You are on page 1of 78

Regional Drug and Therapeutics Centre Cost comparison charts

REGIONAL DRUG AND THERAPEUTICS CENTRE


(NEWCASTLE)

COST COMPARISON CHARTS

January 2020
INTRODUCTION
The charts included within this report are organised by BNF classification (legacy)
and show comparative costs at the NHS Basic price1,2 (as of January 2020) for
selected agents. Except where indicated otherwise, each chart shows the cost of 1
year3 of treatment at a commonly prescribed daily dose (shown in brackets). The
doses given are not intended to imply therapeutic equivalence and for some BNF
sub-classifications, such as angiotensin converting enzyme inhibitors (ACE
inhibitors), the doses may vary according to indication. Additionally, in some
therapeutic areas, for instance antibacterial drugs, the duration of treatment may
differ from that shown. Primarily, this report focuses on costs related to prescribing in
Adults. There are however a few exceptions where products specifically for use in
children are represented, such as in the Emollients and Infant formulas sections.
Additional notes to highlight any relevant cost related information are also added
where appropriate, to improve the clarity of the information presented.
Rationale for inclusion: The cost comparison charts (CCCs) aim to represent the
diversity of products available; including the least expensive, most prescribed, higher
cost products being prescribed and products with additional features. The products
included are furthermore considered in the context of National and local guidance
and stakeholder formulary decisions. It is not possible to represent all
pharmaceuticals within these charts.

1
NHS Business Services Authority (NHS BSA). Drug tariff. https://www.nhsbsa.nhs.uk/pharmacies-
gp-practices-and-appliance-contractors/drug-tariff
2
NHS BSA. Dictionary of medicines and devices (dM+d) https://www.nhsbsa.nhs.uk/pharmacies-gp-
practices-and-appliance-contractors/dictionary-medicines-and-devices-dmd
3
1 year in this instance is equal to 364 days (rather than 365) standardising 1 month as equal to 28
days.
NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES
1 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

Stakeholders (under password protection) can access the current version of the
CCCs via our website in three formats: PDF, Word and Excel. The Excel version
incorporates a more detailed comparison of contraceptives and allows charts to be
split by BNF subsections in some instances. The PDF format of the previous CCC
report is available for free access.

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


2 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

To navigate to the chart required, hover the cursor over the section required, press CTRL
and click with the left mouse button.
Contents by BNF Legacy / ePACT2 classification Page
1.1 Dyspepsia and gastro-oesophageal reflux disease ................................................................ 6
1.2 Antispasmodics and other drugs altering gut motility ............................................................. 6
1.3 Antisecretory drugs and mucosal protectants ........................................................................ 7
1.5.1 Aminosalicylates .................................................................................................................. 8
1.5.2 Corticosteroids: rectal foams ............................................................................................... 9
1.6 Laxatives ............................................................................................................................... 10
2.2 Diuretics ................................................................................................................................ 11
2.4 Beta-adrenoceptor blocking drugs ........................................................................................ 12
2.5.4 Alpha-adrenoceptor blocking drugs ................................................................................... 13
2.5.5 Drugs affecting the renin-angiotensin system ................................................................... 14
2.6.1/2.6.3 Nitrates and other antianginal drugs ......................................................................... 15
2.6.2 Calcium-channel blockers .................................................................................................. 16
2.8.1/2.8.2 Parenteral anticoagulants/oral anticoagulants.......................................................... 17
2.9 Antiplatelet drugs .................................................................................................................. 18
2.12 Lipid-regulating drugs ......................................................................................................... 19
3.1 Bronchodilators ..................................................................................................................... 20
3.2 Corticosteroids (respiratory): (i) corticosteroid inhalation devices ........................................ 21
3.2 Corticosteroids (respiratory): (ii) combination with bronchodilators, inhalation devices ....... 22
3.1 & 3.2 Inhaled therapy licensed for COPD ............................................................................. 23
3.3 Cromoglicate & related therapy, leukotriene receptor antagonists, and phosphodiesterase
type-4 inhibitors ........................................................................................................................... 24
3.4.1 Antihistamines.................................................................................................................... 24
4.1.1/4.1.2 Hypnotics/Anxiolytics ................................................................................................ 25
4.2.1/4.2.3 Antipsychotic drugs and drugs used for mania and hypomania: maintenance doses
(adults with psychosis) ................................................................................................................ 26
4.2.1 Antipsychotic drugs: low dose ........................................................................................... 27
4.3 Antidepressant drugs ............................................................................................................ 28
4.4 CNS stimulants and drugs used for attention deficit hyperactivity disorder: (i) stimulant ..... 29
4.4 CNS stimulants and drugs used for attention deficit hyperactivity disorder: (ii) stimulant;
methylphenidate modified release preparations only ................................................................. 30
4.4 CNS stimulants and drugs used for attention deficit hyperactivity disorder: (iii) non-stimulant31
4.6 Drugs used in nausea and vertigo ........................................................................................ 31
4.7 Analgesics ............................................................................................................................. 32
4.7.2 Opioid analgesics: (i) oral preparations ............................................................................. 33
4.7.2 Opioid analgesics: (ii) transdermal patches ....................................................................... 34
4.7.2 Opioid analgesics: (iii) modified release preparations ....................................................... 35
4.7.2 Opioid analgesics: (iv) subcutaneous infusion; strong opioids .......................................... 36

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


3 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.7.3 Neuropathic pain ................................................................................................................ 36


4.7.4.1 Treatment of acute migraine ........................................................................................... 37
4.8 Antiepileptic drugs................................................................................................................. 37
4.9.1 Dopaminergic drugs used in Parkinson’s disease: (i) dopamine receptor agonists .......... 38
4.9.1 Dopaminergic drugs used in Parkinson’s disease: (ii) levodopa, COMT and MAO-B
inhibitors ...................................................................................................................................... 39
4.10.2 Nicotine dependence ....................................................................................................... 40
4.11 Drugs for dementia ............................................................................................................. 41
5 Infections: miscellaneous antibacterial and anthelmintic drugs ............................................... 42
5.1 Antibiotics: solid and liquid formulations ............................................................................... 43
5.1.1 Penicillins ........................................................................................................................... 44
5.1.2 Cephalosporins .................................................................................................................. 44
5.1.3 Tetracyclines ...................................................................................................................... 45
5.1.12 Quinolones ....................................................................................................................... 45
5.2 Antifungal drugs: miscellaneous, including topical and gynaecological ............................... 46
6.1.1 Insulin: prefilled (PF) pens and cartridges ......................................................................... 47
Hypodermic equipment: (i) needles for PF and reusable insulin pens (4mm to 6 mm) ............. 48
Hypodermic equipment: (ii) needles for PF and reusable insulin pens (8 mm) .......................... 49
Hypodermic equipment: (iii) lancets ............................................................................................ 50
6.1.6 Blood glucose monitoring: (i) test strips (50) greater than £10 .......................................... 51
6.1.6 Blood glucose monitoring: (ii) test strips (50) less than £10 .............................................. 52
6.1.2 Antidiabetic drugs (i) .......................................................................................................... 53
6.1.2 Antidiabetic drugs: (ii) new agents ..................................................................................... 54
6.4.1 Female sex hormones and their modulators: (i) combination HRT preparations .............. 55
6.4.1 Female sex hormones and their modulators: (ii) oestrogen only HRT patches ................ 56
6.4.1 Female sex hormones and their modulators: (iii) oestrogen only HRT preparations except
patches ....................................................................................................................................... 57
6.6.2 Bisphosphonates and other drugs affecting bone metabolism .......................................... 58
7.3.1 Combined hormonal contraceptives .................................................................................. 59
7.3.2 Progestogen-only contraceptives ..................................................................................... 60
7.4.1 Drugs for urinary retention ................................................................................................. 61
7.4.2 Drugs for urinary frequency, enuresis, and incontinence .................................................. 62
7.4.5 Drugs for erectile dysfunction ............................................................................................ 63
8.3.4.2 Gonadorelin analogues: prostate cancer indication ....................................................... 63
9.6.4 Vitamin D: (i) calcium and vitamin D combination products .............................................. 64
9.6.4 Vitamin D: (ii) prevention of deficiency .............................................................................. 64
9.6.4 Vitamin D: (iii) treatment of deficiency ............................................................................... 65
10.1.1 Non-steroidal anti-inflammatory drugs ............................................................................. 66
10.3.2 Rubefacients, topical NSAIDs, capsaicin, and poultices ................................................. 67
11.4.2 Eye: other anti-inflammatory preparations ....................................................................... 67
NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES
4 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

11.6 Treatment of glaucoma ....................................................................................................... 68


11.8.1 Tear deficiency, ocular lubricants, and astringents ......................................................... 69
12.2.1 Drugs used in nasal allergy: corticosteroids .................................................................... 69
13.2.1 Emollients: (i) cost of 1 year’s treatment ......................................................................... 70
13.2.1 Emollients: (ii) cost per 100g or 100ml ............................................................................ 71
13.2.1 Emollients: (iii) bath and shower preparations, cost per 100g or 100ml.......................... 72
13.4 Topical corticosteroids (skin): (i) cost per 30g .................................................................... 73
13.4 Topical corticosteroids (skin): (ii) combination corticosteroid and antimicrobial products .. 74
13.5 Preparations for eczema and psoriasis: scalp .................................................................... 74
13.5.2 Preparations for psoriasis: corticosteroid and vitamin D combination topical preparations75
13.6.1 Topical preparations for acne .......................................................................................... 75
Specialised infant and child milk formulas .................................................................................. 76
Stoma adhesive removers (liquid preparations only) ................................................................. 77
Patent expiry table January 2020 to December 2020 ................................................................ 78

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


5 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

1.1 Dyspepsia and gastro-oesophageal reflux disease


January 2020: Dyspepsia and gastro-oesophageal reflux disease - cost of 1 year's
treatment
Sodium alginate, calcium carbonate & sodium
bicarbonate: Gaviscon® (10ml QDS) £172.54

Magnesium trisilicate with magnesium carbonate and


sodium bicarbonate oral suspension (10ml TDS) £120.12

Co-magaldrox: Mucogel® (10ml QDS) £87.07

Simeticone with aluminium hydroxide and magnesium


hydroxide: Maalox plus® (5ml QDS) £84.74

Sodium alginate, calcium carbonate & sodium


bicarbonate: Acidex® (10ml QDS) £74.55

Sodium alginate with potassium bicarbonate:


Gaviscon® Advance (5ml QDS) £74.55

Sodium alginate, calcium carbonate & sodium


bicarbonate: Peptac® (10ml QDS) £56.78

Sodium alginate with potassium bicarbonate: Acidex®


Advance (5ml QDS) £55.91

£0 £20 £40 £60 £80 £100 £120 £140 £160 £180 £200
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

1.2 Antispasmodics and other drugs altering gut motility


January 2020: Antispasmodics and other drugs altering gut motility - cost of 1 year's
treatment
Dicycloverine
(20mg TDS) £3,067.87

Dicycloverine
(10mg TDS) £2,448.48

Alverine (120mg TDS) £423.88

Fybogel® Mebeverine sachets S/F


(1 BD) £350.17

Propantheline
(15mg TDS and 30mg ON) £337.03

Kolanticon® gel (10ml QDS) £174.72

*Peppermint oil capsules E/C M/R:


Colpermin® (1 TDS) £156.48

Hyoscine butylbromide
(20mg QDS) £156.00

Mebeverine MR
(200mg BD) £111.87

Alverine (60mg TDS) £94.89

*Licensed for up to 3
*Peppermint oil capsules E/C:
£91.52 months. Cost reported is
Mintec® (1 TDS)
based on 1 year supply
Mebeverine for cost-comparison
(135mg TDS) £52.63 purposes only.

£0 £250 £500 £2,250 £2,500 £2,750 £3,000 £3,250


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


6 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

1.3 Antisecretory drugs and mucosal protectants


January 2020: Antisecretory drugs and mucosal protectants -
cost of 1 year's treatment

Famotidine
(40mg OD) £506.87

Misoprostol
(200mcg QDS) £243.39

Cimetidine
(400mg BD) £193.04

Nizatidine
(300mg OD) £187.22

Losec® MUPS
(20mg OD) £180.96

Ranitidine 75mg/5ml oral solution


(150mg BD) £160.40

Omeprazole tablets (10mg OD) £102.70

Omeprazole tablets
(20mg OD) £87.36

Lansoprazole orodispersible tablets


(30mg OD) £61.75

Nizatidine
(150mg OD) £54.36

Pantoprazole
(40mg OD) £46.80

Lansoprazole orodispersible tablets


(15mg OD) £39.65

Esomeprazole
(20mg OD) £32.89

Rabeprazole
(20mg OD) £21.32

Ranitidine
(150mg BD) £18.81

Lansoprazole capsules
(30mg OD) £15.73

Omeprazole capsules
(10mg or 20mg OD) £13.39

Lansoprazole capsules
(15mg OD) £12.22

£0 £100 £200 £300 £400 £500 £600


Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


7 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

1.5.1 Aminosalicylates
January 2020: Aminosalicylates: treatment doses - cost of 28 days treatment

Olsalazine capsules
(3g max single dose 1g) £432.00

Asacol® 400mg or 800mg tablets


(4.8g daily in 2-3 divided doses) £109.80

Mezavant® XL tablets
(4.8g once daily) £80.17

Octasa® 800mg tablets


(4.8g daily in 2-3 divided doses) £75.37

Pentasa® tablets/granules
(4g daily in 2-3 divided doses) £68.86

Colazide® capsules
(2.25g three time daily) £58.97

Salofalk® tablets
(3g daily in 3 divided doses) £54.40

Salofalk® granules
(3g once daily) £45.59

Octasa® 400mg tablets


(2.4g once daily) £30.94

£0 £50 £100 £150 £200 £250 £300 £350 £400 £450 £500
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

January 2020: Aminosalicylates: maintenance doses - cost of 1 year's treatment

Olsalazine capsules
(500mg twice daily) £1,872.00

Asacol® 400mg or 800mg tablets


(2.4g daily in 2-3 divided doses) £713.70

Mezavant® XL tablets
(2.4g once daily) £521.13

Octasa® 800mg tablets


(2.4g once daily) £489.88

Pentasa® tablets/granules
(2g once daily) £447.60

Salofalk® tablets
(1.5g daily in 3 divided doses) £353.59

Colazide® capsules
(1.5g twice daily) £340.70

Salofalk® granules
(1.5 daily in 3 divided doses) £313.84

Octasa® 400mg tablets


(1.2g once daily) £201.11

£0 £200 £400 £600 £800 £1,000 £1,200 £1,400 £1,600 £1,800 £2,000

Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


8 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

1.5.2 Corticosteroids: rectal foams


January 2020: Rectal foams - cost of 14 days treatment

Prednisolone 20mg/application
£187.00
foam enema

Budenofalk® 2mg foam enema £57.11

Hydrocortisone 10% foam


£9.33
aerosol enema

£0 £20 £40 £60 £80 £100 £120 £140 £160 £180 £200
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


9 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

1.6 Laxatives

January 2020: Laxatives - cost of 14 days treatment

Prucalopride 2 mg (Resolor®) £29.76

Naloxegol 25mg (Moventig®) £25.76

Linaclotide 290mcg (Constella®) £18.78

Sodium citrate enema (Micolette® 1 daily) £5.25

Sodium picosulfate 5 mg/5 ml


oral solution (10 ml) £3.77

Macrogols (2 sachets for 14 days) £3.51

Manevac® (8 g) £2.66

Ispaghula husk (Fybogel® 2 sachets) £2.64

Sterculia (Normacol® 10 g) £2.22

Docusate (200 mg) £1.95

Lactulose (20 ml) £1.62

Methylcellulose (2 g) £1.61

Bisacodyl (10 mg) £1.57

Glycerol suppository (4 g) £1.51

Senna (15 mg) £0.98

£0 £5 £10 £15 £20 £25 £30 £35

Doses given do not imply therapeutic equivalence copyright © RDTC 2020


Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


10 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

2.2 Diuretics

January 2020: Diuretics - cost of 1 year's treatment

Chlortalidone
(50mg OD) £1,068.22

Amiloride
(5mg OD) £155.22

Eplerenone
£81.64
(50mg OD)

Torasemide
(5mg OD) £71.89

Amiloride and furosemide


(Co-amilofruse) (5/40mg OD) £68.77

Spironolactone
(50mg OD) £62.53

Indapamide MR
(1.5mg OD) £41.25

Indapamide
(2.5mg OD) £30.68

Bumetanide
(1mg OD) £27.04

Amiloride and hydrochlorothiazide


(Co-amilozide) (5/50mg OD) £24.31

Spironolactone
(25mg OD) £15.99

Furosemide
(40mg OD) £10.66

Bendroflumethiazide
(2.5mg OD) £9.75

£0 £50 £100 £150 £200 £1,050 £1,100

Doses given do not imply therapeutic equivalence copyright © RDTC 2020


Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


11 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

2.4 Beta-adrenoceptor blocking drugs

January 2020: Beta-adrenoceptor blocking drugs - cost of 1


year's treatment

Timolol
(10mg BD) £968.00

Acebutolol
(400mg BD) £484.12

Metoprolol
(50mg TDS) £169.65

Nadolol
(160mg OD) £156.00

Nebivolol
(2.5mg OD) £153.14

Labetalol
(200mg BD) £127.66

Celiprolol
(200mg OD) £72.41

Propranolol M/R caps


(80mg OD) £64.35

Nebivolol 5 mg tablets are cross


Nebivolol scored and licensed to be divided
(5mg OD) £48.10
into equal quarters to achieve lower
doses e.g. 1.25 mg and 2.5 mg
Propranolol tabs
(40 mg TDS) £41.73

Sotalol
(80mg BD) £36.92

Carvedilol
(25mg OD) £31.33

Bisoprolol
(5mg OD) £11.05

Atenolol
(50mg OD) £9.49

£0 £200 £400 £600 £800 £1,000 £1,200

Doses given do not imply therapeutic equivalence copyright © RDTC 2020


Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


12 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

2.5.4 Alpha-adrenoceptor blocking drugs


January 2020: Alpha-adrenoceptor blocking drugs - cost of 1 year's treatment

Prazosin 1mg tablets


(5mg OD) £104.95

*Doxazosin MR
(4mg OD) £65.00

Terazosin
(5mg OD) £32.63

Doxazosin
(4mg OD) £15.34

*see NHSE and NHSI (2019).


