Format for preparing the Project Report for Summer Internship

1) Name of the Trainee : SWATI YADAV

2) Degree Admitted : BTECH BIOTECHNOLOGY

3) Name of the Company/Institute : DR DY PATIL BIOTECHNOLOGY AND

BIOINFIORMATICS INSTITUTE

4) Name of the Supervisor/Guide : PROF NILESH SHARMA

5) Title of Project : Likes and dislikes of lipids: A metabolic reprogramming strategy by

tumors

6) Area of the project : CANCER RESEARCH

(Molecular Biology, Immunology,
Diagnostics, Management, IPR,
OMICS technology etc.)

7) Abstract : Reprogramming of lipid metabolism is a newly

recognised hallmark of malignancy. As lipid are source of energy and basic building block of
all living cells. It nourishes all the cells including tumour cells. Their growth, nourishment
etc. Development of cancer is closely tied to the metabolism lipid. Also, there are
experiments showing the cancer growth and metastasis can be involved or inhibited or by the
exogenous addition of lipid. Cancer cells can alter their lipid metabolism to meet their
metabolic requirements and thus potential tumorigenesis and tumour-suppressive mechanism
in which lipids are involved. Also, we have to see the autophagy which means consumption
of the body’s own tissue as a metabolic process occurring in starvation and certain disease.
Lipids act as a promotors and suppressor both for tumour cells. De novo lipogenesis is
considered as the primary source of fatty acids for lipids synthesis in cancer cells. A tumour
marker is a biomarker found in blood, urine, or body tissue that can be elevated by the
presence of one or more types of cancer.
This review summarises the recent likes, dislikes, developments in tumour cells by lipids and
their function in them.

8) Description of the project work :

a) In case of Review paper
i. Introduction:-
Lipids are main players in cancer biology. Cancer cell and other cells also
make of use of different ways to obtain lipids and redefine the metabolism.
The changes In lipids also help cancer cells to grow in a changing micro-
environment by the help of oncogeninc function and cancer hallmarks. Cancer
cells generally leads to the genetic changes which further leads to activation
and inactivation of tumour cells organs and cellular oncogenes. Also
carcinogenesis have important changes in cells function especially in
carbohydrate, lipid, nucleic acid, and amino acid, and in a way to support and
do rapid proliferation. Lipogenesis is a benchmark of nearly all cancers and is
required for cellular transformation and progress of cancer. We will see that
weather cancer cells are efficient enough of inclusion of exogenous free fatty
 acids. Also using of advance scenerios which metabolically show how fatty
acids are remodelling within cancer cells. Free fatty derived lipid is altered
during cancer progression.

ii. Conclusion:-
By doing this review we conclude that lipid are the basic building block for
tumour cells weather its their dislike or like. They are energy blocks and also
provide structure.

9) Specific achievements/Comments :

 I learnt that how lipids change the metabolism and everything of tumour cell.
 Potential of lipids blocks in body regarding cancerous cells.