Tabell.

Efek yang diamati pada marmut janta n set elah penyuntikan dosis t unggal ke-6 bet s vaksin tifoid konj ugat Vi DT secara intramuskular

Vaksin uji: ViDT Conjugate

Efek yang diamati Vi DT-1 Vi DT-2 ViDT-3 Vi DT-4
HO T2 H1 H3 H7 H10 H14 HO T2 H1 H3 H7 H10 H14 HO T2 H1 H3 H7 H10 H14 HO T2 H1 H3 H7 H10 H14
1'
Aktivitas
N 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
motorik
-.1-
N 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Sikap Tubuh
TN
Piloe reksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Refl e ks Pineal 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Refl e ks Ko rn eal 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Refl e ks Fle ksi 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vomiting 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vasodil atasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Writhing 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Tre mor (b ad an) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Konvulsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Grooming 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Urinasi 10 40 0 30 20 40 40 30 20 60 40 20 20 0 30 0 40 20 40 20 40 40 0 40 0 0 40 20
Diare 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
De nyut Jantung (N) 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Pernapasan (N) 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Resp. Haffn er(+) 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Lethargy 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
n = 10, T2= dua jam sete lah pe mberi an vaksin uji; Angka menyat akan jumah hewan ya ng memberi efe k
Ta be l l (la njutan )

Vaksin uji: ViDT Conj ugate

kont rol (PBS)
Efek yang diamati Vi DT-5 ViDT-6
HO T2 H1 H3 H7 H10 H14 HO T2 H1 H3 H7 H10 H14 Ho T2 H1 H3 H7 H10 H14
1'
Aktivitas
N 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
motorik
-.1-
N 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Sikap Tubu h TN
Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Pt osis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Vaksi n uji: ViDT Conjugate
Refleks Pinea l 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 ViDT-1Vaksin tifoid konjugat single dose,
Refleks Korn eal 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 (25 ~g/0 .5ml)
Refleks Fleksi 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 Batch No : ViDT10115
Kata lepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ViDT-<Vaksin tifoid konjugat single dose,
Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (25~g/0.5ml)
Vomiting 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Batch No : ViDT10215
Salivas i 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ViDT-~ Vaksin tifoid konjugat single dose,
Vasodilatasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (25~g/0.5m l)
Writhing 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Batch No : ViDT1 0315
Tremor (badan) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ViDT-L Vaksin tifoid konjugat multi dose,
Konvulsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (25~g/0 . 5ml)
Grooming 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Batch No : ViDT20115
Urin asi 50 30 40 40 50 20 0 50 0 0 40 30 0 0 30 20 50 20 20 40 40 ViDH Vaksin tifoid konjugat multi dose,
Diare 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (25~g/0 . 5ml)
DenyutJantung (N) 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 Batch No: ViDT202 15
Pern apasan (N) 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 ViDT-EVaksin tifoid konjugat multi dose,
Resp. Haf fne r(+) 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 (25~g/0 . 5ml)
Leth argy 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Batch No: ViDT20315
n = 10, T2= dua j am setelah pemberi an vaksin uji; Angka menyat akan jumah hewan yang memberi efek
 Tabel 2. Efek yang diamati pada marmut betina setelah penyu ntikan dosis t unggal ke-6 bet s vaksin tifoid konjugat Vi DT secara int ram uskular

Vaksin uji: Vi DT Conj ugate

Efek yang dia mati ViDT-1 Vi DT-2 Vi DT-3 ViDT-4
HO T2 H1 H3 H7 H10 H14 HO T2 H1 H3 H7 H10 H14 HO T2 H1 H3 H7 H10 H14 HO T2 H1 H3 H7 H10 H14
1'
Aktivitas
N 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
moto rik
.,!,
N 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Sikap Tu buh TN
Pil oe re ksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Refl eks Pin eal 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Refl eks Korn eal 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Refl eks Fleksi 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Katale psi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vo miting 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vasodilat asi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Writhing 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Tre mor {badan) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Konvulsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Grooming 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Uri nasi 40 40 60 0 0 20 40 20 20 20 40 0 0 60 40 40 20 60 20 40 40 60 60 20 40 40 60 60
Diare 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
DenyutJ antung(N) 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Pernapasa n (N) 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Resp. Haffn er(+) 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
:Letha rgy ---- -
0
-~
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -
0 0 0 0 0 0 0 0 0 0 0 0
n = 10, T2= dua jam sete lah pemberi an vaksin uji; Angka menyata kan jumah hewan yang me mbe ri efe k
 Tabel 2. (lanjutan)

