N.Y. Yao, M.E.

O’Donnell,
Comparison of Bacterial and Eukaryotic Replisome Components,
Editor(s): Ralph A. Bradshaw, Philip D. Stahl,
Encyclopedia of Cell Biology,
Academic Press,
2016,
Pages 396-417,
ISBN 9780123947963,
https://doi.org/10.1016/B978-0-12-394447-4.10038-0.
(http://www.sciencedirect.com/science/article/pii/B9780123944474100380)
Abstract: Replisomes that duplicate genome DNA are composed of many different
proteins that work together like gears in a machine. Sequence and structure
comparisons reveal that replisome machines have evolved twice, once for bacteria
and again for eukaryotes/archaea. This review compares the current state of
knowledge on the structure and mechanisms of the central proteins that act directly
at replication forks in bacteria to those of eukaryotes. Then the way these
proteins organize their functions within a dynamic replisome machine is compared
for these two distinct domains of life.
Keywords: Clamp loader; CMG; DNA polymerase; DNA replication; Evolution; Helicase;
Primase; Replisome; Single-strand binding protein; Sliding clamp