Peptides, Inhibitors, Agonists

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Product Data Sheet

Product Name: PPT

Cat. No.: GC14370

Chemical Properties

Cas No. 263717-53-9

Chemical
4-(1,5-bis(4-hydroxyphenyl)-4-propyl-1H-pyrazol-3(2H)-ylidene)cyclohexa-2,5-dienone
Name
Canonical
OC1=CC=C(C=C1)C(N(C(C=C2)=CC=C2O)N/3)=C(CCC)C3=C(C=C4)/C=CC4=O
SMILES

Formula C24H22N2O3 M.Wt 386.45

≤10mg/ml in ethanol;20mg/ml in
Solubility Storage Store at -20°C
DMSO
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath
General tips
for a while.Stock solution can be stored below -20℃ for several months.
Shipping Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon
Condition request.

Structure

Background

Estrogen receptor α (ERα) and ERβ are ligand-activated transcription factors that mediate the actions of estrogen.
Activation of ERα, but not ERβ, is required for the cardioprotective effects of estradiol. Propylpyrazole triol (PPT) is an

Caution: Producthasnot been fully validated for medical applications. For research use only.
Tel: (626) 353-8530 Fax: (626) 353-8530 E-mail: tech@glpbio.com
Address: 10292 Central Ave. #205, Montclair, CA, USA

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 Peptides, Inhibitors, Agonists
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Product Data Sheet

ERα selective agonist with a 410-fold relative binding affinity for ERα (49%) versus ERβ (0.12%) and therefore
activates gene transcription only through ERα.[1],[2] In an in vivo rabbit model of ischemia-reperfusion injury,
treatment with estradiol and PPT, but not diarylpropinitrile (a selective agonist of ERβ) significantly decreased the
infarct size compared with vehicle.[3]

Reference:
[1]. Stauffer, S.R., Coletta, C.J., Tedesco, R., et al. Pyrazole ligands: Structure-affinity/activity relationships and
estrogen receptor-α-selective agonists. Journal of Medicinal Chemistry 43, 4934-4947 (2000).
[2]. Meyers, M.J., Sun, J., Carlson, K.E., et al. Estrogen receptors-β potency-selective ligands: Structure-activity
relationship studies of diarylpropionitriles and their acetylene and polar analogus. Journal of Medicinal Chemistry 44,
4230-4251 (2001).
[3]. Booth, E.A., Obeid, N.R., and Lucchesi, B.R. Activation of estrogen receptor-α protects the in vivo rabbit heart
from ischemia-reperfusion injury. American Journal of Physiology 289, H2039-H2047 (2005).

Caution: Producthasnot been fully validated for medical applications. For research use only.
Tel: (626) 353-8530 Fax: (626) 353-8530 E-mail: tech@glpbio.com
Address: 10292 Central Ave. #205, Montclair, CA, USA

2 www.glpbio.com