Vaksin uji: ViDT Conjugat e

Kontrol (PBS)
Efek yang diamati ViDT-5 ViDT-6
HO T2 H1 H3 H7 H10 H14 HO T2 H1 H3 H7 H10 H14 HO T2 H1 H3 H7 H10 H14

1'
Aktivitas
N 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
mot orik
,J.,
N 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
SikapTubuh TN
Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Vaksin uji: ViDT Conjugate
Refleks Pin eal 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 ViDT-1 Vaksin tifoid konjugat single dose,
Refleks Korneal 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 (25 ~g/0 . 5ml)
Refl eks Fl eksi 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 Batch No : ViDT1 011 5
Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ViDT-2 Vaksin tifoid konjugat single dose,
l.akrim asi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (25 ~g/0 . 5ml)
Vomiting 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Batch No: ViDT1021 5
Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ViDT-3 Vaksin tifoid konjugat single dose,
Vasodilatasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (25 ~g/0 . 5ml)
Writhing 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Batch No: ViDT1031 5
Tremor (badan) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ViDT-4 Vaksin tifoid konjugat multi dose,
Konvulsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (25 ~g/0. 5ml)
Grooming 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Batch No: ViDT2011 5
Uri nasi 100 100 100 80 40 20 40 20 20 80 60 40 20 60 40 40 20 60 20 40 40 ViDT -5 Vaksin tifoid konjugat multi dose,
Diare 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (25 ~g/0. 5ml)
DenyutJantung (N) 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 Batch No: ViDT20215
Pern apasa n (N) 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 ViDT-6 Vaksin tifoid konjugat multi dose,
Res p. Haffn er(+) 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 (25 ~g/0 . 5m l)
Lethargy 0 0 ' ( )_ 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Batch No: ViDT20315
- - - - - - -- - - ---- - - - -- -

n = 10, T2 = dua jam setelah pemberian vaksin uji; Angka menyatakan jumah hew an yang memberi efek
Tabel 3. Kondisi ot ot paha kaki marmut j antan dan betin a setelah pemberian dosis tunggal ke-6 bets vaksin tifoid konjugat Vi DT seca ra intramuskular

keadaa n ot ot paha tempat pe nyunt ikan int ramuskular vaksin uji

Kel. Vaksin kel
H1 H2 H3 H4 H5 H6 H7 H8 H9 H10 Hll H12 H13 H14
uji hew an
u E u E u E u E u E u E u E u E u E u E u E u E u E u E
ViDT-1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Jantan
ViDT-5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
kontrol
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
(PBS)

ViDT-1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-4 Betina 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 i

kontrol
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
(PBS) - - L_ ~-
:_______ ____
~
-

n =10; U =udem; E =eritema

ViDT-1 = Vaksin tifoid konjugat single dose (2 5f.lg/0. 5ml), Batch No: ViDT1011 5
ViDT-2 = Vaksin tifoid konjugat single dose (25f.lg/O.SmL), Bat ch No: ViDT10215
ViDT-3 =Vaksin tifoid konjugat single dose (25!-!g/O.SmL), Bat ch No: ViDT10315
ViDT-4 =Vaksin tifoid konjugat multi dose (2 5f.lg/O .S mL), Bat ch No: Vi DT20115
ViDT-5 =Vaksin tifoid konjugat multi dose (251l&f0.5mL), Batch No: Vi DT20215
ViDT-6 = Vaksin tifoid konjugat multi dose (2 5f.lg/O.SmL), Batch No: ViDT20315
Tabel 4. Perubahan bobot badan marmut jantan setelah pemberian dosis tunggal ke-6 bet s vaksin tifoid konjugat Vi DT secara intramuskular

Peru bahan bobot bada n (%)

Kel. Vaksin uji
H1 H3 H7 H10 H13 H15

ViDT-1 1.61±0.53 4.91±1.97 12.67±4.10 16.42±3.54 19.09±3.59b 22.80±3.49

ViDT-2 1.01±0.58 5.53±3.29 12.03±3.81 17.07±5.49 20.35±5.49 23.11±5.71

ViDT-3 1.15±0.96 6.71±2.73 12.92±3.43 16.79±3.88 20.51±2.87 23.22±3.23

ViDT-4 1.22±0.63 5.11±1.94 11.93±3.70 17.59±4.94 20.78±4.89 23.52±4.78 !