Items which should not routinely be
Doxazosin prescribed in primary care:
(2mg OD) £12.87 Guidance for CCGs. Select the link
beneath the chart.

£0 £20 £40 £60 £80 £100 £120


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Items which should not routinely be prescribed in primary care: Guidance for CCGs
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


13 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

2.5.5 Drugs affecting the renin-angiotensin system


January 2020: Drugs affecting the renin-angiotensin system -
cost of 1 year's treatment

Sacubitril (97mg) / Valsartan


(103mg) BD £1,190.28

*Aliskiren (300 mg) £445.51

Eprosartan (600 mg) £236.08

Azilsartan medoxomil (40mg) £218.40

Valsartan (80 mg) £168.09

Quinapril (20 mg) £140.27

Imidapril (10 mg) £93.86

*Perindopril arginine (5 mg) £76.20

Telmisartan (40 mg) £67.86

Fosinopril (10 mg) £64.74

Irbesartan (150 mg) £61.49

Trandolapril (2 mg) £34.84

Ramipril tablets (5 mg) £27.17

Perindopril erbumine (4 mg) £26.69

Enalapril (10 mg) £25.87

Losartan (50 mg) £24.70

Captopril (25 mg BD) £22.88

Candesartan (8 mg) £21.19


*see NHSE and NHSI (2019).
Olmesartan (20 mg) £19.89 Items which should not routinely be
prescribed in primary care:
Lisinopril (10 mg) £11.96 Guidance for CCGs. Select the link
beneath the chart.
Ramipril capsules (5 mg) £11.57

£0 £100 £200 £300 £400 £500£1,100 £1,200


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Items which should not routinely be prescribed in primary care: Guidance for CCGs
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


14 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

2.6.1/2.6.3 Nitrates and other antianginal drugs


January 2020: Nitrates and other antianginal drugs - cost of 28
days treatment

Ranolazine (375mg, 500mg, 750mg BD) £45.71

Isosorbide dinitrate (20 mg QDS) £27.04

Transiderm Nitro® (5 mg/24 hours) £20.46

Deponit® (5 mg/24 hours) £12.77

Minitran® (5 mg/24 hours) £10.85

Isosorbide mononitrate MR tabs (60 mg) £10.50

Isosorbide mononitrate MR caps (60 mg) £8.86

Ivabradine (10 mg) £4.98

Nicorandil (20 mg BD) £3.74

Glyceryl trinitrate (500 mcg, 100 tablets) £2.15

Isosorbide mononitrate (40 mg BD) £1.35

Glytrin® spray (200 dose) £0.48

Nitromin® spray (200 dose) £0.38

£0 £10 £20 £30 £40 £50


Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


15 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

2.6.2 Calcium-channel blockers


January 2020: Calcium-channel blockers - cost of 1 year's
treatment
Diltiazem MR tablets
(60 mg TDS) £558.09

Dilzem XL®
(180 mg) £150.15

Adizem XL®
(180 mg) £134.81

Nicardipine
(30 mg BD) £123.89

Verapamil
(120 mg BD) £115.18

Nifedipine MR tabs
(20 mg BD) £114.53

Adizem SR®
(90 mg BD) £110.50

Viazem XL®
(180 mg) £95.68

Tildiem Retard®
(90 mg BD) £94.51

Zemret XL®
(180mg) £91.00

Nifedipine MR tablets
(30 mg) £89.05

Zemtard XL®
(180 mg) £80.60

Nifedipine MR capsules
(20 mg BD) £65.64

Felodipine MR
(5 mg) £54.73

Lercanidipine
(10 mg) £31.20

Lacidipine
(4 mg) £28.34

Amlodipine
(5 mg) £10.79

£0 £100 £200 £300 £400 £500 £600


Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


16 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

2.8.1/2.8.2 Parenteral anticoagulants/oral anticoagulants

January 2020: Anticoagulants - cost of 28 days treatment

Enoxaparin inj 150mg (BD) £559.50

Enoxaparin inj 120mg (BD) £492.41

Enoxaparin inj 150mg (OD) £279.75

Enoxaparin inj 120mg (OD) £246.20

Enoxaparin inj 100mg (OD) £202.44

Enoxaparin inj 40mg (BD) £169.51

Enoxaparin inj 80mg (OD) £154.36

Enoxaparin inj 60mg (OD) £109.93

Enoxaparin inj 40mg (OD) £84.76


Parenteral anticoagulants
Enoxaparin inj 20mg (OD) £58.41

Tinzaparin inj 18,000u (OD) £299.82

Tinzaparin inj 20,000u (OD) £295.85

Tinzaparin inj 16,000u (OD) £266.56

Tinzaparin inj 10,000u (OD) £166.60

Tinzaparin inj 8,000u (OD) £133.28

Dalteparin inj 18,000u (OD) £284.59

Dalteparin inj 15,000u (OD) £237.10

Dalteparin inj 12,500u (OD) £197.62

Dalteparin inj 10,000u (OD) £158.09

Dalteparin inj 7,500u (OD) £118.55

Apixaban 2.5mg or 5mg


£53.20
tablets (BD)
Rivaroxaban 15 or 20mg
£50.40
tablets (OD)
Edoxaban 30mg or 60mg
£49.00
tablets (OD)
Dabigatran 75 or 110 or 150mg
£47.60 Oral anticoagulants
capsules (BD)
Warfarin 500microgram tablets (OD) £1.45

Warfarin 5mg tablets (OD) £0.99


Does not include cost
Warfarin 3mg tablets (OD) £0.87 of INR monitoring

Warfarin 1mg tablets (OD) £0.82

£0 £100 £200 £300 £400 £500 £600


Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


17 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

2.9 Antiplatelet drugs


January 2020: Antiplatelet drugs - cost of 1 year's treatment

Ticagrelor
(90mg BD) £709.80

Prasugrel
(5mg OD) £313.04

Aspirin
25mg/Dipyridamole £163.80
MR 200mg BD

Dipyridamole MR
(200mg BD) £159.55

Prasugrel
(10mg OD) £85.67

Clopidogrel
(75mg OD) £19.37

Aspirin EC
(75mg OD) £10.92

Aspirin Dispersible
(75mg OD) £10.01

£0 £100 £200 £300 £400 £500 £600 £700 £800


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


18 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

2.12 Lipid-regulating drugs


January 2020: Lipid-regulating drugs - cost of 1 year's treatment

Evolocumab (140mg every 2 weeks) £4,422.60


Alirocumab (75/150mg every 2 weeks ) £4,368.00
Ciprofibrate (100 mg) £1,592.89
Colesevelam (6 tablets) £1,399.22
Colestipol (20 g) £730.43
Gemfibrozil (1.2 g) £586.17
Simvastatin (80 mg) / Ezetimibe (10 mg) £535.73
Simvastatin (40 mg) / Ezetimibe (10 mg) £506.74
Colestyramine sugar free (12 g) £468.69
Simvastatin (20 mg) / Ezetimibe (10 mg) £434.46
Acipimox (500 mg) £374.76
Atorvastatin chewable tablets (20mg) £320.32
Atorvastatin chewable tablets (10mg) £167.44
Fenofibrate (145mg) / Simvastatin (40mg) £101.07
Bezafibrate MR (400 mg) £92.58
Fenofibrate (160 mg) £44.46
Fenofibrate (200 mg) £42.12
Fluvastatin (40 mg) £34.06
Fluvastatin (20mg) £29.64
Rosuvastatin (40mg) £29.38
Atorvastatin (80mg) £24.05
Rosuvastatin (20mg) £23.66
Simvastatin (80 mg) £21.97
Ezetimibe (10 mg) £20.93
Pravastatin (40 mg) £18.59
Rosuvastatin (10 mg) £18.20
Atorvastatin (40mg) £16.12
Rosuvastatin (5 mg) £15.86
Pravastatin (20 mg) £15.08
Simvastatin (40 mg) £13.26
Atorvastatin (20 mg) £13.00
Simvastatin (20 mg) £11.70
Atorvastatin (10 mg) £11.31
£0 £1,000 £2,000 £3,000 £4,000 £5,000
Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


19 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

3.1 Bronchodilators
January 2020: Bronchodilators - cost of 1 year's treatment
Salmeterol Accuhaler® DPI
£426.00
(50 mcg BD)
Tiotropium Handihaler® refill DPI
£406.47
(18 mcg OD)
Indacaterol/glycopyrronium Breezhaler® DPI
£394.33
(85mcg/43mcg, 1 act OD)
Vilanterol/Umeclidinium Ellipta® DPI
£394.33
(22mcg/55mcg, 1 act OD)
Aclidinium Genuair® DPI
£394.33
(322 mcg, 1 act BD)
Aclidinium/formoterol Genuair® DPI
£394.33
(340mcg/12mcg, 1 act BD)
Olodaterol/tiotropium Respimat® SMI
£394.33
(2.5mcg/2.5mcg, 2 act OD)
Indacaterol inhalation powder caps DPI
£390.57
(150 mcg, 1 act)
Salmeterol inhaler MDI
£355.02
(25 mcg, 2 act BD)
Umeclidinium Ellipta® DPI
£333.67
(65mcg, 1 act OD)
Glycopyrronium Breezhaler® DPI
£333.67
(50mcg, 1 act)
Olodaterol Respimat® SMI
£319.71
(2.5mcg, 2act OD)
Tiotropium Braltus Zonda® DPI
£313.04
(10 mcg OD)
Formoterol Turbohaler® DPI
£300.91
(6 mcg BD)
Tiotropium Respimat® SMI
£279.07
(5 mcg OD)
Soltel® (Salmeterol) inhaler MDI
£242.06
(25 mcg, 2 act BD)
Formoterol Easyhaler®
£144.08
(12 mcg, 1 act BD)
Terbutaline Turbohaler® DPI
£100.71
(500 mcg, 1 act QDS)
Salamol Easi-Breathe® MDI
£91.73
(100 mcg, 2 act QDS)
Airomir Autohaler® MDI
£87.65
(100 mcg, 2 act QDS)
Salbutamol Accuhaler® DPI
£87.36
(200 mcg, 1 act QDS)
Ipratropium inhaler MDI
£80.95
(20 mcg, 2 act QDS)
Salbutamol Easyhaler® DPI
£48.27
(200 mcg, 1 act QDS)
Salbutamol Easyhaler® DPI
£48.19
(100mg, 2 act QDS)
Airomir® inhaler MDI
£28.68
(100 mcg, 2 act QDS)
Salbutamol inhaler CFC-free MDI
£21.84
(100 mcg, 2 act QDS)
Ventolin Evohaler® MDI
£21.84
(100 mcg, 2 act QDS)
£0 £50 £10 0 £15 0 £20 0 £25 0 £30 0 £35 0 £40 0 £45 0
Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


20 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

3.2 Corticosteroids (respiratory): (i) corticosteroid inhalation devices

January 2020: Corticosteroids - cost of 1 year's treatment


Fluticasone Accuhaler®
£526.22 High dose ICS
(500 mcg, 1 act BD)
in adult - only
Fluticasone Evohaler® after referring
£438.50
(250 mcg, 2 act BD) to secondary
Clenil Modulite® inhaler care
£118.59 High dose
(250 mcg, 2 act BD)
therapy stage
Soprobec® inhaler
£88.96
(250mcg, 2 act BD)
Fluticasone Accuhaler®
£309.52
(250 mcg, 1 act BD)
Fluticasone Evohaler®
£257.95
(125 mcg, 2 act BD)
Fluticasone Evohaler®
£219.25 Medium dose
(250 mcg, 1 act BD)
ICS in adult
Mometasone Twisthaler® Additional
£218.70
(400 mcg 1 act OD) add-on
therapies
Budesonide 400 Turbohaler® stage
£207.48
(1 act BD)
Easyhaler® Budesonide
£128.93
(400mcg, 1 act BD)
Qvar 100 Easi-Breathe®
£123.40
(2 act BD)
Ciclesonide inhaler
£117.15
(160 mcg, 1 act OD)
Budesonide 200 Turbohaler®
£103.74
(1 act BD)
Fluticasone Accuhaler®
£97.07
(100 mcg, 1 act BD)
Fluticasone Evohaler®
£79.23
(50 mcg, 2 act BD)
Easyhaler® Budesonide
£64.46
(200mcg, 1 act BD)
Qvar 100® inhaler Low dose ICS
£62.64 in adult
(1 act BD)
Regular
Qvar 50® inhaler Preventer
£57.29
(2 act BD) stage or
inhaler add-
Qvar 50 Easi-Breathe®
£56.35 on therapy
(2 act BD) stage
Easyhaler® Beclomethasone
£54.35
(200mcg, 1 act BD)
Clenil Modulite® inhaler
£54.02
(100 mcg, 2 act BD)
Kelhale 50® inhaler
£37.86
(2 act BD)
Soprobec® inhaler
£20.27
(100mcg, 1 act BD)
Kelhale 100® inhaler
£18.93
(1 act BD)
£0 £100 £200 £300 £400 £500 £600

