Chapter 04 - Movement of Molecules Across Cell Membranes

Chapter 04
Movement of Molecules Across Cell Membranes
 

Multiple Choice Questions

 

1.  Which of the following statements regarding the structure and function of cell membranes
is correct?  
A.  The phospholipid bilayer is arranged so that the hydrophilic heads of the phospholipid
molecule face the extra- and intracellular fluids
B.  Some proteins integrated into the membrane serve as channels for the passage of nonpolar
molecules through the membrane
C.  Some proteins integrated into the membrane function as channels associated with transport
of ions through the membrane
D.  Both the phospholipid bilayer is arranged so that the hydrophilic heads of the
phospholipid molecule face the extra- and intracellular fluids and some proteins integrated
into the membrane function as channels associated with transport of ions through the
membrane are correct
E.  All of the choices are correct

Bloom's Level: 1. Remember

Section 4.01
Topic: Cells
 

2. Diffusion 
A. Depends upon the random motion of molecules
B. Results in net movement of molecules from regions of low concentration to regions of high
concentration
C. Is important for moving molecules over large distances in the body
D. Requires energy in the form of ATP to be carried out
E. Includes all of the choices

Bloom's Level: 1. Remember

Section 4.01
Topic: Chemistry
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

3. When a solute, X, is placed in compartment A of a two compartment container and allowed

to diffuse to compartment B and attain diffusion equilibrium, then 
A. There will no longer be any movement of solutes between compartments
B. Solutes will be moving in both directions equally
C. Solutes will only continue to move from A to B
D. Solutes will only continue to move from B to A
E. Solutes will continue to move to the side with the higher concentration

Bloom's Level: 1. Remember

Section 4.01
Topic: Chemistry
 

4. Which of the following statements regarding the diffusion of nonpolar solutes across cell
membranes is correct? 
A. At equilibrium for solute X, the flux of X across cell membranes is zero
B. At equilibrium for solute X, the net flux of X across cell membranes is zero
C. At equilibrium for solute X, the concentration of X inside the cell is equal to its
concentration outside the cell
D. Both at equilibrium for solute X, the flux of X across cell membranes is zero and at
equilibrium for solute X, the concentration of X inside the cell is equal to its concentration
outside the cell are correct
E. Both at equilibrium for solute X, the net flux of X across cell membranes is zero and at
equilibrium for solute X, the concentration of X inside the cell is equal to its concentration
outside the cell are correct

Bloom's Level: 2. Understand

Section 4.01
Topic: Cells
 

5. The net flux of a penetrating solute into a cell will increase if the 
A. Permeability constant for that solute increases
B. Temperature increases
C. Concentration of that solute in the extracellular fluid increases
D. Both permeability constant for that solute increases and concentration of that solute in the
extracellular fluid increases are correct
E. All of the choices are correct

Bloom's Level: 1. Remember

Section 4.01
Topic: Cells
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

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Chapter 04 - Movement of Molecules Across Cell Membranes

6. Which of the following would decrease the rate of diffusion? 

A. Increasing the size of the diffusing solute
B. Increasing the temperature
C. Increasing the concentration gradient
D. Increasing the surface area for diffusion
E. All of the choices would increase the rate of diffusion

Bloom's Level: 2. Understand

Section 4.01
Topic: Chemistry
 

7. Equal concentrations of two solutes, A and B, are placed into the same beaker at the same
time. Solute A reaches diffusion equilibrium faster than solute B. What is the most likely
explanation for this observation? 
A. The temperature was greater for solute A than solute B
B. The concentration gradient for A was greater than B
C. Solute A is smaller than solute B
D. Solute A traveled a shorter distance than solute B
E. All of the choices are logical explanations

Bloom's Level: 3. Apply

Section 4.01
Topic: Chemistry
 

8. If it takes solute A 1 second to diffuse 1 millimeter, how long will it take solute A to diffuse
10 millimeters under the same conditions? 
A. 1 second
B. 10 seconds
C. 50 seconds
D. 100 seconds
E. 1000 seconds

Bloom's Level: 3. Apply

Section 4.01
Topic: Chemistry
 

4-4
Chapter 04 - Movement of Molecules Across Cell Membranes

9. In general, polar molecules diffuse more rapidly through the lipid bilayer part of cell
membranes than do nonpolar molecules. This statement is 
A. True
B. False. Polar molecules diffuse through less rapidly because the bilayer is polar throughout
its width
C. False. Polar molecules diffuse through less rapidly because the bilayer is nonpolar
throughout its width
D. False. Nonpolar molecules diffuse through more rapidly because much of the bilayer is
nonpolar
E. False. The rate of diffusion of nonpolar and polar molecules through the bilayer is
essentially the same as long as the molecules are the same size

