Important questions of medicinal chemistry 2

1) Define Histamine and classify H1 antagonist with suitable example ?

2) Write down synthesis of Cimetidine and Promethazine HCl ?

3) Classify H2 antagonist with suitable example. Explain SAR of

antihistamine. Discuss Synthesis of Diphenhydramine HCl.

4) write a note on Gastric proton pump inhibitors ?

5) Classify alkylating agents of antineoplastic Class . Give Synthesis

of methotrexate and Meclorethamine.

6) Classify antineoplastic agents with suitable examples. Discuss

mode of action of alkylating agents.

7) Discuss SAR of local anaesthetics ?

8) Classify Anti arrhythmic Drugs and antihypertensive agents with

suitable example. Discuss mode of action of calcium channel blockers

9) Classify Diuretics with examples. Explain Mechanism of action of

Diuretics and SAR of Thiazide Diuretics.

10) Write Nomenclature, stereochemistry and metabolism of steroids.

11) Define calcium channel blockers .Give mechanism of action of

vasodilators. Write down synthesis of Furosemide and warfarin.

12) Classify Oral hypoglycaemic drugs . Discuss SAR of anti hypertensive

drugs .Give synthesis of Acetazolamide.

13) Short Notes on –

a) Antidiabetic agents

b) Oral contraceptives

c) Antihyperlipidemic agents

d) Coagulant and anticoagulant

e) Vasodilators

f) Insulin and it’s Preparation