TITLE AUTHORS
 Studies have documented
Documentation of
Underutilized Fruit Trees
(UFTs) across indigenous
communities in West Java,
Indonesia
Traditional preparations and
methanol extracts of
medicinal plants from Papua
New Guinea exhibit similar
cytochrome P450 inhibition
Cholesterol lowering
potentials of a blend of
standardized methanol
extracts of Moringa oleifera
INFORMATION
Mochammad Fikry Pratama,
Angga Dwiartama, Dian
Rosleine, Rizqi Abdulharis,
Arifin Surya Dwipa Irsyam
Erica C. Larson, Christopher D.
Pond, Prem P. Rai, Teatulohi
K. Matainaho, Pius Piskaut,
Michael R. Franklin, and Louis
R. Barrows
Gururaja, G.M., Deepak
Mundkinajeddu, Senthil
Kumar A., Joshua Allan J,
Shekhar M. Dethe, Amit
CITATION CATEGORY CONTRIBUTOR
the importance of fruits as
an additional source of
nutrition, including vitamins,
minerals, and fibers, which
altogether contribute to
food security
 Underutilized Fruit Tress
Underutilized Fruits and Fruit
(UFTs) are tree species [CITATION PRA19 \l 1033 ] Leah Zaldua
Trees
which edible fruits are
consumed locally, but less
known in a wider
geographical context.
 UFTs, as a consequence,
exist in a very low
dominance.
 The data indicate that
methanol extraction of
dried plant material is
probably a reasonable
surrogate preparation
method when fresh plant
samples cannot be obtained
for analysis.
Method; Traditional
 Factors that influence use of [CITATION Lar \l 1033 ] Leah Zaldua
Medicine
traditional medicine for
health promotion include
cost of Western medicines,
limited access to
distribution centers, and
poorly stocked aid posts
and healthcare facilities in
rural areas
 Hypercholesterolemia is the
root cause for major health Hypercholesterolemia and
issues like coronary heart [ CITATION Gur16 \l 1033 ] Leah Zaldua
Statins; Method
disease and atherosclerosis.

leaves and fruits in albino
Wistar rats
2018
AHA/ACC/AACVPR/AAPA/ABC Stone, Alison L. Bailey, Craig
/ Beam, Kim K. Birtcher, Roger
ACPM/ADA/AGS/APhA/
ASPC/NLA/PCNA Guideline on
management of blood
cholesterol: Executive
Agarwal
Scott M. Grundy, Neil J.
S. Blumenthal, Lynne T.
Braun, Sarah de Ferranti,
Joseph Faiella-Tommasino,
Daniel E. Forman, Ronald
Control of plasma
cholesterol, a biosynthetic
product in the human body,
has become one of the main
therapeutic strategies to
effectively control these
diseases
 Elevated cholesterol in the
blood can cause coronary
artery diseases
 Statins (STs) are drugs of
the first choice for the
patients with
hypercholesterolemia,
especially in those who are
at high cardiovascular risk.
However, some of these
patients are intolerant to
STs
 Though many synthetic
drugs have been established
for reduction of cholesterol,
still there is a need for
searching natural remedies
for the treatment due to
side effects associated with
conventional drug therapy.
 (Methodology portion of
research may serve as
reference for own study)
 (May be used as a guide in
own study)
 Among lipid-lowering drugs, [ CITATION Gru19 \l 1033 ] Statins Leah Zaldua
statins are the cornerstone
of therapy, in addition to
healthy lifestyle
interventions. Other LDL-
lowering drugs include
ezetimibe, bile acid

