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Goldmann perimetry, the Goldmann and Octopus 900 perimeter. This sur- inability to provide informed consent;
technology is no longer produced since vey was conducted with local ethical and (3) aged under 18 years. Table 1
2007 and will therefore be disappearing approval and in accordance with the illustrates the general characteristics of
in the coming years. Hence, there is a Tenets of the Declaration of Helsinki. the investigated patients.
need for alternative technologies which
can replace the Goldmann perimeter as
Patients Examination procedure
reference technique in kinetic perimetry.
This led to the introduction of (semi-) Twenty-eight patients were enrolled in The study protocol consisted of per-
automated kinetic perimetry (SKP), the first study group, the second group forming three (group 1) or four (group
that is computer-assisted kinetic perime- consisted of thirty patients. Each study 2) assessments with Goldmann, Octo-
try. Theoretically, SKP helps to stan- group was divided into three subgroups: pus 900 and/or HFA3 perimetry on the
dardize the examination procedure, (1) patients diagnosed with glaucoma, same day. An online available random-
assists in inter-test comparison and who were followed-up in the glaucoma ization program was used to program
requires less technical expertise. Haag- clinic with the Goldmann perimeter due the testing order (www.random
Streit (Koenig, Switzerland) developed to extensive visual field defects; (2) ization.com). Between the examina-
a computer-assisted kinetic examina- patients suffering from neurological dis- tions, every patient had a minimum
tion mode using test stimuli and a eases, who have an abnormal peripheral 5-min break. The same testing strategy
bowl-shaped design similar to the Gold- visual field; and (3) healthy control was applied for each device, whereby a
mann perimeter: Octopus 101 and its patients who do not have any diseases. direct comparison could be done. The
successor Octopus 900. These two Healthy individuals were recruited peripheral visual field boundaries were
devices differ mainly in the applicable during the general ophthalmological assessed using a I4e and V4e target. If
software programs. Octopus 900 offers consultation, where they had an app- the I4e target could not be seen by the
the ability to assess a reaction time ointment for fitness to drive consulta- patient, we performed a test using the
vector, which makes it possible to cor- tion or general screening. Detailed III4e target. This means that two
rect the given responses for the RT that medical history was taken to exclude isopters were obtained for each device.
the patient exhibits. In parallel, Carl relevant systemic diseases which could A minimum of twelve vectors was used
Zeiss Meditec (Jena, Germany) also influence the visual field examination. to evaluate the subject’s peripheral
developed computer-assisted kinetic An extensive ophthalmological exami- visual field. The mean stimulus speed
perimetry, the Humphrey visual field nation was performed to exclude dis- on Octopus 900 and HFA3 was 5°/
analyzer was introduced as another eases. All patients were recruited at the second. On Goldmann perimetry, the
potential successor of Goldmann University Hospitals UZ Leuven. perimetrist kept a constant stimulus
perimetry as it offers a kinetic testing Patients in study group 1 were asked presentation speed with an average of
mode too. to undergo three examinations: one on 5°/second. Every patient always had
Unfortunately, little information is a Goldmann perimeter and the second the same perimetrist who guided him/
yet available on the reproducibility of and third examination using the HFA3 her during the examinations. Only two
SKP (using Octopus 900 and HFA3) in and the Octopus 900. Study group 2 different perimetrists were involved in
comparison to Goldmann perimetry, underwent four examinations, one on a this study, one perimetrist for each
with only few studies yet published. In Goldmann perimeter and three test study group.
this study, we compared these two new strategies on the Octopus 900: (1) with The Goldmann perimeter was cali-
technical devices (Octopus 900 and RT vector, no headphone; (2) without brated on a weekly basis, and no
HFA3) to the reference technique. RT vector, no headphone; and (3) aberrations were detected throughout
Preliminary results suggested that for without RT vector, with headphone. the study period. The automated
Octopus 900, two important parame- Only one eye per subject was tested. perimeters perform an auto-calibration
ters have an influence on the results, If the two eyes were evaluated with each time they are restarted (which was
namely the reaction time vector and an Goldmann perimetry, the eye with the done on a daily basis).
auditory factor, given that the Octopus most affected visual field performed the
900 produces a notable sound when additional investigations. An informed
Data analysis
projecting the stimuli. Hence, we intro- consent was given to the patients prior
duced two separate study groups, one to any study examination and only The obtained isopters for the different
comparing Goldmann to both the those who agreed were included in the perimeters were compared quantita-
Octopus 900 and the HFA3 and study. Exclusion criteria were as fol- tively by assessing the visual field
another one comparing Goldmann to lows: (1) inability to perform a periph- (VF) area inside the different isopters.
the Octopus 900 with or without RT eral visual field examination; (2) We used the software of ‘Image J’ to
vector and with or without headphone
to mask the auditory stimulus.