ViDT-5 1.05±0.37 4.71±1.35 9.47±3.87 14.57±5.68 17.69±5.72b 23.11±4.26

ViDT-6 1.06±0.80 4. 99±1.74 11.92±3.87 16.24±5,43 19.29±5.70 22.49±5.84

Kontrol (PBS) 1.19±0.42 5.81±2.39 10.44±1.71 18.68±5.19 23.33±5.14 L__ ___

25.85±5.47
--

n = 10; Statistik pe ngujia n: a = p<O,l; b = p<O,OS; da n c = p<O,Ol d iba ndingka n t e rh adap ko ntro l (PBS)
ViDT-1 = Vaksin tifoid konjugat single dose (2 5!lg/0.5ml), Bat ch No: ViDT10115
ViDT-2 = Vaksin tifoid konjugat single dose { 25 ~0 .5 mL), Bat ch No: ViDT10215
ViDT-3 =Vaksin tifoid konjugat single dose (2 5!lg/0.5mL), Batch No: ViDT10315
ViDT-4 = Vaksin tifoid konjuga t multi dose {25.ug/O.SmL), Batch No: Vi DT2 0115
ViDT-5 = Vaksin tifoid konjugat multi dose ( 25 ~/0.5 mL), Bat ch No: Vi DT20215
ViDT-6 =Vaksin tifoid konjuga t multi dose {25!-lg/O.S ml), Bat ch No: ViDT20315
Tabel 5. Perubahan bobot badan marmut betina setelah pemberian dosis tunggal ke-6 bets vaksin tifoid ViDT secara intramuskular

Perubahan bobot badan (%)

Kel. Vaksin uji
H1 H3 H7 H10 H13 H15
ViDT-1 2.28±1.39 6.45±2.65 10.98±3.09b 14.17±3.91( 17 .33±4.58b 19.72±4.53
ViDT-2 1.24±0.86b 3.41±1.98 7.31±3.78 9.36±3.63 13.80±2.93 17.79±3.82
ViDT-3 1.53±1.11 5.17±2.61 10.34±2.58b 13.65±2.90( 17.09±2.93b 19.38±3.09
ViDT-4 1.61±0.98 5.78±2.98 10.43±4.61a 12.31±5.35a 15.89±4.90 19.01±4.71
ViDT-5 1.48±0.93 3.88±3.22 6.64±3.59 9.41±3.07 14.42±3.64 18.94±3.63
ViDT-6 1.06±0.78b 3.64±2.15 6.93±3.14 9.58±3.75 13.67±4.04 18.06±4.43
Kontrol (PBS) 2.29±1.23 5.01±2.33 ---- -- ----
6.93±3.99 8.47±4.11 13.21±3.73 17.43±3.02
n =10; Statistik pengujian: a =p<O,l; b =p<O,OS; dan c =p<O,Ol dibandingkan terhadap kontrol (PBS)
ViDT-1 = Vaksin tifoid konjugat single dose {25J..Lg/O.SmL), Batch No: ViDT10115
ViDT-2 = Vaksin tifoid konjugat single dose {25J..Lg/O.Sml), Batch No: ViDT10215
ViDT-3 =Vaksin tifoid konjugat single dose {25J..Lg/0.5ml), Batch No: ViDT10315
ViDT-4 = Vaksin tifoid konjugat multi dose {25J..Lg/0.5ml), Batch No: ViDT20115
ViDT-5 =Vaksin tifoid konjugat multi dose {25!lg/0.5mL), Batch No: ViDT20215
ViDT-6 =Vaksin tifoid konjugat multi dose {25J..Lg/O.Sml), Batch No: ViDT20315
Tabel 6. Jumlah pakan yang dimakan marmut jantan set elah pemberian dosis tungga l ke-6 bets vaksin tifoid konjugat Vi DT seca ra intramuskular