Heidenreich, Mark A. Hlatky,
Pajares, Chiadi E. Ndumele,
summary
Sidney C. Smith JR, Laurence
Phytochemical profile and
acute toxicity studies of
ethanolic extract
of Syzygium alternifolium
(WIGHT) WALP.
Acute and subacute toxicity of
methanol extract of Syzygium
guineense leaves on the
histology of the liver and
kidney and biochemical
compositions of blood in rats
Goldberg, Paul A.
Daniel W. Jones, Donald
Lloyd-Jones, Nuria Lopez-
Carl E. Orringer, Carmen A.
Peralta, Joseph J. Saseen,
Sperling, Salim S. Virani,
Joseph Yeboah,
S. Mohan, N.
Chidambaranathan, Grace
Lydial Pushpalatha, M.
Dhanasekaran, and G. C
Abraham
Million Loha, Abay Mulu,
Solomon M. Abay,
Wondwossen Ergete, and
Bekesho Geleta
sequestrants, and PCSK9
inhibitors. Triglyceride-
lowering drugs are fibrates
and niacin; they have a mild
LDL lowering action, but
RCTs do not support their
use as add-on drugs to
statin therapy
 (Contains doses for statins)
 Syzygium (Myrtaceae) is
among the largest genus of
Dicotyledonae which is pan
global with about 1,200
species reported from
around the world
 Ethanol extract made by
[ CITATION Moh19 \l 1033 ] Syzygium, Method Prince Hibo
continuous hot percolation
method was tested for its
phytochemical constituents
and were evaluated for its
toxic effects.
 (Contains different tests for
constituent identification)
 Herbal medicine flourishes [ CITATION Loh19 \l 1033 ] Herbal Medicine; Method Prince Hibo
today as the primary form of
medicine for perhaps as
much as 80% of the world’s
population. Usually, a
specific part of the plant
(root, leaves, fruit, flowers,
 and seeds) is used in
traditional preparations or
as pure active principles
formulated into a suitable
preparation. Many
medicines commonly used
today are of herbal origin.
Indeed, about 25% of
prescription drugs contain
at least one active
ingredient derived from
plant material.
 2.1. Collection and
Extraction of Plant Materials
(reference for method)
 Detected the presence of
one particular type of
anthocyanin of the fruit
extract of igot, the cyanidin
Isolation and partial
 The extract from the fruit of
characterization of
Syzygium poleycephaloides
anthocyanin in Syzygium
Melinda C. Getalado Merr. C. Rob. contains a bio- [ CITATION Get19 \l 1033 ] Syzygium polycephaloides Prince Hibo
poleycephaloides MERR C. B.
chemically active substance,
Rob.(IGOT)fruit extract by thin
in which the experimental
layer chromatography
work of this research was
identified as anthocyanin
with rich color of deep red
of considerable amount.

 One of the greatest benefits

In vitro antibacterial activity of associated with herbal
crude ethanolic extract from medicine is the less
Jasmine P. Camacho and Herbal Medicines; Syzygium
the leaves of lipote (Syzygium existence of side effects. [ CITATION Cam18 \l 1033 ] Prince Hibo
Samantha Joy N. Valenzuela polycephaloides
polycephaloides) against They also have an
Mycobacterium tuberculosis advantage of being very

Potency of turmeric (Curcuma
longa L.) extract and curcumin
as anti-obesity by inhibiting
the cholesterol and
triglycerides synthesis in
HepG2 cells
cheap in comparison to the
conventional form of
medication
 Medicinal plants and their
derivatives are natural
resources that play critical
roles in modern drug
development
 Lipote (Syzygium
polycephaloides) is a
syzygium specie that is
endemic in the Philippines.
It is a small to medium-sized
tree found in primary
forests at low and medium
altitude. Lipote is
occasionally cultivated for
its edible fruit
 Lipote has high total
flavonoid content, and
flavonoids are known as an
antibacterial agent against a
wide range of pathogenic
microorganisms
 Lipote (Syzygium
polycephaloides) will be
used in this study as it is a
native plant in the
Philippines and despite their
potential as a source of
drugs, lipote does not have
a lot of studies.
Iwan Budiman, Rita  High fat diet associated with [ CITATION Bud15 \l 1033 ] Cholesterol in correlation Tonette Caratao
Tjokropranoto, Wahyu obesity correlated with with obesity
Widowati, Nurul Fauziah, elevated level of the
Pande Putu Erawijantari cholesterol and triglycerides
that caused adipogenesis.
 Inhibiting the synthesis of
cholesterol and triglycerides

