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Lab 8: Population Genetics Multiple Choice Questions

1. In a certain group of African people, 4 percent are born with sickle cell anemia.
What percentage of the group has the selective advantage of being more
resistant to malaria than those individuals who are homozygous for normal
hemoglobin or for sickle cell anemia?
(A) 2%
(B) 4%
(C) 8%
(D) 16%
(E) 32%
(1986 #54)

Questions 2-3

(A.) 1/16
(B.) 1/4
(C.) 1/2
(D.) 9/16
(E.) 1

Galactosemia is a simple, inherited, autosomal recessive trait. A normal couple


has a child affected with galactosemia. For each of the following situations, select
from the list above the appropriate probability.

2. The probability that the next two children will both be affected with galactosemia
(1986 #74)

3. The probability that the father if the galactosemic child is heterozygous for the
recessive allele
(1986 #74)

4. The replacement of glutamic acid by valine at a specific position in the beta


chains of hemoglobin leads to sickle cell anemia. This change represents which
of the following mutational events?
(A.) DNA base-pair substitution
(B.) DNA base-pair deletion
(C.) DNA base-pair addition
(D.) Chromosomal deletion
(E.) Frame-shift mutation
(1990 #32)

Copyright © 1970 to 2005 by College Entrance Examination Board, Princeton, NJ. All rights reserved. For face-to-face teaching purposes,
classroom teachers are permitted to reproduce the questions. Web or Mass distribution prohibited.
5. ABCDEF... Æ ABDCEF...
A rearrangement in the linear sequence of genes as shown in the diagram above is
known as
(A.) duplication
(B.) deletion
(C.) inversion
(D.) polyploidy
(E.) translocation
(1990 #37)

6. In a population that is in a Hardy-Weinberg equilibrium, the frequency of a


recessive allele for a certain hereditary trait is .20. What percentage of the
individuals in the next generation would be expected to show the dominant trait?
(A) 8%
(B) 16%
(C) 32%
(D) 64%
(E) 96%
(1990 #61)

The relative location of four genes on a chromosome can be mapped from the
following data on crossover frequencies.
Genes Frequency of crossover
B and C 5%
C and A 15%
A and B 30%
C and B 45%
C and D 50%
7. Which of the following represents the relative positions of these four genes on
the chromosomes?
(A.) ABCD
(B.) ADCB
(C.) CABD
(D.) CBAD
(E.) DBAC
(1990 #71)

Copyright © 1970 to 2005 by College Entrance Examination Board, Princeton, NJ. All rights reserved. For face-to-face teaching purposes,
classroom teachers are permitted to reproduce the questions. Web or Mass distribution prohibited.
Questions 8-11 refer to the following pedigree that illustrates the inheritance of
sickle cell anemia. Shading indicates the presence of sickle cell anemia.

(A.)

8. The phenotype of individual C is best explained by the fact that this individual
received an allele for sickle cell anemia from
(A) an autosomal chromosome of each parent
(B) the Y chromosome contributed by the father
(C) the X chromosome contributed by the mother
(D) the X chromosome contributed by the father
(E) the Y chromosome contributed by the mother
(1990 #109)

9. What is the probability that the next child of parents A and B would have had
sickle cell anemia?
(A) 0%
(A.) 25%
(B.) 60%
(C.) 75%
(D.) 100%
(1990 #110)

10. The most reasonable explanation for the fact that the offspring of C and D do
not have sickle cell anemia is that each received a
(A) sickle allele from the mother
(B) normal allele from the father
(C) sickle allele from the parent
(D) normal allele from each parent
(E) pair of normal alleles from the father
(1990 #111)

Copyright © 1970 to 2005 by College Entrance Examination Board, Princeton, NJ. All rights reserved. For face-to-face teaching purposes,
classroom teachers are permitted to reproduce the questions. Web or Mass distribution prohibited.
11. Which of the following statements is correct about the four offspring of C and D?
(A) Only females are carriers of the sickle cell trait.
(B) Only males are carriers of the sickle cell trait.
(C) Only the females are heterozygous for the sickle cell trait.
(D) All are homologous for the sickle cell trait.
(E) All are carriers of the sickle cell trait.
(1990 #112)

12. If 2n=48 for a particular cell, then the chromosome number in each cell after
meiosis would be

(A) 96
(B) 48
(C) 24
(D) 12
(E) 6
(1994.#4)

Questions 13-14. In a certain flock of sheep, 4 percent of the population has black
wool and 96 percent has white wool. Assume that the population is in Hardy-
Weinberg equilibrium.