Table 1. General characteristics of the enrolled patients.
Materials and Methods Number of Number of Mean Left eye Right eye
We conducted a prospective interven- patients examinations age tested tested
tional study in which we compared
Study group 1 28 3 52 14 14
three different kinetic perimeters:
Study group 2 30 4 60 15 15
Goldmann manual perimeter, HFA3
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assure size equivalency between the confidence interval (Konietschke et al. p-value < 0.001) and the HFA3 (9.02°;
different devices and to measure the 2010). This mathematical solution then p-value<0.001). (Table 3).
VF area inside the obtained isopters. mimics the behaviour of confidence
These data (in square degrees) were intervals for normally distributed data.
Comparison of the position of the isopters
translated into the mean radius of the When the Shapiro-Wilks test indicated
in study group 1
isopter (MIR, in degrees) which gives a nonsignificant deviation from the nor-
more comprehensive way to compare mality, we performed multiple compar- For V4e and I4e stimuli, all data were
the different outcomes (M€ onter et al. ison tests for paired normally not normally distributed. A compar-
2017). Besides quantitative comparison distributed data using the multcomp ison was made with respect to the
of the isopter areas, the position of the R package and taking the Goldmann distances of the isopters in relation to
isopters was also tested. We measured group as reference (Bretz et al. 2011). the central visual axis. HFA3 produced
the distance of the isopter (in degrees) Sample size calculation was made with larger distances for V4e stimuli in
in relation to the central visual axis. TrialSize R package. inferior, temporal and nasal quadrants
The distances were measured in four (p-value < 0.001), but did not result in
directions: superior, inferior, nasal and statistically significant differences for
temporal, each one 90° perpendicular
Results superior limits (p-value = 0.046; CI
to each other. 0.268 to 0.002). The Octopus 900
Comparison of MIR in study group 1
demonstrated higher limits (12.7% on
The data of V4e stimuli were not average) in all four directions (p-
Sample size calculation
normally distributed. Median MIR of value < 0.001).
Sample size calculations were based on Goldmann perimetry was 50.1° and of I4e stimuli also produced longer
previous reports on differences between HFA3 was 50.3°. Statistical analysis distances in the four directions with
Octopus and Goldmann kinetic for V4e stimuli showed no statistically the Octopus 900 and in temporal and
perimetry (Nowomiejska et al. 2012). significant difference between Gold- nasal direction on HFA3 compared to
For a cross-over design with an alpha mann and HFA3 (p-value = 0.144; CI the Goldmann. Distances for superior
equal of 0.025 in the first study group, 0.152 to 0.019). The Octopus 900 (p-value 0.676; CI 0.083 to 0.614) and
0.017 in the second study group, a (with reaction time vector) on the inferior (p-value 0.224; CI 0.027 to
power of 80%, and an expected effect other hand had a median MIR of 0.128) quadrants on HFA3 were not
size between the Goldmann and Octo- 59.9°, which showed a statistically sig- significantly different from Goldmann
pus 900 V4e area of 3000 square nificantly wider (19.5%) mean isopter perimetry.
degrees, a sample size of 28 patients is radius than Goldmann perimetry Figure 1 shows the visual field of a
necessary to achieve significance. To (p-value < 0.001; CI 0.112–0.290) patient in study group 1, performed on
accommodate for an expected exclu- (Table 2). the three different devices.
sion rate of 10%, we included 31 I4e stimuli data were normally dis-
patients. The TrialSize R package was tributed. The mean difference in MIR
Comparison of MIR in study group 2
used to calculate the sample size (Chow for I4e isopters was significantly smal-
et al. 2008). ler for the Goldmann perimeter in Data for V4e and I4e stimuli were not
comparison to the Octopus 900 (16.3°; normally distributed. Median mean
Statistical analysis
Statistical analysis was made with the Table 2. Median mean isopter radius (MIR) for V4e stimuli (in degrees) in study group 1.
