Guangbin Luo, Ph. D.

CURRICULUM VITAE

Name: Guangbin Luo

Title: Associate Professor

Affiliation:
Department of Genetics and
Case Comprehensive Cancer Center
Case Western Reserve University
University Hospitals of Cleveland
Cleveland, Ohio 44106

Date of Birth: June 15, 1963

Place of Birth: Guangxi, China

Citizenship: People's Republic of China

Immigration Status: U. S. Permanent Resident

Contact Information:
17719FernwayRoad,ShakerHeights,OH44122(US)
phone number. (216) 752-0809
2HKYF18183H526985
June 15, 1963
15101659527
Luol35@hotmail.com
Luoguangbin35(Wechat)

Department of Genetics and Genome Sciences

Case Western Reserve University
BRB 720
10900 Euclid Avenue
Cleveland, Ohio 44106
Tel: (216) 368-4883
Fax: (216) 368-3432
E-mail: guangbin.luo@case.edu

Education:

Ph. D. Molecular Genetics, 1993

University of Illinois at Urbana-Champaign
Urbana, Illinois, USA.
Advisor: Angus Hepburn, Ph. D. and Jack Widholm, Ph. D.

M.S. Molecular Genetics, 1988

University of Illinois at Urbana-Champaign
Urbana, Illinois, USA.

B.S. Genetics, 1985

Beijing Agricultural University
Beijing, China

Employment:
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 Guangbin Luo, Ph. D.
Associate Professor, 2010-
Assistant Professor, 2000-2010
Department of Genetics
Case Western Reserve University

Postdoctoral Fellow, 1996-2000

Department of Molecular & Human Genetics

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 Guangbin Luo, Ph. D.
Howard Hughes Medical Institute
Baylor College of Medicine
Mentor: Allan Bradley, Ph.D.

Postdoctoral Fellow, 1992-1995

Department of Molecular Genetics
The University of Texas M. D. Anderson Cancer Center
Mentor: Gerald Karsenty, M.D.

Research Assistant, 1989-1992

University of Illinois at Urbana-Champaign

Honors and Awards:

1. Howard Temin Award, National Cancer Institute, USA, 2000.
2. Basil O’Connor Starter Scholar Award, March of Dimes Foundation, 2001.
3. Searle Scholar Award, Kinship Foundation, Chicago, USA, 2001.
4. Outstanding Young Oversea Chinese Scientist, CNSF, Beijing, China, 2006.

Study Sections:
1. Genetics Study Section, Chinese National Natural Science Foundation, 2003-2010
2. Oncology Study Section, Chinese National Natural Science Foundation, 2010-
3. NF-A Study Section, US Army Neurofibromatosis Research Program, 2004-

Institutional Services:
1. Committee for Appointment, Promotion and Tenure (CAPT), Department of Genetics, Case Western
Reserve University, 2003-present.
2. Graduate Student Admission Committee for the Biomedical Science Training Program (BSTP) at Case
Western Reserve University School of Medicine, 2003-2004.

Teaching:
1. DNA replication in C3MB (Correlated Curriculum in Cell and Molecular Biology), a required course for all
graduate students in the BSTP program.
2. DNA Repair and Recombination in C3MB, a required course for all graduate students in the BSTP program.
3. Medical Genetics and Molecular Biology, Small Group Sessions for first year medical student.

Editorial Activities:

1. Editorial Board: Associate Editor of Current Genomics

2. Reviewer: Cancer Letter, Mammalian Genomes, Human Molecular Genetics, Genesis, Molecular and
Cellular Biology.

Invitations:
1. Speaker, Bloom Syndrome Workshop: Molecular Basis of Genomic Instability. April 7-8, 2005, NIH,
Methesda, Maryland, USA.
2. Speaker, Keystone Synposium: Genome Instability (C2). March 15 - 20, 2005, Tao, New Mexico, USA.
3. Speaker, Annual Meeting of Outstanding Young Scientists, Chinese National Sceince Foundation. August
20-24, 2003, Guangzhou, China.
4. Speaker, Frontiers of Biological Sciences in the 21st Century, June 21-25, 2003, Beijing, China.
5. Participant, Annual Meeting of the US National Academic of Science: US Frontiers of Science. November 8-
10, 2001, Irvine, Californai, USA.
6. Speaker, A Satelite Meeting for the Neuroscience Society Annual Meeting, 1998, Los Angelis, USA.
7. Participant, Workshop on Werner Syndrome and Related Helicase Diseases, August 17-18, 1997, Bethesda,
MD, USA.

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 Guangbin Luo, Ph. D.