Bloom's Level: 2. Understand

Section 4.01
Topic: Cells
 

10. Which of the following statements regarding the movement of molecules across cell
membranes is correct? 
A. The diffusion of molecules across a cell membrane occurs at a rate that is influenced by the
surface area of the membrane and the magnitude of the concentration difference across it
B. The net flux of molecules that cross cell membranes by diffusion is always from regions of
lower concentration to regions of higher concentration
C. Molecules that enter a cell by diffusion must directly permeate the lipid portion of the
plasma membrane, whereas those that enter by facilitated diffusion utilize membrane-bound
proteins
D. Both the diffusion of molecules across a cell membrane occurs at a rate that is influenced
by the surface area of the membrane and the magnitude of the concentration difference across
it and the net flux of molecules that cross cell membranes by diffusion is always from regions
of lower concentration to regions of higher concentration are correct
E. Both the diffusion of molecules across a cell membrane occurs at a rate that is influenced
by the surface area of the membrane and the magnitude of the concentration difference across
it and molecules that enter a cell by diffusion must directly permeate the lipid portion of the
plasma membrane, whereas those that enter by facilitated diffusion utilize membrane-bound
proteins are correct

Bloom's Level: 2. Understand

Section 4.01
Topic: Cells
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

11. The permeability of the plasma membrane to mineral ions 

A. Is dependent upon channels formed by proteins
B. Varies from one cell to another
C. Is affected by differences in electrical charge on the two sides of the membrane
D. Both is dependent upon channels formed by proteins and is affected by differences in
electrical charge on the two sides of the membrane are correct
E. All of the choices are correct

Bloom's Level: 1. Remember

Section 4.01
Topic: Cells
 

12. Ion channels in cell membranes 

A. Are nonspecific
B. May open in response to a change in potential difference across the membrane
C. May open in response to binding a ligand
D. Both are nonspecific and may open in response to a change in potential difference across
the membrane are correct
E. Both may open in response to a change in potential difference across the membrane and
may open in response to binding a ligand are correct

Bloom's Level: 1. Remember

Section 4.01
Topic: Cells
 

13. Mediated transport across cell membranes 

A. Refers to the movement of ions through protein channels
B. Refers both to diffusion and to the active transport of molecules
C. Is characterized by saturable carriers and a maximum velocity of transport
D. Both refers to the movement of ions through protein channels and refers both to diffusion
and to the active transport of molecules are correct
E. Both refers both to diffusion and to the active transport of molecules and is characterized
by saturable carriers and a maximum velocity of transport are correct

Bloom's Level: 1. Remember

Section 4.02
Topic: Cells
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

14. Carrier-mediated transport 
A. Involves a specific membrane protein that functions as a carrier molecule
B. Always involves the movement of substances against a concentration gradient
C. Always requires the direct expenditure of energy
D. Both involves a specific membrane protein that functions as a carrier molecule and always
involves the movement of substances against a concentration gradient are correct
E. All of the choices are correct

Bloom's Level: 1. Remember

Section 4.02
Topic: Cells
 

15. Which of the following is a feature that distinguishes active transport from facilitated
diffusion? 
A. Saturability
B. Requirement for a carrier molecule
C. Specificity
D. Presence of a transport maximum
E. Requirement for metabolic energy

Bloom's Level: 2. Understand

Section 4.02
Topic: Chemistry
 

16. The mediated transport of a substance across a plasma membrane 

A. Depends upon the binding of that substance to a specific site on the membrane protein
B. Depends upon movement of proteins from one side of the membrane to the other
C. Always increases in direct proportion to the increasing concentration of the substance on
one side of the membrane
D. Both depends upon the binding of that substance to a specific site on the membrane protein
and depends upon movement of proteins from one side of the membrane to the other are
correct
E. All of the choices are correct

Bloom's Level: 1. Remember

Section 4.02
Topic: Cells
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

17. Which form of membrane transport is being described? The passage of molecules into
cells without passing through the plasma membrane's structural matrix. 
A. Diffusion
B. Osmosis
C. Facilitated diffusion
D. Endocytosis
E. Apoptosis

