SOAL ASAM NUKLEAT

What type of ring structure is present in structures A and B? 

a) quinoline
b) purine
c) naphthalene

d) pyrimidine
Question 2

What type of structures are the compounds (i) - (iv)?

a) nucleic acids
b) nucleotides
c) nucleosides

d) deoxyriboses
Question 3

To which of the following does thymine form hydrogen bonds in DNA?

a) adenine
b) thymine
c) cytosine

d) guanine
Question 4
 What term is used to describe the process by which DNA is copied to produce two
daughter DNA molecules?

a) reproduction
b) replication
c) translation

d) transcription
Question 5

What term is used to describe the process by which a segment of DNA is copied to
produce a molecule of messenger RNA?

a) reproduction
b) replication
c) translation

d) transcription
Question 6

What term is used to describe the process by which proteins are synthesised from a
genetic code?

a) reproduction
b) replication
c) translation

d) transcription
Question 7

What role does messenger RNA play in the synthesis of proteins?

a) it catalyses the process

b) it provides the genetic blueprint for the protein
c) it translates the genetic code to a specific amino acid

d) it modifies messenger RNA molecules prior to protein synthesis

Question 8

What role does small nuclear RNA play in the synthesis of proteins?
 a) it catalyses the process
b) it provides the genetic blueprint for the protein
c) it translates the genetic code to a specific amino acid

d) it modifies messenger RNA molecules prior to protein synthesis

Question 9

On which of the following molecules would you find a codon?

a) messenger RNA
b) ribosomal RNA
c) transfer RNA

d) small nuclear RNA

Question 10

On which of the following molecules would you find an anticodon?

a) messenger RNA
b) ribosomal RNA
c) transfer RNA

d) small nuclear RNA

Question 11

What amino acid is coded by the triplet of bases UAU?

a) phenylalanine
b) serine
c) tyrosine

d) cysteine
Question 12

Which of the following mutations is most likely to be disruptive to protein synthesis or

function?

a) UAU to UAC
b) UAU to UUU
c) UAU to UAA
 d) UAU to CAU
Question 13

To which of the following does guanine form hydrogen bonds in DNA?

a) adenine
b) thymine
c) cytosine

d) guanine
Question 14

What type of enzyme is used in recombinant DNA technology to split a specific sugar
phosphate bond in each strand of a DNA double helix?

a) esterase
b) restriction enzyme
c) lipase

d) ligase

PROTEIN

Question 1

Which of the following statements about amino acids is correct?

a) Amino acids are classified according to the structures and properties of their
side chains.
b) Amino acids are uncharged at neutral pH.
c) Amino acids in proteins are mainly in the D-configuration.

d) Twenty four amino acids are commonly used in protein synthesis.

Question 2

Which type of bonding is responsible for the secondary structure of proteins?

a) Disulphide bridges between cysteine residues.

 b) Hydrogen bonding between the C=O and N-H groups of peptide bonds.
c) Peptide bonds between amino acids.

d) Salt bridges between charged side chains of amino acids.

Question 3

Which term below best defines the 'quaternary structure' of a protein?

a) The arrangement of two or more polypeptide subunits into a single

functional complex
b) The folding of the polypeptide backbone in three-dimensional space.
c) The interaction of amino acid side chains.

d) The sequence of amino acids in a polypeptide chain.

Question 4

Which of the following statements about collagen is correct?

a) Collagen contains a high proportion of hydroxylated proline residues.

b) Collagen is a globular, intracellular protein.
c) Post-translational modification of collagen involves vitamin A.

d) The structure of collagen consists of a superhelix of three α helices twisted

together.
Question 5

Which of the following statements about haemoglobin is correct?

a) 2,3-Bisphosphoglycerate (BPG) increases the affinity of haemoglobin for

oxygen.
b) Deoxygenated haemoglobin has a higher binding affinity for protons than
has oxyhaemoglobin.
c) Haemoglobin has a higher affinity for oxygen than does myoglobin.

d) One molecule of haemoglobin binds sixteen molecules of oxygen - four per

subunit.
Question 6

Which of the following amino acids is mostly likely to disrupt an alpha helix?
 a) Proline.
b) Leucine.
c) Glycine.

d) Valine.
Question 7

Which of the following most accurately describes how secondary structures in proteins
are stabilised?

a) Through ionic bonds operating between oppositely charged amino acid side
chains.
b) Through covalent bonds joining different parts of the peptide backbone.
c) Through hydrogen bonds between different amino acid side chains.

d) Through hydrogen bonds joining different parts of the peptide backbone.