Publications:

Luo G., Hepburn A. and Widholm J. (1992). Preparation of plant DNA for PCR analysis: a fast, general and
reliable procedure. Plant Mol. Biol. Rep. 10: 319-323.
Luo G., Hepburn A. and Widholm J. (1994). A simple procedure for the expression of exogenous genes in soybean
callus tissues. Plant Cell Rep.13: 632-636.
Luo G., Dsouza R., Hogue D., and Karsenty G. (1995). The Matrix gla protein gene is a marker of the
chondrogenesis cell lineage during mouse development. J. Bone & Min. Res. 10: 325-334.
Luo G., Hofmann C., Bronckers A. L. J. J., Sohoki M. Bradley A. and Karsenty, G. (1995). BMP 7 is an inducer of
nephrogenesis and is required for eye development and skeletal patterning. Genes & Dev. 9: 2808-2820.
Karsenty G., Luo G., Hofmann C., and Bradley A. (1996). BMP 7 is required for nephrogenesis, eye development,
and skeletal patterning. Ann. N Y Acad. Sci. 785: 98-107.
Hofmann C., Luo G., Balling R., and Karsenty G. (1996). Analysis of limb patterning in BMP-7-deficient mice. Dev.
Genet. 19: 43-50.
Luo G., Ducy P., Mckee M. D., Pinero G. J., Loyer E., Behringer R., and Karsenty G. (1997). Spontaneous
calcification of soft tissues in matrix gla protein-deficient mice. Nature 386: 78-81.
Luo G., Ivics Z., Izsvak Z., and Bradley A. (1998). Chromosomal transposition of a Tc1/mariner-like element in
mouse embryonic stem cells. Proc. Natl. Acad. Sci. 95: 10769-10773.
Bradley A., and Luo G. (1998). The PTENtative nature of mouse knockouts. Nat. Genet. 20: 322-323.
Luo G., Yao M., Bender C. F., Mills M., Bladl T., Bradley A. and Petrini J. (1999). Disruption of mRad50 causes ES
cell lethality, abnormal embryonic development and sensitivity to ionizing radiation. Proc. Natl. Acad. Sci.
96: 7376-81.
Liu Q., Guntuku S., Cui X.-S., Matsuoka S., Cortez D.,Tamai K., Luo G, Carattini-Rivera S., DeMayo F., Bradley
A., Donehower L. A., Elledge S. J. (2000). Chk1 is an essential kinase that is regulated by Atr and required
for the G2/M DNA damage checkpoint. Gen. & Dev. 14: 1448-1459.
Luo G., Santoro I., McDaniel L. D., Nishijima I., Mills M., Youssoufian H., Vogel H., Schultz R. and Bradley A.
(2000). Cancer predisposition caused by elevated mitotic recombination in Bloom mice. Nat. Genet. 26:
424-429.
Criswell T, Leskov K, Miyamoto S, Luo G, Boothman DA. (2003). Transcription factors activated in mammalian
cells after clinically relevant doses of ionizing radiation. Oncogene. 22: 5813-27.
Zheng G, Hu L, Huang W, Chen K, Zhang X, Yang S, Sun J, Jiang Y, Luo G, Kong X. (2004). CYLD mutation
causes multiple familial trichoepithelioma in three Chinese families. Hum. Mutat. 23: 400.
Du X, Shen J, Kugan, N, Furth EE, Lombard DB, Cheung C, Pak S, Luo G, Pinolo RJ, DePinho RA, Guarente L,
and Johnson FB. (2004). Telomere shortening exposes functions for the mouse Werner and Bloom syndrome
genes. Mol. Cell. Biol. 24: 8437-46.
Yan M, Rerko RM, Platzer P, Dawson D, Willis J, Tong M, Lawrence E, Lutterbaugh J, Lu S, Willson JKV, Luo G,
Hensold J, Tai H, Wilson K, Markowitz SD. (2004). 15-Hydroxyprostaglandin Dehydrogenase, a COX-2
oncogene antagonist, is a TGF-ß induced suppressor of human gastrointestinal cancers. Proc. Natl. Acad.
Sci. 101: 17468-73.
Ren XR, Zhou LJ, Luo G, Lin B, Xu A. (2005) Inhibition of hepatitis B virus replication in 2.2.15 cells by expressed
shRNA. J. Viral. Hepat. 12: 236-42.
Mann MB, Hodges CA, Barnes E, Vogel H, Hassold TJ, and Luo G. (2005). Defective sister-chromatid cohesion,
aneuploidy and cancer predisposition in a mouse model of Type II Rothmund-Thomson syndrome. Hum.
Mol. Genet. 14: 813-25.
Hu Y, Lu X, Barnes E, Yan M, Lou H, and Luo G. (2005). Recql5 and Blm RecQ DNA helicases have non-
redundant roles in suppressing crossovers. Mol. Cell. Biol. 25: 3431-42.
Luo G, Molter J, Desai G, Anderson P, Dale J, Majewski S, Zorn C, Weisenberger A, Duerk J, and Lee Z. (2005). A
new mouse model with an Afp-driven dual-reporter gene for studying hepatoma by tri-modality imaging.
Mol. Imaging 4: 390.
Ren X, Luo G, Xie Z, Zhou L, Kong X, Xu A. (2006). Inhibition of multiple gene expression and virus replication of
HBV by stable RNA interference in 2.2.15 cells. J Hepatol. 44: 663-70
Myung SJ, Rerko RM, Yan M, Platzer P, Guda K, Dotson A, Lawrence E, Dannenberg AJ, Lovgren AK, Luo G,
Pretlow TP, Newman RA, Willis J, Dawson D, Markowitz SD. (2006) 15-Hydroxyprostaglandin
dehydrogenase is an in vivo suppressor of colon tumorigenesis. Proc Natl Acad Sci 103: 12098-102.
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 Guangbin Luo, Ph. D.
Mann MB, Hodges CA, Barnes E, Vogel H, Hassold TJ, and Luo G. (2005). Defective sister-chromatid cohesion,
aneuploidy and cancer predisposition in a mouse model of Type II Rothmund-Thomson syndrome. Hum.
Mol. Genet. 14:813-25.
Hu Y, Lu X, Barnes E, Yan M, Lou H, and Luo G. (2005). Recql5 and Blm RecQ DNA helicases have non-
redundant roles in suppressing crossovers. Mol. Cell. Biol. 25:3431-42.
Hu Y, Raynard R, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EB, Chi P, Janscak P, Jasin M, Vogel H,
Sung P and Luo G (2007) RECQL5/Recql5 helicase regulates homologous recombination and suppresses
tumor formation via disruption of Rad51 presynaptic filaments. Genes & Dev. 21:3073-84.
Hu Y, Lu X, Zhou G, Barnes EL, Luo G (2009) Recql5 plays an important role in DNA replication and cell survival
after camptothecin treatment. Mol Biol Cell. 20(1):114-23.
Hu Y, Lu X, Luo G (2010) Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apcmin mice. World J.
Gastroenterol. 16:1482-1486.
Lu X, Rios HF, Jiang B, Xing L, Kadlcek R, Greenfield GM, Luo G (co-corresponding author), and Feng JQ (2009).
A new osteopetrosis ntl mutant strain with odontoma like proliferations and lack of tooth roots. Eur. J. Oral
Sci. 117:625-653.
Zhou G, Liu Y, Wu SY, Tie F, Lou H, Chiang CM, Luo G. (2010) Purification of a novel RECQL5-SWI/SNF-
RNAPII super complex. Int. J. Biochem. Mol. Biol. 1(1):101-111.
Lu X, Guo H, Molter J, Lee Z, and Luo G (co-corresponding author), and Wang B. (2010). Alpha-fetoprotein-
Thymidine Kinase-Luciferase Knockin Mice: A Novel Model for Dual Modality Longitudinal Imaging of
Tumorigenesis in Liver. J. Hepatol. 55:96-102.
Lu X, Lou H, Luo G. (2011) A Blm-Recql5 partnership in replication stress response. J. Mol. Cell. Biol. 3(1):31-8
(Review).
Zhou HL, Hinman MN, Barron VA, Geng C, Zhou G, Luo G, Siegel RE, Lou H. (2011) Hu proteins regulate
alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner. Proc Natl
Acad Sci. 108(36):E627-35.
Wang X, Lu X, Zhou G, Lou H, Luo G. (2011) RECQL5 is an important determinant for camptothecin tolerance in
human colorectal cancer cells. Biosci. Rep. (in press).

