Flexible Bioactive Glass Nanofiber-Based Self-Expanding Cryogels with

Superelasticity and Bioadhesion Enabling Hemostasis and Wound Healing

Xuyan Lu,†,§ Zirui Liu,‡,§ Qirui Jia,‡ Qiusheng Wang,† Qi Zhang,*,‡ Xiaoran Li,*,† Jianyong

Yu,† and Bin Ding*,†

†Innovation Center for Textile Science and Technology, College of Textiles, Donghua

University, Shanghai 201620, China.

‡School of Radiation Medicine and Protection, State Key Laboratory of Radiation Medicine

and Protection, Medical College of Soochow University, Suzhou, Jiangsu 215123, China.

*E-mail: qzhang2012@suda.edu.cn; xiaoranli@dhu.edu.cn; binding@dhu.edu.cn

§X.Y.L. and Z.R.L. contributed equally to this work.

Supporting Information contains:

Movies S1−5

Figures S1−9

1
Description of Movie S1−5

Movie S1
Underwater compression process of the BGNCs.

Movie S2
Injection and self-expanding behavior of the BGNCs.

Movie S3
Hemostatic performance of the BGNCs in rabbit liver noncompressible hemorrhage model.

Movie S4
Hemostatic performance of the BGNCs in rabbit femoral artery hemorrhage model.

Movie S5
Hemostatic performance of the BGNCs in rat heart hemorrhage model.

2
Figure S1. Schematic illustration of the crosslinking network of PVA on the nanofiber surface.

Figure S2. EDS spectra of the flexible BG nanofibers.

3
Figure S3. (a) FESEM image and (b) nanofiber length distribution of the homogenized BG

fibers.

Figure S4. (a) Photographs of the PVA gels and BGNCs. (b) FESEM image of the PVA gels.

4
Figure S5. Schematic of the inversion of the fibrous cell walls.

Figure S6. (a) Adhesion energy of BGNCs on the dry outer part (organ capsule) and wet inner

part (parenchyma) of porcine liver. (b) Comparison of the adhesion energy of commercially

available gelatin sponges, PVA gels, and BGNCs on diverse porcine tissue surfaces.

5
Figure S7. The weight loss of the BGNCs after soaking in Tris-HCl solution at 7, 14, 21, and

28 days.

Figure S8. Photographs of subcutaneously implanted PVA gels and BGNCs in rats at 14 and

28 days.

6
Figure S9. H&E staining images showing the PVA gels and BGNCs and the nearby tissues

after (a) 14 days and (a) 28 days post-implantation.