R software version 3.2.2. A mixed
95% Confidence
model for continuous data was utilized interval (J–I)
to test differences in paired data (Ver-
beke & Molenberghs 2000). The Sha- Mean isopter radius Median (Q25–Q75) Lower Upper p-Value
piro-Wilks test was used to test
Goldmann (I) 50.1 (41.2–60.1)
whether the mixed model had normally
HFA (J) 50.3 (43.1–54.9) 0.15 0.017 0.144
distributed data. Some data were not Octopus 900 (J) 59.9 (50.9–59.9) 0.112 0.290 <0.001
normally distributed, in this case we
performed Dunnett’s multiple compar- Q25 = lower quartile; Q75 = upper quartile.
isons tests for paired nonparametric
data using the nparcomp R package,
taking Goldmann perimetry as refer- Table 3. Mean isopter radius for I4e stimuli (in degrees) in study group 1.
ence (Konietschke et al. 2015). The 95% Confidence
statistical proposition developed by interval (J–I)
Konietschke and implemented in the
nparcomp R Package calculates 95% Mean isopter radius Mean (SD) Mean difference (J–I) Lower Upper p-Value
confidence intervals (CI) for rank data
Goldmann (I) 28.1 (19.6)
which comprise the zero value when no HFA (J) 37.1 (15.9) 9.0 5.7 12.3 <0.001
difference is observed between the Octopus 900 (J) 44.3 (17.0) 16.3 13.0 19.6 <0.001
groups and, when a difference is found,
the zero is not comprised in the SD = Standard deviation.
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Table 4. Median mean isopter radius for V4e stimuli (in degrees) in study group 2. cannot be negative. A more interesting
issue is whether eliminating a patient’s
95% Confidence
reaction time reduces visual field vari-
interval (J–I)
ability. Further research is needed to
Mean isopter radius Median (Q25–Q75) Lower Upper p-Value investigate this assumption.
To eliminate the influence of the
Goldmann (I) 50.2 (43.1–59.2) reaction time vector on Octopus 900, a
Octopus 900 + RTv (J) 57.0 (51.9–62.7) 0.09 0.25 <0.001 second study group was introduced,
Octopus 900 – RTv – H (J) 54.2 (46.0–59.9) 0.011 0.095 0.130
comparing Goldmann to the Octopus
Octopus 900 – RTv + H (J) 52.4 (44.9–58.1) 0.023 0.081 0.347
without RT vector. These findings did
RTv = reaction time vector, H = headphone, Q25 = lower quartile, Q75 = upper quartile. not show any difference in mean
isopter radius for V4e stimuli on either
Goldmann perimetry or Octopus 900
Table 5. Median mean isopter radius for I4e stimuli (in degrees) in study group 2. without RT vector. Overall, the shape
95% Confidence
of the visual field was also comparable.
interval (J–I) When comparing the mean VF area,
findings for the Goldmann were 16%
Mean isopter radius (MIR) Median (Q25–Q75) Lower Upper p-Value smaller then for the Octopus without
RT vector. These findings are compa-
Goldmann (I) 30.0 (22.3–40.8)
rable to other studies conducted earlier,
Octopus 900 + RTv (J) 47.6 (37.6–52.6) 0.16 0.36 <0.001
Octopus 900 – RTv – H (J) 42.6 (28.3–49.8) 0.086 0.24 <0.001
including the study of Nowomiejska
Octopus 900 – RTv + H (J) 42.0 (29.0–49.1) 0.084 0.22 <0.001 (et al.) in which the visual fields from
patients with advanced visual loss were
RTv = reaction time vector; H = headphone; Q25 = lower quartile; Q75 = upper quartile. obtained by using two devices, that is
the Octopus 101 and Goldmann
perimetry, both being quantitatively
Figure 2 shows the visual field of a lot of opportunities, a new vector was compared. The latter research con-
patient in study group 2, evaluated in introduced to the Octopus 900: the RT cluded that in general, the Gold-
four different examination modes. vector. This enables to register individ- mann’s VF was 20% smaller than
ual reaction times for each patient by those for the Octopus 101 (Nowo-
presenting a stimulus in the intact miejska et al. 2005). Rowe & Rowlands
Discussion seeing area of the visual field. The time (2014) compared the diagnostic accu-
In this study, we compared two devices period between the presentation of the racy between the Octopus 900 and the
for automated kinetic perimetry stimulus and the reaction of the patient Goldmann kinetic visual fields. This
(Octopus 900 and HFA3) to the refer- is then recorded and represents the research again showed that the Gold-
ence technique, (manual) Goldmann patient’s reaction time. The measured mann results were qualitatively smaller
perimetry, thereby using the mean reaction time can then be corrected for in the isopter area when compared to
isopter radius and the distance in four each given response (Ramirez et al. those measured by the Octopus.