Doses given do not imply therapeutic equivalence copyright © RDTC 2020


Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


21 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

3.2 Corticosteroids (respiratory): (ii) combination with bronchodilators,


inhalation devices

January 2020: ICS/LABA and ICS/LABA/LAMA combination


inhalers - Cost of treatment for 1 year [Dotted Bars = licensed for
COPD]
Symbicort 400 /12 Turbo haler® (2 act BD) DPI £679.47
DuoResp Spiromax® 3 20/9 (2 act B D) DPI £678.74
Flutifor m® 250/10 inha ler (2 a ct B D) MDI £552.79
Fobumix E asyha ler® 3 20/9 (2 act B D) DPI £521.73
Ser etid e 5 00 Accuha ler® (1 a ct B D) DPI £397.25
AirFluS al Forspir o® 50 0/5 0 (1 act BD) DPI £363.64 High dose ICS in
adult
Relvar Ellipta® 1 84/22 inhale r (1 act OD) DPI £357.93 High dose
Ser etid e 2 50 Evo haler® (2 act BD) MDI £355.75 therapy stage -
only after
Fostair 20 0/6 or NEXThale r® (2 act BD) MDI/DPI £355.75 referring to
secondary care
Sird upla 250 inha ler (2 act BD) MDI £343.62
Combisal® 2 5/2 50 inhaler (2 act BD) MDI £339.61
Fusaco mb Ea syhale r® 50 /50 0 (1 act BD) DPI £327.48
Stalpex® 50/500 (1 act BD) DPI £297.99
Ser eflo ® 25/250 inh aler (2 act BD) MDI £242.55
Trelegy Ellipta® 92/22/55 (1 a ct OD) DPI £539.93
Trimbow® 87 /5/9 inhal er ( 2 a ct B D) MDI £539.93
Ser etid e 2 50 Accuha ler® (1 a ct B D) DPI £424.67
Fostair 10 0/6 or NEXThale r® (2 act BD) MDI/DPI £355.75
Symbicort Turboh aler® 200/6 (2 act BD) & 400 /12 (1 act BD) DPI £339.73
Flutifor m® 125/5 or K-hale r® inh aler (2 act BD) MDI £339.73
Medium dose
Symbicort 200 /6 (2 act BD) MDI £339.73 ICS in adult
Additional add-
DuoResp Spiromax® 1 60/4.5 (2 act BD) & 320/9 (1 a ct B D) DPI £339.37 on therapy
Ser etid e 1 25 Evo haler® (2 act BD) MDI £284.53 stage
Sird upla 125 inha ler (2 act BD) MDI £272.39
Relvar Ellipta® 9 2/2 2 i nhaler (1 act OD) DPI £266.93
Fusaco mb Ea syhale r® 50 /25 0 (1 act BD) DPI £260.87
Fobumix E asyha ler® 1 60/4.5 (2 act BD) & 320/9 (1 a ct B D) DPI £260.87
Combisal® 2 5/1 25 inhaler (2 act BD) MDI £213.43
Ser eflo ® 25/125 inh aler (2 act BD) MDI £181.88
Symbicort 100 /6 Turboh aler® (2 act BD) DPI £339.73
Fobumix E asyha ler® 8 0/4 .5 (2 act BD) DPI £260.87
Ser etid e 5 0 E voh aler® (2 act BD) MDI £218.40
Low dose ICS
Ser etid e 1 00 Accuha ler® (1 a ct B D) DPI £218.40 in adult
*Fo stair 100/6 or NE XThaler® (1 act BD) DPI £177.87 Regular
*Low dose LABA - 12mcg Preventer or
Flutifor m® 50/5 or K -haler ® inha ler (2 act BD) MDI £174.72 formoterol inhaler add-on
therapy stage
*Symbi cor t 200/6 Tu rbohal er® (1 act BD) DPI £169.87
DuoResp Spiromax® 1 60/4.5 (1 act BD) DPI £169.68
Combisal® 2 5/5 0 in haler (2 act BD) MDI £163.80
Fobumix E asyha ler® 1 60/4.5 (1 act BD) DPI £130.43
£0 £20 0 £40 0 £60 0 £80 0
Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


22 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

3.1 & 3.2 Inhaled therapy licensed for COPD


January 2020: Inhaled therapy licensed for COPD (ICS/LABA
combinations, LABAs, LAMAs, LABA/LAMA combinations &
ICS/LABA/LAMA combinations) - Cost of treatment for 1 year

Beclometasone/formoterol/glycopyrronium [Trimbow®] 87/5/9


MDI (2 act BD) £539.93
Fluticasone/vilanterol/umeclidinium [Trelegy Ellipta®] 92/22/55
DPI (1 act OD) £539.93
Salmeterol [Serevent Accuhaler®]
DPI (25 mcg, 2 act BD) £426.00
Tiotropium [Spiriva Handihaler®] refill
DPI (18 mcg, 1 act OD) £406.47
Fluticasone/salmeterol [Seretide Accuhaler®] 500/50
DPI (1 act BD) £397.25
Aclidinium/formoterol [Duaklir Genuair®] 340/12
DPI (1 act BD) £394.33
Olodaterol/tiotropium [Spiolto Respimat®]
SMI (2.5mcg/2.5mcg, 2 act OD) £394.33
Indacaterol/glycopyrronium [Ultibro Breezhaler] 85/43
DPI (1 act OD) £394.33
Umeclidinium/vilanterol [Anoro Ellipta®] 55/22
DPI (1 act OD) £394.33
Aclidinium [Eklira Genuair®] DPI
(322 mcg, 1 act BD) £394.33
Indacaterol [Onbrez Breezhaler®]
DPI (150 mcg, 1 act) £390.57
Fluticasone/salmeterol [AirFluSal Forspiro®] 500/50
DPI (1 act BD) £363.64
Beclometasone/formoterol [Fostair®] 100/6
MDI or NEXThaler® DPI (2 act BD) £355.75
Salmeterol [Serevent Evohaler®]
MDI (25 mcg, 2 act BD) £355.02
Formoterol [Foradil®] inhalation powder
DPI (12mcg, 1act BD) £340.46
Budesonide/formoterol [Symbicort Turbohaler®] 200/6
DPI (2 act BD) & 400/12 DPI (1 act BD) £339.73
Budesonide/formoterol [Symbicort®] 200/6
MDI (2 act BD) £339.73
Budesonide/formoterol [DuoResp Spiromax®] 160/4.5
DPI (2 act BD) & 320/9 DPI (1 act BD) £339.37
Glycopyrronium [Seebri Breezhaler®]
DPI (50mcg, 1 act OD) £333.67
Umeclidinium [Incruse Ellipta®]
DPI (65 mcg, 1 act OD) £333.67
Fluticasone/Salmeterol [Fusacomb Easyhaler®] 500/50
DPI (1 act BD) £327.48
Olodaterol [Striverdi Respimat®]
SMI (2.5mcg, 2 act OD) £319.71
Tiotropium [Braltus Zonda®]
DPI (10 mcg, 1 act OD) £313.04
Fluticasone/salmeterol [Stalpex®]
500/50 DPI (1 act BD) £297.99
Tiotropium [Spiriva Respimat®]
SMI (2.5mg, 2 act OD) £279.07
Fluticasone furoate/vilanterol [Relvar Ellipta®] 92/22
DPI (1 act OD) £266.93
Budesonide/formoterol [Fobumix Easyhaler®] 160/4.5
DPI (2 act BD) & 320/9 DPI (1 act BD) £260.87
Formoterol modulite [Atimos®]
MDI (12mcg, 1act BD) £218.84
Formoterol Easyhaler®
DPI (12 mcg, 1 act BD) £144.08

£0 £100 £200 £300 £400 £500 £600


Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


23 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

3.3 Cromoglicate & related therapy, leukotriene receptor antagonists, and


phosphodiesterase type-4 inhibitors
January 2020: Cromoglicate & related therapy, leukotriene receptor antagonists, and
phosphodiesterase type 4 inhibitors - cost of 1 year's treatment

Sodium cromoglycate CFC-Free


inhaler (5mg, 2 act QDS) £476.58

Roflumilast
(500mcg OD) £457.55

Montelukast
(10mg OD) £53.04

£0 £100 £200 £300 £400 £500 £600


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

3.4.1 Antihistamines
January 2020: Antihistamines - cost of 1 year's treatment

Alimemazine (10 mg BD) £2,934.88

Acrivastine (8 mg TDS) £291.20

Cyproheptadine (4 mg TDS) £218.04

Ketotifen (1mg BD) £91.36

Clemastine (2 mg) £88.94

Mizolastine MR (10 mg) £83.96

Levocetirizine (5 mg) £49.87

Promethazine (25 mg) £32.37

Chlorphenamine (4 mg TDS) £30.42

Fexofenadine (120 mg) £26.33

Desloratadine (5 mg) £16.14

Loratadine (10 mg) £12.74

Cetirizine (10 mg) £12.25

Hydroxyzine (25 mg) £8.06

£0 £100 £200 £300 £2,900 £3,000


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


24 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.1.1/4.1.2 Hypnotics/Anxiolytics
January 2020: Hypnotics and anxiolytics - cost of 14 days treatment

Clomethiazole capsules (2 ON) £15.31

Clomethiazole syrup (10 ml ON) £14.00

Loprazolam 1 mg £11.25

Lormetazepam 1 mg £8.27

Oxazepam 15 mg (BD) £7.30

Melatonin MR 2 mg £7.18

Buspirone 10 mg (TDS) £5.25

Lorazepam 2.5 mg £3.70

Zolpidem 10 mg £0.96

Temazepam 20 mg £0.78

Zopiclone 7.5 mg £0.56

Nitrazepam 5 mg £0.52

Diazepam 10 mg £0.51

£0 £2 £4 £6 £8 £10 £12 £14 £16 £18


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


25 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.2.1/4.2.3 Antipsychotic drugs and drugs used for mania and hypomania:
maintenance doses (adults with psychosis)
January 2020: Drugs used for adults with psychosis:
maintenance doses - cost of 1 year's treatment

Paliperidone 12mg (9mg+3mg) OD £3,161.60

Quetiapine 600mg MR OD £2,062.67

Paliperidone 9mg OD £1,896.96

Paliperidone 6mg OD £1,264.64

Paliperidone 3mg OD £1,264.64

Lurasidone (Latuda®) 18.5mg – 74mg OD £1,179.36

Cariprazine (Reagila®) 1.5mg - 6mg OD £1,044.68

Olanzapine 20mg orodispersible OD £1,019.20

Risperidone 4mg (disp) OD £653.77

Risperidone 6mg OD £639.73

Asenapine (Sycrest®) 5mg OD £622.44 N.B.: Asenapine is only intended


for use in acute crisis and not
licensed for maintenance therapy
Asenapine (Sycrest®) 10mg OD £622.44

Amisulpride 400mg BD £510.57

Olanzapine 5mg orodispersible OD £377.39

Aripiprazole 30mg OD £178.36

Amisulpride 200mg BD £160.52

Quetiapine 225mg (200mg+25mg) BD £111.38

Risperidone 4mg OD £81.84

Quetiapine 150mg BD £67.58

Olanzapine 20mg OD £27.69

Aripiprazole 15mg OD £20.54

Olanzapine 5mg OD £19.63

£0 £500 £1,000 £1,500 £2,000 £2,500 £3,000 £3,500


Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


26 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.2.1 Antipsychotic drugs: low dose


January 2020: Antipsychotic drugs: low dose - cost of 1 year's treatment
Risperidone 1mg
(orodispersible) BD £562.38

Risperidone 500microgram
(orodispersible) BD £475.28

Sulpiride 200mg BD £126.91

Risperidone 1mg BD £99.74

Risperidone 500microgram BD £78.62

Amisulpride 50mg tablets BD £73.89

Quetiapine 25mg BD £25.36

Olanzapine 2.5mg tablets £18.85

Haloperidol 500micrograms £14.32

Quetiapine 25mg OD £12.68

£0 £100 £200 £300 £400 £500 £600


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


27 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.3 Antidepressant drugs

January 2020: Antidepressant drugs - cost of 1 year's


treatment
*Trimipramine (75 mg) £7,819.50

Mianserin (30 mg) £480.74

Agomelatine (25mg) £408.46

Vortioxetine (10mg) £360.36

Phenelzine (60 mg) £327.60

Lofepramine (140 mg) £285.09

Reboxetine (8 mg) £229.44

*Dosulepin (75 mg) £223.21

Fluvoxamine (100 mg) £214.76

Moclobemide (300 mg) £169.75

Clomipramine (75 mg) £132.60

Nortriptyline (75 mg) £100.90

Trazodone (150 mg) £53.82

Imipramine (75 mg) £47.97

Escitalopram (10mg) £43.94

Venlafaxine (75 mg MR) £33.80

Amitriptyline (75 mg) £33.15

Duloxetine (60 mg) £29.64

Flupentixol (1 mg) £29.48

Mirtazapine (30 mg) £20.67

Venlafaxine (75 mg) £20.22


*see NHSE and NHSI (2019).
Sertraline (50 mg) £16.51 Items which should not routinely
be prescribed in primary care:
Paroxetine (20 mg) £15.77 Guidance for CCGs. Select the
link beneath the chart.
Fluoxetine (20 mg) £12.25

Citalopram (20 mg) £11.83

£0 £100 £200 £300 £400 £500 £7,800 £7,900

Doses given do not imply therapeutic equivalence copyright © RDTC 2020


Items which should not routinely be prescribed in primary care: Guidance for CCGs
Contents
NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES
28 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.4 CNS stimulants and drugs used for attention deficit hyperactivity disorder:
(i) stimulant

January 2020: Drugs used for attention deficit hyperactivity


disorder - Stimulant - cost of 28 days treatment

Dexamfetamine 5mg/5ml oral solution


(5mg QDS) £128.23

Dexamfetamine 5mg/5ml oral solution


(5mg BD) £106.86

Dexamfetamine 5mg/5ml oral solution


(2.5mg BD) £106.86
Oral solution has
shelf life of 30
days after opening
Dexamfetamine tabs
(Generic, 5mg QDS) £98.84

Dexamfetamine tabs
(Generic, 5mg BD) £49.42

Dexamfetamine tabs
(Generic, 2.5mg BD) £24.71

Dexamfetamine tabs
(Amfexa®, 5mg QDS) £74.26

Dexamfetamine tabs
(Amfexa®, 5mg BD) £37.13

Dexamfetamine tabs
(Amfexa®, 2.5mg BD) £18.56

Lisdexamfetamine caps
(70mg OD) £83.16

Lisdexamfetamine caps
(50mg OD) £68.60

Lisdexamfetamine caps
(30mg OD) £58.24

Methylphenidate
(20mg BD) £20.38

Methylphenidate
(10mg BD) £7.28

Methylphenidate
(5mg BD) £5.66

£0 £20 £40 £60 £80 £100 £120 £140 £160


Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


29 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.4 CNS stimulants and drugs used for attention deficit hyperactivity disorder:
(ii) stimulant; methylphenidate modified release preparations only

January 2020: Drugs used for attention deficit hyperactivity


disorder - Stimulant - Methylphenidate MR only - cost of 28 days
treatment
Concerta XL® tabs (54mg OD) £68.71
Concerta XL® tabs (36mg OD) £39.62
18mg Concerta XL
Concerta XL® tabs (27mg OD) £34.36 equivalent to 15mg
total daily dose of
Concerta XL® tabs (18mg OD) £29.11 standard release

Delmosart® MR tabs (54mg OD) £34.34


Delmosart® MR tabs (36mg OD) £19.80
Delmosart® MR tabs (27mg OD) £17.16
Delmosart® MR tabs (18mg OD) £14.53

Matoride XL® tabs (54mg OD) £34.35


Matoride XL® tabs (36mg OD) £19.81
Matoride XL® tabs (18mg OD) £14.54

Xaggitin XL® tabs (54mg OD) £34.35


Xaggitin XL® tabs (36mg OD) £19.81
Xaggitin XL® tabs (27mg OD) £17.17
Xaggitin XL® tabs (18mg OD) £14.54

Xenidate XL® tabs (54mg OD) £34.34


Xenidate XL® tabs (36mg OD) £19.80
Xenidate XL® tabs (27mg OD) £17.16
Xenidate XL® tabs (18mg OD) £14.53

Equasym XL® caps (30mg OD) £32.67 Equasym and Medikinet


Equasym XL® caps (20mg OD) capsules can be opened and
£28.00
sprinkled on apple sauce
Equasym XL® caps (10mg OD) £23.33

Medikinet XL® caps (5mg OD) £22.44


£0 £10 £20 £30 £40 £50 £60 £70 £80
Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


30 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.4 CNS stimulants and drugs used for attention deficit hyperactivity disorder:
(iii) non-stimulant
January 2020: Drugs used for attention deficit hyperactivity disorder - Non-stimulant -
cost of 28 days treatment
Atomoxetine 4mg/ml oral
solution sugar free (100mg OD) £198.33
Atomoxetine caps
(80mg-100mg OD) £67.33
Atomoxetine caps
(10mg, 18mg or 60mg OD) £50.56
Atomoxetine caps
(25mg or 40mg OD) £49.76

