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Product Data Sheet

Product Name: Taurocholic Acid 3-sulfate

Cat. No.: GC44994

Chemical Properties

Cas No. 67030-62-0

Chemical
2-[[(3α,5β,7α,12α)-7,12-dihydroxy-24-oxo-3-(sulfooxy)cholan-24-yl]amino]-ethanesulfonic acid
Name
Canonical C[C@H](CCC(NCCS(O)(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@
SMILES H](OS(O)(=O)=O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C

Formula C26H45NO10S2 M.Wt 595.8

0.3mg/mL in DMSO, 1mg/mL in

Solubility Storage Store at -20°C
DMF
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath
General tips
for a while.Stock solution can be stored below -20℃ for several months.
Shipping Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon
Condition request.

Structure

Background

Taurocholic acid 3-sulfate (TCA3S) is a metabolite of the conjugated bile acid taurocholic acid.[1] Plasma levels of
TCA3S are elevated in wild-type and Sortilin 1 (Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and
are further elevated in Sort1 knockout mice at 24 hours post-BDL.[2]

Reference
[1]. Lefebvre, P., Cariou, B., Lien, F., et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol.
Rev. 89(1), 147-191 (2009).
[2]. Li, J., Woolbright, B.L., Zhao, W., et al. Sortilin 1 loss-of-function protects against cholestatic liver injury by
attenuating hepatic bile acid accumulation in bile duct ligated mice. Toxicol. Sci. 161(1), 34-47 (2018).

Caution: Producthasnot been fully validated for medical applications. For research use only.
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