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1 s2.0 S0007091217424639 Main PDF
1 s2.0 S0007091217424639 Main PDF
(1983), 55,1005
SUMMARY
A ventilator, of new design, is described which has been evaluated on a lung model and in animals. It is
simple, versatile, inexpensive and easy to sterilize. A single breathing tube is used in which the respiratory gas
is introduced near the patient's airway while a jet in a more distal part of the tube drives the respiratory gas
into the patient's lungs. Provided the internal volume between the respiratory gas inlet and the driving jet it at
least one tidal volume, the driving gas does not take part in respiratory gas exchange. During controlled
ventilation only normal ventilation volumes of respiratory fresh gas are required during both normal and high
frequency ventilation. It can be used for any age group with any desired respiratory gas, and is suitable for use
in the operating theatre and the intensive care unit. As there are no valves in the breathing system, which is
open to the atmosphere at all times, complicated systems for synchronizing the machine with spontaneous
breathing are not required. PEEP, NEEP, CPAP and IMV are applied easily.
In recent years a variety of new techniques have The present paper describes a new, simple, valve-
been developed to promote appropriate artificial less, all-purpose ventilator which overcomes many
ventilation and weaning from mechanical ventila- of the problems associated with the use of existing
tion: IMV, SIMV, MMV, PEEP, CPAP and high machines. A subsequent paper will be concerned
frequency ventilation (HFV) (Hewlett, Platt and with its clinical evaluation.
Terry, 1977; Lawler and Nunn, 1977; Mushin et
al., 1980; Sjostrand, 1980). In seeking to provide BASIC PRINCIPLE OF VENTILATOR
many of these facilities in one unit, modern conven- The principle is to use a single breathing tube in
tional ventilators (Mushin et al., 1980) are becoming which the respiratory gas is introduced near the
increasingly complicated and expensive. However, patient's airway while a jet in a more distal part of
there has been little change in their breathing sys- the tube drives the respiratory gas into the lungs
tems which still use wide-bore tubing and, since (fig. 1). The jet driving gas is independent of the
they contain humidifiers in the system, have large respiratory gas. The distance between the respirat-
compressible volumes. In addition they contain val- ory gas inlet and the jet is sufficient to prevent the
ves which can fail or cause obstruction and, thus, are driving gas taking part in gas exchange in the lungs.
potentially dangerous. During weaning procedures There are no valves or other obstructions in the
they require complicated sensing systems. How- breathing system, which remains open to atmos-
ever, apart from their cost and complexity, their phere at all times.
main problem is a lack of versatility, particularly in
relation to the age of the patient and the frequency of DESCRIPTION OF VENTILATOR
ventilation. A developed form of the ventilator is illustrated in
Jet ventilators without large breathing systems figure 2.
have been developed for specific purposes such as
high frequency ventilation (Borg et al., 1977; Sjos- Breathing system
trand, 1980). These ventilators present problems in This consists of a single tube, of any convenient
delivering a humidified respiratory gas of variable available type, with an internal volume between the
but known composition. driving jet and the respiratory gas inlet of at least one
tidal volume, and of sufficient internal diameter to
provide a negligible resistance to peak flows. For the
M. K. CHAKRABARTI, B.SC.,M.PHIL.: J. G. WHITWAM,M.B.,CH.B.,
adult any conventional, standard disposable tubing
PH.D., F.R.C.P., F.F.A.R.C.S.; Department of Anaesthetics, Royal
Postgraduate Medical School, Du Cane Road, London with an internal diameter and length of approxi-
W120HS. mately 22 mm and 1.5m, respectively, is adequate
© The Macmillan Press Ltd 1983
1006 BRITISH JOURNAL OF ANAESTHESIA
Exhaust
expired gas
-y
Endotracheal tube
Breathing tube
Chopper
Reducing valve
FIG. 1. Simplified circuit diagram of the ventilator.
