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Undercorrected Refractive Error in Singaporean Chinese Adults The Tanjong Pagar Survey 2004 PDF
Undercorrected Refractive Error in Singaporean Chinese Adults The Tanjong Pagar Survey 2004 PDF
Objective: To study the prevalence of undercorrected refractive error and associated sociodemographic
factors among Singaporean Chinese adults.
Design: Cross-sectional, population-based survey.
Participants: Singaporean Chinese adults aged 40 to 79 years (n ⫽ 1152).
Methods: The Singapore electoral register of Tanjong Pagar was used as a sampling frame, and disproportion-
ate, stratified, clustered, random sampling was performed. There were 1717 eligible adults and 1232 (71.8%)
participated. Analysis was performed among 1152 adults with complete habitual and best-corrected visual acuity
data.
Main Outcome Measure: Undercorrected refractive error was defined as improvement of better eye visual
acuity of at least 2 lines or more with best possible refractive correction.
Results: The age- and gender-adjusted rate of undercorrected refractive error standardized directly by age
and gender was 17.3% (95% confidence interval, 15.0, 19.5). Undercorrected refractive error rates were more
common in older adults who had completed fewer years of education and in those who had cataract. People who
did not wear spectacles tended to have poorer vision.
Conclusions: The undercorrected refractive error rate among Singaporean Chinese is relatively common com-
pared with data from other populations. Ophthalmology 2004;111:2168 –2174 © 2004 by the American Academy of
Ophthalmology.
Undercorrected refractive error has been found to be one of showed that 73% of visual impairment in that population
the leading causes of visual impairment in recent years.1–5 was the result of undercorrected refractive error.3 Similarly,
As a consequence, the correction of refractive errors in 68.9% of visual impairment was explained by undercor-
developed and developing countries is one of the main rected refractive error in a study of 3441 adults 60 years and
priorities of the Vision 2020: The Right to Sight initiative of older in the Shatin area of Hong Kong.7
the World Health Organization.6 In Australia, the Victoria Data on the extent of undiagnosed and partially cor-
Visual Impairment Project found that the prevalence rate of rected refractive error and their associated risk factors in
undercorrected refractive error in 4735 participants age 40 urban Asian environments, areas where “outbreaks” of
years and older was 10%.1 Data from Mexican Americans myopia exist, are sparse.8 Despite available refractive
aged 40 years and older in the Proyecto VER in Arizona services and affordable spectacle lenses, the undercorrec-
9
Originally received: March 22, 2004. Department of International Health, Johns Hopkins Bloomberg School of
Accepted: May 26, 2004. Manuscript no. 240216. Public Health, Baltimore, Maryland.
1
Department of Community, Occupational and Family Medicine, National Supported by the National Medical Research Council, Republic of Singapore,
University of Singapore, Republic of Singapore. and the British Council for the Prevention of Blindness. Dr Friedman is a
2
Singapore National Eye Centre, Republic of Singapore. Research to Prevent Blindness (New York, New York) Robert E. McCormack
3 Scholar and an American Geriatrics Society (New York, New York) Jahnigen
Singapore Eye Research Institute, Republic of Singapore. Scholar.
4
Department of Ophthalmology, National University of Singapore, Re- The authors have no proprietary interests.
public of Singapore.
5 Reprint requests to Steve Seah, FRCS(G), FRCOphth, Singapore National
Department of Epidemiology and International Eye Health, The Institute
Eye Centre, 11 Third Hospital Avenue, Singapore 168751, Republic of
of Ophthalmology, London, United Kingdom.
Singapore.
6
Glaucoma Research Unit, Moorfields Eye Hospital, London, United Kingdom.
Correspondence to Seang-Mei Saw, MBBS, PhD, Department of Commu-
7
Department of Ophthalmology, St. Thomas Hospital, London, United Kingdom. nity, Occupational and Family Medicine, National University of Singapore,
8
Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns 16 Medical Drive, Singapore 117597, Republic of Singapore. E-mail:
Hopkins University, Baltimore, Maryland. cofsawsm@nus.edu.sg.
