Peptides, Inhibitors, Agonists

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Product Data Sheet

Product Name: Gastrin I (human)

Cat. No.: GC15133

Chemical Properties

Cas No. 10047-33-3

(3S,4Z,6S,7Z,9S,10Z,13Z,15S,16Z,18S,19Z,21S,22Z,24S,25Z,27S,28Z,30S,31Z,33S)-9-((1H-indol-3-
Chemical
yl)methyl)-21,24,27,30-tetrakis(2-carboxyethyl)-5,8,11,14,17,20,23,26,29,32-decahydroxy-3-((Z)-
Name
hydroxy(((S)-1-hydroxy-1-imino-3-phenylpropan-2-yl)imino)methyl)-33-
CC(C[C@@](/N=C(O)/[C@](/N=C(O)/[C@]1([H])CCCN1C(C/N=C(O)/[C@]2([H])CCC(O)=N2)=O)([H])CC
Canonical 3=CNC4=CC=CC=C34)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)
SMILES =N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C
@

Formula C97H124N20O31S M.Wt 2098.22

Solubility Soluble in 5% NH4OH Storage Desiccate at -20°C

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath
General tips
for a while.Stock solution can be stored below -20℃ for several months.
Shipping Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon
Condition request.

Structure

Protocol

Caution: Producthasnot been fully validated for medical applications. For research use only.
Tel: (626) 353-8530 Fax: (626) 353-8530 E-mail: tech@glpbio.com
Address: 10292 Central Ave. #205, Montclair, CA, USA

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Product Data Sheet

Animal experiment: Rats[1]The first set of experiments is carried out on rats with intact vagus nerves which are
acutely treated with CCK-8S or Gastrin-1 at the doses of 1.5, 5, 15 and 45 nmol/kg. Both
these peptides are administered i.v. as a bolus immediately after the collection of basal
effluent samples. In experiments investigating the involvement of muscarinic, histamine H or
CCK receptors in the gastric 2 secretory responses elicited by CCK-8S or Gastrin-1, the
animals are pretreated with atropine 1 μmol/kg i.v., cimetidine 10 μmolrkg i.v., devazepide
1.25-2.5 μmol/kg i.v. or L-365,260 2.5-5 μmol/kg i.v., 10 min before ending the collection of
the second basal effluent sample. Additional experiments are performed in animals
pretreated with the irreversible inhibitor of histidine decarboxylase, α-fluoromethylhistidine
(450 mmol/kg i.p. twice daily for two consecutive days), in order to suppress endogenous
histamine production from digestive enterochromaffin-like cells[1].
References:
[1]. Noble F, et al. International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin
receptors. Pharmacol Rev. 1999 Dec;51(4):745-81.
[2]. Blandizzi C, et al. CCK1 and CCK2 receptors regulate gastric pepsinogen secretion. Eur J Pharmacol. 1999 May
28;373(1):71-84.

Background

Gastrin-1, human is the endogenous peptide produced in the stomach, and increases gastric acid secretion via
cholecystokinin 2 (CCK2) receptor.

Gastrin-1, human is the endogenous peptide produced in the stomach, and acts via cholecystokinin 2 (CCK2)
receptor[1].

Gastrin-1 (1.5, 5, 15 and 45 nmol/kg, i.v.) increases pepsinogen and acid secretion in rats[1].

References:
[1]. Noble F, et al. International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin
receptors. Pharmacol Rev. 1999 Dec;51(4):745-81.
[2]. Blandizzi C, et al. CCK1 and CCK2 receptors regulate gastric pepsinogen secretion. Eur J Pharmacol. 1999 May
28;373(1):71-84.

Caution: Producthasnot been fully validated for medical applications. For research use only.
Tel: (626) 353-8530 Fax: (626) 353-8530 E-mail: tech@glpbio.com
Address: 10292 Central Ave. #205, Montclair, CA, USA

2 www.glpbio.com