Name _ __ _ _ __ _ _ _ _ __

Class _ _ _ _ _ _ __ _ Date _ _ _ _ _ _

-;:;H~
um=a:::n::-H;-;e:::r-ed-:;i~ty:------
::: -- - -- - - - - - SK ILL AC Tl VI T Y-
lnterpreting diagrams

Applied Genetics

A. Duchenne muscular dystrophy is a deadly disorder in which the muscles grow progressively
weaker• The disease is caused by a recessive gene on the X chromosome. The pedigree chart
below illustrates the inheritance of this gene. Use the chart to answer the questions that follow,

Key:

0 Normal female

Normal male

0 Carrier female

• Female with
disorder

Male with
disorder

I. is Duchenne muscular dystrophy more likely to occur in males or in females? Explain your answer.
i':\Qle"< mco-.";& D.x: benr f \So. re cce.ss,ve.. +r~+,

2. Individual H is a female with this disorder, Explain how she inherited this disease. D "ivilig,.r:',¾{\ ·
\he.... Q\bor h r 6:C?M ,A. ,o,d , ,(!__ \\1'7',~ \\ \o \-\,
. . u

3. Individual K has this disorder, yet his father did not. Explain how this is genetically possible. _ /;_ _
17 e>, Co.Y- r1-en OW\J\ CQ vl ~ b9've.: t;M t, \\ -\-o I'-,

4. Individual G does not have the disease, yet his mother was a carrier and his father had the disease.
Explain how this is possible. lnen ·,s o, e.,c:,·1, r,'now,ce., ror C'::i .\ c:, \'\\--PY'\,-
1

\-h'-- t\',;l,?r- M,r,

II:) Prentice-Hall, Inc. 229

 5. Why is the genotype of the father unimportant when investigating sex-linked traits inherited
by male offspring? T\-\R., '. ~~ H&- o{) ~ne.,, R7--\\::U:' l"S. f>..WOl'{S dQM.)'.W'l'Yo-

8. Huntington disease, a disease of the nervous system, is caused by an autosomal domimµ1t

gene. The pedigree chart below illustrates a family with individuals who have Huntington
disease. Use the chart to answer the questions that lollow.

Key:

0 Female

Male

Huntington
H
disease

h Normal gene

· ~ V\ ,'hn \ .. .
6. What is the probable genotype of individual D? Explain your answer. 1 • \ 1 lOe..CO'V.S IL-·

:tbR.rt 'fc--., Os ~ I, tnm&- \tQ , ei* \-\1..,n\ \ "'@i@ ,

7. What are the probable genotypes of individuals Hand I? Explain your answer ::X = \-\'<- \.\::: ill--.\h\,
~ o..\e,_ •S (}.\\,lll\\( 'a QoM)\orit: hJ\- tJ\~\L '6 So-/, ,
8. What is the probability that N will not have Huntington disease? __,(...,__,,,('t
) "-"g,,,c,M__,::_'i-'----------
>
9. Which individuals can be determined to have Huntington disease? A~-i--clc+-D =-------
10. Identify the individuals whose genotypes cannot be determined without more information. 'i\ - l -

230 © Prentice-Hall, Inc.