2168 © 2004 by the American Academy of Ophthalmology ISSN 0161-6420/04/$–see front matter
Published by Elsevier Inc. doi:10.1016/j.ophtha.2004.05.032
Saw et al 䡠 Undercorrected Refractive Errors in Singapore
tion of refractive error still may remain a public health interviews conducted in either English or Chinese. The interview-
problem in Asian cities. The present study was designed ers were masked to the results of the eye examinations.
to evaluate the prevalence of undercorrected refractive
error and associated risk factors in middle-aged and Definitions and Analysis
elderly Chinese adults in Singapore. Undercorrected refractive error was defined as improvement of at
least 2 lines of better eye VA with best possible refractive correc-
tion. Refractive error was expressed as spherical equivalent (SE;
Materials and Methods defined as sphere⫹half cylinder). Myopia was defined as an SE of
at least ⫺0.5 diopters (D), hyperopia as an SE of at least ⫹0.5 D,
The Tanjong Pagar Study was a population-based eye survey and astigmatism as cylinder of at least ⫺1.0 D in any eye. Non-
among Singaporean Chinese adults aged 40 to 79 years in 1997 spectacle wearers were defined as individuals without spectacle
and 1998. The study methodology has been described else- correction at the clinic visit (i.e., adults who do not wear spectacles
where.9 –13 Tanjong Pagar is an area situated in the central part of or adults who have spectacles but do not wear them habitually).
Singapore and consists of a community that includes socially and Nonspectacle wearers with undercorrected refractive error were
economically diverse groups that are largely representative of the defined as adults with an improvement of at least 2 lines of better
general Singaporean population. Because registration and voting eye VA on best correction who do not have spectacles or who do
are legal requirements for all Singaporean citizens aged 21 years not wear spectacles habitually. Glaucoma (categories 1, 2, or 3)
and older, the electoral register of Tanjong Pagar was used as the was diagnosed according to the International Society of Geograph-
sampling frame. Two thousand names (13% of 15,082) were ical and Epidemiologic Ophthalmology scheme.14 Cataract in any
sampled using disproportionate, stratified, clustered, random sam- eye was defined as either Lens Opacity Classification System III
pling with more weight given to the older age groups: 500 people score of 4 or more for nuclear opalescence, 4 or more for nuclear
were drawn from each of the 4 age strata, 40 to 49 years, 50 to 59 color, 2 or more for cortical cataract, or 2 or more for posterior
years, 60 to 69 years, and 70 to 79 years. Forty-six persons had subcapsular cataract.13 Population prevalence rates of undercor-
died, 235 persons had moved away from the study area since its rected refractive error were calculated by direct age and gender
beginning, and 2 persons had severe illness; thus, there were 1717 standardization to the 1997 Singaporean Chinese population.15
eligible participants. The overall participation rate was 71.8% Chi-square tests were used to compare proportions. Logistic re-
(1232 of 1717). Analysis was performed on 1152 adults, because gression models were used to examine the relationship between
habitual or best-corrected right or left eye data could not be uncorrected refractive error and selected sociodemographic char-
obtained for 80 adults. There were 526 men (45.7%), and the mean acteristics. Odds ratios and 95% confidence intervals (CIs) were
age was 59.4 years (standard deviation, 11.1). Informed written presented. All P values were 2-sided and were considered statis-
consent was obtained from all participants, and the study proce- tically significant when the values were less than 0.05. A sample
dures followed the tenets of the Declaration of Helsinki. Ethics size of 1154 was needed to detect a prevalence rate of low vision
