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  • Deinococcus Radioduran Application

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    OOI SHI YONG / UPM
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    Deinococcus radiodurans is a bacterium that can survive extreme radiation exposure. It has potential applications in bioremediation and as a model for studying cancer and aging. [1] Due to its radiation resistance, D. radiodurans could be genetically engineered to degrade toxic waste in high radiation environments by transferring genes from other bacteria. [2] Studying D. radiodurans' resistance to oxidative stress may also lead to medical advances against aging and cancer, as it can repair double strand DNA breaks caused by reactive oxygen species that contribute to these conditions.

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    Deinococcus radiodurans is a bacterium that can survive extreme radiation exposure. It has potential applications in bioremediation and as a model for studying cancer and aging. [1] Due to its radiation resistance, D. radiodurans could be genetically engineered to degrade toxic waste in high radiation environments by transferring genes from other bacteria. [2] Studying D. radiodurans' resistance to oxidative stress may also lead to medical advances against aging and cancer, as it can repair double strand DNA breaks caused by reactive oxygen species that contribute to these conditions.

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    21 views1 page

    Deinococcus Radioduran Application

    Uploaded by

    OOI SHI YONG / UPM
    Deinococcus radiodurans is a bacterium that can survive extreme radiation exposure. It has potential applications in bioremediation and as a model for studying cancer and aging. [1] Due to its radiation resistance, D. radiodurans could be genetically engineered to degrade toxic waste in high radiation environments by transferring genes from other bacteria. [2] Studying D. radiodurans' resistance to oxidative stress may also lead to medical advances against aging and cancer, as it can repair double strand DNA breaks caused by reactive oxygen species that contribute to these conditions.

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    Deinococcus radiodurans

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682472/

    https://www.sciencedirect.com/science/article/abs/pii/S0923250819301287

    Application

    1. Bioremediation

    - Some bacteria like Citrobacter and Pseudomonas sp. can biodegrade toxic waste and organic
    pollutants, but the microbes are killed by the radiation before they finish degrading the
    toxins. Thus, their use in bioremediation under high radiation condition is very limited

    - Due to its structure, D. radiodurans can be used to for the treatment of toxic waste

    - D. radiodurans will be genetically engineered by transferring a set of gene from other


    microbe that can degrade the toxic waste into D. radiodurans

    - For example, a set of gene that encode for toluene dioxygenase (TDO) from Pseudomonas
    putida F1 transferred into D.radiodurans resulting into a recombinant bacterium. This
    recombinant bacterium can oxidize a variety organic compound such as toluene in a high-
    radiation environment.

    http://bioinformatica.uab.es/biocomputacio/treballs00-01/Soler_Nuria/Bioremediation%20and
    %20Deinococcus%20radiodurans.htm

    https://www.tandfonline.com/doi/full/10.4161/bbug.3.1.18878

    2. Model for study of cancer and aging

    - The further study of D. radiodurans as a model organism for oxidative stress resistance may
    lead to a development of medical procedure that can prevent aging and cancer

    - Aging and cancer are mainly cause by oxidative stress that induced by reactive oxygen
    species (ROS)

    - Oxidative stress induced by ROS, which can be produced by respiration or due to the
    exposure to physical and chemical agents such as ionizing radiation, desiccation or UV
    radiation that can damage macromolecules such as protein and nucleic acid.

    - D. radiodurans is resistance to various stresses including ionizing radiation, oxidative stress,


    and other DNA-damaging agents due to its ability to repair double strands break in its DNA

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063356/

    https://www.mdpi.com/2076-2607/8/3/451/htm

    https://academic.oup.com/jnci/article/95/17/1270/2520435

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