Guanfacine MR tabs
(Intuniv®) 7mg (4mg + 3mg) OD £141.68
Guanfacine MR tabs
(Intuniv®, 6mg OD) £131.04
Guanfacine MR tabs
(Intuniv®) 5mg (3mg + 2mg) OD £124.04
Guanfacine MR tabs
(Intuniv®, 4mg OD) £76.16
Guanfacine MR tabs
(Intuniv®, 3mg OD) £65.52
Guanfacine MR tabs
(Intuniv®, 2mg OD) £58.52
Guanfacine MR tabs
(Intuniv®, 1mg OD) £56.00
£0 £50 £100 £150 £200 £250
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents
4.6 Drugs used in nausea and vertigo
January 2020: Drugs used in nausea and vertigo - cost of 1 year's treatment
Hyoscine patch
(1mg/72hours, once every 3 days) £777.66

Prochlorperazine buccal tablets


(3 mg BD) £395.01

Hyoscine
(20 mg TDS) £117.00

Promethazine
(Avomine®, 25 mg BD) £81.38

Cinnarizine
(15 mg TDS) £65.13

Promethazine
(Phenergan® 25 mg BD) £64.74

Cyclizine
(50 mg BD) £51.98

Prochlorperazine
(5 mg TDS) £41.34

Metoclopramide
(10 mg TDS) £38.61

Betahistine
(16 mg BD) £37.79

£0 £100 £200 £300 £400 £500 £600 £700 £800 £900


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


31 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.7 Analgesics
January 2020: Analgesics - cost of 7 days treatment

Tramacet®
(8 tablets) £9.03

Tramacet® effervescent
(8 tablets) £9.03

Aspirin 300 mg
(12 tablets) £8.98

Tramadol MR 400 mg
(1 tablet) £7.13

Remedeine®
(8 tablets) £6.41

Buprenorphine 400 micrograms


(4 tablets) £5.64

Co-codamol effervescent 8/500


(8 tablets) £4.64

Co-codamol effervescent 30/500


(8 tablets) £4.57

Nefopam 30 mg
(9 tablets) £3.96

Co-codamol 30/500
(8 capsules) £3.08

DHC Continus® 120 mg


(2 tablets) £2.74

Co-codamol 30/500
(8 tablets) £2.58

Codeine 30 mg
(8 tablets) £2.42

Dihydrocodeine 30 mg
(8 tablets) £2.38

*Tramadol 37.5mg / Paracetamol


325mg (8 tablets) £2.06

Co-dydramol 10/500
(8 tablets) £1.78

Co-codamol 8/500
(8 tablets) £1.78
*see NHSE and NHSI (2019).
Tramadol 50 mg Items which should not routinely be
(8 capsules) £1.53
prescribed in primary care:
Paracetamol 500 mg Guidance for CCGs. Select the link
(8 tablets) £1.33 beneath the chart.

£0 £2 £4 £6 £8 £10
Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Items which should not routinely be prescribed in primary care: Guidance for CCGs
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


32 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.7.2 Opioid analgesics: (i) oral preparations


January 2020: Opioid analgesics - cost of 7 days treatment

Dipipanone 10mg / Cyclizine 30mg tablets


(4 tablets) £246.76

Pethidine 50 mg
£55.91
(8 tablets)

Pentazocine 25 mg tablets
£50.08
(8 daily)

*Oxycodone 20mg / Naloxone 10mg MR


tablets (4 daily) £42.31

Pentazocine 50 mg capsules
(4 daily) £28.50

Oxycodone 40 mg MR tablets
(2 daily) £25.05

Oxycodone 20 mg capsules
£22.86
(4 daily)

Tapentadol 150 mg MR tablets


£18.68
(2 daily)

Tapentadol 75 mg tablets
(4 daily) £18.68

Hydromorphone 2.6 mg capsules


(8 daily) £17.64

Hydromorphone 8 mg MR capsules
(2 daily) £14.02

Meptazinol 200 mg
(8 tablets) £11.06

Tramadol MR 400 mg
(1 tablet) £7.13

Morphine 10 mg / 5 ml oral solution


(50 ml daily) £7.00

Morphine 20 mg
(5 tablets) £6.63

Morphine MR tablets
(60 mg BD) £5.67
*see NHSE and NHSI (2019).
Items which should not routinely
Buprenorphine 400 mcg sublingual be prescribed in primary care:
(4 tablets) £5.64
Guidance for CCGs. Select the
Morphine MR capsules link beneath the chart.
(60 mg BD) £3.78

£0 £10 £20 £30 £40 £50 £60 £240 £250 £260

Doses given do not imply therapeutic equivalence copyright © RDTC 2020


Items which should not routinely be prescribed in primary care: Guidance for CCGs
Contents
NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES
33 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.7.2 Opioid analgesics: (ii) transdermal patches

January 2020: Opioid analgesics - patches only - cost of 7 days


treatment

Osmanil® £23.46

Victanyl® £22.55

Fentalis Reservoir® £19.94

Durogesic DTrans®,
Fentanyl and Yemex® £15.69

Fentanyl patches -
Fencino® £10.55 50mcg per hour, 1
every 3 days
Matrifen® and
Mezolar Matrix® £9.38

Opiodur® £8.91

Transtec® and Buplast®


(1 every 4 days) £10.37

Hapoctasin®
(1 every 3 days) £8.29

Relevtec® Buprenorphine twice


(1 every 4 days) £7.26
weekly patches -
52.5 mcg per hour
Carlosafine®
(1 every 4 days) £6.23

Bupeaze®
(1 every 4 days) £6.12

Butrans® £7.89

Butec®, Reletrans®
and Sevodyne® £3.55
Buprenorphine once weekly
patches - 10 mcg per hour
Panitaz® and Bupramyl® £3.16

Bunov® £2.49

£0 £5 £10 £15 £20 £25

Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


34 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.7.2 Opioid analgesics: (iii) modified release preparations

January 2020: MR opioid analgesics - cost of 7 days treatment

OxyContin 40mg (1 BD) £25.05

Oxylan 40mg (1 BD) £25.00

Carexil 40mg (1 BD) £15.03

Onexila XL 80mg (1 OD) £12.52


Abtard , Longtec and
Reltebon 40mg (1 BD) £12.52

Oxeltra and Oxypro 40mg (1 BD) £6.26

Renocontin 40mg (1 BD) £5.95

OxyContin 20mg (1 BD) £12.52

Oxylan 20mg (1 BD) £12.50

Onexila XL 40mg (1 OD) £6.26


Abtard, Carexil, Longtec and
Reltebon 20mg (1 BD) £6.26
Ixyldone, Oxeltra and
Oxypro 20mg (1 BD) £3.13

Renocontin 20mg (1 BD) £2.97

MXL 120mg
capsules (1 OD) £7.29
MST Continus 60mg
tablets (1 BD) £5.67
Morphgesic SR 60mg
tablets (1 BD) £4.21
Zomorph 60mg modified-release
capsules (1 BD) £3.78

MXL 60mg
capsules (1 OD) £3.74

MST Continus 30mg tablets (1 BD) £2.91 Several NHS bodies recommend
that modified-release forms of strong
Morphgesic SR 30mg opioids be prescribed by brand
tablets (1 BD) £2.16 name to avoid confusion and reduce
risk of harm.
Zomorph 30mg modified-release
capsules (1 BD) £1.94

£0 £5 £10 £15 £20 £25 £30


Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


35 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.7.2 Opioid analgesics: (iv) subcutaneous infusion; strong opioids


January 2020: Costs per 24 hours for strong opioids administered via subcutaneous
infusion

Oxycodone 100mg/24hours £28.04


Diamorphine 100mg/24hours £8.78
Morphine sulphate 150mg/24hours £5.75

Diamorphine 15mg/24hours £5.70 Please Note: Doses shown are only approximately equivalent and for
price comparison purposes only. Extreme caution is required when
Morphine 30mg/24hours £3.45 converting from one parenteral opioid to another and specialist advice
Oxycodone 15mg/24hours £3.20 should always be sought.

There are differences in opinion regarding dose conversion ratios —


Oxycodone 30mg/24hours £4.80 current practice is based on pharmacokinetic data from observational
and uncontrolled studies, and on expert opinion and experience.
Diamorphine 30mg/24hours £3.13 Reported equi-analgesic dose ratios vary widely. When converting
from one opioid to another, regular assessment and reassessment of
Morphine 45mg/24hours £2.96 efficacy and adverse effects is essential because of the lack of
evidence on equi-analgesic doses and inter-individual variations.

Diamorphine 10mg/24hours £3.08


Oxycodone 10mg/24hours £1.60
Morphine 15mg/24hours £1.07

Diamorphine 5mg/24hours £2.56


Morphine 10mg/24hours £1.15
Oxycodone 5mg/24hours £0.80
£0 £5 £10 £15 £20 £25 £30
copyright © RDTC 2020

Contents

4.7.3 Neuropathic pain


January 2020: Neuropathic pain - cost of 1 year's treatment

*Lidocaine patch (1/day) £878.45

Capsaicin 0.075% cream


£176.90
(1.5g/day)

Gabapentin (600mg TDS) £86.60

Gabapentin (2x300mg TDS) £66.39

Carbamazepine (200mg QDS) £66.39

Pregabalin (100mg TDS) £51.48

Pregabalin (150mg BD) £40.17

Nortriptyline (25mg OD) £33.63


*see NHSE and NHSI (2019).
Items which should not routinely be
Duloxetine (60mg OD) £29.64 prescribed in primary care:
Guidance for CCGs. Select the link
beneath the chart.
Amitriptyline (25mg OD) £11.05

£0 £50 £100 £150 £200 £850 £900


Doses given do not imply therapeutic equivalence. Individual responses and prescribed doses vary substantially in the management of neuropathic pain copyright © RDTC 2020

Items which should not routinely be prescribed in primary care: Guidance for CCGs
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


36 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.7.4.1 Treatment of acute migraine


January 2020: Antimigraine drugs (acute) - cost of 1 days treatment

Sumatriptan injection (6 mg) £25.48

Sumatriptan (Imigran Radis® 100 mg) £7.15

Sumatriptan nasal spray (20 mg) £7.08

Zolmitriptan nasal spray (5 mg) £6.08

Rizatriptan wafers (10 mg) £4.46

Eletriptan (20 or 40 mg) £3.75

Almotriptan (12.5 mg) £2.70

Tolfenamic acid (200 mg) £2.46

Migril® (4 tablets) £2.04

Zolmitriptan (2.5 mg) £1.28

Rizatriptan tablets (10 mg) £1.18

Frovatriptan (2.5 mg) £0.99

Naratriptan (2.5 mg) £0.72

Sumatriptan tablets (100 mg) £0.30

Sumatriptan tablets (50mg) £0.25


£0 £5 £10 £15 £20 £25 £30
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents
4.8 Antiepileptic drugs
January 2020: Antiepileptic drugs - cost of 1 year's treatment
Ethosuximide 250mg capsules (QDS) £4,498.00
Perampanel 2mg tablets (OD) £1,820.00
Lacosamide 150mg (BD) £1,686.62
Brivaracetam (Briviact®) 50mg tablets (BD) £1,685.32
Eslicarbazepine 800mg £1,650.13
Primidone 250mg tablets (BD) £831.38
Levetiracetam (Desitrend®) 750mg sachets (BD) £750.69
Vigabatrin 500mg tablets (QDS) £646.61
Topiramate 200mg tablets (BD) £542.00
Epival CR tablets (1200mg daily) £254.36
Epilim Chrono tablets (1200mg daily) £254.25
Clonazepam 2mg tablets (BD) £246.21
Oxcarbazepine 450mg tablets £226.12
Sodium valproate 200mg gastro-resistant tablets £211.19
Episenta MR capsules (1200mg daily) £189.28
Phenytoin sodium 100mg capsules (TD) £143.39
Zonisamide 100mg capsules (QDS) £120.38
Clobazam 10mg tablets (BD) £92.70
Levetiracetam 750mg tablets (BD) £76.93 Levetiracetam (Desitrend®) 750mg sachets (BD) = Levetiracetam (Desitrend®) 500mg sachets (BD) +
Levetiracetam (Desitrend®) 250mg sachets (BD)
Carbamazepine 400mg MR tablets (BD) £65.26
Lamotrigine 100mg tablets (BD) £56.68 Oxcarbazepine 450mg tablets = Oxcarbazepine 300mg tablets (BD) + Oxcarbazepine 150mg (BD) tablets
Modified-release sodium valproate:
Gabapentin 400mg capsules (TD) £42.81 Epilim Chrono tablets 1200mg daily = Epilim Chrono 500mg tablets (BD) + Epilim Chrono 200mg tablet (OD)
Pregabalin 150mg capsules (BD) £40.17 Episenta MR capsules 1200mg daily = 2 x Episenta 300mg MR capsules BD
Epival CR tablets 1200mg daily = 2 x Epival 300mg CR tablets BD
Phenobarbital 30mg tablets (TD) £37.44
£0 £500 £1,000 £1,500 £2,000 £2,500 £3,000 £3,500 £4,000 £4,500 £5,000
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


37 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.9.1 Dopaminergic drugs used in Parkinson’s disease: (i) dopamine receptor


agonists

January 2020: Drugs used in parkinsonism and related disorders


- Dopamine-receptor agonists - cost of 28 days treatment
Pramipexole MR tablets
£211.86
(3.15mg, OD)
Pramipexole MR tablets
£140.54
(2.1mg, OD)
Pramipexole MR tablets
£110.38
(1.57mg, OD)
Pramipexole MR tablets
£52.90
(1.05mg, OD)
Pramipexole MR tablets
£28.69
(520mcg, OD)
Pramipexole MR tablets
£17.59
(260mcg, OD)

Pramipexole tablets
£45.33
(1050mcg [700mcg + 350mcg], TDS)
Pramipexole tablets
£6.41
(700mcg, TDS)
Pramipexole tablets
£38.92
(350mcg, TDS)
Pramipexole tablets
£11.98
(88mcg, TDS)

Rotigotine transdermal patch


£149.93
(8mg per day)
Rotigotine transdermal patch
£149.93
(6mg per day)
Rotigotine transdermal patch
£123.60
(4mg per day)
Rotigotine transdermal patch
£81.10
(2mg per day)

Ropinirole MR tablets
£126.33
(24mg, OD)
Ropinirole MR tablets
£84.22
(16mg, OD)
Ropinirole MR tablets
£42.11
(8mg, OD)
Ropinirole MR tablets
£25.09
(4mg, OD)
Ropinirole MR tablets
£12.54
(2mg, OD)

Spiroco XL® tablets


£56.82
(24mg, OD)
Spiroco XL® tablets
£37.88
(16mg, OD)
Spiroco XL® tablets
Spiroco XL = Branded
£18.94 generic ropinirole MR
(8mg, OD)
Spiroco XL® tablets
£11.28
(4mg, OD)
Spiroco XL® tablets
£5.63
(2mg, OD)

Ropinirole tablets
£323.72
(6mg [5mg + 1mg], QDS)
Ropinirole tablets
£247.51
(5mg, QDS)
Ropinirole tablets
£185.63
(5mg, TDS)
Ropinirole tablets
£36.78
(2mg, TDS)
Ropinirole tablets
£57.16
(1mg, TDS)
£0 £50 £100 £150 £200 £250 £300 £350
Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


38 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.9.1 Dopaminergic drugs used in Parkinson’s disease: (ii) levodopa, COMT


and MAO-B inhibitors

January 2020: Drugs used in parkinsonism and related disorders


- Levodopa, COMT and MAO-B inhibitors - cost of 28 days
treatment
Tolcapone tablets (200mg, TDS) £159.94
Tolcapone tablets (100mg, TDS) £79.97