committee approval from the Singapore National Eye Center was of 0.2 and an allowable difference of 0.02, assuming the type I
obtained. error, ␣, was 0.05. Statistical computation was conducted using the
commercially available software STATA version 8.0.16
Eye Examinations
Details of the eye examination in the research eye clinic or home Results
have been described in detail in prior reports.9 –13 Habitual visual
acuity (VA) of the right and left eye first was determined using The age- and gender-adjusted rates of bilateral low vision (defined
logarithm of the minimum angle of resolution charts (The Light- by better eye habitual Snellen VA worse than 6/18 and 3/60 or
house, Long Island City, NY) at 4 m with distance spectacle better) and blindness (defined as better eye Snellen VA worse than
correction, if any. For clinic subjects, the test began reading at the 3/60) were 5.3% (95% CI, 4.0, 6.6) and 0.5% (95% CI, 0.2, 0.7),
0.3 line. If they were unable to read more than 3 letters on the 0.3 respectively. Undercorrected refractive error caused 66% of bilat-
line, they would read the line above and continue this process until eral low vision, but did not contribute to blindness. The distribu-
they could read at least 3 or more letters. They proceeded to the tions of better eye habitual VA and best-corrected VA are shown
next line each time they read 3 or more letters correctly. The VA in Figure 1. The mean better eye habitual and best-corrected
was recorded as the last line where 3 or more letters were read logarithm of the minimum angle of resolution VAs were 0.16
correctly. If they read fewer than 3 letters on any line, the line (median, 0.01) and 0.07 (median, 0.0), respectively. Table 1 de-
above would be recorded as the VA. Conversion of logarithm of scribes the number of lines gained after refraction for spectacle and
the minimum angle of resolution to Snellen equivalent readings nonspectacle wearers by age and gender. The proportion of adults
were performed to allow direct comparisons of clinic and home with 0 lines gained after refraction was higher in spectacle wearers
visit data. Refractive error was assessed using the handheld au- (66.8%) compared with nonspectacle wearers (49.1%; P⬍0.001),
torefractor (Retinomax K-plus; Nikon, Tokyo, Japan). Manual but was similar in men (56.8%) and women (55.7%; P ⫽ 0.71).
subjective refraction then was attempted to refine vision, and the Similarly, there were 28 nonspectacle wearers and only 3 spectacle
best-corrected VA was documented. An ophthalmologist graded wearers who gained 5 or more lines (P⬍0.001), whereas 11 men
lens opacity using a slit lamp according to the modified Lens and 20 women gained 5 or more lines (P ⫽ 0.25).
Opacity Classification System III.13 Glaucoma was identified by The prevalence rates of undercorrected refractive error (im-
assessment of visual field and examination of the optic disc.9 provement of at least 2 lines of better eye VA after refraction) are
For those who did not attend the clinic visits (n ⫽ 91), domi- depicted in Table 2. The age- and gender-adjusted rate (to the
ciliary examinations were conducted. Habitual VA of the right and Singaporean population older than 40 years) of undercorrected
left eye was assessed using a Snellen chart. If the VA was less than refractive error was 17.3% (95% CI, 15.0, 19.5). The undercor-
6/12, pinhole VA measurements were performed (best-corrected rection of refractive error was 3 times more common in adults 70
visual acuity). Data on general demographic variables such as years of age and older compared with adults 40 to 49 years of age
completed level of education were obtained from face-to-face (P⬍0.001). The rates of undercorrected refractive error also in-
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Ophthalmology Volume 111, Number 12, December 2004
Figure 1. Graph of presenting and best-corrected logarithm of the minimum angle of resolution (logMAR) visual acuity.