for tidal volumes of up to 500 ml. For children and generation of pressures up to lOkPa
neonates the tube size can be decreased for conveni- in the breathing circuit for the application of normal
ence, but this is not essential. tidal volumes at conventional frequencies in patients
with very low pulmonary compliance. The switch
Jets SI automatically returns the driving gas from JO to
The normal driving jet Jl drives the ventilating Jl, whenever the ventilator is switched off, so that
fresh gas into the patient's lungs. It is designed to the high driving pressure can never be applied
generate a maximum pressure in the breathing cir- accidentally to a subsequent patient.
cuit of 3kPa (30cmH2O) when operated from a The tidal volume can be varied by adjusting the
source with a pressure of 400 kPa (60 p.s.i), such as a reducing valve RVl thereby changing the driving
pipeline. pressure. The driving pressure is indicated by the
A second jet JO (overdive) can be brought into pressure gauge PI. J2 and J3 can be activated by the
operation using a special switch SI to allow the switch S2. They provide a continuous flow of gas,
Airway pressure
monitor S alarm
Frequency control
Driving gas
hE control
e.g. Compressed air
(600 p.s.i.)
Ventilator unit
FIG. 2. A developed form of the ventilator circuit. Jl = driving jet; JO —overdrive jet; J2 — PEEP jet;
J3 - NEEP jet; RVl and RV2 = reducing valves; PI and P2 «= pressure gauges; SI and S2 = switches.
VALVELESS VENTILATOR: DESCRIPTION 1007
25"
Inspiration
K \^ - y- V y
Flow (litre min"1) o-*
0 -"
L0-
A/l/l
C
C50 R5 C
5O R 2O 5O R 20 C20R20 C
2O R
20
DP3O DP 30 DP 31 DP 31 DP 55
FIG. 3. Interrelation of respiratory gas flow, airway pressure and tidal volume in a lung model.
r
—) = compliance 50mlcmH 2 O ; Ca) = compliance 20mlcmH 2 O" 1 ; Rj = airway resistance
'min '; Ra)" airway resistance 20 cm H2O litre 'min '; DP "driving pressure of jet Jl (fig. 2)
(p.s.i.) (30 p.s.i. ~ 200 kPa; 31 p.s.i. ~ 207 kPa; 55 p.s.i. ~ 366 kPa). Time (s). Ventilation frequency
10 b.p.m.
Flow
(litre min'1) n "^
ffffffffi
Airway
pressure
(kPa) 10
Alveolar
pressure
(kPa)
PEEP
FIG. 4. Lung model. Respiratory gas flow, airway and alveolar pressures during the application of PEEP
1.0 kPa. Ventilation frequency 10 b.p.m.
The range of tidal volumes at 12 b.p.m. which patient circuit is shown in table I. It can be seen that
will be provided by this ventilator using the max- it is a safe ventilator for any age group since, no
imum driving pressure without any change in the matter what the patients condition, the maximum
airway pressure which will be developed using jet J1
is3kPa(30cmH 2 O).
25
TABLE I. Modtl lung: rangt of tidal voluma at different lung compliance (C) and airway resistance (R)from adult
to ntonau using normal driving jttjl only (fig. 2)
Maximum
Lung Airway airway
compliance (C) resistance (R) Driving pressure Range of Vr
(mlcmHjO" 1 ) (cm H2O litre"'min"1') pressure (kPa) (ml)
Flow
(litre min"1)
0 'f'' A A
Seconds
2.0
Airway
pressure
1.0
(kPa) f ((((tttttititiimimw\mwm\utiwiittn(ftf{ ((f C\
, L_
2.0
Alveolar
pressure 1 0
(kPa)
Frequency (b.p.m.)
FIG. 6. Lung model. Respiratory gas flow, airway and alveolar pressures at different ventilation frequencies
(12-200 b.p.m.).
VALVELESS VENTILATOR: DESCRIPTION 1011
discontinued to allow the return of spontaneous formed using paired t tests and a probability value
respiration when required. At the start the dogs <5% was accepted as significant.
were ventilated with a Starling Ideal Pump (conven-
tional) and then transferred to the new ventilator.