Lipid-lowering property of
Clausena anisum-olens in
hypercholesterolemic rats
Antilipidemic properties of
Calpurnia aurea leaf extract on
high-fat diet induced
hyperlipidemia
Effect of ethanol/water
solvents on phenolic profiles
and antioxidant properties of
Beijing propolis extracts
Anbel M. Bautista, Mario A.
Tan, Jovencio M. Apostol
Welde Mengistu, Seifu Daniel,
Natesan Gnanasekaran
Chunli Sun, Zhengshuang Wu,
Ziyan Wang, and Hongcheng
Zhang
as anti-adipogenesis
become an important role
in antiobesity agent.
 (Refer to Methodology of
study. Philippine-based [ CITATION Bau17 \l 1033 ] Method Tonette Caratao
study)
 Hyperlipidemia is described
by raised in the plasma
lipids including triglycerides 
(TG), cholesterols,
cholesterol esters,
phospholipids as well as
plasma lipoproteins, for [ CITATION Men19 \l 1033 ] Method Tonette Caratao
example, very low-density
lipoprotein (LDL), LDL, and
reduction in the circling
high-density lipoprotein 
(HDL) levels.
 (Refer to Methodology)
 The advantages of the [ CITATION Sun15 \l 1033 ] Method (Ethanol and Water Tonette Caratao
method are simple Extracts)
operation and low energy
consumption. Among
extraction solvents,
nonpolar organic solvents
mainly include ethyl
acetate, chloroform, and n-
butanol and polar solvents
 water, methanol, and
ethanol.
 In previous research,
compared to ethanol
extracts, chloroform, n-
butanol, and ethyl acetate
extracts of propolis
contained the higher
content of total phenolics
and exhibited the strongest
antioxidant activity
 On the contrary, other
studies revealed that
ethanol/water solvents
were more effective in
extracting phenolic
compounds than water, and
the ethanol extracts
exhibited a higher
antioxidant activity than
aqueous extract
 different extraction solvents
can affect phenolic
composition and
antioxidant properties of
propolis extracts.

In vitro evaluation of Gopinath Krishnasamy,  Ethanol extract of S. [ CITATION Kri15 \l 1033 ] Ethanol extract; Method Marjorie Huete
antioxidant and antidiabetic Karthikeyan Muthusamy densiflorum fruits showed
activities of Syzygium higher activity with
densiflorum fruits statistical significance vs.
ethyl acetate and n-hexane
extracts.
 Powered S. densiflorum
dried fruits were subjected

In vivo antihyperglycemic,
antihyperlipidemic,
antioxidative stress and
antioxidant potential activities
of Syzygium paniculatum
Gaertn. in
Streptozotocininduced
diabetic rats
Phytochemical composition
and pleotropic
pharmacological properties of
jamun, Syzygium cumini skeels
Prabhakar Yellanur Konda,
Sreenivasulu Dasari, Sreenath
Konanki, Prabhusaran
Nagarajan
Ganesh Chandra Jagetia
to successive extraction
with n-hexane, ethyl
acetate, and ethanol using a
Soxhlet extractor. Further,
preliminary phytochemical
screening was carried out
with a series of tests. In
vitro free radical scavenging
was evaluated using total
antioxidant estimation, 2,2-
diphenyl-1-picrylhydrazyl
radical, superoxide radical
scavenging, and hydroxyl
radical scavenging assays.
Antidiabetic activity was
estimated using α-amylase
inhibition assay.
 There is a need to find the
medicine without side
effects. Compounds of
medicinal plants were
nontoxic, inexpensive and
Medicinal plants; Syzygium
less or no side effects. [ CITATION Kon19 \l 1033 ] Marjorie Huete
paniculatum
 S. paniculatum possesses
potential antihyperglycemic,
antihyperlipidemic,
antioxidative stress and
antioxidant activity.
 Diabetes afflicts a large [ CITATION Jag17 \l 1033 ] Syzygium cumini Marjorie Huete
number of the world’s
population, and Indians are
especially prone to it.
Despite the fact that this
ailment was uncommon in
ancient times, Ayurveda

Mario Walean, Rostina
Phytochemical screening and
Melpin, Mervina Rondonuwu,
biological activities of pakoba
Kinzie Feliciano Pinontoan,
(Syzygium luzonense) stem
Hendra Pratama Maliangkay,
bark ethanol extract
Meli Astriani
pharmacopeia mentions the
antidiabetic effect of Jamun,
whereby its seed powder is
reported to control high
blood sugar levels
 Preclinical evaluation has
shown that Jamun
possesses several medicinal
activities, including
antioxidant, antibacterial,
antifungal, antiallergic,
antiinflammatory,
antidiabetic
antihyperlipidemic,
gastroprotective,
cardioprotective,
hepatoprotective,
anticancer, and
radioprotective
 It lowers blood suga
 Previous studies have
reported the ability of
bioactivity of Syzygium
species [ CITATION Wal20 \l 1033 ] Syzygium Marjorie Huete
 The genus Syzygium is rich
in bioactive compounds as
antioxidants