Bloom's Level: 2. Understand

Section 4.04
Topic: Cells
 

18. Which of the following statements regarding the active transport of molecules across cell
membranes is correct? 
A. Both primary and secondary active transport are dependent upon energy derived from ATP
B. In secondary active-transport systems in which Na ions are bound to carriers, the actively
transported solute always follows Na ions across the membrane
C. In secondary active-transport systems in which Na ions are bound to carriers, the actively
transported solute always moves across the membrane in the direction opposite of Na ion
movement
D. Both primary and secondary active transport are dependent upon energy derived from ATP
and in secondary active-transport systems in which Na ions are bound to carriers, the actively
transported solute always follows Na ions across the membrane are correct
E. Both primary and secondary active transport are dependent upon energy derived from ATP
and in secondary active-transport systems in which Na ions are bound to carriers, the actively
transported solute always moves across the membrane in the direction opposite of Na ion
movement are correct

Bloom's Level: 2. Understand

Section 4.02
Topic: Cells
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

19. Glucose enters most cells by 

A. Diffusion through the lipid bilayer
B. Primary active transport
C. Secondary active transport
D. Diffusion through a protein channel
E. Endocytosis

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

20. Which of the following is not a difference between primary active transport and secondary
active transport? 
A. Primary active transport uses energy derived from ATP whereas secondary active transport
does not
B. Primary active transport uses a carrier that is an ATPase whereas the latter does not
C. Primary active transport uses a carrier that is phosphorylated whereas the latter does not
D. Primary active transport uses a carrier whose binding affinity for the solute is modified by
covalent modulation whereas the latter does not
E. None of the choices are correct

Bloom's Level: 2. Understand

Section 4.02
Topic: Chemistry
 

21. Which of the following statements regarding the active transport of solutes across cell
membranes is correct? 
A. Primary active transporters are ATPases and secondary active transporters are not
B. Secondary active transporters require binding of Na ion on the extracellular side of the
membrane to transport other solutes either into or out of the cell
C. Solutes transported across cell membranes by primary active transport include glucose, Na
ion and Ca ion
D. Both primary active transporters are ATPases and secondary active transporters are not and
secondary active transporters require binding of Na ion on the extracellular side of the
membrane to transport other solutes either into or out of the cell are correct
E. All of the choices are correct

Bloom's Level: 1. Remember

Section 4.02
Topic: Cells
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

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Chapter 04 - Movement of Molecules Across Cell Membranes

22.  Which of the following statements about the Na, K pump is false?  
A.  It transports Na+ out of cells and K+ into cells
B.  It binds to and hydrolyzes ATP
C.  It is constantly active in all cells
D.  Its activity requires the expenditure of metabolic energy
E.  It transports Na+ and K+ in a 1:1 ratio

Bloom's Level: 1. Remember

Section 4.02
Topic: Cells
 

23.  A cell is placed into a 1 millimolar solution of substance X and over time you witness the
concentration of X inside the cell increase to 5 millimolar. The best explanation for this is:  
A.  X is moving into the cell by simple diffusion
B.  X is moving into the cell by diffusion through a protein channel
C.  X is moving into the cell by facilitated diffusion
D.  X is moving into the cell by primary active transport
E.  It is not possible to tell which mechanism is responsible for the transport of X

Bloom's Level: 3. Apply

Section 4.02
Topic: Cells
 

24. If the ATP-generating mechanisms in a cell are poisoned and the cell has depleted its ATP
reserves, 
A. Primary active transport of molecules would cease immediately
B. Secondary active transport of molecules would cease immediately
C. Eventually there will be no potential difference across the membrane
D. Both primary active transport of molecules would cease immediately and secondary active
transport of molecules would cease immediately are correct
E. Both primary active transport of molecules would cease immediately and eventually there
will be no potential difference across the membrane are correct

Bloom's Level: 3. Apply

Section 4.02
Topic: Cells
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

25. "Osmosis" refers to the movement of ____________ across semipermeable membranes. 

