Virology Exam 2018/2019 Test 44

Single Choice Questions

1. The main cellular effect of the innate immune response during viral infection are:
A. T-Helper cells

B. T cytotoxic cells

C. Antigen representing cells

D. NK cells

2. Viral Antigen presented by MHC class II molecule interacts with:

A. B Cells

B. T CD4 +

C. NK Cells

D. T CD8 Cells

3. Herpes simplex viruses establish latency in:

A. T helper cell

B. B Cells

C. Sensory neurones

D. Motor neurones

4. The following virus can cross the placenta, causing severe congenital abnormalities in
new borns:
A. Measles

B. Rubella

C. Herpes simplex 1

D. Mumps

5. The high rate of chronic infection associated with Hepatitis B virus infection in new
borns is due to:
A. Reverse transcriptase erros

B. Mini genes reassortment

C. Immunotolerance

D. Selection of core/precore mutation

6. Negri Bodies are specific for the following virus:
A. West Nile

B. Zika

C. Measles

D. Rabies

7. The following virus is the ethnological agent of infectious mononucleosis:

A. Measles

B. Epestein Bar Virus

C. Cytomegalovirus

D. Human herpes virus 8

8. Inactivated polio vaccine:

A. Can cause selection of neurotropic revertants

B. Is orally administrated

C. Is administrated by intramuscular injection

D. Is stable at high temperature

9. Subacute sclerosing panencephalitis is a late complication of infection with:

A. Measles

B. Rubella

C. Varicella virus

D. Influenza virus type A

10. Which virus replicates through reverse transcription:

A. Hepatitis C

B. HTLV

C. Hepatitis E

D. Hepatitis D

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Virology Exam 2018/2019 Test 44
Multiple Choice Questions

1. Which events occur during the eclipse phase of viral life cycle
A. Attachment to cell receptor

B. Viral entery

C. Progeny virion release

D. Uncoating

2. West Nile virus:

A. Causes epidemias of severe meningoencephalitis

B. Is transmitted by tick bites

C. Is an positive single stranded RNA virus

D. Causes epidemias of viral hemorrhagic fever with high lethality

3. Which viral genomes serve directly as an mRNA:

A. Polio

B. Influenza A

C. Hepatitis C

D. Measles

4. HIV macrophagotropic strains:

A. Use CCR5 co-receptors

B. Use CXCR4 co-receptors

C. Are syncytium inducing

D. Predominate during the early viral infection

5. The following markers are associated with HBV infectivity:

A. HBs antibodies

B. HBeAg

C. HBV DNA

D. HBe antibodies

6. Persistent HPV infection:

A. Occurs in non permissive cells

B. Can cause cell transformation

C. Causes condyloma accuminata in genital infection

D. Are frequently associated with integration of the viral genome

7. Anti HBs antibodies can indicate:

A. Active chronic hepatitis B

B. Acute hepatitis B

C. Efficient anti hepatitis B vaccination

D. Resolved infection

8. Coxsackie A viruses:
A. Cause frequent asymptomatic infections

B. Can cause aseptic meningitis

C. Are transmitted via enteric routes

D. Are non enveloped positive sense single stranded RNA viruses

9. Latency during Herpes virus infection is characterised by:

A. Absence of progeny virions

B. Expression of non-coating RNAs-LAT

C. Sequential expression of IE-E-L genes

D. Integration of viral DNA in the cells DNA

10. During HIV replication a cellular citidin deaminase-APOBEC3G:

A. Apposes proviral DNA integration

B. Apposes HIV reverse transcription

C. Is blocked by the viral accessory protein-vif

D. Is blocked by the viral regulatory portion-nef

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Virology Exam 2018/2019 Test 44
Open Questions

1. A patient has a positive result in an ELISA test for anti HCV antibodies. What other
markers have to be tested in order to have a diagnosis? Explain the particular features
of this virus replication. Which phases in the viral life cycle can be targeted by specific
antivirals? Can this infection be cured? Why?
2. A 78 years old male is diagnosed with influenza. What are the virological tests indicated
for conformation? What are the possible complications? How can you treat the patient?
What are the mechanisms of the recommended antivirals? How can you explain the
variability of influenza viruses?

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