SENIOR HIGH SCHOOL

General Biology 1
Quarter 1 – Module __:
Title: Cell Cycle
Multiple Choice. Choose the letter of the best answer. Write the chosen letter on a
separate sheet of paper.
1. Cells that rarely divide will spend most of their time in what particular
phase of the cell cycle?
a. G0
b. G1
c. G2
d. S

2. If the cell contains 20 chromatids, how many centromeres are present

inside the cell?
a. 10
b. 20
c. 30
d. 40

3. This phase of cell cycle is commonly known as growth phase, because

during this stage cell grows.
a. G0
b. G1
c. G2
d. S

4. This check point of the cycle dictates whether the cell will
continuously divide or stop, and it also checks the cell size, presence
of growth factors and damage of the DNA.
a. G1 checkpoint
b. G2 checkpoint
c. S checkpoint
d. M checkpoint

5. In this phase, the cell is preparing for the cell division in the mitotic
stage.
a. G0
b. G1
c. G2
d. S
6. In the eukaryotic cell, it is the longest stage of the cell cycle and
generally its function is to prepare the cell to division process.
a. Interphase
b. Mitotic phase
c. Synthesis Phase
 d. All of the above

7. DNA replication occurs in what phase of cell cycle?

a. Interphase
b. Growth phase
c. Mitotic phase
d. Synthesis Phase

8. Which checkpoint ensures sister chromatids are positioned to be split

correctly?
a. G1 checkpoint
b. G2 checkpoint
c. S checkpoint
d. M checkpoint

9. What is the main prerequisite for clearance at the G2 checkpoint?

a. G1 checkpoint
b. G2 checkpoint
c. S checkpoint
d. M checkpoint

10. Inactivation of what kind of gene that can lead to the development of
cancer cells.
a. Cancer cell
b. Oncogene
c. Proto-oncogene
d. Tumor suppressor gene

11. In this phase, the cell is preparing for the cell division of the mitotic
phase.
a. G0
b. G1
c. G2
d. S

12. If the M checkpoint is not cleared, what specific stage of mitosis will
be blocked?
a. Anaphase
b. Metaphase
c. Prophase
d. Telophase

13. Majority of the negative regulator proteins of the cell cycle can be
found in what kind of cells?
a. Cancer cells
 b. Gametes
c. Stem cells
d. All of the above

14. What type of gene can code a positive cell cycle regulator?
a. Apoptosis
b. Oncogene
c. Proto-oncogene
d. Tumor suppressor gene

15. Programmed cell death is known as ____________.

a. Apoptosis
b. Oncogene
c. Proto-oncogene
d. Tumor suppressor gene
FACT OR BLUFF
Tell whether the following statement about the phases of cell cycle and its
checkpoint is a FACT or BLUFF.
FACT 1. The correct sequence of the cell cycle phase is G1 → S → G2 → M.
BLUFF 2. Cell division in prokaryotic and eukaryotic cell is the same.
BLUFF 3. The results of DNA replication is duplicated DNA.
BLUFF 4. Interphase consists of mitosis and cytokinesis as its stage.
BLUFF 5. Bacterial cell divides through binary fission.
FACT 6. Unregulated cell division can lead to cancer cells formation.
FACT 7. Cell spends most its time and life in the first gap phase.
FACT 8. Cell cycle is a repeating series of events that describes the life cycle of a
cell.
FACT 9. A mass of abnormal cells is called a tumor.
FACT 10. The process in which a cell divides is known as mitosis.

Activity 1.1
Match Me, Match Me!!!
Matching Type: Match the terms in Column A, with different words related to cell
cycle and checkpoints in Column B. Write your answer on separate answer
sheet/paper.
Column A Column B
A 1. Cell cycle A. Cell’s series of events
E 2. G0 phase B. Chromosomes alignment and
attachment
D 3. Interphase C. DNA replication
B 4. Metaphase checkpoint D. Period of cell growth
C 5. Synthesis phase E. Resting state
Activity 1.2
Check, check, checkpoints!
Put a check mark on each checkpoints that corresponds to its function.
Functions
Checkpoint Chromosomes Chromosomes
Cell alignment to attachment DNA DNA Molecular
s size the equatorial to the spindle integrity replication signals
Nutrients
plate fibers
Gap1 ✓ ✓ ✓ ✓
Gap2 ✓ ✓
Metaphase ✓ ✓
Think Critically!
Let us have an example, imagine that the cell is a car. For the car to work
properly there are factors that need to be consider like the gas pedal and a brake
pedal. If the gas pedal works normally it helps the cell to divide. But when the gas
pedal gets stuck, it can cause uncontrolled cell division leads to cancer formation.
How about if the brake pedal gets stuck, and the car cannot slow down, accident
happens and causes cell death.

