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process as described in claim 1, where the liquid material is a mixture of liquid states of
elements generally known as “metals” (Alkali metals, Alkaline earth metals, transition
metals, actinides, lanthanides, poor metals) and metaloids of the periodic table, where
the activity modulating compound is of the formula A-B-D-E-G-J or the chemical
acceptable liquid thereof wherein the groups A through J have the values:
wherein
(a) R.sub.1 is selected from the group consisting of alkali metals (Li, Na, K, Rb, Cs, Fr)
(b) R.sub.2 is selected from the group consisting of Alkaline earth metals (Be, Mg, Ca, Sr, Ba,
Ra)
(c) R.sub.3 is selected from the group consisting of transition metals (Sc, Ti, V, Cr, Mn, Fe, Co,
Ni, Cu, Zn, Y, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Rf, Db, Sg,
Bh, Hs, Mt, Ds, Rg, Uub);
(d) R.sub.4 is selected from the group consisting of poor metals (Al, Ga, In, Sn, Ti, Pb, Bi, Uut,
Uuq, Uup, Uuh);
(e) R.sub.5 is selected from the group consisting of actinides (Ac, Th, Pa, U, Np, Pu, Am, Cm,
Bk, Cf, Es, Fm, Md, No, Lr);
(f) R.sub.6 is selected from the group consisting of lanthanides (La, Ce, Pr, Nd, Pm, Sm, Eu, Gd,
Tb, Dy, Ho, Er, Tm, Yb, Lu);
(h) R.sub.21, and R.sub.24 are independently selected from the group
consisting of >C.dbd.O, --CH.sub.2 C(O)--,--NHC(O)--, >C.dbd.S, >SO.sub.2,
and >P(O)X where X is selected from the group consisting of hydroxy,
alkoxy, amino, alkylamino and dialkylamino, with the proviso that when
R.sub.22 -R.sub.23 -R.sub.24 is present, R.sub.21 is >CH.sub.2
(q) R.sub.27 is selected from the group consisting of hydrogen, and aryl;
(r) R.sub.31 is
##STR35##
where m and n are integers independently selected from 0, 1 and 2; (s)
R.sub.32 is
##STR36##
where p and q are integers independently selected from 0, 1 and 2; (t)
R.sub.33 is
##STR37##
where t and v are integers independently selected from 0, 1, 2 and 3; (u)
R.sub.34 is
##STR38##
where r and s are integers independently selected from 0, 1, 2 and 3; (v)
R.sub.35 is
##STR39##
where f is an integer of 0 to 2, X is selected from the group consisting
of >C.dbd.O and --CH.sub.2 -- and R is selected from the group consisting
of hydrogen and lower alkyl, with the provisos that
(ii) when f is 1, X is at C-2 and R is at C-3, C-4 or C-5 and C-3,4 are
saturated or unsaturated;
(iii) when f is 2, X is at C-2, C-3 or C-4 and R is at C-2, C-3, C-4, C-5
or C-6 when the position is unoccupied by X and C-3,4 or C-4,5 are
saturated or unsaturated; and
(w) R.sub.36 is
##STR40##
where g is an integer of from 0 to 3; (x) R.sub.37 is
##STR41##
wherein h is 1 and j is 0 or 1; (y) R.sub.38 is
##STR42##
where k is an integer of from zero to two; (ae) R.sub.44 is
##STR43##
(af) R.sub.1 and R.sub.2, taken together, optionally represent a group
selected from the group consisting of aryl, and hydrogen;
(ah) R.sub.6 and R.sub.7 ; R.sub.9 and R.sub.10 ; R.sub.12 and R.sub.13 ;
R.sub.15 and R.sub.16 ; R.sub.18 and R.sub.19 ; R.sub.21 and R.sub.22 ;
each pair taken together, optionally and independently represent a group
selected from the group consisting of --C(O)NH--, >CH.sub.2,
--(CH.sub.2).sub.3 --, --CH.dbd.CH--, --CH(OH)--,
--C.tbd.C--,--C(.dbd.CH.sub.2)CH.sub.2 --, --CH(OH)CH.sub.2 --, --C(O)O--,
--C(O)S--, --CH.sub.2 C(O)O--, --CH.sub.2 C(O)S--, --CH.sub.2 O--,
--CH.sub.2 S--, and --NHC(O)--, with the provisos that
(i) at least one of said pair, taken together, must be other than
--C(O)NH--; and
(ii) when R.sub.5 is >NR.sub.203 or >C.dbd.CR.sub.205 R.sub.206, R.sub.6
and R.sub.7, taken together, represent --C(O)NH-- or --C(O)NCH.sub.3 ;
(ak) R.sub.100 is selected from the group consisting of hydrogen, and lower
alkyl;
(bb) R.sub.315 and R.sub.316 are independently selected from the group
consisting of hydrogen, lower alkyl, arylalkyl, wherein arylalkyl is
excluded when R.sub.22 -R.sub.23 -R.sub.24 represents an L-arginyl
residue, and (cycloalkyl)alkyl;
(bd) R.sub.325 and R.sub.326 are independently selected from the group
consisting of hydrogen, lower alkyl, aryl, arylalkyl, and
(cycloalkyl)alkyl;
(i) when more than one sulfhydrylalkyl is present in the compound, the
compound exists in the oxidized disulfide form producing a cyclic
molecule, or the two sulfhydryl moieties are connected by a C.sub.2 to
C.sub.8 alkylene chain and
(ii) when the compound contains a free amino group and carboxyl group, they
can be cyclized to give the corresponding lactam.