A. Glucose
B. Charged particles
C. Lipid molecules
D. Water
E. Any substance

Bloom's Level: 1. Remember

Section 4.03
Topic: Chemistry
 

26. If pure water and a solution containing a nonpenetrating solute are separated by a
membrane that is permeable only to water, 
A. Water will diffuse by osmosis until the water concentrations in the two compartments
become equal
B. Both water and the solute will diffuse across the membrane down their concentration
gradients until a state of equilibrium is established
C. Water will diffuse by osmosis until stopped by opposing hydrostatic pressure
D. No movement will occur between the compartments
E. None of the choices will occur

Bloom's Level: 2. Understand

Section 4.03
Topic: Chemistry
 

27. If all other conditions remain the same and the concentration of a nonpenetrating solute
increases inside a cell, 
A. Water will tend to enter the cell because the interior has an increased osmolarity
B. Water will tend to leave the cell because the interior has an increased osmolarity
C. Water will tend to enter the cell because the interior has a decreased osmolarity
D. Water will tend to leave the cell because the interior has a decreased osmolarity
E. The nonpenetrating solute will diffuse across the membrane until its concentration is equal
on both sides of the membrane

Bloom's Level: 2. Understand

Section 4.03
Topic: Cells
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

28. If a cell is placed in a hypotonic solution, it 

A. Will swell
B. Will shrink
C. Will stay the same size
D. May swell, shrink or stay the same size, depending upon the concentration of penetrating
and nonpenetrating solutes in the solution

Bloom's Level: 3. Apply

Section 4.03
Topic: Cells
 

29. If a cell is placed in a hyperosmotic solution, it 

A. Will swell
B. Will shrink
C. Will stay the same size
D. May swell, shrink or stay the same size, depending upon the concentration of penetrating
and nonpenetrating solutes in the solution

Bloom's Level: 3. Apply

Section 4.03
Topic: Cells
 

30. If a cell is placed into an unknown solution and it shrinks, what can be concluded about
the unknown solution? 
A. Its nonpenetrating solute concentration was greater than that of the cell
B. Its nonpenetrating solute concentration was less than that of the cell
C. Its nonpenetrating solute concentration was equal to that of the cell
D. Any of the choices are possible

Bloom's Level: 4. Analyze

Section 4.03
Topic: Cells
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

31. The reason solutions for injection or infusion into people normally contain either 150 mM
NaCl or 300 mM glucose is that these 
A. Solutes are necessary for metabolism
B. Solutions are hypertonic to the blood and cells
C. Solutions are hypoosmotic to the blood and cells
D. Solutions are isotonic to the blood and cells
E. Solutions contain penetrating solutes

Bloom's Level: 3. Apply

Section 4.03
Topic: Cells
 

32.  An example of a hypertonic solution is  

A.  200 mM NaCl
B.  300 mM glucose
C.  100 mM MgCl2
D.  400 mM urea
E.  None of the choices are correct

Bloom's Level: 3. Apply

Section 4.03
Topic: Cells
 

33.  Which of the following solutions is not isotonic to human cells?  

A.  300 mM glucose
B.  300 mM urea
C.  100 mM MgCl2
D.  300 mOsm NaCl

Bloom's Level: 3. Apply

Section 4.03
Topic: Cells
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

34. Regarding the tonicity and osmolarity of solutions, which of the following statements is
not true? 
A. The term "tonicity" refers to the effect that a solution has on the degree of stretch or
shrinking of the cell membrane
B. The term "osmolarity" refers to the osmotic properties of a solution, regardless of its
tonicity
C. Isotonic solutions are always isoosmotic
D. Hypoosmotic solutions are always hypotonic
E. Hypertonic solutions are always hyperosmotic

Bloom's Level: 2. Understand

Section 4.03
Topic: Cells
 

35. Which of the following statements regarding endocytosis and exocytosis is correct? 

A. Endocytosis is a method by which large molecules may be brought into a cell
B. Exocytosis is a method by which large molecules may be secreted from a cell
C. Pinocytosis is a form of endocytosis; phagocytosis is a form of exocytosis
D. Both endocytosis is a method by which large molecules may be brought into a cell and
exocytosis is a method by which large molecules may be secreted from a cell are correct
E. All of the choices are correct

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

36. Which form of endocytosis is nonspecific, in that it occurs by the formation of an

invagination of the plasma membrane which then fills with interstitial fluid of the immediate
area? 
A. Active transport
B. Hyperosmotic vesicular entrapment
C. Phagocytosis
D. Pinocytosis
E. Hydrosmosis

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

37. Receptor mediated endocytosis requires 

A. A specific ligand and functional receptors for it on the external plasma membrane
B. The molecular components necessary for the synthesis of clathrin proteins
C. The ability of the cell to synthesize the proteins which compose the receptor protein
D. The genes in chromosomal DNA for both receptor and clathrin proteins be present in the
cell
E. All of these choices are correct

