DRUG NAME MECAHNISM OF INDICATION SIDE EFFECTS NURSING RESPONSIBILITIES

ACTION
GENERIC NAME: Disturbs DNA synthesis in  Trichomoniasis CNS: dizziness, headache,  Monitor I.V. site. Avoid prolonged use of
Metronidazole hydrochloride susceptible bacterial  Bacterial infections ataxia, vertigo, indwelling catheter. Evaluate hematologic studies,
organisms  Amebiasis incoordination, insomnia, especially in patients with history of blood
 Amebic liver abscess fatigue EENT: rhinitis, dyscrasias.
BRAND NAME:  Bacterial vaginosis sinusitis, pharyngitis GI:  Advise patient to take drug with food if it causes GI
Flagyl IV  Perioperative nausea, vomiting, diarrhea, upset. However, instruct him to take extended-
prophylaxis in abdominal pain, furry release tablets 1 hour before or 2 hours after
CLASSIFICATION: colorectal surgery tongue, glossitis, dry mouth, meals.
Anti-infective, antiprotozoal anorexia GU: dysuria, dark  Tell patient with trichomoniasis to refrain from
urine, incontinence sexual intercourse or to have male partner wear a
Other: unpleasant or metallic condom to prevent reinfection. Explain that
DOSAGE: taste, superinfection, asymptomatic sex partners should be treated
500 mg phlebitis at I.V. site simultaneously.
 Advise patient to report fever, sore throat,
CONTRAINDICATION ADVERSE EFFECTS bleeding, or bruising.
 Inform patient that drug may cause metallic taste
ROUTES:  Hypersensitivity to Hematologic: leukopenia and may discolor urine deep brownish-red.
Parenteral drug, other Skin: rash, urticaria, burning,  Tell patient using topical form to clean area
nitroimidazole mild skin dryness, skin thoroughly with mild cleanser before use and then
derivatives, or irritation, transient redness wait 15 to 20 minutes before applying drug. Tell
FREQUENCY: parabens (topical (with topical forms) her she may apply cosmetics to skin after applying
Q8H form only) drug; with topical lotion, instruct her to let skin dry
 First-trimester at least 5 minutes before applying cosmetics.
TIMING: pregnancy in patients  Tell female patient to consult prescriber if she is
with trichomoniasis pregnant or plans to become pregnant.
8am-4pm-12am-8am
Source: Schull, P.D., (2013).
McGraw – Hill Nurse’s Drug
Handbook 7th Edition.
The Mc-Graw – Hill
Companies, Inc..
 DRUG NAME MECAHNISM OF INDICATION SIDE EFFECTS NURSING RESPONSIBILITIES
ACTION
GENERIC NAME: Binds to beta-subunit of  Travelers’ diarrhea CNS: headache GI: nausea,  Monitor for fever, blood in stools, and worsening
rifaximin bacterial DNA-dependent caused by vomiting, constipation, of diarrhea.
RNA polymerase, inhibiting noninvasive strains of flatulence, abdominal pain,  Monitor patient’s fluid and electrolyte status.
bacterial RNA synthesis Escherichia coli rectal tenesmus, defecation  Monitor for new infections; if needed, consider
BRAND NAME:  Reduction of risk of urgency alternative therapy
Xifaxan Other: pyrexia, overgrowth  Tell patient drug can be taken with or without
overt hepatic
encephalopathy of susceptible organisms food.
CLASSIFICATION: recurrence  Advise patient to stop drug and notify prescriber if
Rifampin-related antibiotic diarrhea symptoms worsen or last beyond 48
Anti-infective hours.
 As appropriate, review all other significant or life-
threatening adverse reactions.
DOSAGE:  Patients who have diarrhea after antibiotic
200 mg/tab therapy may have CDAD, which may range from
CONTRAINDICATION ADVERSE EFFECTS mild to life threatening

