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Objective: To assess a labor-management protocol that man- no severe maternal complications. One neonate had persis-
dated at least 4 hours of oxytocin augmentation before tent fetal circulation and one had a positive blood culture,
cesarean delivery for active-phase labor arrest. but both did well.
Methods: We prospectively evaluated term gravidas in Conclusion: Extending the minimum period of oxytocin
spontaneous labor with active-phase labor arrest (cervix at augmentation for active-phase labor arrest from 2 to at least
least 4 cm dilated and 1 cm or less of cervical progress in 2 4 hours was effective and safe. (Obstet Gynecol 1999;93:
hours). Exclusion criteria included nonvertex presentation, 323– 8. © 1999 by The American College of Obstetricians
previous cesarean, multiple gestation, and a nonreassuring and Gynecologists.)
fetal heart rate tracing or chorioamnionitis at the time of
labor arrest. After the diagnosis of active-phase arrest, oxy-
tocin was initiated with an intent to achieve a sustained
uterine contraction pattern of greater than 200 Montevideo In 1970, the cesarean delivery rate in the United States
units. Cesarean delivery was not performed for labor arrest was 5.5%. By 1978 it had nearly tripled, to 15.2%.1 The
until at least 4 hours of a sustained uterine contraction National Institutes of Health Cesarean Birth Task Force
pattern of greater than 200 Montevideo units, or a minimum determined that dystocia was the single leading factor
of 6 hours of oxytocin augmentation if this contraction contributing to the increase. Accordingly, the Task
pattern could not be achieved.
Force recommended that dystocia and its management
Results: Five hundred forty-two women were managed by
should be the focus of further research.1 Subsequent
the protocol, and 92% delivered vaginally. The subsequent
vaginal delivery rate for parous women who had not pro-
research on uterine contraction pressures contributed to
gressed (1 cm of cervical dilation or less) despite 2 hours of the following 1989 ACOG recommendation: “before the
oxytocin augmentation was 91%, and it was 74% for nullip- diagnosis of arrest in the first stage of labor is made,
aras. With no labor progress after 4 hours of oxytocin both of the following two criteria should be met:
augmentation, the subsequent vaginal delivery rates were
88% for parous women and 56% for nulliparas. There were 1. The latent phase of labor has been completed with
the cervix dilated 4 cm or more.
2. A uterine contraction pattern of $200 Montevideo
From the Division of Maternal-Fetal Medicine, Department of Ob-
stetrics and Gynecology, University of Alabama at Birmingham, Bir- units in a 10-minute period has been present for 2
mingham, Alabama. hours without cervical change.”2
more than 1 cm of cervical dilatation) or delivery had upper limit of the 99% confidence interval for an event
occurred by both 2 and 4 hours after the initiation of with an observed rate of 1% is less than 2%.
oxytocin augmentation. Vaginal delivery rates were
analyzed further for the subset of patients with no labor
Results
progress despite 2 hours of uterine activity greater than
200 Montevideo units. For the purposes of analysis, a From February 1, 1996 through April 6, 1998, 554
patient was considered to have had a “2-hour cervical protocol-eligible women experienced active-phase labor
examination” if a cervical examination was docu- arrest. Twelve (2%) of these women did not receive
mented in the chart from 91 to 179 minutes after the oxytocin because of spontaneous progress of labor
initiation of oxytocin, and a “4-hour cervical examina- before initiation of the drug. These women all delivered
tion” if the examination was performed between 211 vaginally, and because they did not receive oxytocin,
and 299 minutes after the initiation of oxytocin. Patients they were not considered further in the analysis of this
who did not have a cervical examination in the 2- or protocol. Thus, 542 women were eligible for the proto-
4-hour examination window were also analyzed, and col and received oxytocin.
their outcomes were reported for comparison. Of the women managed by the protocol, 288 (53%)
Using Fisher exact test, we compared complication were nulliparous and 254 (47%) were parous. Parous
rates among three groups: the group that progressed, and nulliparous women were similar demographically:
the group that did not progress, and the group that was The mean age was 23 and 20 years, respectively; mean
not examined 2 or 4 hours after the initiation of oxytocin weight was 81 and 79 kg; 68% and 74% were black; and
augmentation. Data were analyzed using the SAS sys- 27% and 24% were white. The mean gestational age at
tem 6.12 for personal computers (SAS Institute, Cary, delivery was 40 weeks for both groups; the mean birth
NC). P , .05 was considered significant. We established weight was 3427 and 3301 g, respectively; and 89% and
a target sample size of at least 500 women. A cohort of 96% received lumbar epidural analgesia for labor.
