The Drug Interaction Probability Scale

from Horn JR, et al. 2007.

Proposal for a New Tool to Evaluate Drug Interaction ases.
!nn P"ar#acot"er. $%&$'( )7$.

T"e Drug Interaction Pro*a*ilit+ ,cale &DIP,' is -esigne- to assess t"e pro*a*ilit+ of a
causal relations"ip *etween a potential -rug interaction an- an event. It is patterne-
after t"e Naran.o !DR Pro*a*ilit+ ,cale &lin P"ar#acol T"er %/0%120(22/3$4'.

Directions(
3 ircle t"e appropriate answer for eac" 5uestion, an- a-- up t"e total score.
3 6*.ect -rug 7 Drug affecte- *+ t"e interaction.
Precipitant -rug 7 Drug t"at causes t"e interaction.
3 8se t"e 8n9nown &8n9' or Not !pplica*le &N!' categor+ if &a' +ou -o not "ave t"e
infor#ation or &*' t"e 5uestion is not applica*le &eg, no -ec"allenge1 -ose not
c"ange-, etc.'.

Questions
Yes No* Unknown or
NA**
%. !re t"ere previous credible reports of t"is interaction in
"u#ans:
;% <% 0
2. Is t"e o*serve- interaction consistent wit" t"e 9nown
interactive properties of precipitant -rug:
;% <% 0
2. Is t"e o*serve- interaction consistent wit" t"e 9nown
interactive properties of o*.ect -rug:
;% <% 0
$. Is t"e event consistent wit" t"e 9nown or reasona*le ti#e
course of t"e interaction &onset an-=or offset':
;% <% 0
4. Di- t"e interaction re#it upon -ec"allenge of t"e precipitant
-rug wit" no c"ange in t"e o*.ect -rug: &if no -ec"allenge, use
8n9nown or N! an- s9ip >uestion )'
;% <2 0
). Di- t"e interaction reappear w"en t"e precipitant -rug was
rea-#inistere- in t"e presence of continue- use of o*.ect -rug:
;2 <% 0
7. !re t"ere reasona*le alternative causes for t"e event:??? <% ;% 0
0. @as t"e o*.ect -rug -etecte- in t"e *loo- or ot"er flui-s in
concentrations consistent wit" t"e propose- interaction:
;% 0 0
/. @as t"e -rug interaction confir#e- *+ an+ o*.ective evi-ence
consistent wit" t"e effects on t"e o*.ect -rug &ot"er t"an -rug
concentrations fro# 5uestion 0':
;% 0 0
%0. @as t"e interaction greater w"en t"e precipitant -rug -ose
was increase- or less w"en t"e precipitant -rug -ose was
-ecrease-:
;% <% 0
Total score
?! N6 answer presu#es t"at enoug" infor#ation was presente- so t"at one woul- eApect an+
alternative causes to *e #entione-.
??@"en in -ou*t, use 8n9nown or N! -esignation.
???onsi-er clinical con-itions, ot"er interacting -rugs, lac9 of a-"erence, ris9 factors &eg, age,
inappropriate -oses of o*.ect -rug'.

Hig"l+ Pro*a*le( B0
Pro*a*le( 4<0
Possi*le( 2<$
Dou*tful( C2

,ource( Horn JR, Hansten PD, "an DN. 2007. Proposal for a New Tool to Evaluate
Drug Interaction ases. !nn P"ar#acot"er. $% &$'( )7$.