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  • Light Chain A - : Domain 1

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    Andrea Luna Avila
    10 views13 pages
    The document describes two protein chains - Light Chain A and Heavy Chain B. Each chain consists of two domains. Domain 1 of Light Chain A contains subunits labeled la through lg connected in a chain. Domain 2 similarly contains subunits li through ln connected in a chain. Heavy Chain B also contains two domains with subunits ha through hi in Domain 1 and hj through hq in Domain 2. The subunits in each domain are labeled and connected to show the protein structure.

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    antibody-paper-modelrecortes

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    The document describes two protein chains - Light Chain A and Heavy Chain B. Each chain consists of two domains. Domain 1 of Light Chain A contains subunits labeled la through lg connected in a chain. Domain 2 similarly contains subunits li through ln connected in a chain. Heavy Chain B also contains two domains with subunits ha through hi in Domain 1 and hj through hq in Domain 2. The subunits in each domain are labeled and connected to show the protein structure.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    10 views13 pages

    Light Chain A - : Domain 1

    Uploaded by

    Andrea Luna Avila
    The document describes two protein chains - Light Chain A and Heavy Chain B. Each chain consists of two domains. Domain 1 of Light Chain A contains subunits labeled la through lg connected in a chain. Domain 2 similarly contains subunits li through ln connected in a chain. Heavy Chain B also contains two domains with subunits ha through hi in Domain 1 and hj through hq in Domain 2. The subunits in each domain are labeled and connected to show the protein structure.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 13

    Light

     Chain  A  |  Domain  1  

    la  
    NH3+  

    1A  

    lb  
    1B  

    AL1  
    la  

    lc  
    1F  
    1G  
    lb  

    ld  
    1E  
    lc  

    le  
    1D  
    ld  

    1C  

    lf  
    1H  
    AL2  
    le  

    lg  
    1I  
    lf  

    lh  

    Chain  A  
    lg  

    2  
    Developed  as  part  of  the  RCSB  Collabora@ve  Curriculum  Development  Program  2014.    
    Light  Chain  A  |  Domain  2  

    li  
    AL  

    2A  
    lh  

    lj  
    2B  
    AL3  
    li  

    lk  
    2E  
    lj  

    ll  
    2D  

    Chain  A  
    lk  

    lm  
    2C  
    ll  

    ln  
    2F  
    lm  

    AL4  
    COO-­‐  
    2G  
    ln  

    3  
    Developed  as  part  of  the  RCSB  Collabora@ve  Curriculum  Development  Program  2014.    
    Heavy  Chain  B  |  Domain  1  

    ha  
    NH3+  

    1A  

    hb  
    1B  
    BH1  
    ha  

    hc  
    1G  
    hb  

    hd  
    1F  

    1E  
    hc  

    he  
    1D  
    hd  

    hf  
    1C  
    he  

    hg  
    1H  
    BH2  
    hf  

    hh  
    1I  
    hg  

    hi  

    Chain  B  
    hh  

    4  
    Developed  as  part  of  the  RCSB  Collabora@ve  Curriculum  Development  Program  2014.    
    Heavy  Chain  B  |  Domain  2  

    hj  
    2A  

    BH  
    hi  

    hk  
    2B  

    BH3  
    hj  

    hl  
    2E  
    hk  

    hm  
    2D  
    hl  

    hn  
    hm  

    ho  
    2C  
    hn  

    hp  
    2F  
    BH4  
    ho  

    hq  
    2G  
    hp  

    hr  
    Chain  B  
    hq  

    BHA   BHB  

    5  
    Developed  as  part  of  the  RCSB  Collabora@ve  Curriculum  Development  Program  2014.    
    Heavy  Chain  B  |  Domain  3  

    hs  
    3A  
    BHC  
    hr  

    ht  
    hs  

    hu  
    3B  

    BH5  
    ht  

    hv  
    3E  
    hu  

    hw  
    3D  
    hv  

    hx  
    3C  
    hw  

    hy  
    3F  
    BH6  
    hx  

    hz  
    3G  
    hy  

    haa  

    Chain  B  
    hz  

    6  
    Developed  as  part  of  the  RCSB  Collabora@ve  Curriculum  Development  Program  2014.    
    Heavy  Chain  B  |Domain  4  

