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  • Principles of Muscle Biopsy

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    Muscle biopsies are indicated to evaluate causes of muscle weakness like myopathies or neuropathies, inflammatory myopathies, metabolic diseases, and drug-induced myopathies. The quadriceps, deltoid or biceps muscles should be biopsied as they are moderately affected and allow disease progression to be monitored. The procedure involves an open skin incision or needle biopsy of the muscle belly under local anesthesia to avoid crushing or stretching the sample.

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    Muscle biopsies are indicated to evaluate causes of muscle weakness like myopathies or neuropathies, inflammatory myopathies, metabolic diseases, and drug-induced myopathies. The quadriceps, deltoid or biceps muscles should be biopsied as they are moderately affected and allow disease progression to be monitored. The procedure involves an open skin incision or needle biopsy of the muscle belly under local anesthesia to avoid crushing or stretching the sample.

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    18 views1 page

    Principles of Muscle Biopsy

    Uploaded by

    NEPDOC OFFICIAL
    Muscle biopsies are indicated to evaluate causes of muscle weakness like myopathies or neuropathies, inflammatory myopathies, metabolic diseases, and drug-induced myopathies. The quadriceps, deltoid or biceps muscles should be biopsied as they are moderately affected and allow disease progression to be monitored. The procedure involves an open skin incision or needle biopsy of the muscle belly under local anesthesia to avoid crushing or stretching the sample.

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    © All Rights Reserved
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    Principles of Muscle Biopsy

    Indications
    1. Muscle weakness – static and progressive
    2. Differentiate myogenic and neurogenic causes of weakness
    3. Inflammatory myopathy and collagen vascular diseases
    4. Metabolic diseases affecting muscles
    5. Drug induced myopathy
    6. To assess disease progress and prognosis

    Selection of muscle
    1. Moderately affected or muscle in which disease is evolving should be selected
    2. Ideal site – Quadriceps, deltoid, biceps
    3. Should be taken from muscle belly away from tendinous insertion
    Procedure
    1. Open
    a. Skin incision under LA
    b. Avoid infiltration of anesthetic into muscle
    2. Needle
    Precautions
    1. Do not crush
    2. Do not stretch
    3. Do not immerse directly into saline

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