Question 8

Which amino acid can form disulphide bonds?

a) Glycine.
b) Proline.
c) Glutamate.

d) Cysteine.
Question 9

Which of the following pairs of amino acids might contribute to protein conformation by
forming electrostatic interactions?

a) Glycine and leucine.

b) Glutamate and lysine.
c) Phenylalanine and tyrosine.

d) Lysine and arginine.

Question 10

Which of the following best describes a protein domain?

a) The α-helical portion of a protein.

 b) A discrete region of polypeptide chain that has folded into a self-contained
three-dimensional structure.
c) The β-pleated sheet portion of a protein.

d) A feature that rarely occurs in globular proteins.

Question 11

As haemoglobin binds oxygen molecules, its affinity for oxygen increases, driving the
binding of further oxygen molecules. Which term best describes this phenomenon?

a) Catalysis.
b) Saturation.
c) Allostery.

d) Isomerism.
Question 12

Which of the following statements correctly describes the behaviour of the haemoglobin
protein in sickle-cell disease?

a) The haemoglobin protein dissociates into four subunits.

b) The haemoglobin protein lacks a haem group.
c) Neighbouring haemoglobin proteins aggregate together.

d) The haemoglobin protein possesses an iron atom in the Fe (III) form rather
than the normal Fe (II) form.
1 Which of the following amino acids has an amide side chain?

A)aspartic acid

B)glutamic acid

C)asparagine

D)methionine

2 Which of the following amino acids is achiral?

 A)alanine

B)glycine

C)serine

D)cysteine

3 Which of the following amino acids does NOT have an aromatic ring?

A)tyrosine

B)histidine

C)tryptophan

D)proline

4 Which of the following ionic structures is NOT reasonable for histidine? 

A)
 B)

C)

D)

5 Which compound is an intermediate in the Strecker synthesis (RCHO, HCN, NH ) of amino

3
acids? 

A)a

B)b

C)c

D)d
6 How would you accomplish the following synthesis of aspartic acid? 

1. NH3, HCN
2. H3O+, H2O, heat
A)3. NaOH
4. Neutralize

1. NH3
B)2. H3O+, H2O, heat

1. HCN
C)2. NH3
3. H3O+, H2O, heat

1. NH3, HCN
D)2. H3O+, H2O, heat

7 What is the product of the following synthesis? 

A)

B)

C)
 D)

8 Which of the following structures is NOT a dipeptide?

A)

B)

C)

D)

9 The following peptide is hydrolyzed under strong acidic conditions. What are the products of
the reaction? 
 A)

B)

C)

D)

1 A tripeptide contains glycine, alanine, and serine. How many different sequences are
0 possible?
3
 A)

B)4

C)5

D)6

1 Which of the following is NOT a part of the primary protein structure?

1

A)the amino acid sequence

B)the disulfide linkages

C)the planar nature of the amide linkage

D)the conformation of the polypeptide backbone

1 Which of the following is the correct structure of the tripeptide Gly–Phe–Ala?

2

A)

B)

C)
 D)

1 Which of the following statements about the conformation (secondary and tertiary structure)
3 of proteins is FALSE?
The four atoms of an amide linkage (–CO–NH–) lie in a plane as a result of
A)resonance between the nitrogen and the carbonyl group.

B)Electrostatic attraction occurs between basic and acidic side chains.

The favored conformation of a protein is always that which has the greatest number
C)of hydrogen bonds.

The presence of the amino acid proline has the effect of turning a corner in a
D)protein.

1 Which of the following statements about the arrangement of a protein in three dimensions is
4 FALSE?
As a result of hydrogen bonding, a portion of a protein may exist as a right-handed
A)α-helix with 3.6 amino acid residues per turn, and a repeat unit of 5.4 Å.

As a result of hydrogen bonding a portion of a protein may exist as a pleated sheet,

B)in which the repeat unit is 7.0 Å.

C)In a pleated sheet, the polyamide chains may be parallel or antiparallel.