    hab  
    4A  
    haa  

    hac  
    4B  
    hab  

    BH7  

    had  
    hac  

    4E  

    hae  
    Chain  B  
    had  

    4D  

    haf  
    hae  

    4C  

    hag  
    haf  

    4F  

    BH8  
    COO-­‐  
    hag  

    4G  

    7  
    Developed  as  part  of  the  RCSB  Collabora@ve  Curriculum  Development  Program  2014.    
    Light  Chain  C  |  Domain  1  

    la  
    NH3+  

    1A  

    lb  
    1B  

    CL1  
    la  

    lc  
    1F  
    1G  
    lb  

    ld  
    1E  
    lc  

    le  
    1D  
    ld  

    1C  

    lf  
    1H  
    CL2  
    le  

    lg  
    1I  
    lf  

    lh  

    Chain  C  
    lg  

    8  
    Developed  as  part  of  the  RCSB  Collabora@ve  Curriculum  Development  Program  2014.    
    Light  Chain  C  |  Domain  2  

    li  
    CL  

    2A  
    lh  

    lj  
    2B  
    CL3  
    li  

    lk  
    2E  
    lj  

    ll  
    2D  

    Chain  C  
    lk  

    lm  
    2C  
    ll  

    ln  
    2F  
    lm  

    CL4  
    COO-­‐  
    2G  
    ln  

    9  
    Developed  as  part  of  the  RCSB  Collabora@ve  Curriculum  Development  Program  2014.    
    Heavy  Chain  D  |  Domain  1  

    ha  
    NH3+  

    1A  

    hb  
    1B  
    DH1  
    ha  

    hc  
    1G  
    hb  

    hd  
    1F  

    1E  
    hc  

    he  
    1D  
    hd  

    hf  
    1C  
    he  

    hg  
    1H  
    DH2  
    hf  

    hh  
    1I  
    hg  

    hi  

    Chain  D  
    hh  

    10  
    Developed  as  part  of  the  RCSB  Collabora@ve  Curriculum  Development  Program  2014.    
    Heavy  Chain  D  |  Domain  2  

    hj  
    2A  

    DH  
    hi  

    hk  
    2B  

    DH3  
    hj  

    hl  
    2E  
    hk  

    hm  
    2D  
    hl  

    hn  
    hm  

    ho  
    2C  
    hn  

    hp  
    2F  
    DH4  
    ho  

    hq  
    2G  
    hp  

    hr  
    Chain  D  
    hq  

    DHA   DHB  

    11  
    Developed  as  part  of  the  RCSB  Collabora@ve  Curriculum  Development  Program  2014.    
    Heavy  Chain  D  |  Domain  3  

    hs  
    3A  
    DHC  
    hr  

    ht  
    hs  

    hu  
    3B  

    DH5  
    ht  

    hv  
    3E  
    hu  

    hw  
    3D  
    hv  

    hx  
    3C  
    hw  

    hy  
    3F  
    DH6  
    hx  

    hz  
    3G  
    hy  

    haa  

    Chain  D  
    hz  

    12  
    Developed  as  part  of  the  RCSB  Collabora@ve  Curriculum  Development  Program  2014.    
    Heavy  Chain  D  |  Domain  4  

    hab  
    4A  
    haa  

    hac  
    4B  
    hab  

    DH7  

    had  
    hac  

    4E  

    hae  
    Chain  D  
    had  

    4D  

    haf  
    hae  

    4C  

    hag  
    haf  

    4F  

    DH8  
    COO-­‐  
    hag  

    4G  

    13  
    Developed  as  part  of  the  RCSB  Collabora@ve  Curriculum  Development  Program  2014.    
    Disulfide  Linkages  

    DHA  
    AL2  

    CL2  

    BHA  
    AL1  

    CL1  

    DHB  
    AL4  

    CL4  

    BHB  
    AL3  

    CL3  

    DHC  
    DH  
    BH  

    BHC  
    AL  

    CL  

    DH2  
    BH2  
    BH1  

    DH1  

    DH4  
    BH4  
    BH3  

    DH3  

    DH6  
    BH6  
    BH5  

    DH5  

    DH8  
    BH8  
    BH7  

    DH7  

    14  
    Developed  as  part  of  the  RCSB  Collabora@ve  Curriculum  Development  Program  2014.    

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