Kel. Vaksin Jumlah pa kan yang dimakan per kelompok

uji Hl H2 H3 H4 HS H6 H7 H8 H9 HlO Hll H12 H13 H14
ViDT-1 240.9 350.3 350.3 399.4 384.1 415.9 347.7 372.8 384.4 328.4 382.5 307.0 361.0 398.5
ViDT-2 179.3 298.4 266.1 311.4 258.8 277.8 234.0 276.0 277.7 262.4 288.4 299.3 349.4 323.7
ViDT-3 204.7 338.4 348.9 350.6 380.0 384.0 295.8 333.9 330.2 282.3 360.4 302.9 345.3 378.0
ViDT-4 168.2 300.1 286.3 321.2 305.8 346.8 289.0 333.3 342.6 300.7 349.8 292.0 307.4 352.1
ViDT-5 144.2 272.8 252.7 280.5 274.7 298.9 212.2 275.8 293.4 267.1 305.2 239.9 284.8 332.2
ViDT-6 167.5 281.1 265. 2 285.8 277.0 315.1 244 .0 278.8 293.6 278.5 326.2 278.5 312.7 340.8
kontrol
216.1 347.8 330.3 345.0 322.5 345.5 280.1 310.5 328.3 300.9 341.4 292.0 305.8 355.3
(PBS)
n = 10
ViDT-1 =Vaksin tifoid konjugat single dose (25J.!g/0.5 mL), Bat ch No: ViDT10115
ViDT-2 =Vaksin tifoid konjuga t sin gle dose {25 J.!g/0.5mL), Batch No: ViDT102 15
ViDT-3 = Vaksin tifoid konjuga t single dose (25J.!g/O.Sml), Bat ch No : ViDT103 15
ViDT-4 =Vaksin t ifoid konjuga t multi dose {25J.!g/O.S mL), Bat ch No: ViDT20115
ViDT-5 =Vaksin tifoid konjuga t multi dose { 25 ~/0 . 5 m l), Batch No: Vi DT20 215
ViDT-6 = Vaksin tifoid konjugat multi dose (25J.!g/O.SmL), Bat ch No: Vi DT20315
Tabel 7. Jumlah pakan yang dimakan marmut betin a set elah pemberian dosis tungga l ke-6 bet s vaksin tifoid konjugat Vi DT secara
intramuskul ar

Kel. Vaksin Jumlah pa kan yang dimakan per kelompok

uji Hl H2 H3 H4 HS H6 H7 H8 H9 HlO Hll H12 H13 H14
ViDT-1 143.3 330.9 315.6 346.9 350.1 305.8 318.5 347.6 359.2 357.6 349.7 347. 6 350.7 355.3
ViDT-2 177.6 275.1 281.6 293.8 293.0 239.8 264.2 298.2 315.4 325.6 322.3 334.1 311.8 345.9
ViDT-3 159.4 298.9 257.0 295.5 321.3 312.8 340.8 353.6 358.1 359.1 359.2 350.6 358.2 354.4
ViDT-4 185. 1 333.9 296.4 334.7 347.4 304.0 323.0 355.7 358.9 349.5 357.5 350.4 371.2 363.3
ViDT-5 196.5 337.1 328.8 350.4 354.3 332.8 346.7 359.3 357.0 363.8 359.1 365.3 373.4 375 .4
ViDT-6 167 .3 340.3 328.7 343.8 360.7 349.1 358.2 363.5 358.3 367 .0 357.2 372.6 367. 6 354.6
kontrol
214.0 344.5 350.5 360.1 389.5 360.3 367.3 377.8 367.1 385.9 359.2 367.8 371.2 351.5
(PBS)
n = 10
ViDT-1 =Vaksin tifoid konjugat single dose {2 5!J.g/0.5mL), Batch No: ViDT1011 5
ViDT-2 = Vaksin tifoid konjugat single dose {2 5!J.g/O.SmL), Batch No: Vi DT10215
ViDT-3 = Vaksin t ifoid konjugat single dose {2 5!J.g/0.5ml), Bat ch No : Vi DT10315
ViDT-4 =Vaksin t ifoid konjugat multi dose {25!J.g/O.SmL), Batch No: ViDT2011 5
ViDT-5 = Vaksin tifoid konj uga t multi dose {251lg/O.SmL), Batch No: Vi DT20 21 5
ViDT-6 =Vaksi n tifoid konjugat multi dose {2 5!J.g/0.5mL), Batch No: Vi DT20315
Tabel8. lnd eks organ marmut j antan setelah pemberian dosis tunggal ke-6 bets vaksin tifoid konjugat ViDT secara intramuskular