creased with age in both men and women. The age-adjusted wearers (i.e., those spectacle wearers with inadequate corrective
undercorrected refractive error rates were not different among men lenses) and undercorrected refractive error among nonspectacle
(16.3%) and women (18.1%; P ⫽ 0.93). Undercorrected refractive wearers (i.e., adults who have undercorrected refractive error but
error rates were most common among adults with refractive error do not have spectacles or adults with undercorrected refractive
of ⫹2.0 to ⫹3.0 D, followed by adults with ⫹3.0 D or more, ⫺1.0 error who do not wear spectacles habitually) were 10.6% (95% CI,
to ⫺2.0 D, and ⫺2.0 to ⫺3.0 D (Fig 2). 7.9, 13.7) and 29.3% (95% CI, 26.0, 32.9), respectively. There
The rates of undercorrected refractive error among spectacle were 464 adults (40.4%) who wore spectacles. Spectacle wearers
Table 1. Distribution of Number of Lines Gained after Table 2. Prevalence Rates of Undercorrected Refractive Error
Refraction by Sociodemographic Factors
Number of Spectacle Nonspectacle Undercorrected
Lines Gained Total, n (%) Wearers, n (%) Wearers, n (%) Refractive Error, P Value
Men and women % (95% (chi-square
0 646 (56.2) 310 (66.8) 336 (49.1) Confidence test for
1 253 (22.0) 105 (22.6) 148 (21.6) n Interval) trend)
2 129 (11.2) 34 (7.3) 95 (13.9) Total 1152 21.7 (19.4–24.2)
3 68 (5.9) 11 (2.4) 57 (8.3) Age- and gender-adjusted* 17.3 (15.0–19.5)
4 22 (1.9) 1 (0.2) 21 (3.1) Both men and women
5 18 (1.6) 1 (0.2) 17 (2.5) 40–49 yrs of age 269 10.0 (6.7–14.3) ⬍0.001
6 or more 13 (1.1) 2 (0.4) 11 (1.6) 50–59 yrs of age 296 18.9 (14.6–23.9)
Total 1,149 (100.0) 464 (100.0) 685 (100.0) 60–69 yrs of age 326 26.4 (21.7–31.5)
Men 70 and older 261 31.0 (25.5–37.0)
0 299 (56.8) 121 (66.1) 178 (51.9) Men
1 110 (20.9) 41 (22.4) 69 (20.2) 40–49 yrs of age 121 8.3 (4.0–14.7) ⬍0.001
2 59 (11.2) 14 (7.7) 45 (13.1) 50–59 yrs of age 113 20.4 (13.4–29.0)
3 37 (7.0) 6 (3.3) 31 (9.0) 60–69 yrs of age 166 22.9 (16.7–30.0)
4 10 (1.9) 0 (0.0) 10 (2.9) 70 yrs and older 126 36.5 (28.1–45.6)
5 5 (1.0) 0 (0.0) 5 (1.5) All men 526 22.2 (18.8–26.0)
6 or more 6 (1.1) 1 (0.6) 5 (1.5) Men (age adjusted) 16.3 (13.0–20.0)
Total 526 (100.0) 183 (100.0) 343 (100.0) Women
Women 40–49 yrs of age 148 11.5 (6.8–17.8) ⬍0.001
0 347 (55.7) 189 (67.3) 158 (46.2) 50–59 yrs of age 183 18.0 (12.7–24.4)
1 143 (23.0) 64 (22.8) 79 (23.1) 60–69 yrs of age 160 30.0 (23.0–37.7)
2 70 (11.2) 20 (7.1) 50 (14.6) 70 yrs and older 135 25.9 (18.8–34.2)
3 31 (5.0) 5 (1.8) 26 (7.6) All women 626 21.2 (18.1–24.7)
4 12 (1.9) 1 (0.4) 11 (3.2) Women (age adjusted) 18.1 (15.1–21.3)
5 13 (2.1) 1 (0.4) 12 (3.5)
6 or more 7 (1.1) 1 (0.4) 6 (1.8)
Total 623 (100.0) 281 (100.0) 342 (100.0) *To the 1997 Singaporean Chinese adult population.
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Saw et al 䡠 Undercorrected Refractive Errors in Singapore
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Ophthalmology Volume 111, Number 12, December 2004
Table 3. Multiple Logistic Regression Model of the Predictors of Undercorrected Refractive Error*
Covariates in the model are age group, educational level, spectacle wear, and cataract.
*Defined as a gain of at least 2 lines in the logarithm of the minimum angle of resolution visual acuity chart.
†
Controlling for all other factors in the table.