Joint position statement on
“Nutraceuticals for the
treatment of
hypercholesterolemia” of the
Italian Society of Diabetology
(SID) and of the Italian Society
for the Study of
M. Pirro, C. Vetrani, C.  The initial therapeutic [ CITATION Pir17 \l 1033 ] Nutraceuticals Camille Orillo
Bianchi, M.R. Mannarino, F. approach to
Bernini, A.A. Rivellese hypercholesterolemia
includes dietary
modifications but the
compliance to
recommendations is often

Arteriosclerosis (SISA)
Lipote (Syzygium
polycephaloides)
Evaluation of cholesterol-
lowering activity of Mundkinajeddu, A. Senthil
standardized extract
of Mangifera indica in albino Dethe, J. Joshua Allan, Amit
Wistar rats
inadequate.
 Some dietary components
with potential cholesterol-
lowering activity are present
in small amounts in food.
Therefore, in recent years
the use of “nutraceuticals”
(i.e., nutrients and/or
bioactive compounds with
potential beneficial effects
on human health) has
become widespread. Such
substances may be added to
foods and beverages, or
taken as dietary
supplements (liquid
preparations, tablets,
capsules).
 (General information on
Ecosystems Research and
Lipote) [ CITATION Eco17 \l 1033 ] Syzygium polycephaloides Camille Orillo
Development Bureau
G.M. Gururaja, Deepak  (Refer to methodology.
Methanol extract was used)
Kumar, Shekar Michael [ CITATION Gur17 \l 1033 ] Method Camille Orillo
Agarwal

Global health risks: mortality
and burden of disease
attributable to selected major
risks
World Health Organization
 Diets high in saturated fat, [ CITATION Wor19 \l 1033 ] High cholesterol Camille Orillo
physical inactivity and
genetics can increase
cholesterol levels. Recent
research shows that levels
of low-density lipoproteins
and high-density
 lipoproteins are more
important for health than
total cholesterol.
 Cholesterol increases the
risks of heart disease, stroke
and other vascular diseases.
Globally, one third of
ischaemic heart disease is
attributable to high blood
cholesterol. High blood
cholesterol increases the
risk of heart disease, most
in the middle-income
European countries, and
least in the low- and middle-
income countries in Asia.
References
Bautista, A. M., Tan, M. A., & Apostol, J. M. (2017). Lipid-lowering property of Clausena anisum-olens in hypercholesterolemic rats. Pharmaceutical Biology, 55(1), 833-836. doi:10.1080/13880209.2016.1260596

Budiman, I., Tjokoropranoto, R., Widowati, W., Fauziah, N., & Erawijantari, P. P. (2015, May). Potency of tumeric (Curcuma longa L.) extract and curcumin as anto-obesity by inhibiting the cholesterol and
triglycerides synthesis in HepG2 cells. International Journal of Research in Medical Sciences, 3(5), 1165-1171. doi:10.5455/2320-6012.ijrms20150525

Camacho, J. P., & Valenzuela, S. N. (2018, October). In vitro antibacterial activity of crude ethanolic extract from the leaves of lipote (Syzygium polycephaloides) against Mycobacterium tuberculosis.

Ecosystems Research and Development Bureau. (2017). Lipote (Syzygium polycephaloides)(C.B. Rob.) Merr. Research Information Series on Ecosystems, 29(2).

Getalado, M. C. (2019). Isolation and partial characterization of anthocyanin in Syzygium polycephaloides MERR C. B. ROB. (IGOT) fruit extract by thin layer chromatography. J.Bio.Innov, 8(3), 364-374.

Grundy, S. M., Stone, N. J., Baiely, A. L., Beam, C., Birtcher, K. K., Bluementhal, R. S., . . . Yeboah, J. (2019). 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the
managament of blood cholesterol: Executive summary. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 73(24), 3168–3209. Retrieved from https://doi.org/10.1016/j.jacc.2018.11.002

Gururaja, G. M., Mundkinajeddu, D., Senthil, K. A., Allan, J. J., Dethe, S. M., & Agarwal, A. (2016). Cholesterol lowering potentials of a blend of standarized methanol extracts of Moringa oleifera leaves and fruits
in albino Wistar rats. International Journal of Pharmacy and Pharmaceutical Sciences, 8(11), 262-268. Retrieved from http://dx.doi.org/10.22159/ijpps.2016v8i11.14014

Gururaja, G., Mundkinajeddu, D., Kumar, A. S., Dethe, S. M., Allan, J. J., & Agarwall, A. (2017). Evaluation of cholesterol-lowering activity of standardized extract of Mangifera indica in albino Wistar rats.
Pharmacognosy Research, 9(1), 21-26. doi:10.4103/0974-8490.199770

Jagetia, G. C. (2017). Phytochemical composition and pleotropic pharmacological properties of Jamun, Syzygium cumini skeels. J Explor Res Pharmacol, 2(2), 54-66. doi:10.14218/JERP.2016.00038.