13. If black wool is a recessive trait, what percent of the population is heterozygous
for this trait?
(A.) 4%
(B.) 20%
(C.) 32%
(D.) 64%
(E.) 80%
(1994.#49)

14. What percent of the population is homozygous for white wool?


(A) 20%
(B) 40%
(C) 64%
(D) 80%
(E) 96%
(1994.#50)

Copyright © 1970 to 2005 by College Entrance Examination Board, Princeton, NJ. All rights reserved. For face-to-face teaching purposes,
classroom teachers are permitted to reproduce the questions. Web or Mass distribution prohibited.
15. In a small group of people living in a remote area, there is a high incidence of
“blue skin,” a condition that results from a variation in the structure of
hemoglobin. All of the “blue-skinned” residents can trace their ancestry to one
couple, who were among the original settlers of this region. The unusually high
frequency of “blue skin” in the area is an example of
(A.) mutation
(B.) genetic drift
(C.) natural selection
(D.) sexual selection
(E.) heterozygote advantage
(1999 # 44)

16. Which of the following is the most likely explanation for a high rate of crossing-
over between two genes?
(A.) The two genes are far apart on the same chromosome.
(B.) The two genes are both located near the centromere.
(C.) The two genes are sex-linked.
(D.) The two genes code for the same protein.
(E.) The two genes are on different chromosomes
(1999 #51)

17. Which of the following principles is NOT part of Darwin’s theory of evolution by
natural selection?
(A.) Evolution is a gradual process that occurs over long periods of
time.
(B.) Variation occurs among individuals in a population.
(C.) Mutations are the ultimate source of genetic variation.
(D.) More individuals are born than will survive.
(E.) Individuals that possess the most favorable variations have the
best chance of reproducing.
(1999 #53)

Copyright © 1970 to 2005 by College Entrance Examination Board, Princeton, NJ. All rights reserved. For face-to-face teaching purposes,
classroom teachers are permitted to reproduce the questions. Web or Mass distribution prohibited.
18. In the pedigree above, squares represent males and circles represent females.
Individuals who express a particular trait are represented by shaded figures.
Which of the following patterns of inheritance best explains the transmission of
the trait? (99)

(A.) Sex-linked dominant


(B.) Sex-linked recessive
(C.) Autosomal recessive
(D.) Autosomal dominant
(E.) Incompletely dominant
(1999 #56)

Questions 19-20 refer to the birth of a child with blood type A to a mother with blood
type B

19. The father must have which of the following blood types?
(A.) AB only
(B.) Either AB or B
(C.) Either AB or O
(D.) Either AB or A
(E.) AB or A or O
(1999 #102)

20. If the father has blood type AB, which of the following statements is correct
about the mother?

(A.) She contributes an IB allele, which is recessive to the father’s IA allele.


(B.) She contributes an i allele, which is recessive to the father’s IA allele.
(C.) She contributes an IB allele, which is codominant to the father’s IA allele.
(D.) She contributes an i allele, which is codominant to the father’s IB allele.
(E.) She is homozygous for the IB allele.
(1999 #103)

Copyright © 1970 to 2005 by College Entrance Examination Board, Princeton, NJ. All rights reserved. For face-to-face teaching purposes,
classroom teachers are permitted to reproduce the questions. Web or Mass distribution prohibited.
Questions 21-22

21.
Which of the following statements about this population is correct?
(A.) This is an example of heterozygote superiority.
(B.) This is an example of balanced polymorphism.
(C.) The red beetles feed on the black beetles.
(D.) The gene frequency of the black variety is increasing overall.
(E.) There is no differential mortality.
(1986 #98)

22. The most likely conclusion from the information in the graph is that

(A) ladybird beetles mate in the fall, but the eggs so not hatch until the following
spring
(B) two different species are involved
(C) there are more red beetles in the fall than in the spring of each year
(D) the allele for red color is codominant with the allele for black
(E) one variety may be adaptively superior at one time and the other variety at another
time
(1986 #99)

Copyright © 1970 to 2005 by College Entrance Examination Board, Princeton, NJ. All rights reserved. For face-to-face teaching purposes,
classroom teachers are permitted to reproduce the questions. Web or Mass distribution prohibited.

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