MCQ Part I Aug 08

1. Regarding atypical antipsychotics, which one of the following endocrine

abnormalities has been shown?
a. Olanzapine produced minimal increase in body mass index
b. Risperidone induces significantly greater elevation in triglyceride than
Olanzapine
c. The Olanzapine- induced elevation of triglyceride plateau by 6 months*
d. Elevation in cholesterol and LDL (low density lipids) were consistently
present with both Olanzapine and Risperidone
e. The is a minimal risk for ultimate development of type II Diabetes
Mellitus in patients treated with Olanzapine

2. Antiparkinsonian medications are:

a. given routinely to all patients on antipsychotic medication
b. usually continued after 6 months
c. Decreasing the anticholinergic effects of antipsychotics
d Reducing the likelihood of later tardive dyskinesia
e liver enzymes inducers*

3. Which one of the following is a sign of intoxication with lithium?

a. Drowsiness*
b. Fine tremor of the hands
c. Nephrogenic diabetes insipidus
d. Hyperthyroidism
e. Hyperparathyroidism

4. Which one of the following is caused by barbiturate intoxication?

a. Lethargy
b. Drowsiness
c. Increased slow activity in EEG
d. Increased reflexes*
e. Paradoxical excitement

2. Which one of the following is a proved Basic Principle in

Neuropharmacology?
a. pharmacodynamics concern with the study of how the body absorbs,
distributes and eliminates a drug
b. agonist is an agent occupies receptors leading to a stimulus which evokes a
response*
c. contragonist is an agent occupies receptors but it produces no stimulus and
therefore no response
d. partial agonist is an agent which occupies receptors and it leads to a potent
stimulus
e. antagonist is an agent which induces a stimulus and an opposite response
6. Which one of the following definitions is an accurate Quantitative Variable
in Neuropharmacology?
a. Zero-order elimination follows an exponential decline
b. zero-order elimination means that the rate of elimination is
proportional to the drug concentration
c. plasma half-life is the time taken for the plasma concentration to fall
by half*
d. biological half-life is the time taken for the total amount of the drug in
the serum to decline by one half
e. steady state means that the amount of drug entering the body equals
the half life of the drug

7. Donepezil (Aricept) is:

a. an acetylcholine inhibitor
b. used for the treatment of Parkinson's disease
c. avoided in patients with heart block*
d. used with an average dose from 20-30 mg daily
e. most effective in severs cases

8. Which one of the following is a common adverse event of lithium?

a. Muscle twitching
b Ataxia
c Course tremors
d leucocytosis*
e. Slurred speech

9. Which one of the following is a recognized cardiovascular side effect of

tricyclic antidepressants?
a. Bradycardia
b. prolong the P-R interval on the ECG*
c. hypertension
d. ST elevation on ECG
e. T inversion on ECG

10. Which one of the following is safe in combination with monoamine

oxidase inhibitors?
a. L-tryptophan
b. pethidine
c. pseudoephedrine
d. one pint of beer*
e. banana skin
11. In neuroleptic malignant syndrome which one of the following is a
recognized feature?
a. hypothermia is common
b. level of consciousness is preserved
c. mortality around 1 %
d. muscle tone is deceased
e. the blood pressure is labile*

12. Tardive dyskinesia :

a. Is characterized by athetoid movements of face and mouth.*
b. Frequently involves limbs and trunk
c. Is commoner in patients receiving intermittent anticholinergic therapy.
d. The over all prevalence for people receiving long term neuroleptic
therapy is 45%.
e. The use of a more potent dopamine-blocking drug aggravates the
condition in short term.

13. Following oral administration drugs are characteristically absorbed:

a. Mainly in the stomach unless they are enteric coated
b. Primarily by active transport
c. Better when in the ionized form
d. Less readily in the presence of food in the gut
e. More slowly than when given by the intramuscular injection*

14. Which of the following is a drug of choice in depressed patient with

recent myocardial infarction?
a. Flouxetine
b. Venlafaxine
c. Citalopram
d. Paroxetine
e. Sertraline*

15. Which one of the following has been shown regarding the atypical anti-
psychotic drugs?
a. Clozapine has high affinity for D2 site, but it has low affinity for 5HT2
and 5HT3 receptors
b. Risperidone has a lower affinity for D2 and 5HT2 receptors than
Clozapine
c. Quetiapine has a high affinity to D2 and moderate affinity for the
muscarinic Binding site
d. Olanzapine has relatively low muscarinic and histaminergic blockade
e. Ziprasidone has the highest 5HT2/D2 ratio*

16. atypical antipsychotic drugs:

a. have no incidence of extrapyramidal symptoms
 b. are selective dopamine D2 or D3 receptor antagonists
c. are all 5-HT2 antagonists
d. have been shown to have limbic selective action in pre-clinical tests*
e. are all effective in primary enduring negative symptoms

17. Which one of the following is a weight neutral medication?

a. Clozapine
b. Olanzapine
c. Risperidone
d. Ziprasidone*
e. Quetiapine