Steps Involved In Tablet Formulation/ Procedure for Active Pharmaceutical Ingredient

Manufacturing Tablets Acetazolamide

1. Dispensing
Trade Name
2. Sizing
Cidomex
3. Powder blending

4. Granulation Chemical Name

5. Drying and dry screening 5-acetamido-1, 3, 4-thiadiazole-2-sulphonamide; N-(5-sulphamoyl-1, 3, 4, thiadiazole-2-yl) acetamide

6. Tablet compression USES

7. Coating
carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes

Dispensing useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures

There are many ways to design a weighing area; however, it must be designed SO as to Sampling
minimize the generation of dust. By having adequate dust-collection equipment placed
Twenty tablets were weighed accurately and powdered . the powder equivalent to 20 mg of Cidamex
strategically, material may be prevented from becoming airborne and from unnecessarily
settling on table and floor surfaces. This will greatly reduce the time required to clean each (ACM) and transferred into a small conical flask, extracted three successive times each with 30 ml of
area after the specific weighing is accomplished. methanol
-The weighing must be performed on calibrated weighing devices that are sufficiently
sensitive to the quantity of materials being weighed. Procedure for its method of analysis
-Each raw material must be weighed by one operator and checked by a second operator. - Spectrophotometric
A weigh ticket must be generated for each material weighed
A simple and sensitive spectrophotometric method was developed for the
-At the end of each raw material lot, reconciliation must be performed and any determination of acetazolamide (ACM) in pure form and pharmaceutical
significant discrepancies thoroughly investigated.
preparations.

References Sara Atef Hassan

SHimaa Ebrahim Omar Prof.Dr/ Hesham Salem
1. World journal of pharmaceutical science
Reem AHmed Othman
2. http://wjpsonline.org
Sara Tarek Abd El-Azeem
Lamiaa Moustafa Dr. Ommia