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

38. The removal of cholesterol from the blood during times when its concentrations are high 
A. Is heavily dependent upon the activity of phagocytosis
B. Requires that it be bound to circulating lipoproteins which attach to absorbtive cell
membranes
C. Is promoted by the increased production of lipoprotein receptors in the cholesterol
absorbing cells
D. Both requires that it be bound to circulating lipoproteins which attach to absorbtive cell
membranes and is promoted by the increased production of lipoprotein receptors in the
cholesterol absorbing cells are correct
E. All of these choices are correct

Bloom's Level: 3. Apply

Section 4.04
Topic: Cells
 

39. Cholesterol levels in the blood are regulated via the activity of the liver utilizing the
process known as _____, which can be regulated to increase uptake as the cell ______ the
number of cholesterol+ lipoprotein receptors on its surface. 
A. Phagosomolysis, increases
B. Endosomolysis, decreases
C. Receptor mediated endocytosis, increases
D. Potocytosis, decreases
E. Pinocytosis, increases

Bloom's Level: 2. Understand

Section 4.04
Topic: Cells
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

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Chapter 04 - Movement of Molecules Across Cell Membranes

40. Once formed inside of the cell most endocytic vesicles will fuse with which organelle for
sorting? 
A. Endoplasmic reticulum
B. Golgi apparatus
C. Endosome
D. Nucleus
E. Mitochondria

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

41. At any given time it is possible to see endocytotic vesicles docked to intracellular
organelles such as those which may receive their contents for modification, synthesis,
packaging and then release. Which organelle would be most likely to be involved in this
process as a destination for a transport vesicle formed for this purpose along the plasma
membrane? 
A. Golgi apparatus
B. Peroxisome
C. Lysosome
D. Mitochondrion
E. Ribosome

Bloom's Level: 2. Understand

Section 4.04
Topic: Cells
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

42.  Which of the following statements about epithelial cells and epithelial transport is
correct?  
A.  Epithelial cells are polarized
B.  Epithelial cells lining the small intestine have Na, K-ATPase pumps only in their
basolateral membranes
C.  The "active" component of active transport across epithelial cells occurs only from the
lumen side into the cells
D.  Both epithelial cells are polarized and epithelial cells lining the small intestine have Na,
K-ATPase pumps only in their basolateral membranes are correct
E.  Both epithelial cells are polarized and the "active" component of active transport across
epithelial cells occurs only from the lumen side into the cells are correct

Bloom's Level: 1. Remember

Section 4.05
Topic: Cells
 

43. Potocytosis 
A. Involves simple diffusion of low molecular weight molecules across the plasma
membrane, following a concentration gradient
B. Is triggered by ligands which lead to the formation of caveolae delivering low molecular
weight molecules directly to the cytosol
C. Is the process which directly regulates and often limits receptor mediated endocytosis to
remain within homeostatic parameters
D. Involves active transport of high molecular weight lipoprotein complexes through the
participation of clathrin in the formation of endosomal vesicles
E. Both is triggered by ligands which lead to the formation of caveolae delivering low
molecular weight molecules directly to the cytosol and is the process which directly regulates
and often limits receptor mediated endocytosis to remain within homeostatic parameters are
correct

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

4-19
Chapter 04 - Movement of Molecules Across Cell Membranes

44. Which of the following are possible combinations of mechanisms for transport of a

particle against a concentration gradient across an epithelial cell? 
A. Passive diffusion from a lumen into the cell followed by facilitated diffusion from the cell
into the blood
B. Passive diffusion on the apical side into the cell followed by primary active transport on
the basolateral side
C. Secondary active transport on the mucosal side followed by facilitated diffusion on the
serosal side
D. Both passive diffusion from a lumen into the cell followed by facilitated diffusion from the
cell into the blood and passive diffusion on the apical side into the cell followed by primary
active transport on the basolateral side are correct
E. Both passive diffusion on the apical side into the cell followed by primary active transport
on the basolateral side and secondary active transport on the mucosal side followed by
facilitated diffusion on the serosal side are correct