Ke l. Vaksin lndeks organ (%)

uji Jantung Paru Hati Limpa Ginj al Kel. Adrenal Testes V seminalis Epididimis

ViDT-1 0.306±0.054 0.736±0.047 3.658±0.432 0.148±0.032 0.860±0.077 0.049±0.005 0.309±0.083 0.196±0.060 0.159±0.033

ViDT-2 0.282±0.031 0.789±0.113 3.631±0.229 0.147±0.027 0.836±0.059 0.052±0.009 0.321±0.042 0.188±0.019 0.161±0.020

ViDT-3 0.300±0.038 0.744±0.105 4.154±0.406. 0.178±0.075 0.940±0.091 0.054±0.009 0.326±0.065 0.196±0. 095 0.156±0.068

ViDT-4 0.307±0.051 0.802±0.155 4.139±0.419. 0.142±0.045 0.904±0.067 0.058±0.007 0.312±0.072 0. 189±0. 099 0.159±0.028

ViDT-5 0.291±0.038 0.811±0.171 4.084±0.241. 0.157±0.027 0.920±0.077 0.052±0.011 0.327±0.050 0.187±0.062 0.166±0.024

ViDT-6 0.287±0.032 0.803±0.311 3.996±0.398 0.152±0.075 0.889±0.065 0.052±0.010 0.296±0.080 0.184±0.037 0.165±0.023

kontrol
0.290±0.038 0.806±0.157 3.758±0.453 0.146±0.017 0.883±0.088 0.050±0.008 0.277±0.102 0.189±0.043 0.167±0.014
(PBS) . ...

n = 10; Statistik pengujian: a= p<0,1; b = p<0,05; dan c = p<O,Ol dibandingkan terhadap kontrol (PBS)
ViDT-1 =Vaksin tifoid konjugat single dose (2Sj.ig/O .SmL), Batch No: ViDT10115
ViDT-2 =Vaksin tifoid konjugat single dose (2 Sj.ig/O.SmL), Batch No: ViDT10215
ViDT-3 =Vaksin tifoid konjugat singl e dose {2 Sj.ig/O .SmL), Batch No: ViDT10315
ViDT-4 = Vaksin tifoid konjugat multi dose (2Sj.ig/O.Sml), Batch No: ViDT20115
ViDT-5 =Vaksin tifoid konjugat multi dose (25j.lg/0.5mL), Batch No : ViDT20215
ViDT-6 =Vaksin t ifoid konjugat multi dose (2Sj.ig/O.SmL), Batch No: ViDT20315
Tabel 9. lndeks organ marmut betina sete lah pemberian dosis tunggal ke-6 bets vaksin tifoid konjugat ViDT secara intramuskular

lndeks organ (%)

Ke l. Vaksin uji
Jantung Pa r u Hati Limpa Ginja l Kel. Adrenal Uterus Ovarium

Vi DT-1 0.290±0.031 0.772±0.143 3.763±0.355( 0.191±0.036b 0.912±0.081 0.068±0.009 0.251±0.072 0.018±0.003

Vi DT-2 0.288±0.025 0.816±0.132 3.659±0.438b 0.157±0.053 0.942±0.059 0.063±0.008 0.244±0.027 0.019±0.004

ViDT-3 0.295±0.030 0.728±0.100 3.802±0.392( 0.165±0.021 0.935±0.136 0.062±0.006 0.266±0.049 0.021±0.006

ViDT-4 0.271±0.022 0.777±0.170 3.612±0.450. 0.154±0.022 0.944±0.086 0.063±0.005 0.234±0.123 0.021±0.008

Vi DT-5 0.285±0.032 0.764±0.083 3.271±0.459 0.172±0.042 0.890±0.112 0.064±0.007 0.267±0.057 0.020±0.009