D)A portion of a protein may exist as a flat sheet with a repeat unit of 7.2 Å.

1 Which of the following is NOT an example of secondary structure found in proteins?

5

A)β-pleated sheet

B)α-helix
 C)hydrophobic folding

D)random coil

1 What does the quaternary structure of a protein involve?

6

A)the association of two or more peptide chains

B)the complete three-dimensional conformation

C)partial denaturation

D)random coil alternating with α-helix

1 Which of the following is not considered part of the tertiary structure of proteins?
7

A)the hydrophobic effect

B)the restricted rotation in amide bonds

C)the electrostatic interactions

D)the hydrogen bonds

1 Which of the following statements about an enzyme is FALSE?

8

A)An enzyme is usually a large protein.

An enzyme is a catalyst for biological reactions.

B)
 C)An enzyme is a chiral molecule.

D)An enzyme changes the equilibrium constant of a reaction.

1 What is the main function of enzymes in biological systems?

9

A)catalysis of a reaction

B)altering the equilibrium of a reaction

C)energy transport

D)protein sysnthesis

  1. The repeating units of proteins are

a) glucose units b) amino acids c) fatty acids d) peptides 

2. Amino acids are joined by

a) peptide bond b) hydrogen bond c) ionic bond d) glycosidic bond

3. The primary structure of protein represents

a) Linear sequence of amino acids joined by peptide bond b) 3-dimensional structure
of protein c) helical structure of protein
d) sub unit structure of protein

4. Peptide bond is
a) rigid with partial double bond character b) planar, covalent c)  covalent d) all of the
above 

5. Enzymes are
a) proteins b) carbohydrates c) nucleic acids d) DNA molecule 

6. The first protein sequenced by Frederick Sanger is

a) Haemoglobin b) myoglobin c) insulin d) myosin 

7. A dipeptide has 
a) 2 amino acids and 1 peptide bond b) 2 amino acids and 2 peptide bonds c) 2
amino acids and 3 peptide bonds d) 2 amino acids and 4 peptide bonds 
8. The most common secondary structure is
a) α-helix b) β-pleated sheet c) β-pleated sheet parallel d) β-pleated sheet non
parallel 

9. Myoglobin is a
a) protein with primary structure b) protein with secondary structure c) protein with
tertiary structure d) protein with quaternery structure 

10. Fibrous protein such as silk fibroin consists of polypeptide chains

arranged in
a) α-helix b) β-pleated sheet c) β-helix d) none of these 

11. α-helix has
a) 3.4 amino acid residues/turn b) 3.6 amino acid residues/turn c) 3.8 amino acid
residues/turn d) 3.0 amino acid residues/turn 

12. Tertiary structure is maintained by 

a) peptide bond b) hydrogen bond c) di-sulphide bond d) all of the above 

13. Haemoglobin has

a)  primary structure b)  secondary structure c)  tertiary structure d) quaternery
structure 

14. Disulphide bonds are formed between 

a) cysteine residues that are close together b) cystine residues that are close
together c) proline residues that are close together d) histidine residues that are
close together 

15. The 3-D structure of protein can be determined by 

a) Nuclear magnetic resonance b) X-ray crystallography c) both a and b d)
Spectroscopy 

Answers 1-b 2-a 3-a 4-d 5-a 6-c 7-a 8-a 9-c 10-b 11-b 12-d 13-d 14-a 15-c 

Biology Multiple Choice Quizzes QuizBiology.com

1. The primary structure is primarily maintained by

Peptide bond
Hydrogen bond
Ionic bond
Hydrophobic bonds

2. Which of the following statements are true regarding primary structure of

proteins
Primary structure denote the number of amino acids in a protein
Primary structure denote the sequence of amino acids in a protein
Primary structure determines the biological activity of a protein
all of these

3. Which of the following amino acid is a alpha helix terminator

cysteine 
alanine
proline
isoleucine

4. The secondary structure is primarily maintained by

Van der waals force
Hydrogen bond
Ionic bond
Hydrophobic bonds

5. Which of the following is the most common and stable conformation for a
polypeptide chain
Alpha helix
Beta pleated sheets
Anti parallel beta pleated sheet
Tertiary structure