Stalevo® tablets (any dose, 2 TDS) £116.44


Stalevo® tablets (any dose, 1 TDS) £58.22

Opicapone capsules (50mg, OD) £87.64

Sastravi® tablets (any dose, 2 TDS) £58.23


Sastravi® tablets (any dose, 1 TDS) £29.11 COMT inhibitors

Stanek® tablets (any dose, 2 TDS) £58.21


Stanek® tablets (any dose, 1 TDS) £29.11

Entacapone tablets (2000mg, daily) £33.41


Entacapone tablets (200mg, QDS) £13.37
Entacapone tablets (200mg, TDS) £10.02

Safinamide tablets (100mg, OD) £64.40


Safinamide tablets (50mg, OD) £64.40

Zelapar® oral lyophilisates (1.25mg, OD) £40.28


MAO-B inhibitors
Selegiline tablets (10mg, OD) £9.02
Selegiline tablets (5mg, OD) £4.63

Rasagiline tablets (1mg, OD) £2.43

Co-careldopa tablets (25mg/250mg, TDS) £29.39


Co-careldopa tablets (12.5mg/50mg, TDS) £14.35
Co-careldopa tablets (25mg/100mg, TDS) £7.93

Co-careldopa MR tablets (25mg/250mg, TDS) £16.24


Co-careldopa MR tablets (25mg/100mg, TDS) £16.24 Levodopa products

Co-beneldopa MR capsules (25mg/100mg, TDS) £10.73

Co-beneldopa capsules (50mg/200mg, TDS) £9.90


Co-beneldopa capsules (25mg/100mg, TDS) £5.80
Co-beneldopa capsules (12.5mg/50mg, TDS) £4.17

£0 £50 £100 £150 £200


Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


39 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.10.2 Nicotine dependence


January 2020: Nicotine dependence - cost of 7 days treatment

Nicotine 2 mg sublingual tablets (40) £42.64

Nicorette QuickMist® (single pack) 1mg/spray (64


sprays) £38.92

Nicorette® nasal spray (64 sprays) £36.24

Nicorette QuickMist® (double pack) 1mg/spray


(64 sprays) £30.73

Nicotinell® lozenge 1 mg (25 lozenges) £16.63

Nicotinell® chewing gum 2 mg (25 pieces) £15.06

Varenicline 1 mg (BD) £13.65

Niquitin® 7, 14, or 21 mg (1 patch) £11.48

Nicorette® chewing gum 4 mg (15 pieces) £11.22

Nicotinell® chewing gum 4 mg (15 pieces) £11.22

Nicorette® patches 5, 10, or 15 mg (1 patch) £10.99

Niquitin® lozenges 2 or 4 mg (15 lozenges) £10.79

Nicorette® chewing gum 2 mg (15 pieces) £10.27

Nicotinell TTS 30® (1 patch) £9.97

Bupropion 150 mg MR (BD) £9.74

Nicotinell TTS 20® (1 patch) £9.40

Nicotinell TTS® 10 (1 patch) £9.12

Doses given do not imply therapeutic equivalence £0 £10 £20 £30 £40 £50
copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


40 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

4.11 Drugs for dementia


January 2020: Drugs for dementia - cost of 1 year's treatment

Galantamine 24mg
MR capsules £1,037.40

Galantamine 12mg
tablets £963.30

Rivastigmine 4.6mg/24
hours patches £946.04

Memantine hydrochloride
5 mg/actuation oral solution £897.04

Galantamine 16mg
MR capsules £843.70

Rivastigmine 6mg
capsules £836.94

Galantamine 8mg
tablets £805.61

Gatalin XL® 24mg


capsules £518.70

Gatalin XL® 16mg


capsules £421.85

Rivastigmine 9.5mg/24
hours patches £242.30

Donepezil 10mg orodispersible


tablets £134.68

Donepezil 5mg orodispersible


tablets £115.31

Rivastigmine 3mg
capsules £72.80

Memantine 20mg
tablets £25.48

Donepezil 10mg
tablets £14.95

Donepezil 5mg
tablets £12.87

£0 £200 £400 £600 £800 £1,000 £1,200

Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


41 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

5 Infections: miscellaneous antibacterial and anthelmintic drugs


January 2020: Miscellaneous antimicrobial and anthelmintic drugs - cost of 5 days
treatment
Nitrofurantoin MR (200 mg) £6.79
Pivmecillinam (400mg initially,
200mg TDS for 3 days) £5.40

Fosfomycin 3g (1 sachet) £4.86

Nitrofurantoin capsules (200 mg) £3.48

Metronidazole tablets (1.2 g) £2.84

Nitrofurantoin tablets (200 mg) £2.76

Co-trimoxazole 480 mg (4) £1.36


Azithromycin (500 mg, three
doses only) £1.26

Erythromycin (1g) £1.21

Clarithromycin (250 mg BD) £1.04

Trimethoprim (400 mg) £0.65


Mebendazole (100 mg, single-
dose only) £0.22

£0 £1 £2 £3 £4 £5 £6 £7 £8
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


42 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

5.1 Antibiotics: solid and liquid formulations


January 2020: Antibiotics: solid and liquid formulations - cost
per course of treatment

250mg/5ml
£16.14
Flucloxacillin oral solution:
250mg QDS (7 days)
250mg caps: £1.67

250mg/5ml
Erythromycin suspension: £8.77
250mg QDS (5 days)
250mg tabs: £1.21

250mg/62mg/5ml
Co-Amoxiclav suspension: £5.00
TDS (5 days) 250mg/125mg
tabs: £1.56

50mg/5ml
Trimethoprim suspension: £4.99
100mg BD (3 days)
100mg tabs: £0.19

250mg/5ml
Clarithromycin suspension: £4.84
250mg BD (5 days)
250mg tabs: £1.04

250mg/5ml
Penicillin V oral solution: £4.78
250mg QDS (5 days)
250mg tabs: £0.81

250mg/5ml
suspension: £3.84
Amoxicillin 250mg caps: £1.86
500mg TDS (5 days)
500mg caps: £1.05

The chart is based on course


length. Liquid preparations
250mg/5ml
£1.40 are costed to the nearest
suspension:
Cefalexin pack required to meet the
250mg TDS (5 days) 250mg tabs: £1.27 prescription course length.

250mg caps: £1.03

£0 £5 £10 £15 £20


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


43 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

5.1.1 Penicillins
January 2020: Penicillins - cost of 5 days treatment

Ampicillin (1 g) £14.39

Augmentin 375® (3 tablets) £3.59

Co-fluampicil 250/250 (4 capsules) £1.86

Co-amoxiclav 250/125 (3 tablets) £1.56

Flucloxacillin (1 g) £0.96

Amoxicillin (750 mg) £0.93

Phenoxymethylpenicillin / Penicillin
V (1 g) £0.81

£0 £2 £4 £6 £8 £10 £12 £14 £16


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents
5.1.2 Cephalosporins
January 2020: Cephalosporins - cost of 5 days treatment

Cefuroxime (250 mg BD) £12.66

Cefixime (200 mg) £9.45

Cefaclor MR (375 mg BD) £6.50

Cefadroxil (500 mg BD) £3.23

Cefradine (500 mg BD) £2.49

Cefalexin tablets (500 mg BD) £1.36

Cefalexin capsules (500 mg BD) £1.02

£0 £2 £4 £6 £8 £10 £12 £14


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


44 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

5.1.3 Tetracyclines
January 2020: Tetracyclines - cost of 5 days treatment

*†Minocycline tablets (100 mg) £2.53

*†Minocycline capsules (100


£2.34
mg)

*Tetracycline (1 g) £1.88

† see NHSE and NHSI (2019).


Items which should not routinely be
*†Minocycline MR (100 mg) £1.79 prescribed in primary care:
Guidance for CCGs. Select the link
beneath the chart.

Lymecycline (816 mg) £1.56

*Oxytetracycline (1 g) £1.36

*Doxycycline (100 mg) £1.03

*Lymecycline (408 mg) £0.78


*courses for acne will be
longer than 5 days
£0 £1 £1 £2 £2 £3 £3
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Items which should not routinely be prescribed in primary care: Guidance for CCGs
Contents
5.1.12 Quinolones
January 2020: Quinolones - cost of 5 days treatment

Ofloxacin (800 mg) £26.72

Levofloxacin (500 mg) £12.14

Moxifloxacin (400 mg) £11.00

Ciprofloxacin (500 mg BD) £1.01

Ciprofloxacin (250 mg BD) £0.81

£0 £5 £10 £15 £20 £25 £30


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


45 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

5.2 Antifungal drugs: miscellaneous, including topical and gynaecological


January 2020: Miscellaneous antifungal drugs (including topical and gynaecological) -
cost of 28 days treatment unless otherwise stated

Clotrimazole pessary (500 mg x 1) £5.54

Miconazole oral gel (15 g, 1 tube) £4.01


Ketoconazole 2% shampoo (120
ml) £3.90

Terbinafine (250 mg OD, 28 days) £3.56

Itraconazole (200 mg OD, 7 days) £2.93


Nystatin suspension (1 ml, QDS, 1
week) £2.56
Fluconazole (50 mg OD for 2
weeks) £1.86

Miconazole 2% cream (30 g, 1 tube) £1.82


Clotrimazole 1% cream (20 g, 1
tube) £1.21

Fluconazole (150 mg, single-dose) £0.87

Itraconazole (200 mg BD, 1 day) £0.84

£0 £1 £2 £3 £4 £5 £6
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


46 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

6.1.1 Insulin: prefilled (PF) pens and cartridges


January 2020: Insulins (prefilled pens) - cost of 1 year's treatment
Long-acting insulin+GLP-1
Xultophy® (40 units) £1,545.46 combination
Humalog® Mix 25 KwikPen (40 units) £300.71
Humalog® Mix 50 KwikPen (40 units) £300.71
NovoMix® 30 FlexPen (40 units) £290.13 Mixed Insulins
Humulin M3® KwikPen (40 units) £210.63
Insuman® Comb 25 SoloStar (40 units) £192.19
Suliqua® 100u/50mcg/ml (40 units) £1,092.00
Suliqua® 100u/33mcg/ml (40 units) £829.92
Tresiba® FlexTouch (40 units) £452.33
Levemir® FlexPen (40 units) £407.68
Toujeo® SoloStar (45 units) £401.98
Lantus® SoloStar (40 units) £366.62 Intermediate and long acting insulins

Abasaglar® KwikPen (40 units) £342.45


Semglee® (40 units) £291.10
Humulin I® KwikPen (40 units) £210.63
Insulatard® InnoLet (40 units) £198.02
Insuman® Basal SoloStar (40 units) £192.19
NovoRapid® FlexPen (40 units) £297.02
Humalog® KwikPen (40 units) £285.96 Short acting insulins
Apidra® SoloStar (40 units) £274.70
Insulin Lispro Sanofi® SoloStar (40 units) £243.05
£0 £200 £400 £600 £800 £1,000 £1,200 £1,400 £1,600 £1,800
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

Mi January 2020: Insulins (cartridges) - cost of 1 year's treatment

Humalog® Mix 50 (40 units) £285.96


Humalog® Mix25 (40 units) £285.96
NovoMix® 30 (40 units) £279.45
Humulin M3® (40 units) £185.20 Mixed Insulins
Insuman® Comb 25 (40 units) £169.87
Insuman® Comb 50 (40 units) £169.87
Tresiba® (40 units) £452.33
Levemir® (40 units) £407.68
Lantus® (40 units) £366.62
Abasaglar® (40 units) £342.45
Insulatard® (40 units) £222.28
Intermediate and long acting insulins
Humulin I® (40 units) £185.20
Insuman® Basal (40 units) £169.87
Humalog® (40 units) £274.80
NovoRapid® (40 units) £274.80
Apidra® (40 units) £274.70
Short acting insulins
Insulin Lispro Sanofi® (40 units) £233.54
Humulin S® (40 units) £185.20
Insuman Rapid® (40 units) £169.87
£0 £50 £100 £150 £200 £250 £300 £350 £400 £450 £500
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


47 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

Hypodermic equipment: (i) needles for PF and reusable insulin pens (4mm to 6
mm)4
January 2020: Needles for Pre-filled and Reusable Insulin Pens
4mm to 6mm - cost of 100 needles [Blue signifies safety needles]
Registered trade names ®
BD AutoShield Duo £30.41
Microdot Dual Safety £25.00
Dropsafe Safety £23.00
Mylife Clickfine AutoProtect £19.00
Microdot Safety £17.00
Neon Verifine Safety £14.89
NovoFine £13.02
NovoTwist £12.99
GlucoRx Safety £12.95
Microdot Max Safety £12.89
Insupen 33G £12.69
Unifine Pentips 33G + Unifine
Pentips Plus £12.50
Unifine Pentips 5mm/31G £12.00
Unifine Pentips 31G & 32G £11.75
IME-FINE £11.20
BD Micro-Fine Ultra
& BD Micro-Fine+ £9.80
Mylife Clickfine £9.11 NHS Clinical Commissioners and NHS
England guidance recommends that
Nanopass £7.60 prescribers in primary care should not
NeedleBay Fine
initiate insulin needles that cost more than
£6.95
£5 per 100 needles for any diabetes
Omnican Fine 31G £6.01 patient. For further details, select the link
Glucoject, Insupen & Unifine beneath the chart
Pentips Plus £5.95
HaemoFine £5.35
Microdot Droplet £4.95
GlucoRx FinePoint and Neon BD Viva pen needles
Verifine £4.50
supplied in packs of
BD Viva £3.99 90 costing £3.59
TriCare, 4SURE 31G & 32G
+ Omnican Fine 32G £3.95
PROFine £3.80
Mylife Penfine Classic £3.55
GlucoRx CarePoint
and CareFine £2.75
Microdot Max £2.74

£0 £5 £10 £15 £20 £25 £30 £35

Needles may not be interchangeable - consult product literature copyright © RDTC 2020

Items which should not routinely be prescribed in primary care: Guidance for CCGs
Contents

4
NHS BSA Drug tariff, Part IXA: Appliances
NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES
48 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

Hypodermic equipment: (ii) needles for PF and reusable insulin pens (8 mm)4
January 2020: Needles for Pre-filled and Reusable Insulin Pens 8mm -
cost of 100 needles [Blue signifies safety needles]
Registered trade names ®

Dropsafe Safety £23.00

NovoFine Autocover £22.28

Mylife Clickfine AutoProtect £19.00

Neon Verifine Safety £14.89

GlucoRx Safety £12.95

NovoFine £9.24

Mylife Clickfine £9.11

Unifine Pentips £8.25

IME-FINE £8.20

BD Micro-Fine+ £7.99

Nanopass £7.60
NHS Clinical Commissioners and NHS
NeedleBay Fine £6.95 England guidance recommends that
prescribers in primary care should not
Omnican Fine £6.01 initiate insulin needles that cost more than
£5 per 100 needles for any diabetes
Glucoject, Insupen & Unifine patient. For further details, select the link
Pentips Plus £5.95
beneath the chart
HaemoFine £5.35

Microdot Droplet £4.95


GlucoRx FinePoint and Neon
Verifine £4.50
BD Viva pen needles
BD Viva £3.99 supplied in packs of
90 costing £3.59
TriCare and 4SURE £3.95

PROFine £3.80

Mylife Penfine Classic £3.55


GlucoRx CarePoint
and CareFine £2.75

£0 £5 £10 £15 £20 £25


Needles may not be interchangeable - consult product literature copyright © RDTC 2020

Items which should not routinely be prescribed in primary care: Guidance for CCGs
Contents

4
NHS BSA Drug tariff, Part IXA: Appliances
NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES
49 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

Hypodermic equipment: (iii) lancets4


January 2020: Hypodermic equipment: lancets - cost of 100
Registered trade names ®
lancets
Unistik 3 Comfort lancets
1.8mm/28gauge £6.17