The left femoral artery and vein were cannulated for RESULTS
measurements of arterial pressure and blood-gas The effects of changing the ventilator (Starling
tensions, and the infusion of fluid and drugs, respec- pump to the new machine), doubling the RFG,
tively. Arterial blood samples were taken in heparin- increasing VF from 12 to 60 b.p.m. and changing
ized plastic syringes for immediate blood-gas the jet driving gas, on airway pressure, ftiOj and
analysis with a Radiometer ABL1 blood-gas anal- ftiCCh are shown in table II (columns 1,2,3 and 4).
yser. Arterial pressure and airway pressures were Changing the jet driving gas from air to nitrogen
recorded using calibrated strain gauges and dis- caused no significant change in Pa.O2 (table II, col-
played on either an ultra-violet recorder (2112 S.E. umns 7 and 8), indicating that the jet driving gas was
Laboratories) or a heated stylus recorder (Devices not participating in gas exchange in the lungs.
MX2). The inspiratory and expiratory flows were
recorded using a pneumotachograph system (Gould High frequency ventilation (HFV)
Medical), the head of which was placed near the Increasing VF from 12 to 60 b.p.m. caused a
endotracheal tube. The end-tidal carbon dioxide decrease in mean P&c&i from 5.39 to 4.49 kPa and in
tension was monitored continuously using a rapid airway pressure from 1.05 to 0.75 kPa (table II,
response infra-red carbon dioxide analyser (Gould columns 4 and 5). It can also be seen (fig. 7) that a
Medical), the calibration of which was confirmed PEEP of approximately 0.15kPa developed during
repeatedly with a standard carbon dioxide gas mix- HFV. A decrease in the driving pressure from 25 to
ture. At least 20 min was allowed before a blood-gas 22p.s.i. was sufficient to restore P&cOi to 5.2 kPa
measurement was taken after any change in the and the airway pressure decreased even further, to
ventilation system. 0.58 kPa (table II, columns 5 and 6).
The driving gas of the ventilator was either air or
nitrogen. Oxygen was used as the respiratory gas PEEP and NEEP
throughout. The effects of using J2 and J3 to apply PEEP and
Where appropriate, statistical analysis was per- NEEP respectively are illustrated in figure 8.
TABLE II. Data from five dogs, ventilated with new valveless ventilator. Values rtfer to meani. SEM. The superscript figures indicate
statistically significant differtnces (P < 0.05) between the relevant columns
Sample No. 1 2 3 4 5 6 7 8
Ventilator Starling pump NEW NEW NEW NEW NEW NEW NEW
Respiratory gas Oi Oj O2 O2 (h Oj O: Oz
Respiratory 4.0 4.0 8.0 4.0 4.0 4.0 4.0 4.0
gas flow
Jet driving pressure — 25.0 25.0 25.0 25.0 22.0 25.0 25.0
(p.s.i.) ±3.1 ±3.1 ±3.1 ±3.1 ±2.3 ±3.1 ±3.1
Jet driving gas — Air Air Air Air Air Air Nitrogen
Frequency 12 12 12 12 60 60 12 12
(b.p.m.)