6. The amyloid protein deposition associated with Alzheimer’s disease is

composed of
Alpha helix
Beta pleated sheets
Beta bends
Tertiary structure

7. In alpha helix, the bonding is between the 

Adjacent amino acids
Carbonyl oxygen of one peptide bond to the NH group of the 4th amino acid away
Carbonyl oxygen of second peptide bond to the NH group of the 3rd amino acid
away
Carbonyl oxygen of second peptide bond to the NH group of the 5th amino acid
away

8. Which of the following statements are true regarding tertiary structure of

proteins
3 dimensional structure of a protein
It is the biologically active conformation
Primary structure of protein determines the tertiary structure
All of these

9. The most common amino acid in beta bend is 

cysteine
glycine
serine 
methionine

10. Which of the following statements are true regarding quaternary structure
of proteins
Refers to organisation and spatial arrangements of amino acids within a polypeptide
chain
Refers to organisation and spatial arrangements of proteins with many polypeptide
chains
Both a and b
None of these

MCQ on Biochemistry - Amino acids 

1. Amino acids are
a) building blocks of carbohydrates b) building blocks of nucleic acids c) building
blocks of lipids d) building blocks of proteins 

2. Amino acids has a) both amino group and carboxyl group b) both amino group
and keto group c) amino group only d) carboxyl group only

3. The simplest amino acid is 

a) Proline b) methionine c) glycine d) serine

4. Which of the following amino acid is 

a ‘α-helix terminator’ a) tryptophan b) phenyl alnine c) tyrosine d) proline

5. The first amino acid in a polypeptide chain is 

a) Serine b) Valine c) Alanine d) Methionine

6. Which of the following amino acid has buffering capacity

a) Tryptophan b) cysteine c) histidine d) arginine

7. Which of the following is an α imino acid 

a) serene b) threonine c) valine d) proline

8. The naturally occurring form of amino acid in proteins 

a) L-amino acids only b) D-amino acids only c) both L and D amino acids d) none of
these

9. Sulphur containing amino acids are

a) Cysteine and methionine b) Methionine and threonine c) Cysteine and
threonine d) Cysteine and serine

10. Aromatic amino acids include 

a) Phenylalanine, tyrosine and tryptophan b) Phenylalanine, serine and tryptophan c)
Threonine, tyrosine and tryptophan d) Asparagine, tyrosine and tryptophan

11. Positively charged basic amino acids are 

a) Lysine and arginine b) Lysine and asparagine c) Glutamine and arginine d) Lysine
and glutamine
12. Acidic amino acids include 
a) Arginine and glutamate b) Aspartate and asparagine c) Aspartate and lysine d)
Aspartate and glutamate

13. Amino acids with hydroxyl groups are 

a) serine and alanine b) Alanine and valine c) serine and threonine d) Valine and
isoleucine

14. The 21st amino acid is 

a) hydroxy lysine b) hydroxyl proline c) selenocysteine d) citrulline

15. Absorbance at 280nm exhibited by protein is due to 

a) aliphatic amino acids b) all amino acids c) Non-polar amino acids d) aromatic
amino acids Online Practice test on