directions. In general, the above results 2008). Earlier studies showed added A notable issue while conducting
indicate that semi-automated kinetic value in measuring the patient’s RT. research on the Octopus 900 was the
perimetry can offer a more standard- For example, an increase in RT can be mechanical sound which can be heard
ized method to evaluate the peripheral an indicator of increased variability each time a stimulus is presented by the
visual field if compared to Goldmann and fatigue (Nowomiejska et al. 2012). movement of the projector. This clearly
perimetry. Given that the stimulus In another study, RT appeared to audible sound can possibly bias
moves at a constant speed and in the increase along with the age of the the patient’s responses, given that the
same direction, a more standardized patient, with the shortest RT at the patient might then anticipate to the
and reproducible examination can be age of 20–30 years. RT was also longer stimulus by the mere sound. Some
achieved. SKP also eliminates the reac- for stimulus combinations producing patients also reported that the sound
tion time of the perimetrist who regis- small isopters compared with those leads to loss of fixation and concentra-
ters the results, thereby producing producing large isopters (Vonthein tion. When comparing Goldmann and
more stable and reliable results. Addi- et al. 2007). Octopus 900 without RT vector and
tionally, the Octopus 900 automatically These findings suggest that, taking with the use of a headphone to mask
measures the VF area of isopters (in into account a patient’s reaction time, the sound, no statistically significant
square degrees), hence enabling the use using a RT vector with the Octopus difference was found for V4e mean
of quantifiable parameters in the fol- 900, produces larger visual fields. This isopter radius. Nonetheless, there was
low-up. suggestion was confirmed in our study: also no difference when the research
Since the Octopus 900 has an orig- Octopus 900 with RT vector, produces was conducted without the applica-
inal Goldmann bowl with a radius of significantly larger isopters in compar- tion of a headphone. This suggests
30 cm in all directions, it aims to retain ison to Goldmann perimetry. The fact that the mechanical sound did not
all the original characteristics and spec- that considering a patient’s reaction have an influence on the test results.
ifications of a manual Goldmann time produces larger visual fields is a One final point to note, however, is
perimeter. As the automation brings a logic consequence since a response time that relatively elderly patients (aged
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Fig. 2. Kinetic visual field of a patient with glaucoma in study group 2. The isopter with the widest range was created with a V4e stimulus, whereas
the smaller isopter was created with a I4e stimulus. (A) Goldmann perimeter. (B) Octopus 900 with RT vector without headphone, the double headed
arrows show the RT vector. (C) Octopus 900 without RT vector, without headphone. (D) Octopus 900 without RT vector, with headphone.
60 on average) were included in the Goldmann perimetry. In our study, the SKP in comparison to Goldmann
study, who could thus already suffer mean isopter radius of V4e stimuli is perimetry. Both Octopus 900 and
from presbyacusis. For younger comparable to Goldmann perimetry. HFA3 showed larger MIR and dis-
patients, a headphone might prove Distances in temporal, nasal and infe- tances when compared to the reference
its use not to overestimate the visual rior direction were, however, statisti- technique. Most probably, this relates
field boundaries. cally significantly wider (in general to a difference in light intensity and
Another worthy competitor for 25% bigger lengths for temporal, nasal contrast sensitivity. We noticed a
Goldmann perimetry, is the Humphrey and inferior direction). In superior striking difference in colour tempera-
field analyzer 3. Besides static perime- direction, distances on HFA3 were ture: the Goldmann device, which was
try, the HFA3 also offers a kinetic shorter in comparison to Goldmann used during the research, produces a
mode. HFA3 offers less options in its perimetry, but it is important to keep in ‘warm’ light, whereas the two SKP
kinetic mode, there is for example no mind that the HFA3 only measures the devices show a ‘cold’ white LED light.
RT vector nor is there a possibility to extent of 40° compared to the Gold- In small stimuli, patients will probably
automatically measure VF areas. mann perimeter which has the extent of have more difficulty in noticing the
Nonetheless, the HFA3 is easy to use 70° superiorly. dimmer Goldmann stimuli than the
and does not produce a specific sound Unlike the results with the V4e stronger SKP stimuli. Many patients
when presenting the stimuli. Previous stimulus, I4e stimuli resulted in overall also reported to our staff that the I4e
studies never compared the HFA3 to statistically significant differences with stimuli in SKP devices were more
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