Guide Questions:
1. Gas pedal that works normally and helps the cell to divide can be
compare to what kind of gene? Is it oncogene, proto-oncogene or
tumor suppressor gene? Explain your answer.

Proto-oncogene. Because it’s a normal gene that codes positive

regulation during cell division just like a gas pedal that works
normally.

2. Gas pedal that gets stuck and causes uncontrolled cell division leads
to cancer is what kind of gene? Is it oncogene, proto-oncogene or
tumor suppressor gene? Explain your answer.

Oncongene. Because when Proto-oncogene are altered it can be an

oncongene which leads to cancer just like a gas pedal gets stuck
and causes sudden accidents.

3. Brake pedal that gets stuck causes car accident and even death can
be compare to what kind of gene? Is it oncogene, proto-oncogene or
tumor suppressor gene? Explain your answer.

Tumor suppressor gene. Because just like a break pedal that is

used to slow down a moving vehicle the tumor suppressor also
acts as break the slows down cell division but if it does not work
properly it can also lead to cancer.
Multiple Choice. Choose the letter of the best answer. Write the chosen letter
on a separate sheet of paper.
1. Cells that permanently or rarely divide, spend most of their time in
this phase of cell cycle?
a. G0
b. G1
c. G2
d. S

2. During this cell cycle phase, cell increase its size and grows.
a. G0
b. G1
c. G2
d. S

3. Programmed cell death is known as ____________.

a. Apoptosis
b. Oncogene
c. Proto-oncogene
d. Tumor suppressor gene

4. In this phase, the cell is preparing for the cell division of the mitotic
stage.
a. G0
b. G1
c. G2
d. S

5. In the eukaryotic cell, it is the longest stage of the cell cycle and
generally its function is to prepare the cell to division process.
a. Interphase
b. Mitotic phase
c. Synthesis Phase
d. All of the above

6. DNA replication occurs in what phase of cell cycle?

a. Interphase
b. Growth phase
c. Mitotic phase
d. Synthesis Phase
7. What type of gene codes a positive cell cycle regulator?
a. Apoptosis
b. Oncogene
c. Proto-oncogene
d. Tumor suppressor gene

8. Which checkpoint ensures sister chromatids are positioned to be split

correctly?
a. G1 checkpoint
b. G2 checkpoint
c. S checkpoint
d. M checkpoint

9. What is the main prerequisite for clearance at the G2 checkpoint?

a. G1 checkpoint
b. G2 checkpoint
c. S checkpoint
d. M checkpoint

10. Inactivation of what kind of gene that can lead to the development of
cancer cells.
a. Cancer cell
b. Oncogene
c. Proto-oncogene
d. Tumor suppressor gene

11. In this phase, the cell is preparing for the cell division of the mitotic
phase.
a. G0
b. G1
c. G2
d. S

12. If the M checkpoint is not cleared, what specific stage of mitosis will
be blocked?
a. Anaphase
b. Metaphase
c. Prophase
d. Telophase

13. Majority of the negative regulator proteins of the cell cycle can be
found in what kind of cells?
a. Cancer cells
b. Gametes
c. Sex cells
d. Stem cells
 14. What type of check point dictates whether the cell will continuously
divide or stop, and also checks the cell size, presence of growth factors
and DNA damage?
a. G1 checkpoint
b. G2 checkpoint
c. S checkpoint
d. M checkpoint

15. Cancer cell formation happens during this phase, wherein the cell
cannot determine the changes in the DNA sequence that code for the
specific regulatory molecules.
a. G0
b. G1
c. G2
d. S

Search Me!
Research one topic and answer the guide questions below.
1. RB as tumor suppressor gene
2. Cancer chemotherapy

Guide Questions:
A. Make a research about cancer.
1. Chemotherapy for cancer, how it works?

Chemotherapy is the use of drugs to destroy cancer cells. It

usually works by keeping the cancer cells from growing,
dividing, and making more cells. Because cancer cells usually
grow and divide faster than normal cells, chemotherapy has
more of an effect on cancer cells. However, the drugs used for
chemotherapy are powerful, and they can still cause damage to
healthy cells. This damage causes the side effects that are
linked with chemotherapy.

2. Write the reference where did you get your answer.

https://www.cancer.net/navigating-cancer-care/how-cancer-
treated/chemotherapy/understanding-
chemotherapy#:~:text=It%20usually%20works%20by
%20keeping,cause%20damage%20to%20healthy%20cells.