Ongoing Research Support

GI Spore Pilot Grant Luo (PI) 07/10-

06/12
“RECQL5 as a Potential Predictive Classifier for Irinotecan-Based Therapies”
The goal of this project is to investigate the potential use of RECQL5 as a diagnostic biomarker for colorectal
cancer therapies that are based on irinotecan.
Role: PI

Completed Research Support (past 3 years)

NF060083 Lou (PI)

03/07-02/10
“Role of neuron-specific Splicing Regulators as Modifiers of Neurofibromatosis type 1”
Role: Collaborator.

RO1-CA112094 Luo (PI) 06/05-05/10

“Genetic control of mitotic recombination in mice”
The major goals of this project are to define mechanisms by which Blm and Recql5 suppress crossovers in
somatic cells and the relative contribution of these two helicases in maintaining genomic stability and
suppressing cancer and aging in mice.
Role: PI

Pilot Grant of P20 CA103736 Nathan A. Bergerg (PI) 11/09-07/10

“To Establish a System in Mouse ES Cells for Addressing Various Issues Related to Recql4 Functions”
Role: PI
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 Guangbin Luo, Ph. D.

RO1-CA114535 Luo (PI) 03/06-02/11

Recq14, chromosome instability and cancer predisposition
The major goals of this project are to define mechanisms by which Recql4 functions in sister chromatid cohesion
and in the suppression of tumorigenesis in mice.
Role: PI

Pending Research Support

RO1-CA112094-06A1 (NCI/NIH)
“Regulation of the DNA Damage Tolerance Pathway by a RecQ Helicase”
The goal of this project is to investigate the molecular mechanisms of drug tolerance for Top1 poison anticancer
agents.
Role: PI

RO1-CA172481-01 (NCI/NIH)
“Cancer-promoting effect of topoisomerase I poisoning”
The goal of this project is to investigate the molecular basis of a novel topoisomerase I poisoning-based
mechanism for causing oncogenic chromosomal rearrangement in mice.
Role: PI