AojCkPa) 58.14 58.43 58.40 58.00 60.39 58.26 59.88 60.04
±0.54 ±1.03 ±2.09 ±1.54 ±1.22 ±0.82 ±1.06 ±1.32
AcOzCkPa) 5.12 5.05 4.93 5.39 4.49<-6 5.20 5.31 5.16
±0.15 ±0.20 ±0.26 ±0.29 ±0.23 ±0.28 ±0.16 ±0.21
pH (unit) 7.241 7.251 7.260 7.250 7.358 7.295 7.273 7.301
±0.058 ±0.050 ±0.040 ±0.050 ±0.011 ±0.001 ±0.011 ±0.010
Airway pressure 1.10 1.05 1.05 1.05 0.754"* 0.58 4 - 5 1.00 1.00
(kPa) ±0.14 ±0.07 ±0.07 ±0.07 ±0.07 ±0.03 ±0.12 ±0.12
Ffe'COj 5.4 5.45 5.25 5.55 4.50^ 5.68*"' 5.50 5.50
±0.141 ±0.07 ±0.35 ±0.071 ±0.707 ±0.23 ±0.36 ±0.28
VT(ml) 282.5 285.00 285.00 265.00 127. SO*-6 UO.OO*-* 280.00 280.00
±17.68 ±7.01 ±7.01 ±7.07 ±3.54 ±4.36 ±3.96 ±4.35
1012 BRITISH JOURNAL OF ANAESTHESIA
Seconds
Airway
pressure
(kPa)
(• f i f I f f f! f f I f
Normal frequency High frequency
FIG. 7. Effect on airway pressure of changing the ventilation frequency from 12 to 60 b.p.m. in a dog.
Seconds
Airway 1,0
pressure
(kPa)
JUlMMJll
O.5
PEEP NEEP
FIG. 8. Airway pressure during the application of PEEP and NEEP in a dog. Ventilation frequency 12 b.p.m.
VALVELESS VENTILATOR: DESCRIPTION 1013
25-
Flow 0
(litre min )
25 -
Seconds
Airway
1.0-
pressure
(kPa)
!; Spontaneous CPAP
FIG. 9. Respiratory gas flow and airway pressure during the application of CPAP 0.8 kPa in a spontaneously
breathing dog.
built machine which will not only serve as a conven- control while still ventilating the patient with any
tional ventilator, but will also provide high frequen- chosen, suitably conditioned gas. The fact that there
cy ventilation merely by adjusting the frequency is as yet no machine commercially available which
25-
Flow 0-
(litre min-1)
25-
Seconds
1.0-
rrr
Airway
pressure
(kPa)
0 -
Suxamethonium
FIG. 10. Respiratory gas flow and airway pressure in a dog. Left side = spontaneous respiration with the
ventilator running at 12 b.p.m., that is IMV. Fb'cc^ was 5.2% at this stage. Suxamethonium 2 mg kg~' was
then administered without any change in the ventilator setting and Fb'cx>2 increased to 6.3% during IPPV.
On the right side, the driving pressure (jet Jl, fig. 2) was increased to increase the tidal volume and return
FE'CQI to 5.0%.
1014 BRITISH JOURNAL OF ANAESTHESIA
will perform this function adequately explains the the compressible volume during inflation.
efforts which are being made to modify existing Moreover, the anatomical deadspace may increase
machines for HFV, for example, the recent modifi- because of the high inspiratory pressures which
cations of the Nuffield Series 200 Penlon Ventilator further decreases alveolar ventilation. Thus, the
by Davey, Lay and Leigh (1982). The idea of using a constant volume/flow generators are incapable of
ventilator (Bird Mk 8) to drive an anaesthetic circuit maintaining constant alveolar ventilation in the pre-
was described by Voss (1967). However, in such sence of large changes in compliance. A pressure
systems the problem of valves remains and they lack generator immediately responds to changes in lung
a high frequency capability. With the simple chop- compliance and, therefore, the measured ventilation
ping device described here only a fixed I:E ratio of volume can indicate deterioration in lung function.
1:2 was available. However, although Borg and This new ventilator, with a simple servo control
colleagues (1977) have recommended an inspiratory system to relate the driving pressure to the ventila-
time of 22% of the respiratory cycle during HFV, tion volume, has the potential to maintain constant
there is as yet little evidence to support this view alveolar ventilation. However, such a system would
throughout a whole frequency range. Given a more have the same problems as a conventional constant
sophisticated chopping device, this new ventilator volume machine, that is high inflation pressures
will allow more careful investigation of this claim. with consequent barotrauma and circulatory im-
When in the ventilation mode, the new ventilator pairment. Under these conditions it would be more
requires only normal flows of respiratory gas, but logical to increase the ventilation frequency to main-
during spontaneous respiration approximately twice tain alveolar ventilation, a facility which is provided
the minute volume is required to ensure carbon easily by this new design, since a change in HFV
dioxide elimination. causes slight hyperventilation.