Bloom's Level: 2. Understand

Section 4.05
Topic: Cells
 

45.  During the active transport of glucose across an epithelium, energy is used to  
A.  Power the Na, K-ATPase pump
B.  Power the Na-glucose cotransporter
C.  Synthesize insulin, which is necessary for glucose reabsorption
D.  Maintain the transport maximum for glucose
E.  Power the facilitated diffusion of glucose across the basolateral membrane of the epithelial
cell

Bloom's Level: 1. Remember

Section 4.05
Topic: Cells
 
 

True / False Questions

 

4-20
Chapter 04 - Movement of Molecules Across Cell Membranes

46.  The greater the concentration difference of a substance between two volumes separated
by a permeable membrane, the lesser the magnitude of the net flux of the substance.  
FALSE

Bloom's Level: 1. Remember

Section 4.01
Topic: Chemistry
 

4-21
Chapter 04 - Movement of Molecules Across Cell Membranes

47.  At any given concentration difference, the rate of diffusion across a permeable surface
will be greater for small molecules than for larger ones.  
TRUE

Bloom's Level: 1. Remember

Section 4.01
Topic: Chemistry
 

48. Molecules increase their rate of diffusion as temperature increases. 

TRUE

Bloom's Level: 1. Remember

Section 4.01
Topic: Chemistry
 

49. In general, polar molecules diffuse more rapidly across cell membranes than do nonpolar
molecules. 
FALSE

Bloom's Level: 1. Remember

Section 4.01
Topic: Cells
 

50. The component of the plasma membrane that acts as the selective barrier for diffusion is
the integral proteins. 
FALSE

Bloom's Level: 1. Remember

Section 4.01
Topic: Cells
 

4-22
Chapter 04 - Movement of Molecules Across Cell Membranes

51. Although permeability to mineral ions does not vary much from one cell to another,
different cells vary considerably in their permeability to nonpolar molecules. 
FALSE

Bloom's Level: 1. Remember

Topic: Cells
 

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Chapter 04 - Movement of Molecules Across Cell Membranes

52. Specific proteins in the membranes mediate movement of lipid-soluble molecules into

cells. 
FALSE

Bloom's Level: 1. Remember

Section 4.01
Topic: Cells
 

53. Integral membrane proteins can form channels through which ions such as Na+ and K+
can diffuse. 
TRUE

Bloom's Level: 1. Remember

Section 4.01
Topic: Cells
 

54.  Mediated transport is required in order for glucose, amino acids and fatty acids to pass
into cells because these substances cannot diffuse through plasma membranes.  
FALSE

Bloom's Level: 1. Remember

Section 4.02
Topic: Cells
 

55.  In active transport, the affinity of any given binding site for the molecule to be
transported changes as the site goes from facing one side of the membrane to facing the other
side.  
TRUE

Bloom's Level: 1. Remember

Section 4.02
Topic: Cells
 

4-24
Chapter 04 - Movement of Molecules Across Cell Membranes

56. The final equilibrium state reached by a molecule that enters a cell by facilitated diffusion
is the same as that for a molecule that enters the cell by diffusion. 
TRUE

Bloom's Level: 1. Remember

Section 4.02
Topic: Cells
 

57.  The Na, K pump is an enzyme that phosphorylates itself.  

TRUE

Bloom's Level: 1. Remember

Section 4.02
Topic: Chemistry
 

58.  In most of the cells in the body there is an electrical difference such that the inside of
cells is positive with respect to the outside.  
FALSE

Bloom's Level: 1. Remember

Section 4.01
Topic: Cells
 

59.  The concentration of calcium in the cytosol of cells is very much lower than the
concentration of extracellular calcium.  
TRUE

Bloom's Level: 1. Remember

Section 4.02
Topic: Cells
 

4-25
Chapter 04 - Movement of Molecules Across Cell Membranes

60.  Because of the active transport of Na+ and K+, the intracellular concentration of Na+ is
lower than the extracellular concentration, whereas the reverse is true for K+.  
TRUE

Bloom's Level: 1. Remember

Section 4.02
Topic: Cells
 

4-26
Chapter 04 - Movement of Molecules Across Cell Membranes

61.  The Na,K-ATPase carrier transports sodium ions out of cells and potassium ions into cells
on a one-to-one basis.  
FALSE

Bloom's Level: 1. Remember

Section 4.02
Topic: Cells
 

62.  Active transport, facilitated diffusion and osmosis all require the expenditure of metabolic
energy.  
FALSE

Bloom's Level: 1. Remember

Section 4.02
Topic: Cells
 

63. Both primary and secondary active transport require the expenditure of metabolic energy. 
TRUE

Bloom's Level: 1. Remember

Section 4.02
Topic: Cells
 

64. Adding one mole of NaCl to one liter of water will lower the water concentration twice as
much as adding one mole of glucose. 
TRUE