this size yields high precision (narrow confidence inter- The vaginal delivery rate for the cohort of protocol-
vals) around observed event rates. For example, the managed women was 92%: 97% for parous women and
Table 2. Vaginal Delivery and Complication Rates of Nulliparas With Active-Phase Labor Arrest Categorized by Labor
Progress After the Initiation of Oxytocin Augmentation
Eventual vaginal
Time delivery rate (%) Chorioamnionitis (%) Endometritis (%) Transfusion (%)
VOL. 93, NO. 3, MARCH 1999 Rouse et al 4-Hour Oxytocin Minimum 325
88% for nulliparas. The median time from the diagnosis ventilation) outside of the delivery room. In the infants
of active-phase labor arrest to the initiation of oxytocin of both parous and nulliparous patients, these compli-
was 15 minutes. Analysis by whether labor had pro- cations did not differ significantly among the three
gressed (including delivery) by 2 and 4 hours after the groups (progress, no progress, and no examination
initiation of oxytocin demonstrated that the majority of groups) at either 2 or 4 hours after the initiation of
women with no progress despite 2 or even 4 hours of oxytocin.
oxytocin augmentation eventually underwent a vaginal Because most women progressed after 2 hours of
delivery (Tables 1 and 2). Parous women with no oxytocin, we identified only 52 women with no
progress despite 2 hours of oxytocin augmentation had progress 2 hours after achieving a uterine contraction
a vaginal delivery rate of 91%, whereas nulliparas had pattern of greater than 200 Montevideo units. The
a vaginal delivery rate of 74%. Even with no labor eventual vaginal delivery rate was 63% for the 40
progress 4 hours after the initiation of oxytocin, 88% of nulliparas in this group and 58% for the 12 parous
parous women and 56% of nulliparas eventually deliv- women. Although this group had a high rate of mater-
ered vaginally. nal infection (chorioamnionitis 27%, endometritis 12%),
No patients experienced uterine rupture or under- their other outcomes were essentially equivalent to
went hysterectomy. Rates of chorioamnionitis and en- those of the overall cohort of protocol-managed
dometritis for nulliparas were 10% and 5%, respec- women, with no severe adverse neonatal outcomes,
tively, and both were 2% for parous women. Labor including sepsis.
progress (and lack thereof) correlated with the risk of Indications for the 42 cesarean deliveries performed
maternal infectious complications: Rates of chorioam- included labor arrest (n 5 24), nonreassuring fetal
nionitis and endometritis were increased among pa- status (n 5 10), and both labor arrest and nonreassuring
tients who had not progressed (or were not examined) fetal status (n 5 8). Women who ultimately underwent
by 2 and 4 hours after the initiation of oxytocin (Tables cesarean for labor arrest either had no cervical progress
1 and 2). Four percent of the patients experienced after the diagnosis of labor arrest or made progress
postpartum hemorrhage and 1% received a red blood initially but had arrest again later. These women re-
cell transfusion. The risk of red blood cell transfusion ceived oxytocin for a median duration of 7.1 hours
was less consistently (and not significantly) related to (range 4.3–13.0). Before cesarean for labor arrest, 88% of
labor progress than was the risk of maternal infection the women achieved a uterine contraction pattern of
(Tables 1 and 2). One patient experienced a postcesar- greater than 200 Montevideo units.
ean abdominal wound infection.