Softclix lancets
0.4mm/28gauge £4.03

FreeStyle lancets
0.5mm/28gauge £3.82

Microlet lancets
0.5mm/28gauge £3.72

Greenlan lancets
0.35mm/28gauge £3.00

CareSens lancets
0.36mm/28gauge £2.95

OneTouch Delcia Plus lancets


0.32mm/30gauge £2.93

FastClix lancets
0.3mm/30gauge £2.89

Vitrex Soft lancets


0.65mm/23gauge £2.85

Palmdoc Lancets
0.38mm/30gauge £2.85

Milward Steri-Let Lancets


0.36mm/28gauge £2.85

Mylife lancets multicolour


0.3mm/30gauge £2.75

Mylife lancets
0.3mm/30gauge £2.75

Glucoject PLUS lancets


0.20mm/33gauge £2.75

AgaMatrix Ultra-Thin lancets


0.35mm/28gauge £2.72

GlucoZen lancets
0.36mm/28gauge £2.50

GlucoRx lancets
0.31mm/30gauge £2.25

Apollo twist lancets


0.36mm/28gauge £2.25

palmdoc iCare Advanced lancets


0.38mm/30gauge £2.23

Microdot Plus lancets


0.3mm/30gauge £2.19

Droplet lancets
0.31mm/30gauge £2.19

£0 £1 £2 £3 £4 £5 £6 £7
copyright © RDTC 2020
Contents

4
NHS BSA Drug tariff, Part IXA: Appliances
NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES
50 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

6.1.6 Blood glucose monitoring: (i) test strips (50) greater than £10
January 2020: Blood glucose monitoring - cost of 50 tests more
than £10
Registered trade names ®
FreeStyle Lite £16.41

FreeStyle £16.40

FreeStyle Optium £16.30

Sensocard £16.30

Aviva and Guide £16.21

Glucomen LX Sensor £15.76

Myglucohealth £15.50

Contour Next £15.16

OneTouch Verio £15.12

Medisense SoftSense £15.05

Breeze 2 £15.00
Betachek C50
Betachek C50 £14.99 testing strips
w hen supplied in
Dario packs of 100
£14.95 costing £29.98

GlucoDock and MediTouch £14.90

Mendor Discreet £14.75

BGStar £14.73

Betachek G5 £14.19

IME-DC £14.10

MODZ and FineTouch £14.00

On-Call Advanced £13.65

palmdoc iCare Advanced Solo £13.50

CareSens N £12.75

MediTouch 2 £12.49

Active £10.03

£0 £5 £10 £15 £20


Test strips are not usually interchangeable - consult manufacturers' literature copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


51 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

6.1.6 Blood glucose monitoring: (ii) test strips (50) less than £10
January 2020: Blood glucose monitoring - cost of 50 tests below
£10
Registered trade names ®
Contour, Mobile and
OneTouch Select Plus £9.99
GlucoMen areo Sensor and
Advocate Redi-Code+ £9.99
Dario Lite and
CareSens PRO £9.95
GlucoRx GO and
GO Professional £9.95
TRUEyou £9.92
OKmeter Core £9.90
Omnitest 3 and 5 £9.89
Element, GlucoLab
and GluNEO £9.89
palmdoc iCare Advanced £9.70
Contour TS £9.60
Mylife Pura and Unio £9.50
Microdot + £9.49
Fora Advanced pro GD40 £9.25
AutoSense testing
AutoSense £9.00 strips w hen
supplied in packs
VivaChek Ino and 4SURE £8.99 of 25 costing £4.50
GlucoRx HCT Glucose
and Nexus £8.95
WaveSense JAZZ
and JAZZ Duo £8.74
Contour Plus £8.50
SURESIGN Resure £8.49
TEE2 £7.75
Performa £7.50
Microdot Max £7.49
SD Codefree and
*Kinetik Wellbeing £6.99
Betachek Visual £6.80
Visually
readable
Glucoflex-R £6.75
*True Metrix £6.25
Finetest Lite £5.95
*The follow ing products are based on
palmdoc £5.90 w hen they are supplied in packs of
100 costing:
GlucoRx Q £5.45 *GlucoZen.auto - £10.85
Kinetik Wellbeing - £13.98
*GlucoZen.auto £5.43 *True Metrix -£12.50

£0 £2 £4 £6 £8 £10 £12
Test strips are not usually interchangeable - consult manufacturers' literature copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


52 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

6.1.2 Antidiabetic drugs (i)


January 2020: Antidiabetic drugs - cost of 1 year's treatment

Exenatide (10mcg BD) £993.60


Exenatide (2mg once weekly) £953.68
*Dulaglutide (1.5mg once weekly) £952.25
*Semaglutide (0.5mg once weekly) £952.25
Tolbutamide (500mg TDS) £826.80
Empagliflozin / Linagliptin (10mg/5mg OD) £726.44
Lixisenatide (20mcg OD) £702.88
Liraglutide (0.6mg OD) £476.11
*Empagliflozin / metformin (12.5mg/1g BD) £475.67
*Dapagliflozin / metformin (5mg/1g BD) £475.67
Empagliflozin (10mg OD) £475.67
Dapagliflozin (10mg OD) £475.67
*Canagliflozin / metformin (50mg/1g BD) £475.63
Canagliflozin (100mg OD) £475.63
Vildagliptin (50mg BD) £433.55
*Vildagliptin / metformin (50mg/1g BD) £432.92
Metformin / sitagliptin (1g/50mg BD) £432.38
*Linagliptin / metformin (2.5mg/1g BD) £432.38
Sitagliptin (100mg OD) £432.38
Linagliptin (5mg OD) £432.38
*Saxagliptin / metformin (2.5mg/1g BD) £410.80
Saxagliptin (5mg OD) £410.80
Pioglitazone / metformin (15mg/850mg BD) £389.35
*Ertugliflozin (5mg OD) £382.20
Alogliptin / metformin (12.5mg/1g BD) £345.80
*Alogliptin (25mg OD) £345.80
Nateglinide (60mg TDS) £339.56
Acarbose (50mg TDS) £176.90
*The cost is identical irrespective
Metformin 500mg MR: Glucophage® SR (1.5g OD) £78.00 of strength of preparation
Glipizide (5mg OD) £65.00
Needles are included in packs of long-acting
Metformin (500mg TDS) £40.95 exenatide (2mg once w eekly), dulaglutide
(1.5mg once w eekly) and Semaglutide
Glimepiride (4mg OD) £38.83 (0.5mg once w eekly) at no extra cost. The
Repaglinide (2mg OD) £21.88 cost of needles for other GLP-1 agonists w ill
vary betw een £22 pa and £95 pa,
Pioglitazone (30mg OD) £21.19 depending on dose frequency and needle
choice.
Gliclazide (80mg OD) £13.78

£0 £500 £1,000 £1,500


Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


53 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

6.1.2 Antidiabetic drugs: (ii) new agents


January 2020: Antidiabetic drugs - Newer agents - cost of 1 year's
treatment

Exenatide (10mcg BD) £993.60

Exenatide (2mg once weekly) £953.68

*Semaglutide (0.5mg once weekly) £952.25

*Dulaglutide (1.5mg once weekly) £952.25

Empagliflozin / Linagliptin (10mg/5mg OD) £726.44

Lixisenatide (20mcg OD) £702.88

Liraglutide (0.6mg OD) £476.11

*Dapagliflozin / metformin (5mg/1g BD) £475.67

Empagliflozin (10mg OD) £475.67

*Empagliflozin / metformin (12.5mg/1g BD) £475.67

Dapagliflozin (10mg OD) £475.67

*Canagliflozin / metformin (50mg/1g BD) £475.63

Canagliflozin (100mg OD) £475.63

Vildagliptin (50mg BD) £433.55

*Vildagliptin / metformin (50mg/1g BD) £432.92

*Linagliptin / metformin (2.5mg/1g BD) £432.38

Linagliptin (5mg OD) £432.38

Metformin / sitagliptin (1g/50mg BD) £432.38

Sitagliptin (100mg OD) £432.38

*Saxagliptin / metformin (2.5mg/1g BD) £410.80 *The cost is identical irrespective


of strength of preparation

Saxagliptin (5mg OD) £410.80 Needles are included in packs of long-acting


exenatide (2mg once w eekly), dulaglutide
*Ertugliflozin (5mg OD) £382.20 (1.5mg once w eekly) and Semaglutide
(0.5mg once w eekly) at no extra cost. The
cost of needles for other GLP-1 agonists w ill
Alogliptin / metformin (12.5mg/1g BD) £345.80 vary betw een £22 pa and £95 pa,
depending on dose frequency and needle
*Alogliptin (25mg OD) £345.80 choice.

£0 £200 £400 £600 £800 £1,000 £1,200


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


54 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

6.4.1 Female sex hormones and their modulators: (i) combination HRT
preparations
January 2020: Combination HRT preparations - cost of 28 days
treatment

Duavive® (Conjugated
oestrogens/bazedoxifene) £15.00

Femoston® Conti (estradiol/dydrogesterone) £8.14


Indivina® (estradiol/medroxyprogesterone)
1mg/2.5 - 2mg/5mg £6.86

Elleste Duet Conti® (estradiol/norethisterone) £5.67 Oral

Kliovance® (estradiol/norethisterone) £4.40

Kliofem® (estradiol/norethisterone) £3.81 Continuous


Premique® (conjugated
oestrogens/medroxyprogesterone) Low dose £2.17

FemSeven® Conti (estradiol/levonorgestrel)


weekly £14.71
Evorel® Conti (estradiol/norethisterone) twice
weekly £12.41 Transdermal

FemSeven® Sequi (estradiol/levonorgestrel)


weekly £12.51
Transdermal
Evorel® Sequi (estradiol/norethisterone) twice
weekly £11.09

Tridestra® (estradiol/medroxyprogesterone) £6.30 Oral (3- monthly cycle)

Femoston® (estradiol/dydrogesterone) Cyclical


1mg/10mg - 2mg/10mg £5.39

Novofem® (estradiol/norethisterone) £3.81

Trisequens® (estradiol/norethisterone) £3.70 Oral (monthly cycle)

Clinorette® (estradiol/norethisterone) £3.08

Elleste Duet® (estradiol/norethisterone) 1mg £3.07

Elleste Duet® (estradiol/norethisterone) 2mg £3.07

£0 £5 £10 £15 £20


Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


55 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

6.4.1 Female sex hormones and their modulators: (ii) oestrogen only HRT
patches
January 2020: Oestrogen only HRT patches - cost of 28 days
treatment

FemSeven® 100mcg weekly £7.28

FemSeven® 50mcg weekly £6.01

Estradot® 100mcg twice weekly £7.27

Estradot® 25mcg twice weekly £5.99

Progynova® TS 100 twice weekly £6.90

Progynova® TS 50 twice weekly £6.30

Estraderm MX® 100mcg twice


weekly £6.66

Estraderm MX® 25mcg twice


weekly £5.49

Elleste Solo® MX 80 twice weekly £5.99

Elleste Solo® MX 40 twice weekly £5.19

Evorel® 100mcg twice weekly £4.28


Highest and lowest cost
Evorel® 25mcg twice weekly £3.42 items displayed only

£0 £1 £2 £3 £4 £5 £6 £7 £8
Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


56 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

6.4.1 Female sex hormones and their modulators: (iii) oestrogen only HRT
preparations except patches
January 2020: Oestrogen only HRT preparations (excluding
patches) - cost of 28 days treatment

Sandrena 1.5mg (1mg + 0.5mg) OD £10.93

Sandrena 0.5mg OD £5.08

Oestrogel 4 doses (3mg) per day £8.40 Topical

Oestrogel 2 doses (1.5mg) per day £4.20

Estring every 3 months £10.47

Vaginal ring

Vagifem 10mcg twice weekly £5.57 Vaginal pessary

Blissel 1 applicator (1g) twice weekly £5.04 Vaginal gel

Ovestin 1 applicator (0.5g) twice weekly £1.19 Vaginal cream

Progynova® 1mg-2mg OD £2.43

Zumenon® 1mg-2mg OD £2.30

Bedol® 2mg OD £1.69

Elleste solo® 1mg OD £1.69 Oral

Elleste solo® 2mg OD £1.69

Premarin® 0.3mg £2.02

Premarin® 0.625mg £1.34 Indications differ


between products and
Premarin® 1.25mg £1.19 strengths

£0 £2 £4 £6 £8 £10 £12
Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


57 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

6.6.2 Bisphosphonates and other drugs affecting bone metabolism


January 2020: Bisphosphonates and other drugs affecting bone metabolism - cost of
1 year's treatment

Denosumab (Prolia®) £396.50

Risedronate sodium (5 mg) £245.44

Risedronate sodium (35 mg weekly) £147.42

Ibandronic acid (150 mg monthly) £116.35

Alendronic acid (10 mg) £34.19

Alendronic acid (70 mg weekly) £12.09

£0 £50 £100 £150 £200 £250 £300 £350 £400 £450


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


58 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

7.3.1 Combined hormonal contraceptives


January 2020: Contraceptives - Combined Hormonal
Contraceptives - cost of 1 year's treatment

Registered trade names ®


Lizinna (21) £20.11
Synphase (21) £15.60 Ethinylestradiol 35 microgram
Norimin (21) £9.88
Brevinor (21) £8.62

Elevin (21) £126.75


Yasmin (21) £63.70
Dretine (28) £48.19
Yacella (21) £35.97
Marvelon (21) £30.77
Femodene (21) £29.16
Alenvona (21) £26.56
Femodene ED (28) £23.08
Katya 30/75 (21) £21.80
Gedarel 30/150 (21) £18.16
Millinette 30/75 (21) £17.85
Cimizt (21) £16.47
Ethinylestradiol 30 microgram
Microgynon 30 ED (28) £12.96
Microgynon 30 (21) £12.22
Ovranette (21) £9.53
Rigevidon (21) £8.19
Levest (21) £7.80

Eloine (28) £63.70


Femodette (21) £38.35
Mercilon (21) £36.57
Sunya (21) £28.69
Millinette 20/75 (21) £23.44 Ethinylestradiol 20 microgram
Gedarel 20/150 (21) £22.01
Bimizza (21) £21.84

Nuvaring (28) £128.70


SyreniRing (28) £102.96
Qlaira (28) £101.32
Zoely (28) £85.80
Evra (21) £84.54
Logynon (21) £16.55
Logynon ED (28) £13.00 Other contraceptives
TriRegol (21) £10.53
Norinyl-1 (21) £9.49
£0 £20 £40 £60 £80 £100 £120 £140
Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents
For a more detailed comparison of contraceptives, access the excel version of the cost comparison
charts via the RDTC website (link available via the title page). This is available to stakeholders only
under password protection
NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES
59 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

7.3.2 Progestogen-only contraceptives


January 2020: Contraceptives - Progestogen-only Contraceptives
- cost of 1 year's treatment

Registered trade names ®

Cerazette (28) £41.38

Aizea (28) £22.58

Cerelle (28) £15.17

Feanolla (28) £15.12

Oral Progestogen-only
Zelleta (28) £12.91 Contraceptives

Desorex (28) £12.78

Norgeston (28) £9.57

Noriday (28) £9.10

Sayana Press (1 every 13


wks) £29.90

Nexplanon (1 every 3 yrs) £27.81

Noristerat (1 every 8 wks) £26.33

Depo-Provera pfs (1 every Parenteral and Intra-


12 wks) £26.04 uterine Progestogen-
only Contraceptives

Jaydess (1 every 3 yrs) £23.07

Mirena (1 every 5yrs) £17.60

Kyleena (1 every 5yrs) £15.20

£0 £5 £10 £15 £20 £25 £30 £35 £40 £45


Doses given do not imply therapeutic equivalence
copyright © RDTC 2020
Contents
For a more detailed comparison of contraceptives, access the excel version of the cost comparison
charts via the RDTC website (link available via the title page). This is available to stakeholders only
under password protection
NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES
60 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

7.4.1 Drugs for urinary retention


January 2020: Drugs for urinary retention - cost of 1 year's treatment
Solifenacin 6mg / Tamsulosin 400microgram
modified-release tablets £335.12
Dutasteride 500microgram / Tamsulosin
400microgram capsules £240.24

Alfuzosin MR (10 mg) £151.79

Indoramin (40 mg) £130.68

Tamsulosin MR tablets (400 micrograms) £127.04

Prazosin (4 mg) £83.96

Tamsulosin MR capsules (400 micrograms) £46.96

Dutasteride (500 micrograms) £34.70

Terazosin (5 mg) £32.63

Alfuzosin (7.5 mg) £30.39

Finasteride (5 mg) £24.18

Doxazosin (4 mg) £15.34

£0 £50 £100 £150 £200 £250 £300 £350 £400


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


61 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

7.4.2 Drugs for urinary frequency, enuresis, and incontinence


January 2020: Drugs for urinary frequency, enuresis and
incontinence - cost of 1 year's treatment