Because there are no valves, the ventilated animal
does not fight the machine and it provides an excel- In conclusion, a new ventilator is described
lent IMV system. The ventilator can be run at any which, in spite of its simplicity, has remarkable
frequency and if the minute volume is not adequate versatility. There are no valves in the breathing
to maintain a normal PSLCOI, spontaneous respira- circuit so that spontaneous respiration can occur at
tion will return which decreases the ftcc>2. Thus, any time without desynchronization. Because the
when the volume delivered by the ventilator is system is open to the atmosphere at all times, exces-
progressively decreased an animal will return to sive pressure cannot develop and this, together with
normal spontaneous respiration. During this pro- the absence of valves, makes it very safe. Any
cess the RFG should be increased to twice the respiratory gases, including anaesthetic gases, can
minute volume to prevent rebreathing. be supplied and humidif ication takes place outside
The machine presents no problems with regard to the breathing system. It is suitable for any age
sterilization since the jet manifold can be autoclaved group. It can provide PEEP, CPAP, NEEP and
and the tubing either sterilized or replaced. How- IMV. It has the capability for high frequency venti-
ever, if required, a second bacterial filter can be lation while using only normal minute volumes of
placed between the manifold and the breathing any chosen respiratory gas. Finally, it is small,
circuit (fig. 2). simple in operation and maintenance, and inexpen-
The principal problem with any pressure sive.
generator is the variation in ventilation volume as a
result of changes in compliance and airway resis-
tance. For this reason flow generators, which can REFERENCES
provide a constant expired volume irrespective of Borg, U., Kyttkens, L., Nillson, L. G., and Sjostrand, U.
such changes, have been preferred for many years. (1977). Physiologic evaluation of the H.F. P.P.V. pneumatic
valve principle and PEEP. An experimental study. Acta Anaa-
However, even such a conventional ventilator does thaiol. Scant., (Suppl.), 64, 37.
not deliver constant alveolar ventilation when pul- Chakrabarti, M. K., and Sykes, M. K. (1976). Evaluation of the
monary compliance decreases. Although there will lung ventilator performance analyser. Anaathaia, 31, 521.
be an increase in the airway pressure, measured in (1980). Cardiorespiratory effects of high frequency
the breathing circuit, the expired volume meter will intermittent positive pressure ventilation in the dog. Br. J.
i4naorA.,52,475.
not indicate the decrease in alveolar ventilation since Davey, A. ] . , Lay, G. R., and Leigh, J. M. (1982). High
it also records, during expiration, the gas taken up in frequency venruri jet ventilation. Anaathaia, 37, 675.
VALVELESS VENTILATOR: DESCRIPTION 1015
Hewlett, A. M., Plan, A. S., and Terry, V. G. (1977). Mandatory EIN NEUES KLAPPENLOSES
minute volume. A new concept in winning from mechanical ALLZWECKBEATMUNGSGERAT
ventilation. Anaesthesia, 32,163. Beschreibung und erprobung im labor
Lawler, P. G. P., and Nunn, J. F. (1977). Intermittent mandat-
ory ventilation. A discussion and a description of necessary ZUSAMMKNFASSUNG
modification to the Brompton Manley ventilator. Anaesthesia, Ein neuer Typ von Beatmungsgerat, das an Lungenmodellen und
32,138. Tieren erprobt wurde, wird beschrieben. Es ist einfach, vie-
Loh, L., Sykes, M. K., and Chakrabarti, M. K., (1978). The lseitig, billig und leicht zu steriUsieren. Es wird ein einfacher
assessment of ventilator performance. Br. J. Anaesth., 50,63. Beatmungstubus benutzt, bei dem das Beatmungsgas in die Nahe
Mushin, W. W., Rendell-Baker, L., Thompson, P. W., and der Luftwege des Patienten einstrbmt, wahrend am distalen Ende
Mapleson, W. W. (1980). Automatic Ventilation of the Lungs. des Tubus ein Luftstrahl das Beatmungsgas in die Lungen des
Oxford, Edinburgh: Blackwell Scientific Publications. Patienten driickt. Liegt das Volumen des einstrfimenden Beat-
Sjostrand, U. (1980). High frequency positive-pressure ventila- mungsgases iiber dem A temminu ten volumen, Hnnn ist der Luft-
tion (H.F. P.P.V.): a review. Crit. CartM*d.,8,M5. strahl nicht am respiratorischen Gasaustausch beteUigt. Bei kon-
Voss, T. J. V. (1967). The adaptation of ventilators for anaes- trollierter Beatmung werden sowohl bei normaler all auch bei
thesia, with particular rrfrinx-^ to paediatric anaesthesia. 5. hochirequenter Beatmung nur normale Beatmungsvolumina von
Afr. Mtd.J., 41,1079. Frischgas benotigt. Das System ist in jeder Altersgruppe und mit
jedem gewiinschten Beatmungsgas verwendbar und kann im
Operauonssaal wie auch auf Intensivstationen benutzt werden.
