Solubilidad

Solvente Densidad (g/mL) (g paracetamol/ Kg solvent)

Agua 1 17.39
methanol 0.791 371.61
ethanol 0.789 232.75
1,2-ethanediol 1.115 144.3
1-propanol 0.803 132.77
2-propanol 0.785 135.01
1-butanol 0.809 93.64
1-pentanol 0.811 67.82
1-hexanol 0.814 49.71
1-heptanol 0.822 37.43
1-octanol 0.827 27.47
acetone 0.786 111.65
2-butanone 0.805 69.99
4-methyl-2-pentanone 0.802 17.81
tetrahydrofuran 0.886 155.37
1,4-dioxane 1.033 17.08
ethyl acetate 0.894 10.73
acetonitrile 0.786 32.83
diethylamine 0.708 1316.9
N,N-dimethylformamide 0.944 1012.02
dimethyl sulfoxide 1.092 1132.56
acetic acid 1.049 82.72
dichloromethane 1.326 0.32
chloroform 1.483 1.54
carbon tetrachloride 1.59 0.89
toluene 0.867 0.34
 Solubilidad
(mg paracetamol / mL solvente) Constante Dielectrica
17.39 80.1 1400
293.94351 32.7
183.63975 24.5 1200
160.8945 39.3
106.61431 20.1
105.98285 18.3 1000
75.75476 17.8
55.00202 13.9 800
40.46394 13.3

Solubilidad
30.76746 12.1
22.71769 10.3 600
87.7569 20.7
56.34195 18.5 400
14.28362 13.1
137.65782 7.58
17.64364 2.25 200
9.59262 6.02
25.80438 37.5 0
932.3652 3.6 .1 .5 .1 .8 .3
80 24 20 17 13
955.34688 36.7
1236.75552 46.7
86.77328 6.15
0.42432 8.93
2.28382 4.81
1.4151 2.24
0.29478 2.38
 1400

1200

1000 80.1 32.7

24.5 39.3
20.1 18.3
800
17.8 13.9
Solubilidad

13.3 12.1
600 10.3 20.7
18.5 13.1
7.58 2.25
400 6.02 37.5
3.6 36.7
46.7 6.15
200 8.93 4.81
2.24 2.38

0
.1 .5 .1 .8 .3 .3 .5 58 02 3.
6 .7 93 24
80 24 20 17 13 10 18 7. 6. 46 8. 2.

Constante dieléctrica
 80.1 32.7
24.5 39.3
20.1 18.3
17.8 13.9
13.3 12.1
10.3 20.7
18.5 13.1
7.58 2.25
6.02 37.5
3.6 36.7
46.7 6.15
8.93 4.81
2.24 2.38

24
2.
 Solubilidad Constante Dielectrica
Solvente (mg paracetamol / mL solvente)
1400
carbon tetrachlor 1.4151 2.24
1,4-dioxane 17.64364 2.25
toluene 0.29478 2.38 1200
diethylamine 932.3652 3.6
chloroform 2.28382 4.81
1000
ethyl acetate 9.59262 6.02
acetic acid 86.77328 6.15
tetrahydrofuran 137.65782 7.58 800
dichloromethane 0.42432 8.93

solubilidad
1-octanol 22.71769 10.3 600
1-heptanol 30.76746 12.1
4-methyl-2-pent 14.28362 13.1
400
1-hexanol 40.46394 13.3
1-pentanol 55.00202 13.9
1-butanol 75.75476 17.8 200
2-propanol 105.98285 18.3
2-butanone 56.34195 18.5
0
1-propanol 106.61431 20.1 24 38 81
2. 2. 4.
acetone 87.7569 20.7
ethanol 183.63975 24.5
methanol 293.94351 32.7
N,N-dimethylfor 955.34688 36.7
acetonitrile 25.80438 37.5
1,2-ethanediol 160.8945 39.3
dimethyl sulfoxid 1236.75552 46.7
Agua 17.39 80.1
 1400

1200

1000

800
solubilidad

600
Column B

400

200

0
24 38 81 15 93 .1 .3 .8 .5 .7 .7 .5 .7
2. 2. 4. 6. 8. 12 13 17 18 20 32 37 46

constante dielectrica
Column B
 Solubilidad
Solvente (mg paracetamol / mL solvente) Constante Dielectrica
toluene 0.29478 2.38
dichloromethane 0.42432 8.93
1400
carbon tetrachlor 1.4151 2.24
chloroform 2.28382 4.81
1200
ethyl acetate 9.59262 6.02
4-methyl-2-pent 14.28362 13.1 1000
Agua 17.39 80.1
1,4-dioxane 17.64364 2.25 800
1-octanol 22.71769 10.3

solubilidad
acetonitrile 25.80438 37.5 600
1-heptanol 30.76746 12.1
1-hexanol 40.46394 13.3 400
1-pentanol 55.00202 13.9
2-butanone 56.34195 18.5 200
1-butanol 75.75476 17.8
acetic acid 86.77328 6.15 0
38 24 02 .1
acetone 87.7569 20.7 2. 2. 6. 80
2-propanol 105.98285 18.3
1-propanol 106.61431 20.1
tetrahydrofuran 137.65782 7.58
1,2-ethanediol 160.8945 39.3
ethanol 183.63975 24.5
methanol 293.94351 32.7
diethylamine 932.3652 3.6
N,N-dimethylfor 955.34688 36.7
dimethyl sulfoxid 1236.75552 46.7
 1400

1200

1000

800
solubilidad

600
Column B
400

200

0
38 24 02 .1 .3 .1 .9 .8 .7 .1 .3 .7 .7
2. 2. 6. 80 10 12 13 17 20 20 39 32 36

constante dielectrica