‡
In diopters.
refractive error was one of the leading causes of blindness in be less conscious of their health, less aware of correctable
a population-based survey of 4284 adults 50 years or older visual disabilities associated with refractive error, and may
in rural Rajasthan, India.24 undertake less visually demanding tasks. The elderly also
The adjusted undercorrected refractive error rates of may have lower visual distance expectations, may be less
17.3% in Singaporean Chinese persons aged 40 to 80 years aware of the need and availability of regular check-ups, and
are higher compared with those reported in other epidemi- may be less able to afford health care. Visual function may
ologic studies. In addition, approximately 4.6% of our pop- not be remarkably impaired in affected individuals with less
ulation had significant (gains of at least 4 lines after refrac- than optimal correction of refractive error because visual
tion) correctable visual loss. This could be attributed to the acuity readings may not be related directly to visual func-
high refractive error rates and lack of awareness of the need tion. Singapore is a small city–state with excellent transport
for refractive examination check-ups in the general popula- facilities, and there are a large number of government and
tion. Comparisons of undercorrected refractive error rates private optometry and ophthalmic practices located in all
across studies, however, are limited by differences in the parts of the island. The accessibility of refractive care in
definition of undercorrected refractive error that vary from 1 Singapore is much better than in developing countries in
line or more to 2 or more lines of improvement, sampling Asia. However, certain segments of the population in Sin-
strategies, participation rates, and the age ranges of the gapore may not be aware of the need to update spectacles
study populations. In adults 40 years or older in Victoria, and may have less available access to refractive services.
Australia, the prevalence rate of undercorrected refractive In Singaporean Chinese, a significant proportion (29.3%)
error with an improvement of 1 or more lines of VA with of nonspectacle wearers have undercorrected refractive er-
refraction was 10%.1 In another Australian study (the Blue rors. The possible reasons for undercorrected refractive
Mountains Eye Study), 7.5% of 3654 adults aged 49 to 97 errors among nonspectacle wearers include the lack of
years had correctable visual impairment defined as visual awareness of the need for refractive examination visits
impairment less than 20/40 in the better eye that improved among those who do not wear spectacles and unwillingness
after refraction to no impairment (20/40 or better).2 to change their present lifestyle because vision was good in
Factors leading to the need for a refractive examination the past or the refractive error may be small in magnitude.
and optical correction to improve vision have not been well Among adults with refractive error who are already wearing
investigated in prior epidemiologic studies. In the present spectacles, undercorrected refractive error may be a prob-
study, adults who are older, with lower education, who do lem (10.6%) because there may be a lack of awareness of
not wear spectacles, or who have cataract are less likely to the need for regular check-ups, poor access to health sys-
wear appropriate refractive correction. Comparable findings tems, or lack of affordability of health care, or they may
were seen in Australia (the Victoria Visual Impairment believe that their present prescription is adequate enough.
Project and the Blue Mountains Eye Study): increasing age, Adults diagnosed with cataract, but not patients with
lower educational levels, and absence of distance correction glaucoma, are more likely to have undercorrected refrac-
were found to be the most important risk factors for under- tive error. Patients with cataract who have not undergone
correction.1,2 Older individuals with lower education may surgery may be subject to more rapid changes in refrac-
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Saw et al 䡠 Undercorrected Refractive Errors in Singapore
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Ophthalmology Volume 111, Number 12, December 2004
in the elderly during sensory perturbations and dual tasking: visual impairment in a population of older Americans: the
the influence of refractive blur. Invest Ophthalmol Vis Sci Salisbury Eye Evaluation Study. Arch Ophthalmol 2000;118:
2003;44:2885–91. 819 –25.
22. Thylefors B, Negrel AD, Pararajasegaram R, Dadzie KY. 24. Murthy GV, Ellwein LB, Gupta S, et al. A population-based
Global data on blindness. Bull World Health Organ 1995;73: eye survey of older adults in a rural district of Rajasthan: I.
115–21. Central vision impairment, blindness, and cataract surgery.
23. Munoz B, West SK, Rubin GS, et al. Causes of blindness and Ophthalmology 2001;108:679 – 85.
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