of Host Gene Expression host protein synthesis
by nsp1 Proteins of Group 2
 Shilajit – Asphaltum

Shilajit, a multi-component natural mineral substance, is known for its

potential antioxidant activity, immune response, and disease resistance
Shilajit - Asphaltum

Research suggests that Shilajit potentially

and significantly increases Phagocytic
activity, Respiratory burst(RB) activity and
glutathione peroxidase activity.
 Supporting research articles for
Shilajit - Asphaltum

01
Effect of Shilajit enriched diet on
immunity, antioxidants, and disease
resistance in Macrobrachium
rosenbergii (de Man)
against Aeromonas hydrophila
02
Immunity Recommendations
of the Hungarian Integrative
Medicine Association
 Jasad Bhama – Zinc oxide

Zinc is known to modulate antiviral and antibacterial immunity and

regulate inflammatory response.
Jasad Bhama – Zinc oxide

In vitro experiments demonstrate that Zn2+

possesses antiviral activity
 Supporting research articles for
Jasad Bhama - Zinc Oxide

01 02
Therapeutic Application of Zinc in Zinc and respiratory tract infections:
Opportunistic Infections Perspectives (Review)

03 04
Inactivation efficacy on a compound Immunity What can we do to
disinfecting nanoemulsion minimizze risks
 Pippali- Piper longum

Commonly known as Pippali or Long pepper which contain piperine,

piplartine, pellitorine, caryophyllene etc. as major chemical constituents.
Pippali- Piper longum

The benefits of Pippali have been claimed in

various studies. Two recent ones being:

Food as medicine: a possible preventive

measure
Immunomodulatory Herbs of Ayurveda 
 Supporting research articles for
Pippali- Piper longum

01 02
Epidemiology, Treatment and Ayurveda practitioners consensus to
Microbiological Surveillance develop strategies for immunity

03
Exploring alternative medicine options for
Immunity- A systematic scoping review
 Artemesia annua

This plant is extensively used in Africa and China and is known for
antimalarial properties

Artemisia shows ‘promise’, say

Artemisia annua to be tested
researchers
Artemisia annua to be tested
Aromatic Herbs, Medicinal Plant-
Derived Essential Oils, and
Discuss about the application of
Phytochemical Extracts as Potential
Artemisia annua
Therapies : Future Perspectives