 Biomolecules / Biomacromolecules /Proteins / Amino acids

Answers 1-d 2-a 3-c 4-d 5-d 6-c 7-d 8-a 9-a 10-a 11-a 12-d 13-c 14-c 15-d 

Multiple Choice Questions- Amino acid and protein chemistry

1-A mutation has changed an isoleucine residue of a protein to Glutamic acid, which
statement best describes its location in a hydrophilic exterior
a) On the surface since it is hydrophilic in nature
b) In side the core of the protein since it is hydrophobic in nature
c) Any where inside or outside
d) Inside the core of protein since it has a polar but uncharged side chain
2- Glycine and proline are the most abundant amino acids in the structure of
a) Hemoglobin
b) Myoglobin
c) Insulin
d) Collagen
3- Some proteins contain additional amino acids that arise by modification of an
amino
acid already present in a peptide, examples include
a) 4 -hydroxy proline
b) 5- hydroxy Lysine
c) Gamma Amino Butyric Acid
d) All of the above
4- Choose the incorrect statement out of the followings
a) Only L amino acids are found in the biological system
b) Glycine is optical inactive
c) Tyrosine is a modified amino acid
d) Seleno cysteine is 21 st amino acid
5- Choose a nano peptide out of the followings
a) Oxytocin
b) Vasopressin
c) Bradykinin
d) All of the above
6- Which out of the following amino acids carries a net positive charge at the
physiological
pH?
a) Valine
b) Leucine
c) Isoleucine
d) None of the followings
7- Which out of the following amino acids is a precursor for a mediator of allergies
and
inflammation?
a) Histidine
b) Tyrosine
c) Phenyl Alanine
d) Tryptophan
8- Mother of a mal nourished child has been instructed to include a complete protein
in diet
for her child, which out of the followings proteins should be recommended?
a) Pulses
b) Wheat
c) Soy Protein
d) Milk
9- All of the below mentioned amino acids can participate in hydrogen bonding
except one
a) Serine
b) Cysteine
c) Threonine
d) Valine
10- All of the following amino acids are both glucogenic as well as ketogenic except
a) Isoleucine
b) Leucine
c) Tyrosine
d) Phenyl alanine
11- Which out of the following amino acid is a precursor of niacin (Vitamin)?
a) Tyrosine
b) Threonine
c) Tryptophan
d) Phenylalanine
12- The greatest buffering capacity at physiological p H would be provided by a
protein
rich in which of the following amino acids?
a) Serine
b) Cysteine
c) Alanine
d) Histidine
13- Which of the following peptides is cyclic in nature-?
a) Glutathione
b) Gramicidin
c) Met encephalin
d) Leuencephalin
14- Which out of the followings is not a fibrous protein?
a)Carbonic anhydrase
b) Collagen
c) Fibrinogen
d ) Keratin
15) -Which of the following amino acid is a limiting amino acid in pulses?
a) Leucine
b) Lysine
c) Methionine
d) Glutamine
16)- Which out of the following is not a haemo protein ?
a) Catalase
b) Myeloperoxidase
c) Glutathione peroxidase
d) Aconitase
17- All the below mentioned proteins are metalloproteins except
a) Carbonic anhydrase
b) Xanthine oxidase
c) Lactate dehydrogenase
d) Superoxide dismutase
18- Which out of the following is a peptide antibiotic?
a) Erythromycin
b) Gramicidin
c) Ciprofloxacin
d) Tetracycline
19- Choose the Anticancer peptide out of the followings
a) Bleomycin
b) Methotrexate
c) Cytosine Arabinoside
d) Dideoxy Inosine
20- Which of the following amino acids is most compatible with an α- helical
structure?
a)Tryptophan
b) Alanine
c) Leucine
d) Proline
21- The highest concentration of cystine can be found in
a)Melanin
b) Keratin
c) Collagen
d) Myosin
22- In scurvy, which amino acid that is normally part of collagen is not synthesized?
a)Hydroxy Tryptophan
b)Hydroxy Tyrosine
c) Hydroxy Alanine
d) Hydroxy Proline
23- A child with tall stature, loose joints, and detached retinas is found to have a
mutation
in collagen. Which of the following amino acids is the recurring amino acid most
likely to
be altered in mutations that distort collagen molecules?
a)Glycine
b) Tyrosine
c) Tryptophan
d) Tyrosine
24- Which one of the following amino acids may be considered a hydrophobic amino
acid
at physiological p H of 7.4?
a)Isoleucine
b) Arginine
c) Aspartic acid
d) Threonine
25- Which of the characteristics below apply to amino acid Glycine?
a) Optically inactive
b) Hydrophilic, basic and charged
c) Hydrophobic
d) Hydrophilic, acidic and charged
26- Which of the following amino acids in myoglobin, a globular protein, is highly
likely to
be localized within the interior of the molecule?
a)Arginine
b) Valine
c) Aspartic acid
d) Lysine
27- Which of the amino acids below is the uncharged derivative of an acidic amino
acid?
a)Cystine
b) Tyrosine
c) Glutamine
d) Serine
28-Choose the correct category for milk protein casein out of the followings
a)Nucleoprotein
b) Phospho protein
c) Lipoprotein
d) Glycoprotein

Answers-
1- a
2- d
3- d
4- c
5- d
6- d
7- a
8- d
9- d
10- b
11- c
12- d
13- b
14- a
15- c
16- d
17- c
18- b
19- a
20- b
21- b
22- d
23- a
24- a
25- a
26- b
27- c
28- b