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Narusuvanja Vo Metabolizmot Na Kalium PDF
Narusuvanja Vo Metabolizmot Na Kalium PDF
Abstract
Disorders of potassium homeostasis are common electrolyte abnormalities encountered in hospitalized patients.
Hypokalemia and hyperkalemia have been estimated to occur in about 21% and 3% of hospitalized patients,
respectively; though the morbidity and mortality associated with the latter is significantly higher. Potassium is a
predominantly intracellular ion and the understanding of its dynamics between intra- and extracellular fluid milieus,
along with its handling by the kidneys, is important in the diagnosis and treatment of potassium disorders. This
article aims to provide a clinically relevant update on management of potassium disorders for internists. ©
PATHOPHYSIOLOGY
Movement of Potassium Between ICF and ECF
Normal daily potassium intake is approximately 40-100
mEq, which is absorbed from the gut, enters the ECF and
is rapidly redistributed into the intracellular compartment
due to the action of post-prandial insulin. This is essential
because an additional 100 mEq of K+ in plasma would
increase plasma K+ concentration several fold, rapidly
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