LSD Microdosing Trial Shows 'Remarkable' Promise For Chronic Pain Sufferers - SlashGear

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LSD microdosing trial shows

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‘remarkable’ promise for chronic

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pain sufferers
Brittany A. Roston (https://www.slashgear.com/author/brittany/) -
Aug 27, 2020, 2:05 pm CDT
Another early investigation into the potential therapeutic use of psychedelics reports
‘remarkable’ effects on pain relief, at least based on the results of a small clinical trial.
The investigation — the first of its kind in several decades — builds upon anecdotal
reports from users who claim they’ve experienced decreased pain while on LSD,
leading researchers to explore whether similar effects are experienced at sub-
psychedelic doses.
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Psychedelic research (at least in the United States) is largely still in its infancy after
decades of suspended work due to the scheduling of these drugs. Despite their illegal
status, many people have still tried psychedelics, a large number of whom take them
regularly or participate in a practice known as ‘microdosing.’
Microdosing involves taking very small, sub-perceptual doses of psychedelics —

typically LSD or psilocybin — a couple or few times a week. The Internet has made it
possible for these psychedelic users to find each other and report their experiences,
many of which have been positive. Many anecdotal microdosing reports include
enhanced emotions, productivity, and creativity.
Researchers have noted that many LSD users also report experiencing a decrease in
pain while on the substance, raising questions about whether regular microdosing of
this substance may offer pain relief without the addiction potential of opioid
medications. That’s where the Maastricht University clinical trial comes in — it
evaluated (https://www.beckleyfoundation.org/can-lsd-microdosing-reduce-pain-
perception/) 24 healthy volunteers across four experiments and three different LSD
microdosing levels.
Participants given the 20µg microdose were found to have ‘remarkable’ increases in
pain tolerance during the testing when compared to participants given either a placebo
or smaller 5µg and 10µg doses. The findings point toward long-term pain relief that
kicked in within 90 minutes of administration of the microdose and that persisted for at
least five hours afterward.
The study states (https://journals.sagepub.com/doi/full/10.1177/0269881120940937):
2 of 7 8/27/20, 6:59 PM
LSD 20 µg significantly increased the time that participants were able to tolerate exposure
to cold (3°C) water and decreased their subjective
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unpleasantness. LSD elevated mean blood pressure within the normal range and slightly
increased ratings of dissociation, anxiety and somatization …
The present study provides evidence of a protracted analgesic effect of LSD at a dose that
is low enough
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research into the analgesic effects of low doses of LSD in patient populations.

At this point in time, there’s no single clear explanation for how the higher LSD
microdose was able to reduce one’s perception of pain while increasing pain tolerance,
but future studies may uncover the answer. How significant is the pain relief? The study
found that based on reports from participants, the microdose’s ability to reduce pain
was akin to that of morphine and oxycodone, two common but highly addictive
painkillers.
Story Timeline
Study: LSD causes a higher state of consciousness (sort of) (https://www.slashgear.com
/study-lsd-causes-a-higher-state-of-consciousness-sort-of-19482810/)
LSD microdosing phase one clinical trial finds almost no side effects
(https://www.slashgear.com/lsd-microdosing-phase-one-clinical-trial-finds-almost-no-
side-effects-19603973/)
MindMed develops an 'off switch' to stop LSD trips during therapy

(https://www.slashgear.com/mindmed-develops-an-off-switch-to-stop-lsd-trips-during-
therapy-28618594/)
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LSD microdosing trial shows

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Microdosing involves taking very small, sub-perceptual doses of psychedelics —

The study states (https://journals.sagepub.com/doi/full/10.1177/0269881120940937):

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