Vi DT-6 0.290±0.026 0.749±0.091 3.725±0.375b 0.167±0.039 0.945±0.104 0.062±0.006 0.252±0.042 0.021±0.004

kontro l (PBS) 0.287±0.027 0.739±0.053 3.264±0.361 0.155±0.024 0.922±0.044 0.069±0.012 0.271±0.089 0.018±0.004
n = 10; St atisti k pengujian: a= p<0,1; b = p<0,05; dan c = p<0,01 diband ingkan terhadap kontrol (PBS)
ViDT-1 = Vaksin t ifo id konjugat single dose (25J.!g/O.Sml), Batch No: ViDT10115
Vi DT-2 =Vaksin tifoid konj ugat single dose (2Sj.!g/O.Sml), Bat ch No: ViDT10215
Vi DT-3 =Vaksin tifo id konj ugat single dose (25J.!g/O.SmL), Batch No: ViDT10315
Vi DT-4 = Vaksin t ifoid konj ugat mu lt i dose (25j.!g/O.SmL), Batch No: ViDT20115
Vi DT-5 =Vaksin tifo id konj ugat multi dose (25j.!g/O.SmL), Batch No : Vi DT20215
Vi DT-6 =Vaksin tifoid konjugat mu lti dose {25J.!g/O.Sml), Batch No: ViDT20315
Tabel 10. Mortalitas marmut jantan dan betina set elah pemberian dosis tunggal ke-6 bet s vaksin tifoid konjugat ViDT secara int ramuskular

Mortalitas (%)
Kel. Vaksin
kel hew an
UJI Hl H2 H3 H4 HS H6 H7 H8 H9 HlO Hl l H12 H13 H14

ViDT-1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-2 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-3 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-4 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Janta n
ViDT-5 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-6 0 0 0 0 0 0 0 0 0 0 0 0 0 0

kontro l (PBS) 0 0 0 0 0 0 0 0 0 0 0 0 0 0

ViDT-1 0 0 0 0 0 0 0 0 0 0 0 0 0 0

ViDT-2 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-3 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-4 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bet ina
ViDT-5 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ViDT-6 0 0 0 0 0 0 0 0 0 0 0 0 0 0

kontrol (PBS) 0 0 0 0 0 0 0 0 0 0 0 0 0 0

n = 10
ViDT-1 = Vaksin tifoid konjugat single dose {2 5!-!g/O.SmL), Bat ch No : ViDT10115
ViDT-2 =Vaksin tifoid konjuga t single dose {25!-!g/O.SmL}, Bat ch No: ViDT10215
ViDT-3 = Vaksin tifoid konjuga t sin gle dose {25!-!g/O.SmL}, Bat ch No: ViDT103 15
ViDT-4 = Vaksin tifoid konjugat multi dose {2 5!-!g/O.S mL), Batch No: Vi DT20115
ViDT-5 = Vaksin tifoid konjugat multi dose {2 5jlg/0.5m l}, Bat ch No: ViDT20215
ViDT-6 =Vaksin tifoid konjugat multi dose (2 5!-!g/O.S mL), Batch No: Vi DT20315
 perubahan bobot badan (%)
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Hl H3 H7 HlO H13 HlS
Waktu (hari)

Gambar 2. Perubahan bobot badan marmut betina setelah pemberian dosis tunggal ke-6 bets vaksin
tifoid konjugat ViDT secara intramusku lar
 ~ ViDT-1 ~ ViDT-2 ~• ViDT-3 ttl ViDT-4 ~~~ ViDT-5 ~ ViDT-6 mkontrol (PBS)

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Hl H3 H7 HlO H12 H14

Waktu (hari)

Gambar 3. Jumlah pakan yang dikonsumsi marmutjantan setelah pemberian dosis tunggal ke-6 bets vaksin
tifoid konjugat ViDT secara intramuskular
 450.0

i:S ViDT-1 X ViDT-2 ~ ViDT-3 ~ ViDT-4 :!?. ViDT-5 ~ ViDT-6 ~ kontrol (PBS)
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Hl H3 H7 HlO H12 H14

Waktu (hari)

Gambar 4 . Jumlah pakan yang dikonsumsi marmut betina setelah pemberian dosis tunggal ke-6 bets vaksin
tifoid konjugat ViDT secara intramuskular