Propiverine (15 mg TDS) £386.10

Oxybutynin patch (Kentera®) £353.60

Mirabegron MR (Betmiga® 25mg/50mg OD) £351.87

Propantheline 15 mg tablets (5) £337.03

Fesoterodine MR (4 or 8 mg OD) £335.14

Oxybutynin MR (10 mg) £334.15

Darifenacin (7.5 or 15 mg OD) £331.24

Propiverine MR (30mg) £317.85

Trospium MR (Regurin® XL 60mg) £299.65

Oxybutynin (3 mg BD) £228.15

Tolterodine MR (Neditol XL, 4 mg) £167.57

Oxybutynin MR (5 mg) £167.08

Flavoxate (200 mg TDS) £141.60

Trospium (20 mg BD) £78.50

Duloxetine (generic 40 mg BD) £54.47

Solifenacin (10 mg) £51.69

Solifenacin (5 mg) £42.95

Oxybutynin (5 mg BD) £32.11

Oxybutynin (2.5 mg BD) £25.74

Tolterodine (2 mg BD) £21.84

£0 £100 £200 £300 £400 £500


Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


62 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

7.4.5 Drugs for erectile dysfunction


January 2020: Drugs for erectile dysfunction - cost of 1 year's treatment
Alprostadil (Caverject vials)
20microgram £620.88

Alprostadil MUSE 1mg £601.12

Alprostadil 3mg/g (Vitaros®) £520.00


Alprostadil (Caverject Dual Chamber)
20microgram £494.00
Phentolamine/Aviptadil (Invicorp®)
2mg/25mcg/0.35ml £494.00

Cialis 20mg £375.44

Viagra 100mg £305.44

Vardenafil 10mg £260.65

Avanafil 200mg £256.10


*see NHSE and NHSI (2019). Items
Vardenafil 20mg £176.80 which should not routinely be
prescribed in primary care: Guidance
Avanafil 100mg £170.69 for CCGs. Select the link beneath the
chart.
*Tadalafil 5mg £98.15
N.B.: Costs, other than for tadalafil
Tadalafil 20mg £25.61 5mg, based on advice from DH
(circulated in HSC 1999/148) that one
Tadalafil 10mg £16.90 treatment per week will be sufficient for
most patients treated for erectile
Sildenafil 100mg £13.65 dysfunction.
Tadalafil 5mg cost assumes daily dose.
Sildenafil 50mg £12.61

£0 £100 £200 £300 £400 £500 £600 £700


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Items which should not routinely be prescribed in primary care: Guidance for CCGs
8.3.4.2 Gonadorelin analogues: prostate cancer indication
January 2020: Prostate cancer treatments - cost of 1 year's treatment

Degarelix (Firmagon® - 80mg) £1,552.44

Triptorelin (Gonapeptyl® - 3.75mg) £1,061.97

Goserelin (Zoladex® - 3.6mg) £910.00


Monthly

Leuprorelin (Prostap SR DCS® - 3.75mg) £902.88

Triptorelin (Decapeptyl® - 3mg) £897.00

Goserelin (Zoladex LA® - 10.8mg) £940.00


3 monthly
Leuprorelin (Prostap 3 DCS® - 11.25mg) £902.88

Triptorelin acetate (Decapeptyl® SR - 11.25mg) £828.00

Triptorelin acetate (Decapeptyl® SR - 22.5mg) 6 monthly


£828.00

£0 £200 £400 £600 £800 £1,000 £1,200 £1,400 £1,600 £1,800


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


63 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

9.6.4 Vitamin D: (i) calcium and vitamin D combination products


January 2020: Calcium + vitamin D preparations - cost of 1 year's treatment

Calcium and ergocalciferol, 2 chewable tablets


£664.04
(194 mg calcium, 800 units vitamin D)
Cacit D3®, 2 sachets dissolved in water
£98.52
(1 g calcium, 880 units vitamin D)
Calcichew D3®, 2 chewable tablets
£55.91
(1 g calcium, 400 units vitamin D)
Calfovit D3®, 1 sachet dissolved in water
£52.42
(1.2 g calcium, 800 units vitamin D)
Calcichew D3 Forte®, 2 chewable tablets
£51.45
(1 g calcium, 800 units vitamin D)
Calceos®, 2 chewable tablets
£47.81
(1 g calcium, 800 units vitamin D)
Adcal D3®, 2 chewable tablets
£47.45
(1.2 g calcium, 800 units vitamin D)
Natecal D3®, 2 chewable tablets
£44.04
(1.2 g calcium, 800 units vitamin D)
Adcal D3®, 4 caplets swallowed whole
£38.35
(1.2g calcium, 800 units vitamin D)
theiCal-D3, 1 chewable tablet (1g calcium, 880
£35.79
units vitamin D)
Accrete D3®, 2 tablets swallowed whole
£35.79
(1.2g calcium, 800 units vitamin D)
Evacal®, 2 chewable tablets
£35.75
(1.2 g calcium, 800 units vitamin D)
Calci-D®, 1 chewable tablet (1g calcium, 1,000
£29.25
units vitamin D)
£0 £20 £40 £60 £80 £100 £660 £680
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

9.6.4 Vitamin D: (ii) prevention of deficiency


January 2020: Vitamin D preparations - Prevention - cost of 28 days treatment
Desunin®, 1 tablet swallowed whole
£4.28
(800iu OD)
Fultium D3® drops,
£3.51
(800iu daily)
Fultium D3®, 1 capsule swallowed whole
£3.36
(800iu OD)
Stexerol-D3®, 1 tablet swallowed whole
£2.95
(1,000iu OD)
InVita D3®, 1 capsule swallowed whole
£2.50
(800 iU OD)
Strivit-D3®, 1 capsule swallowed whole 800iu - 1000iu daily
£2.33
(800iu OD)
Thorens® oral drops,
£1.31
(800iu daily)

Invita D3®, 1 ampoule swallowed orally


£1.48
(25,000iu monthly)
Thorens®, 1 bottle swallowed orally
£1.46
(25,000iu monthly)
Stexerol-D3®, 1 tablet swallowed whole
£1.42
(25,000iu monthly)
20,000iu - 25,000iu
InVita D3®, 1 capsule swallowed whole per 28 days
£1.32
(25,000 iU monthly)
Fultium D3®, 1 capsule swallowed whole
£0.97
(20,000iu monthly)
Plenachol®, 1 capsule swallowed whole
£0.90
(20,000iu monthly)
Aviticol®, 1 capsule swallowed whole
£0.68
(20,000iu monthly)
£0 £1 £2 £3 £4 £5
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


64 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

9.6.4 Vitamin D: (iii) treatment of deficiency


January 2020: Vitamin D preparations - Treatment - cost of 7 weeks treatment

Thorens®, 2 bottles swallowed orally


(50,000iu weekly for 7 weeks) £20.48

Stexerol-D3®, 2 tablets swallowed whole


(50,000iu weekly for 7 weeks) £19.83

Invita D3®, 1 ampoule swallowed orally


(50,000iu weekly for 7 weeks) £14.58

Fultium D3®, 2 capsules swallowed whole


(40,000iu weekly for 7 weeks) £13.53

InVita D3®, 1 capsule swallowed whole


(50,000 iU weekly for 7 weeks) £11.55

Plenachol®, 1 capsule swallowed whole


(40,000iu weekly for 7 weeks) £10.50

Aviticol®, 2 capsules swallowed whole


(40,000iu weekly for 7 weeks) £9.45

£0 £5 £10 £15 £20 £25


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


65 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

10.1.1 Non-steroidal anti-inflammatory drugs


January 2020: Non-steroidal anti-inflammatory drugs - cost of 1
year's treatment

Mefenamic acid (500 mg) £689.52

Aspirin 300 mg tablets (12) £466.83

Naproxen EC (250 mg TDS) £227.96

Tiaprofenic acid MR (300 mg BD) £194.35

Etodolac MR (600 mg) £188.07

Tenoxicam (20 mg) £162.83

Naproxen (250 mg TDS) £128.31

Aceclofenac (100 mg BD) £116.72

Nabumetone (1 g) £89.70

Naprosyn® / Naprosyn EC® (250


mg TDS) £83.66

Celecoxib (200 mg) £80.93

Diclofenac sodium (50 mg TDS) £68.25

Piroxicam (20 mg) £58.24

Ibuprofen (400 mg TDS) £47.84

Indometacin (50 mg BD) £41.34

Etoricoxib (90 mg) £36.79

Meloxicam (7.5 mg) £15.41

£0 £100 £200 £300 £400 £500 £600 £700 £800


Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


66 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

10.3.2 Rubefacients, topical NSAIDs, capsaicin, and poultices


January 2020: Rubefacients, topical NSAIDs, capsaicin, and poultices - cost of 1
year's treatment

Capsaicin 0.025% cream £429.76

Capsaicin 0.075% cream £353.81

Felbinac 3% gel £87.69

Benzydamine 3% cream (Difflam®) £74.69

Ibuprofen 10% gel (Ibugel Forte®) £63.23

Diclofenac 1% gel £50.56

*Rubefacient (e.g. Transvasin® cream) £46.82

N.B. costs are based on


Piroxicam 0.5% gel £39.88 usage of 3g/day

*see NHSE and NHSI (2019).


Ketoprofen 2.5% gel £36.47 Items which should not routinely be
prescribed in primary care:
Guidance for CCGs. Select the link
Ibuprofen 5% gel £28.83 beneath the chart.

£0 £50 £100 £150 £200 £250 £300 £350 £400 £450 £500
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Items which should not routinely be prescribed in primary care: Guidance for CCGs

11.4.2 Eye: other anti-inflammatory preparations


January 2020: Other anti-inflammatory preparations - cost of 7 day's treatment

Catacrom®
(Sodium cromoglicate 2% 0.3ml unit dose) £19.32

Sodium cromoglicate 2% 13.5ml £11.74


Opticrom Aqueous®
(Sodium cromoglicate 2%) 13.5ml £8.03 Mast-cell stabilisers

Alomide®
(Lodoxamide 0.1%) 10ml £5.21 Assumptions & Calculations
A drop equates to 0.05ml. For example a 10ml bottle
Optrex Allergy® contains 200 drops/applications per pack for non-metered-
(Sodium cromoglicate 2%) 10ml £3.88
dose products
Opticrom Allergy® 1 drop/application per eye to both eyes for lodoxamide
(Sodium cromoglicate 2%) 10ml £3.35 and sodium cromoglicate four times daily. For all
antihistamines as above but twice daily.
Pollenase Allergy® Rounded up to nearest full pack
(Sodium cromoglicate 2%) 10ml £3.35
Relestat®
(Epinastine 500 mcg/ml) 5ml £9.90
Zaditen®
(Ketotifen 250 mcg/ml) 5ml £7.80
Ketofall®
(Ketotifen 0.4ml unit dose) £6.95
Optilast®
(Azelastine 0.05%) 8ml £6.40
Antihistamines
Opatanol®
(Olopatadine 1mg/ml) 5ml £4.68
Otrivine-Antistin®
(Antazoline 0.5%, Xylometazoline 0.05%) 10ml £3.35

£0 £5 £10 £15 £20 £25


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


67 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

11.6 Treatment of glaucoma

January 2020: Treatment of Glaucoma - cost of 1 year's treatment

Dorzolamide 2% + timolol 0.5% (Cosopt®) PF £371.67

Dorzolamide 2% (Trusopt®) PF £314.34

Tafluprost + Timolol (Taptiqom®) PF £188.50

Dorzolamide 2% + timolol 0.5% (Eylamdo®) PF £185.77


Bimatoprost 0.03% (Lumigan®) PF £178.75

Latanoprost + timolol (Fixapost®) PF £175.37


Preservative free
Tafluprost (Saflutan®) PF £158.60 preparations
Dorzolamide 2% (Eydelto®) PF £157.17
Bimatoprost (Eyreida®) PF £152.23

Latanoprost (Monopost®) PF £110.37

Timolol gel (Tiopex®) PF £97.37

Pilocarpine 4% £369.20
Pilocarpine 2% £296.27

Pilocarpine 1% £288.60

Bimatoprost + timolol (Ganfort®) £184.08

Travoprost + timolol (Duotrav®) £181.35


Bimatoprost 0.01% (Lumigan®) £152.23

Brinzolamide + timolol (Azarga®) £143.65

Brimonidine + timolol (Combigan®) £130.00

Brinzolamide 1% + Brimonidine 0.2% (Simbrinza®) £119.99


Latanoprost £64.48
Latanoprost + timolol £48.75

Timolol 0.25% LA (Timoptol®-LA) £40.56

Timolol 0.5% LA (Timoptol®-LA) £40.56

Travoprost £38.87
Brinzolamide £36.40

Dorzolamide 2% £31.46

Dorzolamide 2% + timolol 0.5% £30.81

Brimonidine 0.2% £29.77


Betaxolol 0.5% (Betoptic®) £24.70

Levobunolol 0.5% £24.05

Timolol 0.5% £19.24

Timolol 0.25% £18.20

£0 £100 £200 £300 £400


Doses given do not imply therapeutic equivalence
copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


68 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

11.8.1 Tear deficiency, ocular lubricants, and astringents


January 2020: Tear deficiency, ocular lubricants, and astringents - cost of 1 year's
treatment
Sodium hyaluronate 0.15% PF (Hyabak) 10ml £87.89
Carmellose and glycerol (Optive) 10ml £82.39
Carmellose, glycerol and castor-oil (Optive Plus) 10ml £82.39
Sodium hyaluronate 0.4% PF (Clinitas Multi) 10ml £76.89
Sodium hyaluronate 0.20% PF (Hyloforte) 10ml £76.00
Sodium Hyaluronate 0.2% PF (Evolve HA) 10ml £65.89
Sodium hyaluronate 0.15% (Oxyal) 10ml £58.10
Liquid paraffin (Lacrilube ointment) 5g £55.72
Carmellose sodium 0.5% PF (Evolve Carmellose) 10ml £54.89
Sodium hyaluronate (Aeon Protect) 10ml £50.60 NHS Clinical Commissioners and
NHS England guidance recommends
Hypromellose 0.3% PF (Tear-Lac) 10ml £46.40 that a prescription for treatment of
dry or sore eyes should not routinely
Sodium hyaluronate 0.03% PF (Hylofresh) 10ml £39.60 be offered in primary care as the
condition is appropriate for self-care.
Carbomer 980 0.2% (Geltears) 10g £39.20 See guidance link below chart.
Hypromellose 0.3% (Generic) 10ml £18.34 Assumptions & Calculations
200 drops/applications per pack for non-metered-dose products
Polyvinyl alcohol (Sno Tears) 10ml £13.78 1 drop/application per eye to both eyes TDS for 365 days for
drops. 1 application at night for ointments.
Liquid paraffin + retinol (VitA-POS ointment) 5g £8.25 Rounded up to nearest full pack
£0 £20 £40 £60 £80 £100
Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Pe
Conditions for which over the counter items should not routinely be prescribed in primary
care: Guidance for CCGs. (2018)

12.2.1 Drugs used in nasal allergy: corticosteroids


January 2020: Nasal steroids - cost of 28 days treatment

Fluticasone 50 mcg/Azelastine 137 mcg (Dymista®)


1 spray both nostrils bd £13.81

Triamcinolone 55 mcg (Nasacort®)


1 spray both nostrils od £3.45

Fluticasone proprionate 50mcg


1 spray both nostrils od £3.19

Mometasone 50 mcg (Nasonex®)


1 spray both nostrils od £3.07

Fluticasone furoate 27.5 mcg (Avamys®)


1 spray both nostrils od £3.01

Fluticasone proprionate 50mcg (Nasofan®)


1 spray both nostrils od £3.00

Beclometasone 50 mcg (200 dose)


1 spray both nostrils bd £2.04

Budesonide 64 mcg (Rhinocort aqua®)


1 spray both nostrils od £1.76

£0 £2 £4 £6 £8 £10 £12 £14 £16


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


69 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

13.2.1 Emollients: (i) cost of 1 year’s treatment


January 2020: Emollients: cost of 1 year’s treatment - cost of 1
year's treatment