Hypersensitivity to drug, its GI: pseudomembranous

ROUTES: components, or rifamycin colitis
Oral anti-infectives

FREQUENCY:
TID

TIMING:
Source: Schull, P.D., (2013).
McGraw – Hill Nurse’s Drug
Handbook 7th Edition.
The Mc-Graw – Hill
Companies, Inc..
 DRUG NAME MECAHNISM OF INDICATION SIDE EFFECTS NURSING RESPONSIBILITIES
ACTION
GENERIC NAME: Racecadotril is a prodrug of Acute diarrhoea. Significant:  Angioedema.  do not use if patient has abdominal pain (do not
thiorphan, an enkephalinase Respiratory, thoracic and want to stimulate peristalsis or use of sphincters,
Racecadotril inhibitor. It achieves its mediastinal because it might make the pain worse)
antisecretory effect by disorders:  Tonsillitis.  monitor for urinary retention (anticholinergic
protecting enkephalins from effect)
BRAND NAME: enzymatic degradation  do not combine with other meds - take it alone
thereby prolonging their  monitor frequency, volume, and consistency of
Hidrasec action at enkephalinergic stools. (This determines the effectiveness of drug
synapses in the small therapy.)
CLASSIFICATION: intestine and reducing  minimize the risk of dehydration and electrolyte
hypersecretion. imbalance. (These adverse effects may occur
Antidiarrheal
secondary to diarrhea.)
 prevent accidental overdosage. (Overdosage can
cause constipation.)
DOSAGE: CONTRAINDICATION ADVERSE EFFECTS  monitor for dry mouth. (This is a side effect of
100 mg medications.)
Children with fructose Skin and subcutaneous tissue  initiate safety measures to prevent falls. (These
intolerance, glucose disorders:  Rash, erythema, medications may cause drowsiness.)
ROUTES: malabsorption syndrome or urticaria, erythema
 monitor electrolyte levels. (With diarrhea,
Oral sucrase-isomaltase deficiency multiforme, nodular
electrolyte imbalance may occur.)
(granules). erythema, papular rash,
prurigo, pruritus.
Potentially Fatal: Skin
FREQUENCY: reactions.
TID
Source: Schull, P.D., (2013).
McGraw – Hill Nurse’s Drug
TIMING: Handbook 7th Edition.
The Mc-Graw – Hill
Companies, Inc..
DRUG NAME MECAHNISM OF INDICATION SIDE EFFECTS NURSING RESPONSIBILITIES
ACTION
GENERIC NAME: Replaces deficiencies of  Hydrating solution; Metabolic: fluid and  Monitor electrolyte levels and blood chemistry
sodium chloride sodium and chloride and hyperosmolar electrolyte disturbances results. Watch for signs and symptoms of
maintains these electrolytes diabetes (such as hypernatremia and pulmonary edema or worsening heart failure.
at adequate levels  Water and sodium hyperphosphatemia)  Carefully monitor vital signs, fluid balance, weight,
BRAND NAME: Other: pain, swelling, local and cardiovascular status.
chloride
Slo-Salt tenderness, abscess, or tissue  Assess injection site closely to help prevent tissue
replacement;
metabolic alkalosis; necrosis at I.V. site necrosis and thrombophlebitis.
CLASSIFICATION: to dilute or dissolve  Teach patient to recognize and immediately report
Sodium replacement drugs for I.V., I.M., or serious adverse reactions, such as breathing
Electrolyte supplement subcutaneous use; to problems or swelling.
flush I.V. catheter; as  Instruct patient to report pain, tenderness, or
a priming solution in swelling at injection site.
hemodialysis;  As appropriate, review all other significant and
DOSAGE: life-threatening adverse reactions and
CONTRAINDICATION ADVERSE EFFECTS
650 mg/1 tab interactions, especially those related to the tests
mentioned above.
 Normal or elevated CV: edema (when given too
electrolyte levels rapidly or in excess),
ROUTES: (with 3% and 5% thrombophlebitis, heart
solutions) failure exacerbation
Oral
 Fluid retention Metabolic: aggravation of
existing metabolic acidosis
FREQUENCY: (with excessive infusion)
TID Respiratory: pulmonary
edema
Source: Schull, P.D., (2013).
TIMING: McGraw – Hill Nurse’s Drug
Handbook 7th Edition.
The Mc-Graw – Hill
Companies, Inc..