Da im Beatmungssystem keine Klappen sind und es immer zur
Atmosphare hin gedffnet ist, braucht man keine komplizierten
Systeme, um die Maschine mit der Spontanatmung zu syn-
chronisieren. PEEP, NEEP, CPAP und IMV kdnnen leicht
angewandt werden.
SUMARIO
II s'agit de la description d'un respirateur de conception nouvelle Se describe un ventilador de diseno nuevo, el cual hie evaluado en
qui a etc etudie sur un modele de poumons et chez l'animal. II est un modelo pulmonar y en »"™°1« Es sencQlo, versatil, barato y
simple, modulablc, peu cduteux et facile a steriliser. On utilise un de facil esterilizacion. Se us* un tubo de respiracion unico en el
seul tuyau de ventilation dans lequel on administre les gaz cual se introduce el gas cerca de las vias respiratorias del padente
inspires pres des voies respiratoires du patient alors qu'un gaz mientras un cborro en una pane mas distante lleva el gas re-
propulseur en amont de ce point entraine les gaz insires a spiratorio dentro de los pulmones del paciente. Siempre que el
l'intencur des poumons du patient. Dans la mesure ou le volume volumen intemo entre la entrada de gas respiratorio y el chorro
interne entre les gaz inspires ct lc gaz propulseur est au moins egal iguale un volumen respiratorio, el gas no partkapi del intercam-
a un volume courant, le gaz propulseur ne participc pas a bio del gas respiratorio. Durante la ventilari6n bajo control, se
l'hematosc. Au cours dc la ventilation contr61ee, seuls des vol- necesitan solamente volumenes normales de ventilaci6n de gas
umes ventilatoires normaux de gaz respiratoires frais sont neces- respiratorio nuevo tanto durante la ventilacion normal como la de
saires, que la ventilation soit ou non a haute frequence. Ce alta frecuencia. Puede usane en cualquier grupo de edad con
respirateur peut ctre utilise quelle que soit la classe d'age et quel cualquier gas respiratorio deseado y tambien es adecuado para uso
que soit le gaz inspire souhaite, et il convicnt aussi bien au bloc en la sala de operaci6n y la nniHnH de cuidados intensivos. Puesto
operatcrire qu'en unite de joins intensifs. Comme il n'y a pas de que no hay ningimn vilvula en el sistema que se encuentra abierto
valves sur le circuit respiratoire qui est ouvert a l'air ambiant en en la atmosfera en todo momento, no se necesitan sistemas
permanence, on n'a pas besoin de systemes compliques de syn- comphcados de sincronizacidn de la miquina con la respiracion
crhonisation dc la machine et de la ventilation spontanee. II est espontinea. Se aplkan facumente los PEEP, NEEP, CPAP e
facile d'appliquer une PEEP, une NEEP, une CPAP et une IMV. IMV.