Calmurid® (500g) £2,084.16


Balneum® plus (500g) £935.38
E45® Itch relief (500g) £935.38 Preparations containing urea
Hydromol® cream (500g) £756.29
Ultrabase® (500g) £541.01
Aveeno® lotion (500ml) £415.58
Dermol® cream (500g) £413.71
Epaderm® ointment (500g) £410.59
Aveeno® cream (500ml) £403.73
Thirty:30® ointment (500g) £403.73
Epaderm® Junior ointment (125g) £400.40
Diprobase® cream (500g) £394.37
Aqueous cream (500g) £390.00
Dermol® lotion (500ml) £376.90
Diprobase® ointment (500g) £373.78
E45® cream £373.78
Cetraben® (500g) £373.78
Doublebase® gel (500g) £363.79
Oilatum® cream (500ml) £329.47
Zerobase® cream (500g) £328.22
Epaderm® Junior cream (150g) £310.27
Hydromol® ointment (500g) £309.50
Zerodouble® gel (500g) £305.76
MyriBase® gel (500ml) £290.78
E45® lotion (500ml) £286.42
LP/WSP ointment (50:50) (500g) £285.17
Yellow Soft Paraffin (500g) £260.83
Zeroderm® ointment (500g) £255.84
ZeroCream® (500g) £254.59
White Soft Paraffin (500g) £251.47
AproDerm® ointment (500g) £246.48
Fifty:50® ointment (500g) £228.38
ZeroAQS® emollient cream (500g) £205.30
Epimax® ointment (500g) £186.58
ExCetra® cream (500g) £184.08 Volumes can vary between products. Usage is
based on 600g or 600ml per week per adult. For
Isomol® gel (500g) £182.21 Oilatum® Junior cream and Epaderm® Junior
Epimax® cream (500g) £155.38 cream/ointment, usage is based on 250g or
250ml per week.
Oilatum® Junior cream (500ml) £137.28
£0 £500 £1,000 £1,500 £2,000 £2,500
Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


70 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

13.2.1 Emollients: (ii) cost per 100g or 100ml

January 2020: Emollients: cost per 100g or 100ml

Calmurid® (500g) £6.68


Balneum® plus (500g) £3.00
E45® Itch relief (500g) £3.00 Preparations containing urea
Epaderm® Junior ointment (125g) £3.08
Hydromol® Cream (500g) £2.42
Epaderm® Junior cream (150g) £2.39
Ultrabase® (500g) £1.73
Aveeno® Lotion (500ml) £1.33
Dermol® Cream (500g) £1.33
Epaderm® ointment (500g) £1.32
Aveeno® cream (500ml) £1.29
Thirty:30® Ointment (500g) £1.29
Diprobase® Cream (500g) £1.26
Aqueous Cream (500g) £1.25
Dermol® Lotion (500ml) £1.21
Diprobase® Ointment (500g) £1.20
E45® Cream £1.20
Cetraben® (500g) £1.20
Doublebase® Gel (500g) £1.17
Oilatum® Cream (500ml) £1.06
Oilatum® Junior cream (500ml) £1.06
Zerobase® cream (500g) £1.05
Hydromol® ointment (500g) £0.99
Zerodouble® gel (500g) £0.98
MyriBase® gel (500ml) £0.93
E45® Lotion (500ml) £0.92
LP/WSP Ointment (50:50) (500g) £0.91
Yellow Soft Paraffin (500g) £0.84
Zeroderm® ointment (500g) £0.82
ZeroCream® (500g) £0.82
White Soft Paraffin (500g) £0.81
AproDerm® ointment (500g) £0.79
Fifty:50® Ointment (500g) £0.73
ZeroAQS® emollient cream (500g) £0.66
Epimax® ointment (500g) £0.60
ExCetra® cream (500g) £0.59
Isomol® gel (500g) £0.58
Epimax® cream (500g) £0.50
£0 £1 £2 £3 £4 £5 £6 £7 £8
Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


71 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

13.2.1 Emollients: (iii) bath and shower preparations, cost per 100g or 100ml
January 2020: Emollients: bath and shower preparations (cost per
100g or 100ml)
Oilatum® shower gel fragrance free (150g) £3.51

Doublebase® emollient shower gel (200g) £2.61

Dermol® shower emollient (200ml) £1.78

Oilatum® Bath Formula (300ml) £1.67

Oilatum® Plus bath additive (500ml) £1.59

Balneum Plus bath oil (500ml) £1.33

E45 emollient wash cream (250ml) £1.32

Dermol® Bath Emollient (600ml) £1.26

Aqueous Cream (500g) £1.25

Dermol® Lotion (500ml) £1.21

Emulsiderm emollient (1000ml) £1.20

Doublebase® Gel (500g) £1.17

Oilatum® Emollient (500ml) £1.16

Cetraben® emollient bath additive (500ml) £1.15

Oilatum® Junior bath additive (600ml) £1.11

Doublebase emollient bath additive (500ml) £1.09

Balneum® Bath Oil (500ml) £1.08

E45® emollient bath oil (500ml) £1.06

Zerolatum® Emollient bath additive (500ml) £0.96 N.B. see NHSE and NHSI (2019).
Items which should not routinely be
Hydromol® Bath & Shower emollient (500ml) £0.89 prescribed in primary care:
Guidance for CCGs. Select the link
beneath the chart.
LPL 63.4 (500ml) £0.63

£0 £1 £2 £3 £4
Doses given do not imply therapeutic equivalence copyright © RDTC 2020
Items which should not routinely be prescribed in primary care: Guidance for CCGs
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


72 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

13.4 Topical corticosteroids (skin): (i) cost per 30g

January 2020: Topical corticosteroids per 30g

Nerisone Forte® (difluocortolone 0.3%)


oily cream £9.40
Dermovate® (clobetasol 0.05%)
cream/oint £2.37
Very Potent
ClobaDerm® (Clobetasol 0.05%)
cream/oint £2.25

Synalar® (fluocinolone 0.025%)


£5.01
gel
Nerisone® (diflucortolone 0.1%)
£4.95
oily cream
Elocon® (mometasone 0.1%)
cream £4.53
Cutivate® (fluticasone 0.05%)
cream/oint £4.24
Metosyn® (fluocinonide 0.05%)
£4.00
cream
Nerisone® (diflucortolone 0.1%)
cream/oint £3.98
Metosyn® (fluocinonide 0.05%) Potent
£3.95
oint
Elocon® (mometasone 0.1%)
oint £3.73
Synalar® (fluocinolone 0.025%)
£3.53
cream/oint
Diprosone® (betamethasone 0.05%)
£1.84
cream/oint
Locoid® (Hydrocortisone butyrate 0.1%)
cream/oint £1.48
Betnovate® (Betamethasone valerate 0.1%)
£1.22
cream/oint
Audavate® (betamethasone 0.1%)
£1.16
oint

Eumovate® (clobetasone 0.05%)


cream/oint £1.63
Clobavate® (Clobetasone 0.05%)
oint £1.31
Betnovate RD® (betamethasone 0.025%) Moderate
cream/oint £0.95
Audavate RD® (betamethasone 0.025%)
cream/oint £0.90

Hydrocortisone 0.5% ointment £88.00

Hydrocortisone 1% ointment £2.60

Hydrocortisone 0.5% cream Mild


£2.52
Hydrocortisone 1% cream £2.42

£0 £2 £4 £6 £8 £10 £86 £88 £90

Doses given do not imply therapeutic equivalence copyright © RDTC 2020


Contents
NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES
73 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

13.4 Topical corticosteroids (skin): (ii) combination corticosteroid and


antimicrobial products
January 2020: Topical corticosteroids with antimicrobial per 30g
Clobetasol propionate with neomycin
and nystatin cream/oint £87.00 Very Potent

Betamethasone 0.1%, clioquinol 3%


cream/oint £38.88
Betamethasone 0.1%, neomycin 0.5%
cream/oint £31.36
Fucibet® (betamethasone 0.1%,
fusidic acid 2%) cream £6.38
Lotriderm® (betamethasone 0.064%,
clotrimazole 1%) cream £6.34
Xemacort® (betamethasone 0.1%, Potent
fusidic acid 2%) cream £6.23
Synalar C® (fluocinolone 0.025%,
clioquinol 3%) cream/oint £5.32
Synalar N® (fluocinolone 0.025%,
neomycin 0.5%) oint £4.36

Trimovate® (clobetasone 0.05%,


oxtetracycline, nystatin) cream £12.45 Moderate

Fucidin H® (hydrocortisone 1%,


fusidic acid 2%) cream £6.03
Timodine® (hydrocortisone 0.5%,
nystatin) cream £3.37
Mild
Daktacort® (hydrocortisone 1%,
miconazole) oint £2.50
Daktacort® (hydrocortisone 1%,
miconazole) cream £2.49
Canesten HC® (hydrocortisone 1%,
clotrimazole 1%) cream £2.42
£0 £10 £20 £30 £40 £50 £60 £70 £80 £90 £100
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

13.5 Preparations for eczema and psoriasis: scalp


January 2020: Preparations for eczema and psoriasis: scalp (cost per 100g or 100ml)

Elocon® 0.1% scalp lotion (30ml) £14.53

Sebco® ointment (100g) £13.38

Cocois® ointment (100g) £11.69

Dermovate® 0.05% scalp


application (100ml) £10.42

Diprosone® 0.05% lotion (100ml) £7.80

Etrivex® shampoo (125ml) £7.32

Locoid® 0.1% scalp lotion (100ml) £6.83

Betnovate® 0.1% scalp application


(100ml) £4.99

Betacap® 0.1% scalp application


(100ml) £3.75

Alphosyl 2 in 1® shampoo (250ml) £2.32

Psoriderm® scalp lotion (250 ml) £1.90

Capasal® Therapeutic shampoo


(250ml) £1.88

£0 £2 £4 £6 £8 £10 £12 £14 £16


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


74 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

13.5.2 Preparations for psoriasis: corticosteroid and vitamin D combination


topical preparations
January 2020: Corticosteroid and vitamin D combination topical preparations (cost of
single course of treatment)

Dovobet® gel (60g)* £520.94

Dovobet® ointment
(60g)** £277.76

* Licensed Indication: plaque psoriasis (not scalp),


duration 8 week course.
Enstilar® foam (60g)*** £277.76 ** Dovobet ointment licensed Indication: stable plaque
psoriasis, duration 4 week course. Please check individual
generic products licensing.
*** Licensed Indication: plaque psoriasis, duration 4 week
course.

£0 £100 £200 £300 £400 £500 £600


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

13.6.1 Topical preparations for acne


January 2020: Topical preparations for acne (cost per 30g or 30ml)

Duac® (Benzoyl peroxide 3% and 5%,


Clindamycin 1%) gel £13.14
Epiduo® (Adapalene 0.1%,
Benzoyl peroxide 2.5%) gel £13.02
Treclin® (Clindamycin 1%, Tretinoin
0.025%) gel £11.94

Differin® (Adapalene 0.1%) cream/gel £10.95

Zindaclin® (Clindamycin 1%) gel £8.66


Aknemycin Plus® (Erythromycin 4%,
Tretinoin 0.025%) solution £8.46

Finacea® (Azelaic acid 15%) gel £7.48

Erythromycin 2%, Isotretinoin 0.05% gel £7.47


*Freederm® Treatment (Nicotinamide
4%) gel £6.67

*Acnecide® (Benzoyl 5%) gel £5.34


* Pharmacy medicines ‘P’ containing nicotinamide or
benzoyl peroxide available over the counter.
Skinoren® (Azelaic acid 20%) cream £4.49
NHS Clinical Commissioners and NHS England
guidance recommends that a prescription for
*Acnecide® (Benzoyl 5%) wash gel £3.26 treatment of mild acne should not routinely be offered
in primary care as the condition is appropriate for self-
*Brevoxyl® (Benzoyl 4%) cream £2.48 care. See guidance link below chart.

£0 £2 £4 £6 £8 £10 £12 £14


Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Conditions for which over the counter items should not routinely be prescribed in primary
care: Guidance for CCGs. (2018)
Contents

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


75 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

Specialised infant and child milk formulas5


January 2020: Specialised infant and child milk formulas (cost per 100g)
Neocate® Spoon powder sachets
(15x37g) £7.92

Neocate® LCP powder


(400g) £7.39

Nutramigen® PurAmino powder


(400g) £5.75

SMA Alfamino® powder


(400g) £5.75 Amino acid based

Nutramigen 2 with LGG powder®


(400g) £2.80

Nutramigen 1 with LGG powder®


£2.80 Lactose free
(400g)

Similac Alimentum® powder


(400g) £2.36
Hydrolysate formula
Aptamil Pepti 1® powder
(400g) £2.47

SMA Althera® powder


(450g) £2.46 Contain Lactose

Aptamil Pepti 2® powder


(400g) £2.35

SMA Wysoy® powder


£1.27 Soya based
(860g)
£0 £1 £2 £3 £4 £5 £6 £7 £8 £9
Doses given do not imply therapeutic equivalence copyright © RDTC 2020

Contents

5
BNF for Children. Borderline substances.
NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES
76 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

Stoma adhesive removers (liquid preparations only)6


January 2020: Stoma adhesive removers (cost per 50ml)

Pelican Release £9.88

Appeel® £9.73

Dansac £9.66

Appeel® Advance £9.60

EasyLease £9.52

GB Soft Skin® £9.42

Brava® £9.33

Lift Plus® £9.07

ConvaTec Niltac™ £9.04

Sensi-Care® £8.68

Independence £7.28

Adapt™ £7.21

Peel-Easy™ £7.18

Pelican Platinum £7.07

Elite® £6.98

Salts £6.81

Remove £6.80

Dansac EasiSpray™ £6.75

ZenSetiv £5.90

Lifteez £5.60

CliniPeel® £5.50

StoCare Remove £5.30

Lift Plus 360 £5.30

Clear £5.19

Offmate £5.10

Lift £3.28

£0 £2 £4 £6 £8 £10 £12

Doses given do not imply therapeutic equivalence copyright © RDTC 2020


Contents

6
NHS BSA Drug tariff, Part IXC: Stoma appliances.
NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES
77 January 2020
Regional Drug and Therapeutics Centre Cost comparison charts

Patent expiry table January 2020 to December 2020

Expiry dates below take account of the SPC and any paediatric extension. The table
also indicates where a licence for a generic/biosimilar product is in the latter stages
of the EU licensing process or is already available in the EU. However, it does not
follow that a generic/biosimilar product will be available in the UK as patent issues
differ between countries. Patent legislation is complex and the information below
should be used as a guide only.

Note that patent expiries are subject to change when new licence extensions (SPC
or paediatric) are granted to the originator product or if court decisions alter the
patent status of a drug. In addition, the patent expiries detailed only cover the basic,
manufacturing patent. Additional patents on formulations and uses can influence
when a generic or biosimilar becomes available commercially.

Patent expiry date may not give an accurate date as to when a generic version will
actually be marketed in the UK, once a generic has been granted a product licence.
Generic
Patent expiry Date includes
or biosimilar Commissioning
Drug BNF date * = UK patent paediatric
available/ in route
only, no SPC extension
development
Melatonin (controlled
release - Circadin®) 4 2020 Jan - CCG
Asenapine 4 2020 Feb - CCG
Ziconotide 4 2020 Feb -- NHSE
Dexrazoxane 8 2020 Mar - NHSE
Erlotinib HCl 8 2020 Mar - Yes NHSE
Aliskiren 2 2020 Apr - CCG
Cinacalcet 9 2020 Apr Yes Yes NHSE
Eculizumab 9 2020 Apr - NHSE
Temsirolimus 8 2020 Apr - NHSE
Tipranavir 5 2020 May - NHSE
Bevacizumab 8 2020 Jun Yes Yes NHSE
C1-esterase inhibitor 3 2020 Jul - NHSE
Natalizumab 8 2020 Jul Yes NHSE
Tapentadol 4 2020 Jul - CCG
Fosaprepitant 4 2020 Aug Yes NHSE
Micafungin 5 2020 Sep - NHSE
Ambrisentan 2 2020 Oct - Yes NHSE
Depends on
Tocilizumab 10 2020 Dec Yes indication

NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES


78 January 2020

You might also like