In general, fetal and neonatal outcomes were excel-
Discussion
lent. There were no stillbirths or neonatal deaths. Two
infants, one with congenital diaphragmatic hernia and We conducted the present investigation to evaluate a
the other with multiple severe congenital malforma- protocol that focused on three principal elements: 1) an
tions, died after protracted courses of disease. With the intent to achieve a sustained uterine contraction pattern
exception of the latter infant, the lowest 5-minute Apgar of greater than 200 Montevideo units; 2) a more liberal
score was 6. Two infants had an umbilical artery pH of minimum of 4 hours (as opposed to the currently
less than 7.0. This acidemia was respiratory in nature, sanctioned 2 hours5) of oxytocin-augmented labor ar-
and both infants were vigorous at birth. One infant, rest with a sustained uterine contraction pattern of
born to a parous woman who had progressed after 2 greater than 200 Montevideo units before proceeding to
hours of oxytocin, had a positive blood culture, re- cesarean delivery for active-phase labor arrest; and 3)
ceived antibiotics, and was discharged without appar- for patients who could not achieve a sustained uterine
ent sequelae on day 14 of life. Four infants were placed contraction pattern of greater than 200 Montevideo
on mechanical ventilation: the two who died, one with units, a minimum of 6 hours of oxytocin augmentation
Noonan syndrome and an associated cardiac malforma- before proceeding to cesarean delivery for active-phase
tion, and one with persistent fetal circulation. This last labor arrest. Thus, we were able to address what we
infant, born to a parous woman who did not have a perceived as two practical limitations of the current
2-hour cervical examination, was on the ventilator for recommendations5 for active-phase labor arrest: 1) that
48 hours and was discharged on day 10 of life without a 2-hour minimum might deny some women the op-
apparent sequelae. Six percent of the newborns received portunity for a safe vaginal delivery, and 2) that some
antibiotics, and none suffered necrotizing enterocolitis, women are never able to achieve an augmented uterine
intraventricular hemorrhage, or seizures. One percent contraction pattern of greater than 200 Montevideo
had hyperbilirubinemia requiring phototherapy and 2% units.
required supplemental oxygen (exclusive of mechanical This protocol was effective, resulting in a high rate of
VOL. 93, NO. 3, MARCH 1999 Rouse et al 4-Hour Oxytocin Minimum 327
Certain limitations of our data warrant comment. We and the augmentation of labor. ACOG technical bulletin no. 218.
studied only women in spontaneous labor who had Washington DC: American College of Obstetricians and Gynecol-
ogists, 1995.
experienced active-phase labor arrest. Therefore, our 6. Sanchez-Ramos L, Kaunitz AM, Peterson HB, Martinez-Schnell B,
findings are not directly applicable to women undergo- Thompson RJ. Reducing cesarean sections at a teaching hospital.
ing induction of labor. The data also may not be Am J Obstet Gynecol 1990;163:1081– 8.
applicable to women who experience active-phase labor 7. Myers SA, Gleicher N. A successful program to lower cesarean-
arrest while receiving oxytocin (eg, women who receive section rates. N Engl J Med 1988;319:1511– 6.
8. Arulkumaran S, Koh CH, Ingemarsson I, Ratnam SS. Augmenta-
oxytocin for protraction disorders or according to the tion of labour—mode of delivery related to cervimetric progress.
principles of active management of labor). Because we Aust N Z J Obstet Gynaecol 1987;27:304 – 8.
excluded women with previous cesareans and those 9. Sharma SK, Sidawi JE, Ramin SM, Lucas MJ, Leveno KJ, Cunning-
with chorioamnionitis at the time of active-phase labor ham FG. Cesarean delivery. A randomized trial of epidural versus
arrest, the safety of this protocol for such women and patient-controlled meperidine analgesia during labor. Anesthesi-
ology 1997;87:472– 6.
their fetuses requires further investigation. Finally, al- 10. Thorp JA, Parisi VM, Boylan PC, Johnston DA. The effect of
though we studied more than 500 women, our ability to continuous epidural analgesia on cesarean section for dystocia in
perform in-depth subanalyses (eg, by cervical dilatation nulliparous women. Am J Obstet Gynecol 1989;161:670 –5.
at labor arrest) was limited by the relatively small 11. Ramin SM, Gambling DR, Lucas MJ, Sharma SK, Sidawi JE,
numbers of women in specific subgroups. Leveno KJ. Randomized trial of epidural versus intravenous
analgesia during labor. Obstet Gynecol 1995;86:783–9.
The above limitations notwithstanding, this labor- 12. Alexander JM, Lucas MJ, Ramin SM, McIntire DD, Leveno KJ. The
management protocol was safe and effective. We en- course of labor with and without epidural analgesia. Am J Obstet
courage others to investigate this protocol. If, with Gynecol 1998;178:516 –20.
larger samples, the efficacy and safety of this protocol 13. American College of Obstetricians and Gynecologists. Operative
are confirmed, the minimum recommended duration of vaginal delivery. ACOG technical bulletin no. 196. Washington
DC: American College of Obstetricians and Gynecologists, 1994.
oxytocin augmentation for active-phase labor arrest 14. Centers for Disease Control and Prevention. Rates of cesarean
should be increased. delivery. MMWR Morb Mortal Wkly Rep 1993;42:287–9.
15. Notzon FC, Cnattingius S, Bergsjø P, Cole S, Taffel S, Irgens L, et al.
Cesarean section delivery in the 1980s: International comparison
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