www.PDHcenter.com PDH Course M143 www.PDHonline.

org

and should, therefore, be periodically tested (typically every 6 months). The purpose with

the test is to measure any leaks in the filter (or housing), and not, to document the

filtration efficiency “this is the filter suppliers responsibility, as they must supply individual

test certificate with each filter”

• Airborne Molecular Contamination Control: AMC is a type of non-particulate, or

molecular contamination, which is not controlled with traditional HEPA air filtration. AMC

can be in the form of gases, vapors or aerosols that is the result of outdoor air,

manufacturing processes, fugitive emissions from process equipment, cross-

contamination between manufacturing areas, chemical storage areas, accidental spills,

and bio-effluents from clean room personnel. The AMC control is required to eliminate

toxic, odor and irritants particles for operating personnel safety and health and must be

carefully evaluated for each area.

• Prevention of pollution: Prevention of pollution to outside is also a major concern. By

using ANSI standards, good engineering practice, and compliance testing procedures,

the following design requirements are established:

o Exhaust discharge point at least 10 ft above adjacent rooflines.

o Minimum exhaust discharge velocity of 3,000 fpm.

o Minimum outside air intake to exhaust point separation of 100 ft.

o Outside air intake located upstream of exhaust point when considering local
prevailing wind conditions.

• Cross contamination

According to WHO, the cross contamination is the contamination of a starting material,

intermediate product or finished product with another starting material or product during

manufacture. It has been proven that one of the major reasons for cross contamination is

the air handling units and extraction systems. Inadequate procedure for personnel and

equipment and insufficiently clean equipment is another key reason. Cross contamination

could be minimized by

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