Konda, P. Y., Dasari, S., Konanki, S., & Nagarajan, P. (2019). In vivo antihyperglycemic, antihyperlipidemic, antioxidative stress and antioxidant potential activities of Syzygium paniculatum Gaertn. in
Streptozotocin-induced diabetic rats. Heliyon, 5. Retrieved from https://doi.org/10.1016/j.heliyon.2019.e01373

Krishnasamy, G., & Muthusamy, K. (2015). In vitro evaluation of antioxidant and antidiabetic activities of Syzygium densiflorum fruits. Asian Pacific Journal of Tropical Disease, 5(11), 912-917. Retrieved from
https://doi.org/10.1016/S2222-1808(15)60956-2

Larson, E. C., Pond, C. D., Rai, P. P., Matainaho, T. K., Piskaut, P., Franklin, M. R., & Barrows, L. R. (2016). Traditional preparations and methanol extracts of medicinal plants form Papua New Guinea exhibit
similar cytochrome P450 inhibition. Evidence-Based Complementary and Alternative Medicine, 2016, 1-6. Retrieved from http://dx.doi.org/10.1155/2016/7869710

Loha, M., Mulu, A., Abay, S. M., Ergete, W., & Geleta, B. (2019). Acute and subacute toxicity of methanol extract of Syzygium guineense leaves on the histology of the liver and kidney and biochemical
compositions of blood in rats. Evidence-Based Complementary and Alternative Medicine, 2019, 1-15. Retrieved from https://doi.org/10.1155/2019/5702159

Mengistu, W., Daniel, S., & Gnanasekaran, N. (2019, October-December). Antilipidemic properties of Calpurnia aurea leaf extract on high-fat diet induced hyperlipidemia. Pharmacognosy Research, 11(4), 389-
395. doi:10.4103/pr.pr_10_18

Mohan, S., Chidambaranathan, N., Pushpalatha, G. L., Dhanasekaran, M., & Abraham, G. (2019). Phytochemical profile and acute toxicity studies of ethanolic extract of Syzygium alternifolium (WIGHT) WALP.
INTERNATIONAL RESEARCH JOURNAL OF PHARMACY, 10(11), 38-43. Retrieved from http://dx.doi.org/10.7897/2230-8407.1011317
Pirro, M., Vetrani, C., Bianchi, C., Mannarino, M., Bernini, F., & Rivellese, A. (2017, January). Joint position statement on “Nutraceuticals for the treatment of hypercholesterolemia” of the Italian Society of
Diabetology (SID) and of the Italian Society for the Study of Arteriosclerosis (SISA). Nutrition, Metabolism and Cardiovascular Diseases, 27(1), 2-17. Retrieved from
https://doi.org/10.1016/j.numecd.2016.11.122

Pratama, M. F., Dwiartama, A., Rosleine, D., Abdulharis, R., & Irsyam, A. D. (2019, September). Documentation of Underutilized Fruit Trees (UFTs) across indigenous communities in West Java, Indonesia.
BIODIVERSITAS, 20(9), 2603-2611. doi:10.13057/biodiv/d200924

Sun, C., Wu, Z., Wang, Z., & Zhang, H. (2015). Effect of ethanol/water solvents on pheolic profiles and antioxidant properties of Beijing propolis extracts. Evidence-Based Complementary and Alternative
Medicine, 2015, 1-9. Retrieved from http://dx.doi.org/10.1155/2015/595393

Walean, M., Melpin, R., Rondonuwu, M., Pinontoan, K. F., Maliangkay, H. P., & Astriani, M. (2020). Phytochemical screening and biological activities of pakoba (Syzygium luzonense) stem bark ethanol extract.
BIODIVERSITAS, 21(6), 2377-2382. doi:10.13057/biodiv/d210606

World Health Organization. (2019). Global health risks: mortality and burden of disease attributable to selected major risks. World Health Organization. Retrieved from
https://apps.who.int/iris/handle/10665/44203