Bloom's Level: 1. Remember

Section 4.03
Topic: Chemistry
 

4-27
Chapter 04 - Movement of Molecules Across Cell Membranes

65. Adding one gram of NaCl to one liter of water will lower the water concentration twice as
much as adding one gram of glucose. (The molecular mass of NaCl is 58.5; that of glucose is
180.) 
FALSE

Bloom's Level: 1. Remember

Section 4.03
Topic: Chemistry
 

66. The higher the osmolarity of a solution, the higher the concentration of water in it. 
FALSE

Bloom's Level: 1. Remember

Section 4.03
Topic: Chemistry
 

67. The intracellular concentration of water in the cells of the body is the same as the
extracellular concentration of water. 
TRUE

Bloom's Level: 1. Remember

Section 4.03
Topic: Cells
 

68. If a cell were placed in a solution of 0.15 M NaCl, it would shrink. 

FALSE

Bloom's Level: 1. Remember

Section 4.03
Topic: Cells
 

4-28
Chapter 04 - Movement of Molecules Across Cell Membranes

69. In the body, Na ions behave as if they are nonpenetrating solutes because they are actively
transported out of cells. 
TRUE

Bloom's Level: 1. Remember

Section 4.03
Topic: Cells
 

4-29
Chapter 04 - Movement of Molecules Across Cell Membranes

70. In the body, K ions behave as if they are penetrating solutes because they are actively
transported into cells. 
FALSE

Bloom's Level: 1. Remember

Section 4.03
Topic: Cells
 

71. The fate of all endocytotic vesicles is digestion of their contents by lysosomal enzymes. 
FALSE

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

72. A portion of a cell's plasma membrane is removed during endocytosis. 

TRUE

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

73. Endocytosis of any kind requires metabolic energy. 

TRUE

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

74.  Receptor mediated endocytosis can be used as an elegant mechanism to that allows for
the transport and introduction of a vesicle's contents into another membrane-bound organelle
or from one layer of epithelial cells to another.  
TRUE

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

4-30
Chapter 04 - Movement of Molecules Across Cell Membranes

4-31
Chapter 04 - Movement of Molecules Across Cell Membranes

75. Most cells can perform pinocytosis, but only a few kinds can perform phagocytosis. 
TRUE

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

76. Phagocytic leukocytes use the process to engulf foreign bacteria and destroy them within
ribosomes. 
FALSE

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

77. Pinocytosis is a method by which molecules can leave cells whose membranes are
impermeable to the molecules. 
FALSE

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

78. The clathrin protein so important to carrying out receptor mediated transport remains with
an endosome as it moves deep within the cell and is degraded entirely along with the ingested
internal contents. 
FALSE

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

4-32
Chapter 04 - Movement of Molecules Across Cell Membranes

79. The functions of the process known as potocytosis in homeostasis have been extensively
studied and are very well known and understood beyond any speculation to include, cell
signaling, trans-cellular transport and cholesterol homeostasis. 
FALSE

Bloom's Level: 1. Remember

Section 4.04
Topic: Cells
 

80. The luminal side of an epithelial cell is also known as the basolateral side. 
FALSE

Bloom's Level: 1. Remember

Section 4.05
Topic: Cells
 

81. The properties of the plasma membranes of epithelial cells lining hollow organs or tubes
are similar, regardless of the orientation of the cells. 
FALSE

Bloom's Level: 1. Remember

Section 4.05
Topic: Cells
 

82. Most organic solutes cross epithelial membranes by simple diffusion on the lumen side
followed by active transport across the blood side of the membrane. 
FALSE

Bloom's Level: 1. Remember

Section 4.05
Topic: Cells
 

4-33
Chapter 04 - Movement of Molecules Across Cell Membranes

83. Net movement of solute across an epithelium that is permeable to water is always

accompanied by movement of water in the opposite direction. 
FALSE

Bloom's Level: 1. Remember

Section 4.05
Topic: Cells
 

84. The selectivity of ion channels is based upon these two physical properties of the ions. 
FALSE

Bloom's Level: 1. Remember

Section 4.01
Topic: Chemistry
 

4-34